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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | The Genome of Cucurbita argyrosperma (Silver- Seed Gourd) Reveals Faster Rates of Protein- Coding Gene and Long Noncoding RNA Turnover and Neofunctionalization within Cucurbita显示文摘Whole-genome duplications are an important source of evolutionary novelties that change the mode and tempo at which genetic elements evolve within a genome. The Cucurbita genus experienced a wholegenome duplication around 30 million years ago, although the evolutionary dynamics of the coding and noncoding genes in this genus have not yet been scrutinized. Here, we analyzed the genomes of four Cucurbita species, in eluding a newly assembled genome of Cucurbita argyrosperma, and compared the gene con tents of these species with those of five other members of the Cucurbitaceae family to assess the evolutionary dynamics of protein-coding and long intergenic noncoding RNA (lincRNA) genes after the genome duplication. We report that Cucurbita genomes have a higher protein-coding gene birth-death rate compared with the genomes of the other members of the Cucurbitaceae family. C. argyrosperma gene families associated with pollination and transmembrane transport had significantly faster evolutionary rates. lincRNA families showed high levels of gene turnover throughout the phylogeny, and 67.7% of the lincRNA families in Cucurbita showed evidence of birth from the neofunctionalization of previously existing protein-coding genes. Collectively, our results suggest that the whole-genome duplication in Cucurbita resulted in faster rates of gene family evolution through the neofunctionalization of duplicated genes. | Josue Barrera-Red on do Enrique Ibarra-Laclette Alejandra Vazquez-Lobo Yocelyn T. Gutierrez-Guerrero Guillermo Sanchez de la Vega Daniel Pinero Salvador Montes-Hernandez Rafael Lira-Saade Luis E. Eguiarte | 2019 | Molecular Plant2019，12，4： | 9 |
| 3 | Glucocorticosteroid therapy in inflammatory bowel diseases: From clinical practice to molecular biology显示文摘Inflammatory bowel diseases(IBDs),such as ulcerative colitis and Crohn's disease,are chronic pathologies associated with a deregulated immune response in the intestinal mucosa,and they are triggered by environmental factors in genetically susceptible individuals.Exogenous glucocorticoids(GCs)are widely used as anti-inflammatory therapy in IBDs.In the past,patients with moderate or severe states of inflammation received GCs as a first line therapy with an important effectiveness in terms of reduction of the disease activity and the induction of remission.However,this treatment often results in detrimental side effects.This downside drove the development of second generation GCs and more precise(non-systemic)drugdelivery methods.Recent clinical trials show that most of these new treatments have similar effectiveness to first generation GCs with fewer adverse effects.The remaining challenge in successful treatment of IBDs concerns the refractoriness and dependency that some patients encounter during GCs treatment.A deeper understanding of the molecular mechanisms underlying GC response is key to personalizing drug choice for IBDs patients to optimize their response to treatment.In this review,we examine the clinical characteristics of treatment with GCs,followed by an in depth analysis of the proposed molecular mechanisms involved in its resistance and dependence associated with IBDs.This thorough analysis of current clinical and biomedical literature may help guide physicians in determining a course of treatment for IBDs patients and identifies important areas needing further study. | Karen Dubois-Camacho Payton A Ottum Daniel Franco-Munoz Marjorie De la Fuente Alejandro Torres-Riquelme David Díaz-Jiménez Mauricio Olivares-Morales Gonzalo Astudillo Rodrigo Quera Marcela A Hermoso | 2017 | World Journal of Gastroenterology2017，23，36： | 6 |
