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| 1 | The Chinese Society of Clinical Oncology(CSCO):Clinical guidelines for the diagnosis and treatment of gastric cancer,2021显示文摘There exist differences in the epidemiological characteristics,clinicopathological features,tumor biological characteristics,treatment patterns,and drug selections between gastric cancer patients from the Eastern and Western countries.The Chinese Society of Clinical Oncology(CSCO)has organized a panel of senior experts specializing in all sub-specialties of gastric cancer to compile a clinical guideline for the diagnosis and treatment of gastric cancer since 2016 and renews it annually.Taking into account regional differences,giving full consideration to the accessibility of diagnosis and treatment resources,these experts have conducted expert consensus judgment on relevant evidence and made various grades of recommendations for the clinical diagnosis and treatment of gastric cancer to reflect the value of cancer treatment and meeting health economic indexes in China.The 2021 CSCO Clinical Practice Guidelines for Gastric Cancer covers the diagnosis,treatment,follow-up,and screening of gastric cancer.Based on the 2020 version of the CSCO Chinese Gastric Cancer guidelines,this updated guideline integrates the results ofmajor clinical studies from China and overseas for the past year,focused on the inclusion of research data from the Chinese population for more personalized and clinically relevant recommendations.For the comprehensive treatment of non-metastatic gastric cancer,attentions were paid to neoadjuvant treatment.The value of perioperative chemotherapy is gradually becoming clearer and its recommendation level has been updated.For the comprehensive treatment of metastatic gastric cancer,recommendations for immunotherapy were included,and immune checkpoint inhibitors fromthird-line to the first-line of treatment for different patient groups with detailed notes are provided. | Feng-Hua Wang Xiao-Tian Zhang Yuan-Fang Li Lei Tang Xiu-Juan Qu Jie-Er Ying Jun Zhang Ling-Yu Sun Rong-Bo Lin Hong Qiu Chang Wang Miao-Zhen Qiu Mu-Yan Cai QiWu Hao Liu Wen-Long Guan Ai-Ping Zhou Yu-Jing Zhang Tian-Shu Liu Feng Bi Xiang-Lin Yuan Sheng-Xiang Rao Yan Xin Wei-Qi Sheng Hui-Mian Xu Guo-Xin Li Jia-Fu Ji Zhi-Wei Zhou Han Liang Yan-Qiao Zhang Jing Jin Lin Shen Jin Li Rui-Hua Xu | 2021 | Cancer Communications2021，41，8： | 97 |
| 2 | The edaravone and 3-n-butylphthalide ring-opening derivative lob effectively attenuates cerebral ischemia injury in rats显示文摘目的: 复合 10b 是 edaravone 和 3-n-butylphthalide (NBP ) 的戒指洞衍生物的一个混合分子。这研究的目的是在焦点的服的局部缺血以后在老鼠在大脑损坏上检验复合 10b 的效果。 | Kai HUA Xiao SHENG Ting-ting LI Lin-na WANG Yi-hua ZHANG Zhang-jian HUANG Hui JI | 2015 | Acta Pharmacologica Sinica2015，36，8： | 35 |
| 3 | Comparison of parathyroid hormone (1-34) and elcatonin in postmenopausal women with osteoporosis: an 18-month randomized, multicenter controlled trial in China显示文摘 | LI Ying XUAN Miao WANG Bo YANG Jun ZHANG Hong ZHANG Xiu-zhen GUO Xiao-hui Lü Xiao-feng XUE Qing-yun YANG Gang-yi JI Qiu-he LIU Zhi-min LI Cheng-jiang WU Tian-feng SHENG Zheng-yan LI Peng-qiu TONG Jiu-cui | 2013 | Chinese Medical Journal2013，，3： | 24 |
| 4 | Clinical trial with traditional Chinese medicine intervention ''tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment'' for chronic hepatitis B-associated liver failure显示文摘AIM:To study the clinical efficacy of traditional Chinese medicine(TCM)intervention'tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment'('TTK')for treating liver failure due to chronic hepatitis B.METHODS:We designed the study as a randomized controlled clinical trial.Registration number of Chinese Clinical Trial Registry is Chi CTR-TRC-12002961.A total of 144 patients with liver failure due to infection with chronic hepatitis B virus were enrolled in this randomized controlled clinical study.Participants were randomly assigned to the following three groups:(1)a modern medicine control