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| 1 | A heavy mineral viewpoint on sediment provenance and environment in the Qiongdongnan Basin显示文摘Based on heavy mineral data in core samples from eleven drillings, supplemented by paleontological, element geochemical and seismic data, the evolution of sediment provenance and environment in the Qiongdongnan Basin(QDNB) was analysed. The results show that the basement in the QDNB was predominantly composed of terrigenous sediments. Since the Oligocene the QDNB has gradually undergone transgressions and evolution processes in sedimentary environment from terrestrial-marine transitional to littoral-neritic, neritic, and bathyal roughly. The water depth showed a gradually increasing trend and was generally greater in the southern region than that in the northern region in the same time. With changes in sedimentary environment, provenances of the strata(from the Yacheng Formation to the Yinggehai Formation) showed principal characteristics of multisources, evolving from autochthonous source, short source to distant source step by step. During the Early Oligocene, the sediments were mainly proximal basaltic pyroclastic source and adjacent terrigenous clastic source, afterwards were becoming distant terrigenous clastic sources, including Hainan Island on the north,Yongle Uplift on the south, Shenhu Uplift on the northeast, the Red River System on the northwest and Indochina Peninsula on the southwest, or even a wider region. The Hainan Island provenance began to develop during the Early Oligocene and has become a main provenance in the QDNB since the Middle Miocene. The provenances from Yongle Uplift and Shenhu Uplift most developed from the Late Oligocene to the Early Miocene and gradually subsided during the Middle Miocene. During the Late Miocene, as a main source of sediments filled in the central canyon, the Red River System provenance added to the QDNB massively, whose impact terminated at the end of the Pliocene. The western Yinggehai Basin(YGHB) provenance derived from Indochina Peninsula had developed from the Pliocene on to the Pleistocene. In addition, the material contribution of marine authigenous source to the basin(especially to the southern region) could not be ignored. | LIU Xiaofeng ZHANG Daojun ZHAI Shikui LIU Xinyu CHEN Hongyan LUO Wei LI Na XIU Chun | 2015 | Acta Oceanologica Sinica2015，34，4： | 10 |
| 2 | Geology and hydrocarbon accumulations in the deepwater of the northwestern South China Sea——with focus on natural gas显示文摘The deepwater of the northwestern South China Sea is located in the central to southern parts of the Qiongdongnan Basin(QDN Basin),which is a key site for hydrocarbon exploration in recent years.In this study,the authors did a comprehensive analysis of gravity-magnetic data,extensive 3D seismic survey,cores and cuttings,paleontology and geochemical indexes,proposed the mechanism of natural gas origin,identified different oil and gas systems,and established the model of hydrocarbon accumulations in the deep-water region.Our basin tectonic simulation indicates that the evolution of QDN Basin was controlled by multiple-phased tectonic movements,such as Indochina-Eurasian Plate collision,Tibetan Uplift,Red River faulting and the expansion of the South China Sea which is characterized by Paleogene rifting,Neogene depression,and Eocene intensive faulting and lacustrine deposits.The drilling results show that this region is dominated by marineterrestrial transitional and neritic-bathyal facies from the early Oligocene.The Yacheng Formation of the early Oligocene is rich in organic matter and a main gas-source rock.According to the geological-geochemical data from the latest drilling wells,Lingshui,Baodao,Changchang Sags have good hydrocarbon-generating potentials,where two plays from the Paleogene and Neogene