| 4 | An Exploration of Deep-Learning Based Phenotypic Analysis to Detect Spike Regions in Field Conditions for UK Bread Wheat显示文摘Wheat is one of the major crops in the world,with a global demand expected to reach 850 million tons by 2050 that is clearly outpacing current supply.The continual pressure to sustain wheat yield due to the world’s growing population under fluctuating climate conditions requires breeders to increase yield and yield stability across environments.We are working to integrate deep learning into field-based phenotypic analysis to assist breeders in this endeavour.We have utilised wheat images collected by distributed CropQuant phenotyping workstations deployed for multiyear field experiments of UK bread wheat varieties.Based on these image series,we have developed a deep-learning based analysis pipeline to segment spike regions from complicated backgrounds.As a first step towards robust measurement of key yield traits in the field,we present a promising approach that employ Fully Convolutional Network(FCN)to performsemantic segmentation of images to segment wheat spike regions.We also demonstrate the benefits of transfer learning through the use of parameters obtained from other image datasets.We found that the FCN architecture had achieved a Mean classification Accuracy(MA)>82%on validation data and>76%on test data and Mean Intersection over Union value(MIoU)>73%on validation data and and>64%on test datasets.Through this phenomics research,we trust our attempt is likely to form a sound foundation for extracting key yield-related traits such as spikes per unit area and spikelet number per spike,which can be used to assist yield-focused wheat breeding objectives in near future. | Tahani Alkhudaydi Daniel Reynolds Simon Griffiths Ji Zhou Beatriz de la Iglesia | 2019 | Plant Phenomics2019，1，1： | 5 |
| 5 | Potential of soluble CD26 as a serum marker for colorectal cancer detection显示文摘Colorectal cancer is characterized by a low survival rate even though the basis for colon cancer development,which involves the evolution of adenomas to carcinoma,is known.Moreover,the mortality rates continue to rise in economically transitioning countries although there is the opportunity to intervene in the natural history of the adenoma–cancer sequence through risk factors,screening,and treatment.Screening in particular accounted for most of the decline in colorectal cancer mortality achieved in the USA during the period 1975-2000.Patients show a better prognosis when the neoplasm is diagnosed early.Among the variety of screening strategies,the methods range from invasive and costly procedures such as colonoscopy to more low-cost and non-invasive tests such as the fecal occult blood test(guaiac and immunochemical).As a non-invasive biological serum marker would be of great benefit because of the performance of the test,several biomarkers,including cytologic assays,DNA and mRNA,and soluble proteins,have been studied.We found that the soluble CD26(sCD26)concentration is diminished in serum of colorectal cancer patients compared to healthy donors,suggesting the potential utility of a sCD26 immunochemical detection test for early diagnosis.sCD26 originates from plasma membrane CD26 lacking its transmembrane and cytoplasmic domains.Some 90%–95%of sCD26 has been associated with serum dipeptidyl peptidase IV(DPPIV)activity.DPP-IV,assigned to the CD26 cluster,is a pleiotropic enzyme expressed mainly on epithelial cells and lymphocytes.Our studies intended to validate this test for population screening to detect colorectal cancer and advanced adenomas are reviewed here. | Oscar J Cordero Monica Imbernon Loretta De Chiara Vicenta S Martinez-Zorzano Daniel Ayude Maria Paez de la Cadena F Javier Rodriguez-Berrocal | 2011 | World Journal of Clinical Oncology2011，2，6： | 5 |
