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| 1 | Mechanisms of autophagy activation in endothelial cell and their targeting during normothermic machine liver perfusion显示文摘Ischaemia-reperfusion injury(IRI) is the leading cause of injury seen in the liver following transplantation. IRI also causes injury following liver surgery and haemodynamic shock. The first cells within the liver to be injured by IRI are the liver sinusoidal endothelial cells(LSEC). Recent evidence suggests that LSEC coordinate and regulates the livers response to a variety of injuries. It is becoming increasingly apparent that the cyto-protective cellular process of autophagy is a key regulator of IRI. In particular LSEC autophagy may be an essential gatekeeper to the development of IRI. The recent availability of liver perfusion devices has allowed for the therapeutic targeting of autophagy to reduce IRI. In particular normothermic machine liver perfusion(NMP-L) allow the delivery of pharmacological agents to donor livers whilst maintaining physiological temperature and hepatic flow rates. In this review we summarise the current understanding of endothelial autophagy and how this may be manipulated during NMP-L to reduce liver IRI. | Yuri L Boteon Richard Laing Hynek Mergental Gary M Reynolds Darius F Mirza Simon C Afford Ricky H Bhogal | 2017 | World Journal of Gastroenterology2017，23，48： | 4 |
| 2 | Para-aortic lymph node involvement should not be a contraindication to resection of pancreatic ductal adenocarcinoma显示文摘BACKGROUND Para-aortic lymph nodes(PALN)are found in the aortocaval groove and they are staged as metastatic disease if involved by pancreatic ductal adenocarcinoma(PDAC).The data in the literature is conflicting with some studies having associated PALN involvement with poor prognosis,while others not sharing the same results.PALN resection is not included in the standard lymphadenectomy during pancreatic resections as per the International Study Group for Pancreatic Surgery and there is no consensus on the management of these cases.AIM To investigate the prognostic significance of PALN metastases on the oncological outcomes after resection for PDAC.METHODS This is a retrospective cohort study of data retrieved from a prospectively maintained database on consecutive patients undergoing pancreatectomies for PDAC where PALN was sampled between 2011 and 2020.Statistical comparison of the data between PALN+and PALN-subgroups,survival analysis with the Kaplan-Meier method and risk analysis with univariable and multivariable time to event Cox regression analysis were performed,specifically assessing oncological outcomes such as median overall survival(OS)and disease-free survival(DFS).RESULTS 81 cases had PALN sampling and 17(21%)were positive.Pathological N stage was significantly different between PALN+and PALN-patients(P=0.005),while no difference was observed in any of the other characteristics.Preoperative imaging diagnosed PALN positivity in one case.OS and DFS were comparable between PALN+and PALN-patients with lymph node positive disease(OS:13.2 mo vs 18.8 mo,P=0.161;DFS:13 mo vs 16.4 mo,P=0.179).No difference in OS or DFS was identified between PALN positive and negative patients when they received chemotherapy either in the neoadjuvant or in the adjuvant setting(OS:23.4 mo vs 20.6 mo,P=0.192;DFS:23.9 mo vs 20.5 mo,P=0.718).On the contrary,when patients did not receive chemotherapy,PALN disease had substantially shorter OS(5.5 mo vs 14.2 mo;P=0.015)and DFS(4.4 mo vs 9.8 mo;P<0.001).PALN involvement was not identified as an independent predictor for OS after multivariable analysis,while it was for DFS doubling the risk of recurrence.CONCLUSION PALN involvement does not affect OS when patients complete the indicated treatment pathway for PDAC,surgery and chemotherapy,and should not be considered as a contraindication to resection. | Rupaly Pande Shafiq Chughtai Manish Ahuja Rachel Brown David C Bartlett Bobby V Dasari Ravi Marudanayagam Darius Mirza Keith Roberts John Isaac Robert P Sutcliffe Nikolaos A Chatzizacharias | 2022 | World Journal of Gastrointestinal Surgery2022，14，5： | 2 |
| 3 | High prevalence of peripheral arterial disease and low treatment rates in elderly primary care patients with diabetes显示文摘 | Diehm C Darius H | 2004 | Exp Clin Endocrinol Diabetes2004，112，： | 1 |
| 4 | High prevalence ofperipheral arterial disease and low treatment rates in el-derly primary care patients with diabetes 显示文摘 | Lange S Diehm C Darius H | 2004 | Exp ClinEndocrinol Diabetes2004，112，10： | 1 |