group(MMC group,36patients);(2)a'tonifying qi and detoxification'('TQD')group(72 patients);and(3)a'tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment'('TTK')group(36patients).Patients in the MMC group received general internal medicine treatment;patients in the'TQD'group were given a TCM formula'tonifying qi and detoxification'and general internal medicine treatment;patients in the'TTK'group were given a TCM formula of'TTK'and general internal medicine treatment.All participants were treated for 8 wk and then followed at 48 wk following their final treatment.The primaryefficacy end point was the patient fatality rate in each group.Measurements of various virological and biochemical indicators served as secondary endpoints.The one-way analysis of variance and the t-test were used to compare patient outcomes in the different treatment groups.RESULTS:At the 48-wk post-treatment time point,the patient fatality rates in the MMC,'TQD',and'TTK'groups were 51.61%,35.38%,and 16.67%,respectively,and the differences between groups were statistically significant(P<0.05).However,there were no significant differences in the levels of hepatitis B virus DNA or prothrombin activity among the three groups(P>0.05).Patients in the'TTK'group had significantly higher levels of serum total bilirubin compared to MMC subjects(339.40μmol/L±270.09μmol/L vs 176.13μmol/L±185.70μmol/L,P=0.014).Serum albumin levels were significantly increased in both the'TQD'group and'TTK'group as compared with the MMC group(31.30 g/L±4.77g/L,30.72 g/L±2.89 g/L vs 28.57 g/L±4.56 g/L,P<0.05).There were no significant differences in levels of alanine transaminase among the three groups(P>0.05).Safety data showed that there was one case of stomachache in the'TQD'group and one case of gastrointestinal side effect in the'TTK'group.CONCLUSION:Treatment with'TTK'improved the survival rates of patients with liver failure due to chronic hepatitis B.Additionally,liver tissue was regenerated and liver function was restored. | Han-Min Li Zhi-Hua Ye Jun Zhang Xiang Gao Yan-Ming Chen Xin Yao Jian-Xun Gu Lei Zhan Yang Ji Jian-Liang Xu Ying-He Zeng Fan Yang Lin Xiao Guo-Guang Sheng Wei Xin Qi Long Qing-Jing Zhu Zhao-Hong Shi Lian-Guo Ruan Jia-Yao Yang Chang-Chun Li Hong-Bin Wu Sheng-Duo Chen Xin-La Luo | 2014 | World Journal of Gastroenterology2014，20，48： | 20 |
| 5 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 6 | A phase I study on pharmacokinetics and pharmacodynamics of higenamine in healthy Chinese subjects显示文摘瞄准: 调查 higenamine 的 pharmacokinetics,药效学,和安全,乌头属植物根的活跃成分,在健康中国志愿者。 | Sheng FENG Ji JIANG Pei HU Jian-yan ZHANG Tao LIU Qian ZHAO Bi-lu LI | 2012 | Acta Pharmacologica Sinica2012，33，11： | 9 |
| 7 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 8 | Behavioral Abnormality along with NMDAR-related CREB Suppression in Rat Hippocampus after Shortwave Exposure显示文摘Objective To estimate the detrimental effects of shortwave exposure on rat hippocampal structure and function and explore the underlying mechanisms. Methods One hundred Wistar rats were randomly divided into four groups(25 rats per group) and exposed to 27 MHz continuous shortwave at a power density of 5, 10, or 30 m W/cm^2 for 6 min once only or underwent sham exposure for the control. The spatial learning and memory, electroencephalogram(EEG), hippocampal structure and Nissl bodies were analysed. Furthermore, the expressions of N-methyl-D-aspartate receptor(NMDAR) subunits(NR1, NR2 A, and NR2 B), c AMP responsive element-binding protein(CREB) and phosphorylated CREB(p-CREB) in hippocampal tissue were analysed on 1, 7, and 14 days after exposure. Results The rats in the 10 and 30 m W/cm^2 groups had poor learning and memory, disrupted EEG oscillations, and injured hippocampal structures, including hippocampal neurons degeneration, mitochondria cavitation and blood capillaries swelling. The Nissl body content was also reduced in the exposure groups. Moreover, the hippocampal tissue in the 30 m W/cm^2 group had