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| 1 | RVFL-Based Optical Fiber Intrusion Signal Recognition With Multi-Level Wavelet Decomposition as Feature显示文摘光纤维警告前系统(OFPS ) 逐渐地为监视的管道安全被看作了重要工具之一。侵入信号类型正确地被识别它能减少解决和管道的维护的费用。大多数在 OFPS 的以前的特征抽取方法通常从时间领域的看法被寻找。在一些情况中,然而,在时间领域没有区分的特征。在第一,侵入信号跑展示的纸,挖,并且精选鹤嘴锄被多水平小浪分解在频率领域提取,也就是说,侵入信号被分解成五个乐队。第二,不同频率乐队的平均精力比率被获得,它被看作每种侵入类型的特征。最后,特征样品被送到随机的向量功能连接(RVFL ) 为训练完成信号的分类和鉴定联网。试验性的结果证明算法罐头正确地区分不同侵入信号并且完成更高的识别率。 | Yanping WANG Dianjun GONG Liping PANG Dan YANG | 2018 | Photonic Sensors2018，8，3： | 11 |
| 2 | Cyanidin-3-O-galactoside and Blueberry Extracts Supplementation Improves Spatial Memory and Regulates Hippocampal ERK Expression in Senescence-accelerated Mice显示文摘Objective To investigate whether the antioxidation and the regulation on the Extracellular Regulated Protein Kinases(ERK) signaling pathway are involved in the protective effects of blueberry on central nervous system. Methods 30 Senescence-accelerated mice prone 8(SAMP8) mice were divided into three groups and treated with normal diet, blueberry extracts(200 mg/kg·bw/day) and cyaniding-3-O-galactoside(Cy-3-GAL)(50 mg/kg·bw/day) from blueberry for 8 weeks. 10 SAMR1 mice were set as control group. The capacity of spatial memory was assessed by Passive avoidance task and Morris water maze. Histological analyses on hippocampus were completed. Malondialdehyde(MDA) levels, Superoxide Dismutase(SOD) activity and the expression of ERK were detected. Results Both Cy-3-GAL and blueberry extracts were shown effective functions to relieve cellular injury, improve hippocampal neurons survival and inhibit the pyramidal cell layer damage. Cy-3-GAL and blueberry extracts also increased SOD activity and reduced MDA content in brain tissues and plasma, and increased hippocampal phosphorylated ERK(p-ERK) expression in SAMP8 mice. Further more, the passive avoidance task test showed that both the latency time and the number of errors were improved by Cy-3-GAL treatment, and the Morris Water Maze test showed significant decreases of latency were detected by Cy-3-GAL and blueberry extracts treatment on day 4. Conclusion Blueberry extracts may reverse the declines of cognitive and behavioral function in the ageing process through several pathways, including enhancing the capacity of antioxidation, altering stress signaling. Cy-3-GAL may be an important active ingredient for these biological effects. | TAN Long YANG Hong Peng PANG Wei LU Hao HU Yan Dan LI Jing LU Shi Jun ZHANG Wan Qi JIANG Yu Gang | 2014 | Biomedical and Environmental Sciences2014，27，3： | 6 |
| 3 | Genome-wide analysis identified 17 new loci influencing intraocular pressure in Chinese population显示文摘Intraocular pressure(IOP) is a major risk factor for glaucoma. Genetic determinants of intraocular pressure can provide critical insights into the genetic architecture of glaucoma and, as a result, open new avenues for therapeutic intervention. We performed a genome-wide association study and replication analysis of 8,552 Chinese participants. In the genome-wide association study, we identified 51 loci that surpassed the significance of P<9×10^(-7), and we formally replicated these loci. A combined discovery and replication meta-analysis identified 21 genome-wide loci that surpassed the genome-wide significance of P<5×10^(-8), including 4 previously reported loci: rs145063132(7 p21.2, ETV1/DGKB), rs548030386(7 q31.2, ST7 near CAV1/CAV2), rs7047871(9 p24.2, GLIS3), and rs2472494(9 q31.1, ABCA1/SLC44 A1). Of the 17 newly identified loci, five were reported to have ocular related phenotypes: PTCH2(rs7525308 in 1 p34.1), LRIF1/DRAM2(rs1282146 in 1 p13.3), COLEC11(rs201143466 in 2 p25.3),SPTBN1(rs4514918 in 2 p16.2), and CRK(rs11078446 in 17 p13.3). The genetic loci identified in this study not only increase our understanding of the genes involved in intraocular pressure but also provide important genetic markers to improve future genetic screening and drug discovery for intraocular pressure disorders. | Lulin Huang Yuhong Chen Ying Lin Pancy O.S.Tam Yilian Cheng Yi Shi Bo Gong Fang Lu Jialiang Yang Haixin Wang Yi Yin Yong Cao Dan Jiang Ling Zhong Bai Xue Jing Wang Fang Hao Dean-Yao Lee Chi-Pui Pang Xinghuai Sun Zhenglin Yang | 2019 | Science China(Life Sciences)2019，62，2： | 4 |
