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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | Molecular and serologic characterization of DWI, a novel 'high-grade' partial D 显示文摘 | Kormoczi GF Legler TJ Daniels GL | 2004 | Transfusion2004，44，4： | 1 |
| 3 | Ploughing up the word-wide-web? 显示文摘 | Helgason T Daniell TJ Husband R Fitter AH Yong JPW | 1998 | Nature1998，394，： | 1 |
| 4 | Diversity of bacteria associated with natural aphid populations 显示文摘 | Haynes S Darby AC Daniell TJ | 2003 | Applied and Environmental Microbiology2003，69，12： | 1 |
| 5 | Ploughing up the wood-wide web显示文摘 | Helgason T Daniell TJ Husband R | | 0，，： | 1 |
| 6 | Lean consumption显示文摘 | James PW Daniel TJ | 2005 | Harvard Busi- ness Review2005，83，3： | 1 |
| 7 | Arbuscularmycorrhizal community composition associated with two plantspecies in a grassland ecosystem显示文摘 | Vandenkoomhuyse P Husband R Daniell TJ | 2002 | Molecular Ecology2002，11，8： | 1 |
| 8 | The effect of electromagnetic radiation in the Mobile phone range on the behaviour of the rat 显示文摘 | Daniels WM Pitout IL Afullo TJ | 2009 | Metab Brain Dis2009，24，4： | 1 |
| 9 | A novel injectable formulation of diclofenac compared with intravenous ketorolac or placebo for a- cute moderate-to-severe pain after abdominal or pelvic surgery: a multicenter, double-blind, randomized, multiple-dose study 显示文摘 | Gan TJ Daniels SE Singla N | 2012 | Anesth Analg2012，115，5： | 1 |
| 10 | Mechanical and thermal properties of novel polymerized NDGA-gelatin hydrogels显示文摘 | Koob TJ Daniel J Hernande Z | 2003 | Biomaterials2003，24，： | 1 |
| 11 | Genetic analysis of clinical isolated of Streptococcus pneumoniae with highlevel resistance to expanded-spectrum cephalosporins显示文摘 | Coffey TJ Daniels M Mcdougel LK | 1995 | Antimicrobial Agents Chemother1995，39，6： | 1 |
| 12 | Diversity of bacteria associated with natural aphid populations 显示文摘 | Haynes S Darby AC Daniell TJ | 2003 | Applied and Environmental Microbiology2003，69，12： | 1 |
| 13 | A novel injectable for mulation of diclofenac compared with intravenous ketorolac or placebo for acute moderate-to-severe pain aiter abdominal or pelvic surgery: a multicenter, double-blind, randomized, multiple-dose study显示文摘 | Gan TJ Daniels SE Singla N | 2012 | Anesth Analg2012，115，5： | 1 |
| 14 | Prevalence of over-weight and obesity in Australian children and adolescents: reas-international definitions 显示文摘 | Magarey AM Daniels LA Boulton TJ | 2001 | Med J Aust2001，174，： | 1 |
| 15 | Ploughing up the wood-wide web显示文摘 | Daniell TJ Husband R Fitter AH Young JPW | 1998 | Nature1998，，384： | 1 |
| 16 | Comparison of angiotensin converting enzyme inhibition and angiotensin Ⅱ receptor blockade for the prevention of experimental autoimmune myocarditis 显示文摘 | Bahk TJ Daniels MD Leon JS | 2008 | Int J Cardiol2008，125，1： | 1 |
| 17 | Assessment of current practice in the diagnosis and therapy of idiopathic pulmonary fibrosis 显示文摘 | Peikert T Daniels CE Beebe TJ | 2008 | Respire Med2008，102，9： | 1 |
| 18 | A novel injectable formulation of diclofenac compared with intravenous ketorolac or placebo for acute moderate-to-severe pain after abdominal or pelvic surgery:a multicenter,double-blind randomized,multiple-dose study显示文摘 | Gan TJ Daniels SE Singla N | 2012 | Anesth Analg2012，115，5： | 1 |
| 19 | Comparison of angiotensin converting enzyme inhibition and angiotensin Ⅱ receptor blockade for the prevention of experimental autoimmune myoearditis 显示文摘 | Bahk TJ Daniels MD Leon JS | 2008 | Int J Cardiol2008，125，1： | 1 |
| 20 | Comparison of angiotensin converting enzyme inhibition and angiotensin Ⅱ receptor blockade for the prevention of experimental autoimmune myocarditis显示文摘 | Bahk TJ Daniels MD Leon JS | 2008 | Int J Cardio2008，125，1： | 1 |
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