increased expressions of NR2 A and NR2 B and decreased levels of CREB and p-CREB. Conclusion Shortwave exposure(27 MHz, with an average power density of 10 and 30 m W/cm^2) impaired rats' spatial learning and memory and caused a series of dose-dependent pathophysiological changes. Moreover, NMDAR-related CREB pathway suppression might be involved in shortwave-induced structural and functional impairments in the rat hippocampus. | YU Chao BAI Yan Xin XU Xin Ping GAO Ya Bing HAO Yan Hui WANG Hui TAN Sheng Zhi LI Wen Chao ZHANG Jing YAO Bin Wei DONG Ji ZHAO Li PENG Rui Yun | 2019 | Biomedical and Environmental Sciences2019，32，3： | 7 |
| 9 | Effects of ecological factors on secondary metabolites and inorganic elements of Scutellaria baicalensis and analysis of geoherblism显示文摘This study analyzed the effects of ecological factors on secondary metabolites of Scutellaria baicalensis using two sources:92individual roots of S.baicalensis from all over China,and secondary metabolites,medicinal materials and inorganic element contents obtained from the testing of 92 S.baicalensis rhizosphere soil samples.The study used environmental data from the Genuine Medicinal Material Spatial Analysis Database.Most of the chemical constituents of S.baicalensis were negatively correlated to latitude and positively correlated to temperature;generally,the contents of 21 chemical constituents were higher at low latitudes than that at high latitudes.By gradual regression analysis,it was found that the content of baicalin in S.baicalensis was negatively correlated to latitude and generally the content of inorganic elements in soil was excessively high(excluding Mg and Ca),which has a negative effect on the accumulation of chemical constituents in S.baicalensis.Based on the cluster analysis of 21 constituents,S.baicalensis from different places of origin was divided into two groups,and S.baicalensis was not genuine only in a specific small region.Within the zone from Chifeng,Inner Mongolia to Taibai,Shaanxi is suitable for accumulation of secondary metabolites of S.baicalensis and such a zone represents a suitable distribution and potential genuine producing area. | GUO LanPing WANG Sheng ZHANG Ji YANG Guang ZHAO ManXi MA WeiFeng ZHANG XiaoBo LI Xuan HAN BangXing CHEN NaiFu HUANG LuQi | 2013 | Science China(Life Sciences)2013，56，11： | 7 |
| 10 | A combination of follicle stimulating hormone, estradiol and age is associated with the pregnancy outcome for women undergoing assisted reproduction: a retrospective cohort analysis显示文摘To investigate the effect of basal hormone levels including follicle stimulating hormone(FSH) and estradiol(E2) and age on the pregnancy outcomes in women undergoing in vitro fertilization and embryo transfer(IVF-ET), we designed a retrospective cohort analysis and collected information of patients undergoing IVF between January 2014 and April 2017. We found that young women had much better pregnancy outcomes than older women regardless of the hormone levels. The pregnancy outcomes declined in young women with high basal E2, even though they had normal FSH. Older women with higher FSH had a worse outcome of pregnancy, especially with increased E2 level. The results suggest that a combination of FSH, E2 and age could effectively predict the pregnancy outcome for women undergoing IVF-ET, and we should encourage infertile women with diminished ovarian reserve, especially young infertile women, to try the assisted reproduction as early as possible. After 40-yearold, the cost-benefit ratio should be considered according to the ovarian function. | Ziru Jiang Li Jin Weihui Shi Ji Xi Yulian Hu Xinmei Liu Jianzhong Sheng Guolian Ding Hefeng Huang | 2019 | Science China(Life Sciences)2019，62，1： | 7 |