reservoirs were developed.Those reservoirs occur in central canyon structural-lithologic trap zone,Changchang marginal trap zone and southern fault terrace of Baodao Sag.Among them,the central canyon trap zone has a great potential for exploration because the various reservoirforming elements are well developed,i.e.,good coal-measure source rocks,sufficient reservoirs from the Neogene turbidity sandstone and submarine fan,faults connecting source rock and reservoirs,effective vertical migration,late stage aggregation and favorable structural–lithological composite trapping.These study results provide an important scientific basis for hydrocarbon exploration in this region,evidenced by the recent discovery of the significant commercial LS-A gas field in the central canyon of the Lingshui Sag. | WANG Zhenfeng SUN Zhipeng ZHANG Daojun ZHU Jitian LI Xushen HUANG Baojia GUO Minggang JIANG Rufeng | 2015 | Acta Oceanologica Sinica2015，34，10： | 9 |
| 3 | Evaluation of efficacy and safety of gandouling plus sodium dimercaptosulphonate in treatment of patients with neurological Wilson's disease from China显示文摘OBJECTIVE: To evaluate the efficacy and safety of gandouling plus sodium dimercaptosulphonate(DMPS) on neurological Wilson's disease(WD) in patients.METHODS: We retrospectively evaluated the clinical records of 125 WD patients with neurological syndromes who were treated with gandouling plus sodium DMPS or DMPS used alone. All patients had a history of neurological deterioration during their diseases courses. The clinical efficacies, adverse reactions, and results of the various hematological and biochemical investigations were recorded for statistical analysis.RESULTS: 92.30%(60 patients) of the WD patients treated with the combined therapy experienced an improved or stable neurological condition paral-leled by a significantly improved GAS score. Meanwhile, the WBC and PLT counts stabilized, liver function and renal function were improved or remained stable. The combined therapy also obviously promoted the 24-h urinary copper excretion. In particular, only 30.76% of the WD patients experienced mild adverse reactions, including neurological deterioration in 5 patients(7.69%), hepatic worsening in 1 subject(1.89%), which was less frequently than those in the control group treated with DMPS only.CONCLUSION: Our findings indicate that the safety and efficacy of gandou-ling plus DMPS is superior to those of DMPS used alone in the WD patients with neurological symptoms. | Zhang Jing Xie Daojun Guo Yanbing Li Yajun Li Liangyong Han Hui Zhang Juan Chen Huaizhen Wang Meixia | 2018 | Journal of Traditional Chinese Medicine2018，38，5： | 7 |
| 4 | Novel synthesis of fly-ash-derived Cu-loaded SAPO-34 catalysts and their use in selective catalytic reduction of NO with NH3显示文摘A combined acid–alkali hydrothermal method was used to prepare fly ash–derived SAPO-34 molecular sieves from a thermal power plant in Inner Mongolia(China).The specific surface area of the prepared fly-ash-derived SAPO-34 molecular sieves was 579 m^2 g^-1,the total pore volume was about 0.27 cm^3 g^-1,and the pore size was 0.56 nm;the molar ratios of Al2O3:P2O5:SiO2 were 1:0.86:0.45.Cu/SAPO-34 catalysts were prepared by impregnation of low-cost fly-ash-derived SAPO-34 molecular sieves as a support and tested in selective catalytic reduction with NH3(NH3-SCR).Powder X-ray diffraction(XRD),N2 adsorption–desorption,X-ray photoelectron spectroscopy(XPS),H2 temperatureprogrammed reduction(H2-TPR),NH3 temperature-programmed desorption(NH3-TPD),electron paramagnetic resonance(EPR),nuclear magnetic resonance(NMR),X-ray fluorescence analysis(XRF)and scanning electron microscopy(SEM)were used for catalyst characterization and investigation of the relationships between the catalyst structure and the catalytic activity.The actual silica:alumina ratio of