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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | Calcium-acivatedK+channels increase cell proliferation independent of K+conductance显示文摘 | Joanne EM Daniel CD Kirk LH | 2011 | Am J Physiol Cell Physiol2011，300，： | 1 |
| 3 | Structural anomalies of X Chromosome:persnal observation and review of non masaic case显示文摘 | Wyss D Delozier CD Daniell J | 1982 | Clin Cenet1982，21，2： | 1 |
| 4 | Structural anomalies of the X chromosome : personal observation and review of non - mosaic cases 显示文摘 | Wyss D DeLozier CD Daniell J | 1982 | Clin Genet1982，21，： | 1 |
| 5 | Whole-genome analysis of 60G protein-coupled receptors in Caenorhabditis elegans by gene knockout with RNAi显示文摘 | Keating CD Kriek N Daniels M | 2003 | Curr Biol2003，13，19： | 1 |
| 6 | Developmental signaling pathways in lung cancer显示文摘 | Daniel VC Peacock CD Watkins DN | | 0，，03： | 1 |
| 7 | The rat macrophage scavenger receptor CD163:expression,regulation and role in inflammatory mediator production显示文摘 | Polfliet MM Fabriek BO Daniels WP Dijkstra CD van den Berg TK | 2006 | Im m unobiology2006，211，68： | 1 |
| 8 | Synthesis, antibacterial activities, and pharmacological properties of enantiomers of temalloxacin hydrochloride显示文摘 | Daniel T W Chu Carl W Nordeen Dwight J Hardy et cd | 1991 | J Med Chem1991，34，： | 1 |
| 9 | Developmental signaling pathways in lung cancer显示文摘 | Daniel VC Peacock CD Watkins DN | 2006 | Respirology2006，11，3： | 1 |
| 10 | Rodent pharmacokinetic and anti-tumor efficacy studies with a series of synthetic inhibitors of matrix metalloproteinases显示文摘 | Santos O McDermott CD Daniels RG etal | 1997 | Clin Exp Metastasis1997，15，5： | 1 |
| 11 | Rodent pharmacokineticand antitumor efficacy studies with a series of synthetic inhibitors of matrix metalloproteinases显示文摘 | Santos O Mc Dermott CD Daniels RG | 1997 | Clin Exp Metastasis1997，15，5： | 1 |
| 12 | Marfan's syndrome显示文摘 | Daniel PJ Harry CD | 2005 | Lancet2005，366，9501： | 1 |
| 13 | What are the social conse- quences of stroke for working-aged adults? A systematic review 显示文摘 | Daniel K Woffe CD Busch MA et aI | 2009 | Stroke2009，40，6： | 1 |
| 14 | Plasma Homocysteine concentration in a Belgian school-age population 显示文摘 | Laet CD Wautrecht IC Brasseur Daniel | 1999 | Am J Clin Nutr1999，69，： | 1 |
| 15 | Beta-blockers reduce the release and synthesis of endothelin-1 in human endothelial cells显示文摘 | Zhang H Mug ge A Daniel WG | 1999 | Eur J Clin Invest1999，29，1： | 1 |
| 16 | Developmental signal-ling pathways in lung cancer显示文摘 | Daniel VC Peacock CD Watkins DN | 2006 | Respirology2006，11，3： | 1 |
| 17 | Calcium-acivated K + channels increase cell proliferation independent of K + conductance 显示文摘 | Joanne EM Daniel CD Kirk LH | 2011 | Am J Physiol Cell physiol2011，300，4： | 1 |
| 18 | Calcium-acivated K + channels increase cell proliferation independent of K + conductance 显示文摘 | Joanne EM Daniel CD Kirk LH | 2011 | Am J Physiol Cell physiol2011，300，4： | 1 |
| 19 | Developmental signaling pathways in lung cancer显示文摘 | Daniel VC Peaceck CD Watkins DN | | 0，，： | 1 |
| 20 | Structural anomalies of the X chromosome:personal observation and review of non-medic cases显示文摘 | Wyss D DeLozier CD Daniell J | 1982 | Clin Genet1982，1，： | 1 |
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