| 11 | A novel satellite-equipped receiver for autonomous monitoring of GNSS navigation signal quality显示文摘Global navigation satellite system(GNSS) comes with potential unavoidable application risks such as the sudden distortion or failure of navigation signals because its satellites are generally operated until failure. In order to solve the problems associated with these risks, receiver autonomous integrity monitoring(RAIM) and ground-based signal quality monitoring stations are widely used. Although these technologies can protect the user from the risks, they are expensive and have limited region coverage. Autonomous monitoring of satellite signal quality is an effective method to eliminate these shortcomings of the RAIM and ground-based signal quality monitoring stations; thus, a new navigation signal quality monitoring receiver which can be equipped on the satellite platform of GNSS is proposed in this paper. Because this satellite-equipped receiver is tightly coupled with navigation payload, the system architecture and its preliminary design procedure are first introduced. In theory, code-tracking loop is able to provide accurate time delay estimation of received signals. However, because of the nonlinear characteristics of the navigation payload, the traditional code-tracking loop introduces errors. To eliminate these errors, the dummy massive parallel correlators(DMPC) technique is proposed. This technique can reconstruct the cross correlation function of a navigation signal with a high code phase resolution. Combining the DMPC and direct radio frequency(RF) sampling technology, the satellite-equipped receiver can calibrate the differential code bias(DCB) accurately. In the meantime, the abnormities and failures of navigation signal can also be monitored. Finally, the accuracy of DCB calibration and the performance of fault monitoring have been verified by practical test data and numerical simulation data, respectively. The results show that the accuracy of DCB calibration is less than 0.1 ns and the novel satellite-equipped receiver can monitor the signal quality effectively. | YANG Jian YANG YiKang LI Ji Sheng LI HengNian YANG TianShe | 2016 | Science China(Technological Sciences)2016，59，7： | 6 |
| 12 | 间歇性多西他赛联合比卡鲁胺治疗去势抵抗性前列腺癌的前瞻性历史对照研究显示文摘持续性多西他赛(DTX)方案在权衡其疗效及生活质量后是否优于间歇性多西他赛治疗去势抵抗性前列腺癌(CRPC)目前尚不清楚。本研究我们对间歇性每三周DTX联合比卡鲁胺治疗CPPC疗效,安全性及生活质量(QoL)进行了评估。A组纳入42例CRPC患者,三周一次给予静脉DTX(75mg m^-2)联合口服比卡鲁胺(50mg,每日一次)。当血清PSA〉50%并伴随稳定影像学证据时,患者进入化疗休息期(停用DXT),一旦出现PSA〉25%或出现其它疾病进展的依据时化疗休息期中止,再次给予DXT化疗,当达到上述标准时化疗休息期不限。B组纳入60例行持续性多西他赛化疗CRPC进行回顾性分析。A组中位PSA无进展时间(8 vs.9个月,P=0.866)及中位总体生存时间(19 vs.21个月,P=0.753)与B组比较无显著统计学差异。A组发生所有级别的粒细胞减少症(33% vs.58%,P=0.013)及恶心/呕吐(11% vs.29%,P=0.024)明显低于B组,A组化疗后总体健康水平及疲劳方面评分与化疗前比较有显著改善(P〈0.05),B组在化疗后与化疗前比较显著增加疲劳、恶心/呕吐及厌食评分俨〈O.05)。间歇性三周一次DXT联合比卡鲁胺治疗去势抵抗性前列腺癌是安全的,能达到与持续性化疗相当的疗效,并可能伴有更好的生活质量。 | Yun-Fei Li Shao-Feng Zhang Tao-Tao Zhang Lei Li Wei Gan Hong-Tao Jia Sheng Xie Hui-Hua Ji Da-Lin He | 2013 | Asian Journal of Andrology2013，15，6： | 5 |
| 13 | Characteristics of Permafrost along Highway G214 in the Eastern Qinghai-Tibet Plateau显示文摘The characteristics of the permafrost along National Highway No. 214(G214) in Qinghai province(between kilometer markers K310 and K670),including the distribution patterns of permafrost and seasonally frozen ground(SFG), ground ice content and mean annual ground temperature(MAGT), were analyzed using a large quantity of drilling and measured ground temperature data. Three topographic units can be distinguished along the highway: the northern mountains, including Ela Mountain and Longstone Mountain; the medial alluvial plain and the southern Bayan Har Mountains.The horizontal distribution patterns of permafrost can be divided into four sections, from north to south: the northern continuous permafrost zone(K310-K460),the island permafrost zone(K460-K560), the southern continuous permafrost zone(K560-K630),and the discontinuous permafrost zone(K630-K670).Vertically, the permafrost lower limits(PLLs) of the discontinuous zone were 4200/4325 m, 4230/4350 m,and 4350/4450 m on the north-facing/south-facing slopes of Ela Mountain, Longstone Mountain and Bayan Har Mountains, respectively. The permafrost was generally warm, with MAGTs between-1.0°C