| 6 | The human olfactory system in two proteinopathies: Alzheimer’s and Parkinson’s diseases显示文摘Alzheimer’s and Parkinson’s diseases are the most prevalent neurodegenerative disorders.Their etiologies are idiopathic,and treatments are symptomatic and orientated towards cognitive or motor deficits.Neuropathologically,both are proteinopathies with pathological aggregates(plaques of amyloid-β peptide and neurofibrillary tangles of tau protein in Alzheimer’s disease,and Lewy bodies mostly composed of α-synuclein in Parkinson’s disease).These deposits appear in the nervous system in a predictable and accumulative sequence with six neuropathological stages.Both disorders present a long prodromal period,characterized by preclinical signs including hyposmia.Interestingly,the olfactory system,particularly the anterior olfactory nucleus,is initially and preferentially affected by the pathology.Cerebral atrophy revealed by magnetic resonance imaging must be complemented by histological analyses to ascertain whether neuronal and/or glial loss or neuropil remodeling are responsible for volumetric changes.It has been proposed that these proteinopathies could act in a prion-like manner in which a misfolded protein would be able to force native proteins into pathogenic folding(seeding),which then propagates through neurons and glia(spreading).Existing data have been examined to establish why some neuronal populations are vulnerable while others are resistant to pathology and to what extent glia prevent and/or facilitate proteinopathy spreading.Connectomic approaches reveal a number of hubs in the olfactory system(anterior olfactory nucleus,olfactory entorhinal cortex and cortical amygdala)that are key interconnectors with the main hubs(the entorhinal–hippocampal–cortical and amygdala–dorsal motor vagal nucleus)of network dysfunction in Alzheimer’s and Parkinson’s diseases. | Isabel Ubeda-Bañon Daniel Saiz-Sanchez Alicia Flores-Cuadrado Ernesto Rioja-Corroto Melania Gonzalez-Rodriguez Sandra Villar-Conde Veronica Astillero-Lopez Juan Pablo Cabello-de la Rosa Maria Jose Gallardo-Alcañiz Julia Vaamonde-Gamo Fernanda Relea-Calatayud Lucia Gonzalez-Lopez Alicia Mohedano-Moriano Alberto Rabano Alino Martinez-Marcos | 2020 | Translational Neurodegeneration2020，9，2： | 4 |
| 7 | Early-onset colorectal cancer:A separate subset of colorectal cancer显示文摘Colorectal cancer(CRC)has a great impact on the world population.With increasing frequency,CRC is described according to the presenting phenotype,based on its molecular characteristics.Classification of CRC tumors according to their genetic and/or epigenetic alterations is not only important for establishing the molecular bases of the disease,but also for predicting patient outcomes and developing more individualized treatments.Early-onset CRC is a heterogeneous disease,with a strong familial component,although the disease is sporadic in an important proportion of cases.Different molecular alterations appear to contribute to the apparent heterogeneity of the early-onset population and subgroups can be distinguished with distinct histopathologic and familial characteristics.Moreover,compared with late-onset CRC,there are characteristicsthat suggest that early-onset CRC may have a different molecular basis.The purpose of this review was to analyze the current state of knowledge about earlyonset CRC with respect to clinicopathologic,familial and molecular features.Together,these features make it increasingly clear that this subset of CRC may be a separate disease,although it has much in common with late-onset CRC. | Irene Osorio Silla Daniel Rueda Yolanda Rodríguez Juan Luis García Felipe de la Cruz Vigo José Perea | 2014 | World Journal of Gastroenterology2014，20，46： | 4 |
