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8篇 您的检索式:作者名="Darcie Miller"
    题名 作者 年代 出处 被引量
1Magnetic resonance imaging characterization of orbital changes with age and associated contributions to lower eyelid prominence显示文摘Darcy S J Miller T A Goldberg R A 2008Plast Reconstr Surg2008,122,3:1
2Magnetic resonance imaging characterization of orbital changes with age and associated con- tributions to lower eyelid prominence显示文摘DARCY S J MILLER T A GOLDBERG R A 2008Plast Reconstr Surg2008,122,3:1
3A novel library screen identifies immunosuppreresors that promote osteoblast differentiation显示文摘Darcy A Meltzer M Miller J 2012Bone2012,50,6:1
4Magnetic resonance imaging characterization of orbital changes with age and associated contributions to lower eyelid prominence显示文摘Darcy SJ Miller TA Goldburg RA 2008Plast Reconstr Surg2008,122,3:1
5Magnetic resonance imaging characterization of orbital changes with age and associated contributions to lower eyelid prominence 显示文摘Darcy S J Miller TA Goldberg RA 2008Plast Reconstr Surg2008,122,3:1
6Magnetic resonance imaging characterization of orbital changes with age and associatedcontributions to lower eyelid prominence 显示文摘Darcy S J Miller TA Goldberg RA 2008Plast Reconstr Surg2008,122,3:1
7Magnetic resonance imaging characterization of orbital changes with age and associated contributions to lower eyelid prominence显示文摘Darcy SJ Miller TA Goldberg RA 2008Plast Reconstr Surg2008,122,3:1
8Human IFT-A complex structures provide molecular insights into ciliary transport显示文摘Intraflagellar transport(IFT)complexes,IFT-A and IFT-B,form bidirectional trains that move along the axonemal microtubules and are essential for assembling and maintaining cilia.Mutations in IFT subunits lead to numerous ciliopathies involving multiple tissues.However,how IFT complexes assemble and mediate cargo transport lacks mechanistic understanding due to missing highresolution structural information of the holo-complexes.Here we report cryo-EM structures of human IFT-A complexes in the presence and absence of TULP3 at overall resolutions of 3.0–3.9Å.IFT-A adopts a“lariat”shape with interconnected core and peripheral subunits linked by structurally vital zinc-binding domains.TULP3,the cargo adapter,interacts with IFT-A through its N-terminal region,and interface mutations disrupt cargo transport.We also determine the molecular impacts of disease mutations on complex formation and ciliary transport.Our work reveals IFT-A architecture,sheds light on ciliary transport and IFT train formation,and enables the rationalization of disease mutations in ciliopathies.Meiqin Jiang Vivek Reddy Palicharla Darcie Miller Sun-Hee Hwang Hanwen Zhu Patricia Hixson Saikat Mukhopadhyay Ji Sun 2023Cell Research2023,33,4:0
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