and0°C in the northern continuous permafrost zone,approximately-0.5°C in the island permafrost zone,between-1.5°C and 0°C in the southern continuous permafrost zone, and higher than-0.5°C in the discontinuous permafrost zone. In contrast, the spatial variations in ground ice content were mainly controlled by the local soil water content and lithology.The relationships between the mean annual air temperature(MAAT) and the PLLs indicated that the PLLs varied between-3.3°C and-4.1°C for the northern Ela and Longstone Mountains and between-4.1°C and-4.6°C in the southern Bayan Har Mountains. | SHENG Yu CAO Yuan-bing LI Jing WU Ji-chun CHEN Ji FENG Zi-liang | 2015 | Journal of Mountain Science2015，12，5： | 5 |
| 14 | A fully automatic registration approach based on contour and SIFT for HJ-1 images显示文摘To achieve a fully automatic registration between HJ-1 CCD images and HJ-1 infrared images is a difficult task as it must deal with the varying illuminations and resolutions of the images,different perspectives,and the local deformations within the images.In this paper,aimed at those registration issues,a fully automatic registration approach based on contour and SIFT is proposed.The registration technique performs a pre-registration process using contour feature matching algorithm that decides the overlapping region between a reference image and an input image.Once the coarse regions are obtained,it performs a fine registration process based on SIFT detector and a local adaptive matching strategy.In the fine registration process,image blocking theory is used,which not only speeds up the features extraction and matching,but also makes the matching point pairs distributed uniformly in images,and further improves the accuracy of input image rectification.Experiments with visible images and infrared images from HJ-1A/B demonstrate the efficiency and the accuracy of the proposed technique for multisource remote sensing images registration. | NI XiLiang CAO ChunXiang DING Lin JIANG Tao ZHANG Hao JIA HuiCong LI GuangHe ZHAO Jian CHEN Wei JI Wei XU Min GAO MengXu ZHENG Sheng TIAN Rong LIU Cheng LI Sha | 2012 | Science China Earth Sciences2012，55，10： | 5 |
| 15 | Synthesis and biological evaluation of nitric oxide-releasing sixalkoxyl biphenyl derivatives as anticancer agents显示文摘A series of novel nitric oxide-donating sixalkoxyl biphenyl derivatives (14a-l) were synthesized by coupling furoxan with alkoxyl biphenyl skeleton using amino acids as the spacers, and their cytotoxicity against HepG2 cells in vitro were evaluated by MTT method. It was found that 14c, 14d, 14f, 14i, 14j and 14k showed more potent cytotoxic activities than control 5-?uorouracil. NO release assay of target compounds indicated that the maximum amount of NO released by most active compounds 14c and 14j was about 6 10 2 mmol/L, whereas 14a and 14h with very weak activity only released NO of 1 10 2 mmol/L. | Xiang Wen Kong Yi Hua Zhang Li Dai Hui Ji Yi Sheng Lai Si Xun Peng | 2008 | Chinese Chemical Letters2008，19，2： | 5 |
| 16 | Role of MR in the differentiation of IgG4-related from non-IgG4-related hepatic inflammatory pseudotumor显示文摘BACKGROUND:Hepatic inflammatory pseudotumor(IPT)is classified into 2 types based on IgG 4 stain:IgG 4-related and non-IgG4-related; the two types differ not only in their pathological characteristics, but also in the clinical features. This study aimed to investigate the MR character of hepatic IPT,and differentiate the IgG4-related IPT from the non-IgG4-related IPT.METHODS:Twenty-five patients with 27 histologically proven hepatic IPTs were retrospectively analyzed. Ten lesions were diagnosed as IgG4-related IPT, and the other 17 as non-IgG4-related IPT. The MR signal features on T1,T2-weighted, dynamic-enhanced, and diffusion-weighted imaging were evaluated and compared. RESULTS:The dominant lesions were subcapsularly distributed(n=17, 63.0%) with clear boundary(n=20, 74.1%), and showed progressive enhancement pattern(n=21, 77.8%) with diffuse homogeneous(n=12, 