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| 1 | Two Novel Myrinsol Diterpenes from Euphorbia prolifera显示文摘Two novel diterpenes, Euphorprolitherin A (1) and Euphorprolitherin B (2), were isolated from the roots of Euphorbia prolifera. Their structures were elucidated on the basis of spectroscopic methods. | Wan Jin ZHANG, Dao Feng CHEN*, Ai Jun HOU Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 200032 | 2002 | Chinese Chemical Letters2002，13，8： | 5 |
| 2 | The double face of miR-320:cardiomyocytes-derived miR-320 deteriorated while fibroblasts-derived miR-320 protected against heart failure induced by transverse aortic constriction显示文摘MicroRNAs(miRNAs)are aberrantly expressed in the pathophysiologic process of heart failure(HF).However,the functions of a certain miRNA in different cardiac cell types during HF are scarcely reported,which might be covered by the globe effects of it on the heart.In the current study,Langendorff system was applied to isolate card io myocytes(CMs)and cardiac fibroblasts(CFs)from transverse aortic constriction(TAC)-induced mice.Slight increase of miR-320 expression was observed in the whole heart tissue of TAC mice.Interestingly,miR-320 was significantly elevated in CMs but decreased in CFs from TAC mice at different time points.Then,recombinant adeno-associated virus 9 with cell-type-specific promoters were used to manipulate miR-320 expressions in vivo.Both in vitro and in vivo experiments showed the miR-320 overexpression in CMs exacerbated cardiac dysfunction,whereas overexpression of miR-320 in CFs alleviated cardiac fibrosis and hypertrophy.Mechanically,downstream signaling pathway analyses revealed that miR-320 might induce various effects via targeting PLEKHM3 and IFITM1 in CMs and CFs,respectively.Moreover,miR-320 mediated effects could be abolished by PLEKHM3 re-expression in CMs or IFITM1 re-expression in CFs.Interestingly,miR-320 treated CFs were able to indirectly affect CMs function,but not vice versa.Meanwhile,upstream signaling pathway analyses showed that miR-320 expression and decay rate were rigorously manipulated by Ago2,which was regulated by a cluster of cell-type-specific TFs distinctively expressed in CMs and CFs,respectively.Together,we demonstrated that miR-320 functioned differently in various cell types of the heart during the progression of HF. | Xudong Zhang Shuai Yuan Huaping Li Jiabing Zhan Feng Wang Jiahui Fan Xiang Nie Yan Wang Zheng Wen Yanghui Chen Chen Chen Dao Wen Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 4 |
| 3 | Analysis of Schisandra chinensis and Schisandra sphenanthera显示文摘 | Yan Lu Dao - Feng Chen | 2009 | Journal of Chrom - atography A2009，1216，： | 1 |
| 4 | Pharmacokinetics and bioavailability of ginsenoside Rb1and Rg1 from Panax notoginsengin rats显示文摘 | Qing Fang Xu Xiao Ling Fang Dao Feng Chen | 2003 | Journal of Ethnopharmacology2003，84，： | 1 |
| 5 | Reactions of [60]Fullerene with Di(azidomethyl) benzenes显示文摘A diazafulleroid derivative with adacent 5-6 junctions has been synthesized by theregioselective addition of 1,2-di(azidomethyl) benzene to [60]fullerene. Reaction of [60]fullerenewith 1,4-di(azidomethyl) benzene in refluking chlorobenzene gave a copolymer. | Chuan Feng CHEN Ji Sheng LI Gai Jiao JI Dao Ben ZHU(Institute of Chendstry, The Chinese Academy of Sciences, Beijing 100080) | 1998 | Chinese Chemical Letters1998，9，6： | 1 |
| 6 | Quantitation of seven polyoxypregnane glycosides in Marsdenia tenacissima using reversed-phase high-performance liquid chromatography-evaporative light-scattering detection显示文摘 | Deng Jun Shen Fan Chen Dao feng | 2006 | J Chromatogr A2006，1116，12： | 1 |
| 7 | 在为狭窄带宽的软 X 光检查产生的 SXFEL 的单个阶段 EEHG显示文摘使回响能的泛音产生(EEHG ) 计划为高效地在起始的种子激光的很高的泛音产生强烈协调放射保持有希望的前景。在这份报纸,我们学习与单个阶段 EEHG 安装操作上海 X 光检查免费电子的激光测试设备的可行性。与存在数字代码的联合,就各种各样的三维的效果而言的 start-to-end 模拟被执行了显示出 EEHG FEL 的可能的表演。模拟结果证明阶段 EEHG 能高产生的一个单身者从紫外种子激光直接与狭窄的带宽驱动软 X 光检查放射脉搏。在放射激光的泛音的帮助下技术或升级的线性加速器,我们也显示出与单个阶段 EEHG 在水窗户中产生协调软 X 光检查放射的可能性。 | Chao Feng Dazhang Huang Haixiao Deng Jianhui Chen Dao Xiang Bo Liu DongWang Zhentang Zhao | 2016 | Science Bulletin2016，61，15： | 0 |
| 8 | Synthesis and Characterization of Both Enantiomers of a Chiral C_(60) Derivative Bearing the 1, 1'-Binaphthyl Group显示文摘Both enantiomers R-1 and S-1 of a chiral C60 derivative were synthesized by the reactions of C60 with 1, 1’-bi-2-naphthol bis(azidoacetates) and characterized by FD-MS, fT-IR,1H NMR, 13C NMR, UV-VIS, CD spectra. | Chuan Feng CHEN Gai Jiao JI Ji Sheng LI Dao Ben ZHU(Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100080) | 1998 | Chinese Chemical Letters1998，9，10： | 0 |
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