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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | Incremental training of support vector machines显示文摘 | Alistair Shilton M Palaniswami Daniel Ralph Ah Chung Tsoi | 2005 | IEEE Trans on Neural Networks2005，16，1： | 1 |
| 3 | Variability in rates of arthrodesis procedures for patients with cervical spine injuries with and without associated spinal cord injury 显示文摘 | Daniels AH Arthur M Hart RA | 2007 | J Bone Joint Surg Am2007，89，2： | 1 |
| 4 | Ploughing up the word-wide-web? 显示文摘 | Helgason T Daniell TJ Husband R Fitter AH Yong JPW | 1998 | Nature1998，394，： | 1 |
| 5 | Spinal cord compression after percutaneous kyphoplasty for metastatic compression fracture显示文摘 | Esmende SM Daniels AH Palumbo MA | 2013 | Spine J2013，13，7： | 1 |
| 6 | Cognitive outcome 5 years after bilateral chronic stimulation of subthalamic nucleus in patients with Parkinson′s disease显示文摘 | Contarino MF Daniele A Sibilia AH | | 0，，： | 1 |
| 7 | Scanometric microRNA array profiling of prostate cancer markers using spherical nucleic acid-gold nanoparticle conjugates显示文摘 | Alhasan AH Kim DY Daniel WL | 2012 | Anal Chem2012，84，9： | 1 |
| 8 | Preliminary biome- chanical proof of concept for a hybrid locking plate/variable pitch screw construct for anterior fixation of type I1 odon- toid fractures显示文摘 | Daniels AH Magee W Badra M | 2012 | Spine2012，37，19： | 1 |
| 9 | Inducible Nitric Oxide Synthase Binds,S-Nitrosylates,and Activates Cyclooxygenase-2显示文摘 | Sangwon FK Daniel AH Solomon HS | 2005 | Science2005，23，12： | 1 |
| 10 | Adverse events associated withanterior cervical spine surgery显示文摘 | Daniels AH Riew KD Yoo JU | 2008 | J Am Acad Orthop Surg2008，12，： | 1 |
| 11 | Disruptive behavior and clinical outcomes: perceptions of nurses and physicians 显示文摘 | Rosenstein AH 0' Daniel M | 2005 | Am J Nurs2005，105，1： | 1 |
| 12 | Adverse events associated with anterior cervical spine surgery 显示文摘 | Daniels AH Riew DK Yoo JU | 2008 | J Am Acad Orthop Surg2008，16，12： | 1 |
| 13 | Scanometric microRNA array profiling of prostate cancer markers using spherical nucleic acid-gold nanoparticle conjugates显示文摘 | Alhasan AH Kim DY Daniel WL | 2012 | Anal Chem2012，84，： | 1 |
| 14 | Ploughing up the wood-wide web显示文摘 | Daniell TJ Husband R Fitter AH Young JPW | 1998 | Nature1998，，384： | 1 |
| 15 | R-spondin1, A Novel Intestinotrophic Mitogen, Ameliorates Experimental Colitis in Mice显示文摘 | Jingsong Zhao Josephine de Vera Seiko Narushima Eric X. Beck Servando Palencia Pauline Shinkawa Kyung–Ah Kim Yi Liu Michael D. Levy Daniel J. Berg Arie Abo Walter D. Funk | 2007 | Gastroenterology2007，，4： | 1 |
| 16 | Managing disruptive physician behavior:impact on staff relationships and patient care显示文摘 | Rosenstein AH O'Daniel M | 2008 | Neurology2008，70，17： | 1 |
| 17 | Spinal cord compression after percutaneous kyphoplasty for metastatic compression fracture显示文摘 | Esmende SM Daniels AH Palumbo MA | 2013 | Spine J2013，13，7： | 1 |
| 18 | Multidrug resistance ( MDRI ) in leukemia: Is it time to test显示文摘 | Daniel AH | 1992 | Blood1992，79，： | 1 |
| 19 | Spinal cord com- pression after percutaneous kyphoplasty for metastatic com- pression fracture 显示文摘 | Esmende SM Daniels AH Palumbo MA | 2013 | Spine J2013，13，7： | 1 |
| 20 | Traumatic spondyloptosis resulting from high-energy trauma concurrent with a tonic-clonic seizure显示文摘 | Daniels AH Deodhar AA Hart RA | 2009 | Spine J2009，9，： | 1 |
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