44.4%) or heterogeneous(n=8,29.6%) hyperintensity, accompanied by delayed capsule-like enhancement(n=17, 63.0%) and central nonenhanced areas(n=18, 66.7%). Morphological features(P>0.05) were not sufficient to differentiate IgG4-related IPT from non-IgG4-related IPT; the wash-out pattern was only found in 2 IgG 4-related IPT, while the progressive enhancement pattern was more common in the non-IgG4-related lesions(n=16)(P=0.022).During portal and delayed phases, iso-/hypoenhanced lesions were only seen in 3 IgG4-related IPT, and circular-enhanced lesions(n=5) existed exceptionally in the non-IgG4-related group with significant differences(P=0.029 and 0.027). Most IgG4-related IPTs had lower apparent diffusion coefficient compared with the liver parenchyma(n=6), while most non-IgG4-related IPTs had higher apparent diffusion coefficient value(n=13)(P=0.046).CONCLUSIONS:Although MR images of hepatic IPT have certain characteristics, they are not enough to differentiate IgG4-related IPT from non-IgG4-related IPT. The enhancement pattern, signal features on portal and delayed phases, and the apparent diffusion coefficient value of the lesion may be helpful for the diagnosis. | Ruo-Fan Sheng Chang-Wen Zhai Yuan Ji Cai-Zhong Chen Li Yang Meng-Su Zeng | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，6： | 5 |
| 17 | Molecular Characteristics of Neisseria meningitidis Isolated during an Outbreak in a Jail: Association with the Spread and Distribution of ST-4821 Complex Serogroup C Clone in China显示文摘Objective To characterize the meningococcal strains isolated from cases and close contacts with meningococcal disease associated with an outbreak in a jail in May 2010 by investigating the national distribution of hyperinvasive ST-4821 serogroup C clone associated with this outbreak. Methods The cases were described based on the clinical symptoms and laboratory results. Pharyngeal swabs were cultured for N. meningitidis from men in the jail. Meningococcal isolates were identified by serogrouping, pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST), respectively. Four hundred and sixteen serogroup C N. meningitidis strains were collected from 27 provinces between 2003 and 2010 for a nationwide survey and analyzed by PFGE and MLST. Results Three persons in a jail system were infected with invasive N. meningitidis serogroup C. All isolates tested had matching PFGE patterns and belonged to the multilocus sequence type (ST) 4821 clonal complex. All 47 N. meningitidis strains were identified from the pharyngeal swabs of 166 peoples in the jail, and 26 of them belonged to ST-4821 serogroup C clone, and 90.14% (375/416) serogroup C strains identified in the nationwide survey belonged to the ST-4821 complex. The ST-4821 serogroup C clone was spread nationwide, distributed in 24 provinces, especially in eastern provinces between 2003 and 2010. Conclusion Endemic transmission and carriage rate of ST-4821 serogroup C clone are high in this jail system. The ST-4821 serogroup C clone is spreading in China and nationwide distributed despite the existence of some effective vaccines. | ZHANG Ji ZHOU Hai Jian XU Li HU Guang Chun ZHANG Xue Hua XU Sheng Ping LIU Zun Yu SHAO Zhu Jun | 2013 | Biomedical and Environmental Sciences2013，26，5： | 5 |
| 18 | Exposure Effects of Terahertz Waves on Primary Neurons and Neuron-like Cells Under Nonthermal Conditions显示文摘Objective This study aimed to explore the potential effects of terahertz(THz) waves on primary cultured neurons from 4 rat brain regions(hippocampus, cerebral cortex, cerebellum, and brainstem)and 3 kinds of neuron-like cells(MN9 D, PC12, and HT22 cells) under nonthermal conditions.Methods THz waves with an output power of 50(0.16 THz) and 10(0.17 THz) m W with exposure times of 6 and 60 min were used in this study. Analysis of temperature change, neurite growth, cell membrane roughness, micromorphology, neurotransmitters and synaptic-related proteins(SYN and PSD95) was used to evaluate the potential