the molecular sieves did not increase with increasing Cu loading,indicating that increasing the Cu loading does not change the original structure of the SAPO-34 molecular sieves.The XRF and NMR results showed that replacement by Cu results in more Si islands.The molecular sieve acidity decreased because of the increased number of Si islands.The NH3-TPD results showed that for the Cu/SAPO-34 catalysts there was a low correlation between the low-temperature activity and the amount of acidic sites.SCR activity is closely related to the location of Cu.The 4.47 Cu/SAPO-34 catalyst has the highest isolated Cu2+showed the highest NH3-SCR activities(>90%)at 250–350℃.This work opens up new avenues for recycling fly ash formed in coal-fired power plants(reducing environmental pollution)and developing low-cost SCR catalysts for NOx pollution control. | Ge Li Baodong Wang Qi Sun Wayne Qiang Xu Ziran Ma Hongyan Wang Daojun Zhang Jiali Zhou | 2019 | Green Energy & Environment2019，4，4： | 6 |
| 5 | Difference in full-filled time and its controlling factors in the Central Canyon of the Qiongdongnan Basin显示文摘Based on the interpretation of high resolution 2D/3D seismic data,sedimentary filling characteristics and fullfilled time of the Central Canyon in different segments in the Qiongdongnan Basin of northwestern South China Sea have been studied.The research results indicate that the initial formation age of the Central Canyon is traced back to 11.6 Ma(T40),at which the canyon began to develop due to the scouring of turbidity currents from west to east.During the period of 11.6–8.2 Ma(T40–T31),strong downcutting by gravity flow occurred,which led to the formation of the canyon.The canyon fillings began to form since 8.2 Ma(T31) and were dominated by turbidite deposits,which constituted of lateral migration and vertical superposition of turbidity channels during the time of8.2–5.5 Ma.The interbeds of turbidity currents deposits and mass transport deposits(MTDs) were developed in the period of 5.5–3.8 Ma(T30–T28).After then,the canyon fillings were primarily made up of large scale MTDs,interrupted by small scale turbidity channels and thin pelagic mudstones.The Central Canyon can be divided into three types according to the main controlling factors,geomorphology-controlled,fault-controlled and intrusionmodified canyons.Among them,the geomorphology-controlled canyon is developed at the Ledong,Lingshui,Songnan and western Baodao Depressions,situated in a confined basin center between the northern slope and the South Uplift Belt along the Central Depression Belt.The fault-controlled canyon is developed mainly along the deep-seated faults in the Changchang Depression and eastern Baodao Depression.Intrusion-modified canyon is only occurred in the Songnan Low Uplift,which is still mainly controlled by geomorphology,the intrusion just modified seabed morphology.The full-filled time of the Central Canyon differs from west to east,displaying a tendency of being successively late eastward.The geomorphology-controlled canyon was completely filled before3.8 Ma(T28),but that in intrusion-modified canyon was delayed to 2.4 Ma(T27) because of the uplifted southern canyon wall.To the Changchang Depression,the complete filling time was successively late eastward,and the canyon in eastern Changchang Depression is still not fully filled up to today.Difference in full-filled time in the Central Canyon is mainly governed by multiple sediment supplies and regional tectonic activities.Due to sufficient supply of turbidity currents and MTDs from west and north respectively,western segment of the Central Canyon is entirely filled up earlier.Owing to slower sediment supply rate,together with differential subsidence by deep-seated faults,the full-filled time of the canyon is put off eastwards gradually. | SHANG Zhilei XIE Xinong LI Xushen ZHANG Daojun HE Yunlong YANG Xing CUI Mingzhe | 2015 | Acta Oceanologica Sinica2015，34，10： | 5 |