| 4 | Risk factors associated with hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation显示文摘Hemorrhagic cystitis(HC)is a common complication of allogeneic hematopoietic stem cell transplantation(HSCT).The incidence is about 7%to 68%,and some patients have to suffer a long period of frequent,urgent,and painful urination,which brings great pain.This study aimed to analyze risk factors of HC and its effect on patient survival.We collected the medical records of 859 patients who underwent HSCT at our hospital between August 2016 and August 2020.Patients with and without HC were matched using propensity score matching at a 1:1 ratio based on sex,age,and diagnosis,and logistic regression analyses were used to identify factors associated with HC.We used Kaplan–Meier curves to analyze the survival rates of patients in the HC and non-HC groups.We also analyzed the relationship between BK viral load and the occurrence of HC using receiver operating characteristic curve(ROC)analysis.After propensity score matching,there were 131 patients each in the HC and non-HC groups.In the HC group,89 patients(67.9%)had mild HC(stage II°)and 43(32.1%)had severe HC(stage III–IV).The median interval between stem cell transplantation and HC development was 31(3–244)days.Univariate analysis indicated that donor age,hematopoietic stem cell source,HLA,acute graft-versus-host disease,busulfan,anti-thymocyte globulin(ATG),total body irradiation,cytomegalovirus(CMV)(urine),and BK polyomavirus(BKV)(urine)were significantly associated with HC.ATG,CMV(urine),and BKV(urine)were independent risk factors for HC based on the multivariate analysis.The Kaplan–Meier survival analysis showed no significant difference between the HC and non-HC groups(P=0.14).The 1-and 2-year survival rates in the HC group were 78.4%and 69.6%,respectively,and the corresponding rates in the non-HC group were 84.4%and 80.7%,respectively.ROC analysis indicated that a urine BKV load of 1×10^(7) copies/mL was able to stratify the risk of HC.In conclusion,when the BKV load is>1×10^(7),we needtobe aware of the potential for the development of HC. | Biao Shen Yueshen Ma Haixiao Zhang Mingyang Wang Jia Liu Jiaxin Cao Wenwen Guo Dan Feng Donglin Yang Rongli Zhang Xin Chen Qiaoling Ma Weihua Zhai Sizhou Feng Mingzhe Han Aiming Pang Erlie Jiang 无 | 2022 | Blood Science2022，4，2： | 2 |
| 5 | Detection of TMPRSS2-ETS Fusions by a Multiprobe Fluorescence in Situ Hybridization Assay for the Early Diagnosis of Prostate Cancer显示文摘 | Qi-Peng Sun Liao-Yuan Li Zhong Chen Jun Pang Wei-Jiao Yang Xiang-Fu Zhou Jian-Guang Qiu Zu-Lan Su Dan He Xin Gao | 2010 | The Journal of Molecular Diagnostics2010，，： | 1 |
| 6 | Dynamic phenotypic heterogeneity and the evolution of multiple RNA subtypes in hepatocellular carcinoma:the PLANET study显示文摘Intra-tumor heterogeneity(ITH) is a key challenge in cancer treatment, but previous studies have focused mainly on the genomic alterations without exploring phenotypic(transcriptomic and immune)heterogeneity. Using one of the largest prospective surgical cohorts for hepatocellular carcinoma(HCC)with multi-region sampling, we sequenced whole genomes and paired transcriptomes from 67 HCC patients(331 samples). We found that while genomic ITH was rather constant across stages, phenotypic ITH had a very different trajectory and quickly diversified in stage Ⅱ patients. Most strikingly, 30% of patients were found to contain more than one transcriptomic subtype within a single tumor. Such phenotypic ITH was found to be much more informative in predicting patient survival