effects.Results Temperature increase caused by the THz wave was negligible. THz waves induced significant neurotransmitter changes in primary hippocampal, cerebellar, and brainstem neurons and in MN9 D and PC12 cells. THz wave downregulated SYN expression in primary hippocampal neurons and downregulated PSD95 expression in primary cortical neurons.Conclusion Different types of cells responded differently after THz wave exposure, and primary hippocampal and cortical neurons and MN9 D cells were relatively sensitive to the THz waves. The biological effects were positively correlated with the exposure time of the THz waves. | TAN Sheng Zhi TAN Peng Cheng LUO Lan Qing CHI Yun Liang YANG Zi Long ZHAO Xue Long ZHAO Li DONG Ji ZHANG Jing YAO Bin Wei XU Xin Ping TIAN Guang CHEN Jian Kui WANG Hui PENG Rui Yun | 2019 | Biomedical and Environmental Sciences2019，32，10： | 5 |
| 19 | Study on The Method of Quantitative Analysis of Serum Ferritin and Soluble Transferrin Receptor with Protein Microarray Technology显示文摘Objective To establish and evaluate a protein microarray method for combined measurement of serum ferritin(SF) and soluble transferrin receptor(sTfR).Methods Microarrayer was used to print both anti-SF antibodies I and anti-sTfR antibodies I on each protein microarray.Anti-SF antibodies II and anti-sTfR antibodies II were used as detection antibodies and goat antibodies coupled to Cy3 were used as antibodies III.The detection conditions of the quantitative analysis method for simultaneous measurement of SF and sTfR with protein microarray were optimized and evaluated.The protein microarray was compared with commercially available traditional tests with 26 serum samples.Results By comparison experiment,mouse monoclonal antibodies were chosen as the probes and contact printing was chosen as the printing method.The concentrations of SF and sTfR probes were 0.5 mg/mL and 0.5 mg/mL respectively,while those of SF and sTfR detection antibodies were 5 μg/mL and 0.36 μg/mL respectively.Intra-and inter-assay variability was between 3.26% and 18.38% for all tests.The regression coefficients comparing protein microarray with traditional test assays were better than 0.81 for SF and sTfR.Conclusion The present study has established a protein microarray method for combined measurement of SF and sTfR. | YIN Ji Yong SUN Jing HUANG Jian LI Wen Xian HUO Jun Sheng | 2012 | Biomedical and Environmental Sciences2012，25，4： | 4 |
| 20 | Recombinant scorpion insectotoxin AaIT kills specifically insect cells but not human cellss显示文摘The nucleotide sequence deduced from the amino acid sequence of the scorpion insectotoxin AaIT was chemically synthesized and was expressed in Escherichia coli. The authenticity of this in vitro expressed peptide was confirmed by N-terminal peptide sequencing. Two groups of bioassays, artificial diet incorporation assay and contact insecticidal effect assay, were carried out separately to verify the toxicity of this recombinant toxin. At the end of a 24 h experimental period, more than 60% of the testing diamondback moth (Plutella xylostella) larvae were killed in both groups with LCs0 value of 18.4 uM and 0.70 μM respectively. Cytotoxicity assay using cultured Sf9 insect cells and MCF-7 human cells demonstrated that the toxin AaIT had specific toxicity against insect cells but not human cells. Only 0.13 μM recombinant toxin was needed to kill 50% of cultured insect cells while as much as 1.3μM toxin had absolutely no effect on human cells. Insect cells produced obvious intrusions from their plasma membrane before broken up. We infer that toxin AaIT bind to a putative sodium channel in these insect cells and open the channel persistently, which would result in Na+ influx and finally cause destruction of insect cells. | SHENG JIAN JI, FENG LIU, ER Qiu LI, Yu XIAN ZHUThe National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing 100871, China | 2002 | Cell Research2002，12，2： | 4 |
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