| 6 | Abrogation of Hn RNP L enhances anti-PD-1 therapy efficacy via diminishing PD-L1 and promoting CD8^(+) T cell-mediated ferroptosis in castration-resistant prostate cancer显示文摘Owing to incurable castration-resistant prostate cancer(CRPC)ultimately developing after treating with androgen deprivation therapy(ADT),it is vital to devise new therapeutic strategies to treat CRPC.Treatments that target programmed cell death protein 1(PD-1)and programmed death ligand-1(PD-L1)have been approved for human cancers with clinical benefit.However,many patients,especially prostate cancer,fail to respond to anti-PD-1/PD-L1 treatment,so it is an urgent need to seek a support strategy for improving the traditional PD-1/PD-L1 targeting immunotherapy.In the present study,analyzing the data from our prostate cancer tissue microarray,we found that PD-L1 expression was positively correlated with the expression of heterogeneous nuclear ribonucleoprotein L(Hn RNP L).Hence,we further investigated the potential role of Hn RNP L on the PD-L1 expression,the sensitivity of cancer cells to T-cell killing and the synergistic effect with anti-PD-1 therapy in CRPC.Indeed,Hn RNP L knockdown effectively decreased PD-L1 expression and recovered the sensitivity of cancer cells to T-cell killing in vitro and in vivo,on the contrary,Hn RNP L overexpression led to the opposite effect in CRPC cells.In addition,consistent with the previous study,we revealed that ferroptosis played a critical role in T-cell-induced cancer cell death,and Hn RNP L promoted the cancer immune escape partly through targeting YY1/PD-L1 axis and inhibiting ferroptosis in CRPC cells.Furthermore,Hn RNP L knockdown enhanced antitumor immunity by recruiting infiltrating CD8^(+)T cells and synergized with anti-PD-1 therapy in CRPC tumors.This study provided biological evidence that Hn RNP L knockdown might be a novel therapeutic agent in PD-L1/PD-1 blockade strategy that enhanced anti-tumor immune response in CRPC. | Xumin Zhou Libin Zou Hangyu Liao Junqi Luo Taowei Yang Jun Wu Wenbin Chen Kaihui Wu Shengren Cen Daojun Lv Fangpeng Shu Yu Yang Chun Li Bingkun Li Xiangming Mao | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 4 |
| 7 | Effects of kanglaite capsules combined with transcatheter arterial chemoembolization (TACE) on patients with mid or late-stage primary hepatocellular carcinoma (HCC)显示文摘观察囊与 transcatheter 相结合的 kanglaite (KLT ) 的临床的效果的目的动脉的 chemoembolization (不作声) 在与中间或迟了阶段的主要肝细胞癌(HCC ) 对待病人。65 个盒子随机被划分成 2 个组,的方法在联合组的 32 个病人接受了 KLT 囊 + 的治疗不作声,在控制组的 33 个病人被对待与独自不作声。客观反应率(RR ) ,浆液高山哈 fetoprotein (法新社) ,外部血 T 淋巴细胞亚群(T-LS ) ,生命(QOL ) 的质量,前进(TTP ) 的时间和不利反应在 2 之间被遵守并且比较组。客观反应评估的结果和浆液高山哈 fetoprotein 层次没有在二个组之间的有效差量(P >
0.05 ) 。联合组是优异的在生命(QOL ) 的质量控制组,前进(TTP ) 的时间,外部血 T 淋巴细胞亚群(CD3+ , CD4+ , CD4+∖CD8 比率) 并且肝不利反应,与有效差量(P <
0.05 ) 。结论 KLT 囊与结合了不作声是到对待的一个有效方法失去了外科的治疗的机会的主要肝细胞癌(HCC ) 病人。 | Daojun Li Xinhua Xu Dan Bao Feng Xue Delan Dai | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，2： | 4 |
| 8 | MAPT as a predisposing gene for sporadic amyotrophic lateral sclerosis in the Chinese Han population显示文摘A previous study of European Caucasian patients with sporadic amyotrophic lateral sclerosis demonstrated that a polymorphism in the microtubule-associated protein Tau(MAPT) gene was significantly associated with sporadic amyotrophic lateral sclerosis pathogenesis.Here,we tested this association in 107 sporadic amyotrophic lateral sclerosis patients and 100 healthy controls from the Chinese Han population.We screened the mutation-susceptible regions of MAPT–the 3′ and 5′ untranslated regions as well as introns 9,10,11,and 12–by direct sequencing,and identified 33 genetic variations.Two of these,105788 A>G in intron 9 and 123972 T>A in intron 11,were not present