than genomic ITH and explains the poor efficacy of single-target systemic therapies in HCC. Taken together, we not only revealed an unprecedentedly dynamic landscape of phenotypic heterogeneity in HCC, but also highlighted the importance of studying phenotypic evolution across cancer types. | Weiwei Zhai Hannah Lai Neslihan Arife Kaya Jianbin Chen Hechuan Yang Bingxin Lu Jia Qi Lim Siming Ma Sin Chi Chew Khi Pin Chua Jacob Josiah Santiago Alvarez Pauline Jieqi Chen Mei Mei Chang Lingyan Wu Brian K.P.Goh Alexander Yaw-Fui Chung Chung Yip Chan Peng Chung Cheow Ser Yee Lee Juinn Huar Kam Alfred Wei-Chieh Kow Iyer Shridhar Ganpathi Rawisak Chanwat Jidapa Thammasiri Boon Koon Yoong Diana Bee-Lan Ong Vanessa H.de Villa Rouchelle D.Dela Cruz Tracy Jiezhen Loh Wei Keat Wan Zeng Zeng Anders Jacobsen Skanderup Yin Huei Pang Krishnakumar Madhavan Tony Kiat-Hon Lim Glenn Bonney Wei Qiang Leow Valerie Chew Yock Young Dan Wai Leong Tam Han Chong Toh Roger Sik-Yin Foo Pierce Kah-Hoe Chow | 2022 | National Science Review2022，9，3： | 1 |
| 7 | Montmorillonite-supported magnetite nanopartieles for the removal of hexavalent chromium from aqueous solutions 显示文摘 | Yuan Pang Fan Mingde Yang Dan | 2009 | Journal of Hazardous Materials2009，166，23： | 1 |
| 8 | New determination of astrophysical14C(n, γ)15C reaction rate from the spectroscopic factor of 15C显示文摘The14C(n,γ)15C reaction plays an important role in various astrophysical scenarios:(1)it is the slowest in the neutron induced CNO cycle which occurs in asymptotic giant branch(AGB)stars,and therefore controls this cycle[1];(2)it is one of the key reactions for predicting the primordial abundances of the heavy elements in the framework of inhomogeneous big-bang nucleosynthesis(IBBN)[2];(3)it is also important for the synthesis of heavier isotopes in neutrino driven wind scenarios for the r-process in core-collapse supernova(i.e.,Type-II supernova)explosions[3-5]. | TianLi Ma Bing Guo Dan Yang Pang ZhiHong Li Yi Su XinYue Li YangPing Shen YouBao Wang Yun Ju Li Jun Su ShengQuan Yan Sheng Zeng Gang Lian Ding Nan WeiPing Liu | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，1： | 1 |
| 9 | The behavioral significance of resting state network after stroke:A study via graph theory analysis with near-infrared spectroscopy显示文摘Accurate assessment of motor abilties for stroke patients is the basis for optimizing rehabilitation strategy.Previous studies have shown that functional connectivity under resting state(RS)is associated with motor dysfunction after stroke,However,the utlity of topological properties of RS as a potential indicator for motordeficits after stroke has been litle explored and needs more validation.in this study,near-i frared spectroscopywas used to measure the hemodynamic signals at the frontal cortex under RS and investigate the associationbetween the network topological characteristics via graph theory analysis and the motor finction for strokepatients.Seventen patients participated in this study.Our results showed that the frontal network pres ented thesmallworld properties under Rs,The global eficiency of the network was positively correlated with the Fugl.Meyer asssment(FMA)for patients.Meanwhile,there was a trend that the characteristic path length of thenetwork positively corelated with patients'FMA.Our findings suggest that,for patients with mild motordysfunction,the enhanced connection between distant fran tal areas may serve as a compensate mechanism toensure the global eficiency across the network This study demonstrates that topological properties of the frontalnetwork under RS can predict the motar functin of stroke patients to some extent,and highlightsthe clinicalpracticability of RS in stroke.The clinical trial registration number is ChicTR200040137. | Jinyan Sun Dan Wang Sisi Chen Richong Pang Hua Liu Jie Wang Yuting Zhang Congxiao Wang Aoran Yang | 2021 | Medicine in Novel Technology and Devices2021，，3： | 0 |
