|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Lingguizhugan Decoction, a Chinese herbal formula, improves insulin resistance in overweight/obese subjects with non-alcoholic fatty liver disease: a translational approach显示文摘Lingguizhugan Decoction(LGZG)has been investigated in basic studies,with satisfactory effects on insulin resistance in non-alcoholic fatty liver disease(NAFLD).This translational approach aimed to explore the effect and underlying mechanism of LGZG in clinical setting.A randomized,double-blinded,placebo-controlled trial was performed.A total of 243 eligible participants with NAFLD were equally allocated to receive LGZG(two groups:standard dose and low dose)or placebo for 12 weeks on the basis of lifestyle modifications.The primary efficacy variable was homeostasis model assessment of insulin resistance(HOMA-IR).Analyses were performed in two populations in accordance with body mass index(BMI;overweight/obese,BMI 24 kg/m^(2);lean,BMI<24 kg/m^(2)).For overweight/obese participants,low-dose LGZG significantly decreased their HOMA-IR level compared with placebo(0.19(1.47)versus 0.08(1.99),P=0.038).For lean subjects,neither dose of LGZG showed a superior effect compared with placebo.Methylated DNA immunoprecipitation sequencing and real-time qPCR found that the DNA N6-methyladenine modification levels of protein phosphatase 1 regulatory subunit 3A(PPP1R3A)and autophagy related 3(ATG3)significantly increased after LGZG intervention in overweight/obese population.Low-dose LGZG effectively improved insulin resistance in overweight/obese subjects with NAFLD.The underlying mechanism may be related to the regulation of DNA N6-methyladenine modification of PPP1R3A and ATG3.Lean subjects may not be a targeted population for LGZG. | Liang Dai Jingjuan Xu Baocheng Liu Yanqi Dang Ruirui Wang Lijie Zhuang Dong Li Lulu Jiao Jianying Wang Lei Zhang Linda LDZhong Wenjun Zhou Guang Ji | 2022 | Frontiers of Medicine2022，16，5： | 7 |
| 2 | Tall gastrodis tuber combined with antiepileptic drugs repairs abnormal perfusion foci in focal epilepsy显示文摘One hundred patients with focal epilepsy were recruited for the present study and their seizures controlled with antiepileptic drugs. The patients then orally received a capsule of tall gastrodis tuber powder, a traditional Chinese drug, and underwent single photon emission computed tomography, long-term electroencephalogram, and CT/MRI. Blood drug levels were monitored throughout the study. Before treatment with tall gastrodis tuber, 35 of the 100 cases had abnormal CT/MRI scans; 79 cases had abnormal single photon emission computed tomography images; 86 cases had abnormal electroencephalogram; and a total of 146 abnormal perfusion foci were observed across the 100 subjects. After treatment, the number of patients with normal single photon emission computed tomography images increased by 12; normal electroencephalogram was observed in an additional 27 cases and the number of patients with epileptiform discharge decreased by 29 (34% of 86); the total number of abnormal perfusion foci decreased by 52 (36%) and changes in abnormal foci were visible in 65 patients. These changes indicate that the administration of tall gastrodis tuber in combination with antiepileptic drugs repairs abnormal perfusion foci in patients with focal epilepsy. Our results demonstrate that traditional Chinese drugs can repair abnormal perfusion foci and, as such, are a promising new pathway in the treatment of focal epilepsy. | Weimin Wang Zhenyu Fan Yongqin Zhang Yuxia Yang Yaqing Liu Xiaoli Dang Wenjun Song Yinping Wu Jiang Ye | 2013 | Neural Regeneration Research2013，8，3： | 2 |
| 3 | Dynamic model changes of three times interietcal SPECT of epilepsy patients with long-term control with AEDs and its clinical significance(63 case)显示文摘 | Weimin Wang Wenjun Song Xiaoli Dang | 2011 | Epilepsia2011，52，6： | 1 |
| 4 | Na_(2)SO_(4)-NaCl binary eutectic salt roasting to enhance extraction of lithium from pyrometallurgical slag of spent lithium-ion batteries显示文摘Effectively extracting lithium at a relatively low temperature from the slag produced by the pyrometallurgical treatment of spent lithium-ion batteries remains a great challenge,which limits the acquirement of lithium.Herein,we proposed a eutectic system to roast slag at a lower temperature based on sodium sulfate-sodium chloride(Na_(2)SO_(4)-NaCl)binary eutectic salts.The optimal roasting conditions are as follows:the slag was roasted at 750℃with a(SO_(4)^(2-)+Cl^(-))/Li+molar ratio of 5:1 for 120 min.Followed by aqueous leaching 5 min at room temperature with a water/roasted samples mass ratio of 30:1,it can get 97.07%lithium extraction efficiency. | Hui Dang Zhidong Chang Xue Wu Sihang Ma Yifei Zhan Na Li Wenbo Liu Wenjun Li Hualei Zhou Changyan Sun | 2022 | Chinese Journal of Chemical Engineering2022，35，1： | 1 |
| 5 | Breastfeeding, previous Epstein-Barr virus infection, Enterovirus 71 infection, and rural residence are associated with the severity of hand, foot, and mouth disease显示文摘 | Yaping Li Shuangsuo Dang Huiling Deng Wenjun Wang Xiaoli Jia Ning Gao Mei Li Jun Wang | 2013 | European Journal of Pediatrics2013，，5： | 1 |
| 6 | Re-Os dating of pyrite from the Tuolugou stratabound Co (Au) deposit, eastern Kunlun Orogenic Belt, northwestern China 显示文摘 | Feng Chengyou Qu Wenjun Zhang Dequan Dang Xingyan Du Andao Li Daxin She | 2009 | Ore Geol Rev2009，36，13： | 1 |