in the control group.The age of onset in patients with the 105788 A>G and/or the 123972 T>A variant was younger than that in patients without either genetic variation.Moreover,the patients with a genetic variation were more prone to bulbar palsy and breathing difficulties than those with the wild-type genotype.This led to a shorter survival period in patients with a MAPT genetic variant.Our study suggests that the MAPT gene is a potential risk gene for sporadic amyotrophic lateral sclerosis in the Chinese Han population. | Pu Fang Wenyuan Xu Chengsi Wu Min Zhu Xiaobing Li Daojun Hong | 2013 | Neural Regeneration Research2013，8，33： | 2 |
| 9 | Frontier research of ultra-high-speed ultra-large-capacity and ultra-long-haul optical transmission显示文摘极端高速度, ultra-large-capacity 和 ultra-long-haul (3U ) 是光通讯的永久追求。作为光通讯的一个新模式, 3U 传播能极大地支持下一代光因特网和宽带活动通讯网络开发和工艺的进步,因此,它变得国际高技术知识产权竞争的焦点扎根。这篇论文在 3U 传播研究引入科学问题,关键技术和重要成就。 | Daojun XUE Shaohua YU Qi YANG Nan CHI Lan RAO Xiangjun XIN Wei LI Songnian FU Sheng CUI Demin LIU Zhuo LI Aijun WEN Chongxiu YU Xinmei WANG | 2016 | Frontiers of Optoelectronics2016，9，2： | 2 |
| 10 | Template preparation of Pt-Ru and Pt nanowire array electrodes on a Ti/Si substrate for methanol electro-oxidation 显示文摘 | Zhao Guangyu Xu Cailing Guo Daojun Li Hua Li Hulin | 2006 | Journal of Power Sources2006，162，4： | 1 |
| 11 | High activity of novel Pd/TiO2 nanotube catalysts for methanol electro-oxidatin 显示文摘 | Wang Mei Guo Daojun Li Hulin | 2005 | J Solid State Chem2005，178，6： | 1 |
| 12 | Effect of manganese and/or ceria loading on V_2O_5-MoO_3/TiO_2 NH_3 selective catalytic reduction catalyst显示文摘The effect of manganese and/or ceria loading of V2 O5-MoO3/TiO2 catalysts was investigated for selective catalytic reduction(SCR) of NOx by NH3.The manganese and/or ceria loaded V2 O5-MoO3/TiO2 catalysts we re prepared by the wetness impregnation method.The physicochemical characteristics of the catalysts were thoroughly characterized.The catalytic performance of 1.5 wt% V2 O5-3 wt% MoO3/TiO2(V1.5 Mo3/Ti) is greatly enhanced by addition of 2.5 wt% MnOx and 3.0 wt% CeO2(V1.5 Mo3 Mn2.5 Ce3/Ti) below450℃.Compared with the V1.5 Mo3/Ti catalyst with NOx conversion of 75% at 275 ℃,V1.5 Mo3 Mn2.5 Ce3/Ti exhibits higher NOx conversion of 84% with good resistance to SO2 and H2 O at a gas hourly space velocity value of 150000 h-1.The active manganese,cerium,molybdenum,and vanadium oxide species are highly dispersed on the catalyst surface and some synergistic effects exist among these species.Addition of MnOx significantly enhances the redox ability of the cerium,vanadium,and molybdenum species.Addition of Ce increases the acidity of the catalyst.More active oxygen species,including surface chemisorbed oxygen,form with addition of Mn and/or Ce.Because of the synergistic effects,appropriate proportions of manganese in different valence states exist in the catalysts.In summary,the good redox ability and the strong acidity contribute to the high NH3-SCR activity and N2 selectivity of the V1.5 Mo3 Mn2.5 Ce3/Ti catalyst in a wide temperature range.And the V1.5 Mo3 Mn2.5 Ce3/Ti catalyst shows good resistance to H2 O and SO2 in long-time catalytic testing,which can be ascribed to the highly sulfated species adsorbed on the catalyst. | Daojun Zhang Ziran Ma Baodong Wang Tao Zhu Duan Weng Xiaodong Wu Jingyun Chen Hongyan Wang Ge Li Jiali Zhou | 2020 | Journal of Rare Earths2020，38，7： | 1 |
| 13 | Well-dispersed multi-walled carbon nanotube/polyaniline composite films显示文摘 | Guo Daojun Li Hulin | | 0，，06： | 1 |
| 14 | Sirt6通过表观遗传调控Wnt信号通路控制造血干细胞的稳态显示文摘Wnt信号通路对造血干细胞稳态的维持是至关重要的,但Wnt信号在造血干细胞中的表观遗传调控规律仍然是未知的。 | 汪虎 Daojun Diao Zhencan Shi Xudong Zhu Yawei Gao Shaorong Gao Xiaoyu Liu You Wu K.Lenhard Rudolph Guanghui Liu Tangliang Li 鞠振宇 | 2017 | 科学新闻2017，19，4： | 0 |