| 5 | Anticoagulation:the present and future显示文摘 | Van Aken H Bode C Darius H | 2001 | Clin Appl Thromb Hemost2001，，7： | 1 |
| 6 | Incidental gallbladder cancer diagnosis confers survival advantage irrespective of tumour stage and characteristics显示文摘BACKGROUND Incidental gallbladder cancer(IGBC)represents 50%-60%of gallbladder cancer cases.Data are conflicting on the role of IGBC diagnosis in oncological outcomes.Some studies suggest that IGBC diagnosis does not affect outcomes,while others that overall survival(OS)is longer in these cases compared to non-incidental diagnosis(NIGBC).Furthermore,some studies reported early tumour stages and histopathologic characteristics as possible confounders,while others not.AIM To investigate the role of IGBC diagnosis on patients’overall survival,especially after surgical treatment with curative intent.METHODS Retrospective analysis of all patient referrals with gallbladder cancer between 2008 and 2020 in a tertiary hepatobiliary centre.Statistical comparison of patient and tumour characteristics between IGBC and NIGBC subgroups was performed.Survival analysis for the whole cohort,surgical and non-surgical subgroups was done with the Kaplan-Meier method and the use of log rank test.Risk analysis was performed with univariable and multivariable Cox regression analysis.RESULTS The cohort included 261 patients with gallbladder cancer.65%of cases had NIGBC and 35%had IGBC.A total of 90 patients received surgical treatment(66%of IGBC cases and 19%of NIGBC cases).NIGBC patients had more advanced T stage and required more extensive resections than IGBC ones.OS was longer in patients with IGBC in the whole cohort(29 vs 4 mo,P<0.001),as well as in the non-surgical(14 vs 2 mo,P<0.001)and surgical subgroups(29 vs 16.5 mo,P=0.001).Disease free survival(DFS)after surgery was longer in patients with IGBC(21.5 mo vs 8.5 mo,P=0.007).N stage and resection margin status were identified as independent predictors of OS and DFS.NIGBC diagnosis was identified as an independent predictor of OS.CONCLUSION IGBC diagnosis may confer a survival advantage independently of the pathological stage and tumour characteristics.Prospective studies are required to further investigate this,including detailed pathological analysis and molecular gene expression. | Moath Alarabiyat Syed Soulat Raza John Isaac Darius Mirza Ravi Marudanayagam Keith Roberts Manuel Abradelo David C Bartlett Bobby V Dasari Robert P Sutcliffe Nikolaos A Chatzizacharias | 2022 | World Journal of Gastroenterology2022，28，18： | 1 |
| 7 | Efficacy of anterior chamber decompression in controlling early intraocular pressure spikes after uneventful phacoemulsification显示文摘 | G?ran Darius Hildebrand Sanjeewa S Wickremasinghe Paris G Tranos Martin L Harris Brian C Little | 2003 | Journal of Cataract & Refractive Surgery2003，，6： | 1 |
| 8 | An application of social values for ecosystem services (SolVES) to three natlonM forests in Colorado and Wyoming 显示文摘 | BENSON C S DARIUS J S JESSICA M C | 2014 | Ecological Indicators2014，36，1： | 1 |
| 9 | Understanding the determinants of managerial ownership and the link between ownership and performance 显示文摘 | Himmelberg C P Hubbard R G Darius P | 1999 | Journal of Financial Economics1999，53，： | 1 |
| 10 | Technology and Clinical Experiences in131Cases 显示文摘 | Gumprecht Hartmut K Widenka Darius C Lumenta Christianto B | 1999 | Brain Lab Vector Vision Neuronavigation System1999，44，1： | 1 |
| 11 | Understanding the determinants of managerial ownership and the link between ownership and performance显示文摘 | Himmelberg C P Hubbard R G Darius Palia | 1999 | Journal of financial economics1999，53，： | 1 |
| 12 | Positron emission tomography affects surgical management in recurrent colorectal cancer patients显示文摘 | Darius C Desai MD Emanuel E | 2003 | Ann Surg2003，10，： | 1 |
| 13 | Brainlab vector vision neuronavigation system: technology and clinical experiences in 131 cases 显示文摘 | HARTMUT KGFINOS J G FITZPATRICK B C DARIUS C W | 1999 | Neurosurgery1999，44，1： | 1 |
| 14 | Anticoagulation:the Present and Future显示文摘 | Van Aken H Bode C Darius H | 2001 | Clin Appl Thromb Hemost2001，7，： | 1 |
| 15 | Perfusion mapping using computed tomography allows accurate prediction of cerebral infarction in experimental brain ischemia显示文摘 | Darius G Aleksa C Sarah H | 2001 | Stroke2001，32，： | 1 |
| 16 | Inducible nitric oxide syn- thase:a possible key factor in the pathogenesis of chronic- vasospasm after experimental subarachnoid hemorrhage显示文摘 | Darius C W idenka MD Ralph J | 1999 | Neurosurg1999，90，6： | 1 |
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