| 8 | Liver Transplantation for Hepatocellular Carcinoma Under Calcineurin Inhibitors: Reassessment of Risk Factors for Tumor Recurrence显示文摘 | Marco Vivarelli Alessandro Cucchetti Giuliano La Barba Matteo Ravaioli Massimo Del Gaudio Augusto Lauro Gian Luca Grazi Antonio Daniele Pinna | 2008 | Annals of Surgery2008，，5： | 2 |
| 9 | Immunity:研究开发出最优的HIV疫苗递送模式显示文摘HIV已不再占据头条新闻。这主要是因为抗逆转录病毒药物的成功开发已将HIV病毒感染导致的艾滋病(AIDS)转化为一种慢性的可控制的疾病。然而。当前在全世界大约0.367亿名HIV感染者中,仅约一半的人能够获得控制这种病毒所需的药物。与此同时。新的HIV感染率持续保持在非常高的水平,这突出强调了需要开发一种预防性疫苗。然而,几十年来。 | Matthias Pauthner Colin Havenar-Daughton Devin Sok Joseph P. Nkolola Raiza Bastidas Archana V. Boopathy Diane G. Carnathan Abishek Chandrashekar Kimberly M. Cirelli Christopher A. Cottrell Alexey M. Eroshkin Javier Guenaga Kirti Kaushik Daniel W. Kulp Jinyan Liu Laura E. McCoy Aaron L. Oom Gabriel Ozorowski Kai W. Post Shailendra K. Sharma Jon M. Steichen Steven W. de Taeye Talar Tokatlian Alba Torrents de la Peña Salvatore T. Butera Celia C. LaBranche David C. Montefiori Guido Silvestri Ian A. Wilson Darrell J. Irvine Rogier W. Sanders William R. Schief Andrew B. Ward Richard T. Wyatt Dan H. Barouch Shane Crotty Dennis R. Burton | 2017 | 现代生物医学进展2017，17，27： | 2 |
| 10 | Multiple synchronous serous cystadenomas of the pancreas: uncommon CT and MRI findings显示文摘 | Daniel Leonard Jacques Baulieux Agnès Rode Vincent Garbit Eric De La Roche Christian Ducerf Jean-Yves Mabrut | 2007 | Journal of Hepato - Biliary - Pancreatic Surgery2007，，6： | 1 |
| 11 | An early view of the international Sjogren's syndrome registry 显示文摘 | Daniels TE Criswell LA Shiboski C | 2009 | Arthritis Rheum2009，61，5： | 1 |
| 12 | The Effect of SOX Internal Con-trol Deficiencies and Their Remediation on Accrual Quali-ty显示文摘 | Hollis Ashbaugh-Skaife Daniel W.Collins William R. Kinney Jr Ryan La Fond | | 0，，1： | 1 |
| 13 | Suppression of Acquired Docetaxel Resistance in Prostate Cancer through Depletion of Notch- and Hedgehog-Dependent Tumor-Initiating Cells显示文摘 | Josep Domingo-Domenech Samuel J. Vidal Veronica Rodriguez-Bravo Mireia Castillo-Martin S. Aidan Quinn Ruth Rodriguez-Barrueco Dennis M. Bonal Elizabeth Charytonowicz Nataliya Gladoun Janis de la Iglesia-Vicente Daniel P. Petrylak Mitchell C. Benson Jose M | 2012 | Cancer Cell2012，，3： | 1 |
| 14 | Problems and Solutions in Implementing the World Hyper tension League Recommendations for Automated Office Assessment of Blood Pressure显示文摘 | Veiga EV Daniel A CQG Bor tolloto LA | 2016 | J Clin Hypertens2016，18，1： | 1 |
| 15 | Clinical predictors of dysphagia and aspiration risk : outcome measures in acute- stroke patients显示文摘 | Daniels SK Ballo LA Mahoney MC el al | 2000 | Arch Phys Med Rehabil2000，81，8： | 1 |
| 16 | Role of the opioid system in incentive downshift situations显示文摘 | Daniel AM Ortega LA Papini MR | 2009 | Neurobiol Learn Mem2009，92，3： | 1 |
| 17 | Characterization of non-urbanized areas for land-use planning of agricultural and green infrastructure in urban contexts 显示文摘 | Daniele La Rosa Riccardo Privitera | 2012 | Landscape and Urban Planning2012，109，1： | 1 |
| 18 | Analyzing the cost effectiveness of Santiago, Chile’s policy of using urban forests to improve air quality显示文摘 | Francisco J. Escobedo John E. Wagner David J. Nowak Carmen Luz De la Maza Manuel Rodriguez Daniel E. Crane | 2007 | Journal of Environmental Management2007，，： | 1 |
| 19 | Sacral Neuromodulation for Neurogenic Lower Urinary Tract Dysfunction: Systematic Review and Meta-analysis显示文摘 | Thomas M. Kessler David La Framboise Sven Trelle Clare J. Fowler Gustav Kiss Jürgen Pannek Brigitte Schurch Karl-Dietrich Sievert Daniel S. Engeler | 2010 | European Urology2010，，6： | 1 |
| 20 | 1 Hz repetitive transcranial magnetic stimulation of the unaffected hemisphere ameliorates contralesional visuospatial neglect in humans显示文摘 | F. Brighina E. Bisiach M. Oliveri A. Piazza V. La Bua O. Daniele B. Fierro | 2002 | Neuroscience Letters2002，，2： | 1 |
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