| 10 | Algorithm to identify circulating tumor cell clusters using in vivo flow cytometer显示文摘Recent studies in oncology have addressed the importance of detecting circulating tumor cell clusters because circulating tumor cell clusters might survive and metastasize more easily than single circulating tumor cells.Signals with larger peak widths detected by in vivo flow cytometer(IVFC)have been used to identify cell clusters in previous studies.However,the accuracy of this criterion might be greatly degraded by variance in blood°ow and the rolling behaviors of circulating tumor cells.Here,we propose a criterion and algorithm to distinguish cell clusters from single cells.In this work,we first used area-based and volume-based models for single°uorescent cells.Simulating each model,we analyzed the corresponding morphology of IVFC signals from cell clusters.According to the Rayleigh criterion,the valley between two adjacent peak signals from two distinguishable cells should be lower than 73.5%of the peak values.A novel signal processing algorithm for IVFC was developed based on this criterion.The results showed that cell clusters can be reliably identied using our proposed algorithm.Intravital imaging was also performed to further support our algorithm.With enhanced accuracy,IVFC is a powerful tool to study circulating cell clusters. | Kai Pang Dan Wei Pengfei Hai Zhangru Yang Xiaofu Weng Xunbin Wei | 2018 | Journal of Innovative Optical Health Sciences2018，，5： | 0 |
| 11 | 980 nm Near-Infrared Light-Emitting Diode Using All-Inorganic Perovskite Nanocrystals Doped with Ytterbium Ions显示文摘All-inorganic perovskite(CsPbX3)nanocrystals(NCs)have recently been widely investigated as versatile solution-processable light-emitting materials.Due to its wide-bandgap nature,the all-inorganic perovskite NC Light-Emitting Diode(LED)is limited to the visible region(400-700 nm).A particularly difficult challenge lies in the practical application of perovskite NCs in the infrared-spectrum region.In this work,a 980 nm NIR all-inorganic perovskite NC LED is demonstrated,which is based on an efficient energy transfer from wide-bandgap materials(CsPbCl3 NCs)to ytterbium ions(Yb3+)as an NIR emitter doped in perovskite NCs.The optimized CsPbCl3 NC with 15 mol%Yb3+doping concentration has the strongest 980 nm photoluminescence(PL)peak,with a PL quantum yield of 63%.An inverted perovskite NC LED is fabricated with the structure of ITO/PEDOT:PSS/poly-TPD/CsPbCl3:15 mol%Yb3+NCs/TPBi/LiF/Al.The LED has an External Quantum Efficiency(EQE)of 0.2%,a Full Width at Half Maximum(FWHM)of 47 nm,and a maximum luminescence of 182 cd/m?.The introduction of Yb3+doping in perovskite NCs makes it possible to expand its working wavelength to near-infrared band for next-generation light sources and shows potential applications for optoelectronic integration. | Zhenglan Ye Taoran Liu Dan Chen Yazhou Yang Jiayi Li Yaqing Pang Xiangquan Liu Yuhua Zuo Jun Zheng Zhi Liu Buwen Cheng | 2024 | Tsinghua Science and Technology2024，29，1： | 0 |
| 12 | Systematic CDCC calculations for ~11Be+p elastic scattering显示文摘Continuum discretised coupled-channels(CDCC) method with a ^(10)Be(0^+) + n two-body cluster model is applied to systematically analyze the elastic scattering of the halo nucleus ^(11)Be from the proton target at various incident energies below 100 MeV/nucleon.Using the renormalized ^(10)Be- p potential deduced from the ^(10)Be+ p elastic scattering data, the differential cross sections of ^(11)Be + p scattering are well reproduced by the CDCC calculations without any further adjustment parameters, demonstrating the applicability of this approach for describing the scattering of exotic nuclei based on the scattering of the less exotic core nuclei. | Jie Chen Jian Ling Lou Dan Yang Pang Yan Lin Ye | 2016 | Science China(Physics,Mechanics & Astronomy)2016，59，3： | 0 |
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