| 7 | Multifunctional, Catalytic Nanowire Membranes and the Membrane - Based 3 D Devices 显示文摘 | Dang Wenjun Zhan shi shang Lu | 2006 | The Journal of physical chemistry physical chemistry B letters2006，110，： | 1 |
| 8 | Simulating Error-Opening of Pressure Relief Valves of a Station on a Continuous Undulating Oil Pipeline with Large Elevation Difference显示文摘For oil pipeline in mountain areas,high hydrostatic pressure in the pipeline may cause error-opening of pressure relief valves,and oil is discharged from the pipeline to the pressure relief tanks,bringing spilling-over risk of the pressure relief tanks.Therefore,simulating the error-opening situations of the pressure relief valves and investigating the oil discharge process are necessary for checking the possibility of the spilling-over accident and then proposing measures to improve the pressure relief system.This research focuses on a continuous undulating oil pipeline with large elevation difference and a station along this pipeline,which is named B station in this paper,is studied.By OLGA software,simulation model of the pressure relief system of B station is established,and the accuracy of the model is verified by reconstructing a real accident and making a comparison with the actual accident data.The maximum discharge rate reached 8284 m3/h when the pressure relief valve was opened by mistake in the inlet and outlet of the station.The accumulated filling time of the two pressure relief tanks is 200 s,which is in good agreement with the accident data.On this basis,for error-opening of the pressure relief valves at the inlet and outlet of B station,simulation is performed to investigate variations of the discharge velocity,discharge flow rate,accumulated discharge volume and ventilation volume of the vent valve.The discharge velocity is found to be over the maximum velocity allowed for safety consideration.According to the accumulated discharge volume,it is inferred that spilling over of the pressure relief tanks will be caused once error-opening of the pressure relief valve occurs.Also it is judged that the existing breathing valve can not satisfy the ventilation requirement in case of failure of the pressure relief valves.From these simulation results,it is proposed that increasing the number of vent valves,replacing the manual valves with electrically operated valves,and employing security control interlock protection program are improvement measures to guarantee safe,efficient and reliable operation of the pressure relief system at B station. | Xiaohua Chen Caifu Lan Honghao Zheng Wang Li Chao Zhao Wenjun Dang | 2022 | Energy Engineering2022，119，4： | 0 |
| 9 | The Meromorphic Solutions of the Zakharov-Kuznetsov Modified Equal Width Equation显示文摘In this paper, we use the complex method to obtain all meromorphic solutions of the complex Zakharov-Kuznetsov modified equal width equation, then find the exact traveling wave solutions of the Zakharov-Kuznetsov modified equal width equation. At last, we give some computer simulations to illustrate our main results. | Guoqiang Dang Wenjun Yuan Lixia Cui Yongyi Gu | 2017 | Analysis in Theory and Applications2017，33，4： | 0 |
| 10 | Genesis and distribution of oils in Mahu Sag,Junggar Basin,NW China显示文摘Based on the geological and geochemical analysis of potential source rocks in different formations and the classification of crude oil types,combined with the hydrocarbon generation thermal simulation experiments,the source,genesis,and distribution of different types of oils in the Mahu large oil province of the Junggar Basin are investigated.Four sets of potential source rocks are developed in the Mahu Sag.Specifically,the source rocks of the Permian Fengcheng Formation have the highest hydrocarbon generation potential and contain mainly TypesⅡandⅠorganic matters,with a high oil generation capacity.In contrast,the source rocks in other formations exhibit lower hydrocarbon generation potential and contain mainly TypeⅢorganic matter,with dominant gas generation.Oils in the Mahu Sag can be classified as three types:A,B and C,which display ascending,mountainous and descending C_(20)-C_(21)-C_(23)tricyclic terpenes abundance patterns in sequence,and gradually increasing relative content of tricyclic terpenes and sterane isomerization parameters,indicating an increasing oil maturity.Different types of oils are distributed spatially in an obviously orderly manner:Type A oil is close to the edge of the sag,Type C oil is concentrated in the center of the sag,and Type B oil lies in the slope area between Type A and Type C.The results of oil-source correlation and thermal simulation experiments show that the three types of oils come from the source rocks of the Fengcheng Formation at different thermal evolution stages.This new understanding of the differential genesis of oils in the Mahu Sag reasonably explains the source,distribution,and genetic mechanism of the three types of oils.The study results are of important guidance for the comprehensive and three-dimensional oil exploration,the identification of oil distribution in the total petroleum system,and the prediction of favorable exploration areas in the Mahu Sag. | DANG Wenlong GAO Gang YOU Xincai WU Jun LIU Shiju YAN Qi HE Wenjun GUO Liulinbo | 2023 | Petroleum Exploration and Development2023，50，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员