| 15 | Automated Pavement Crack Detection Using Deep Feature Selection and Whale Optimization Algorithm显示文摘Pavement crack detection plays a crucial role in ensuring road safety and reducing maintenance expenses.Recent advancements in deep learning(DL)techniques have shown promising results in detecting pavement cracks;however,the selection of relevant features for classification remains challenging.In this study,we propose a new approach for pavement crack detection that integrates deep learning for feature extraction,the whale optimization algorithm(WOA)for feature selection,and random forest(RF)for classification.The performance of the models was evaluated using accuracy,recall,precision,F1 score,and area under the receiver operating characteristic curve(AUC).Our findings reveal that Model 2,which incorporates RF into the ResNet-18 architecture,outperforms baseline Model 1 across all evaluation metrics.Nevertheless,our proposed model,which combines ResNet-18 with both WOA and RF,achieves significantly higher accuracy,recall,precision,and F1 score compared to the other two models.These results underscore the effectiveness of integrating RF and WOA into ResNet-18 for pavement crack detection applications.We applied the proposed approach to a dataset of pavement images,achieving an accuracy of 97.16%and an AUC of 0.984.Our results demonstrate that the proposed approach surpasses existing methods for pavement crack detection,offering a promising solution for the automatic identification of pavement cracks.By leveraging this approach,potential safety hazards can be identified more effectively,enabling timely repairs and maintenance measures.Lastly,the findings of this study also emphasize the potential of integrating RF and WOA with deep learning for pavement crack detection,providing road authorities with the necessary tools to make informed decisions regarding road infrastructure maintenance. | Shorouq Alshawabkeh Li Wu Daojun Dong Yao Cheng Liping Li Mohammad Alanaqreh | 2023 | Computers, Materials & Continua2023，77，10： | 0 |
| 16 | Phytoplankton community dynamics during Alexandrium blooms in 2019 off the Qinhuangdao coast,Bohai Sea,China显示文摘Alexandrium blooms in the northwest area of the Bohai Sea(Qinhuangdao coastal area),China,produce large amounts of toxins that could be enriched in shellfish and consequently harm human bodies.To understand the succession of the phytoplankton community structure during Alexandrium bloom events in the northwest area of the Bohai Sea off Qinhuangdao from April 2 to May 7,2019,microscopy observations and high-performance chromatography(HPLC)-pigment analysis were performed.Sixty species of phytoplankton were identified,mainly diatoms and dinofl agellates.The abundance of Alexandrium reached the maximum on April 16(3.3×10^(3) cells/L).HPLC-pigment CHEMTAX analysis showed that the phytoplankton community was composed mainly of diatoms,dinofl agellates,prasinophytes,and cryptophytes.Diatoms were the main contributor to the total Chl-a pool.There was a downward trend for the proportion of diatom biomass to the total Chl-a pool,followed by an upward trend.The proportion of dinoflagellate biomass showed the opposite trend,whereas that of the prasinophyte biomass presented an obvious increasing trend.Temperature,nutrients,and nutrient structures were the main factors on the distribution of different phytoplankton groups in the study area as shown in the redundancy analysis.This work illustrates the succession of phytoplankton community structures during Alexandrium blooms and provided a theoretical basis for studies on the mechanism underlying the outbreak of harmful algal blooms in sea areas. | Yixuan XIE Renye DING Daojun ZHA Yu LI Guowang YAN Yaya ZHANG Haiyan WU Guanchao ZHENG Zhijun TAN Tao JIANG | 2022 | Journal of Oceanology and Limnology2022，40，6： | 0 |
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