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| 1 | Para-aortic lymph node involvement should not be a contraindication to resection of pancreatic ductal adenocarcinoma显示文摘BACKGROUND Para-aortic lymph nodes(PALN)are found in the aortocaval groove and they are staged as metastatic disease if involved by pancreatic ductal adenocarcinoma(PDAC).The data in the literature is conflicting with some studies having associated PALN involvement with poor prognosis,while others not sharing the same results.PALN resection is not included in the standard lymphadenectomy during pancreatic resections as per the International Study Group for Pancreatic Surgery and there is no consensus on the management of these cases.AIM To investigate the prognostic significance of PALN metastases on the oncological outcomes after resection for PDAC.METHODS This is a retrospective cohort study of data retrieved from a prospectively maintained database on consecutive patients undergoing pancreatectomies for PDAC where PALN was sampled between 2011 and 2020.Statistical comparison of the data between PALN+and PALN-subgroups,survival analysis with the Kaplan-Meier method and risk analysis with univariable and multivariable time to event Cox regression analysis were performed,specifically assessing oncological outcomes such as median overall survival(OS)and disease-free survival(DFS).RESULTS 81 cases had PALN sampling and 17(21%)were positive.Pathological N stage was significantly different between PALN+and PALN-patients(P=0.005),while no difference was observed in any of the other characteristics.Preoperative imaging diagnosed PALN positivity in one case.OS and DFS were comparable between PALN+and PALN-patients with lymph node positive disease(OS:13.2 mo vs 18.8 mo,P=0.161;DFS:13 mo vs 16.4 mo,P=0.179).No difference in OS or DFS was identified between PALN positive and negative patients when they received chemotherapy either in the neoadjuvant or in the adjuvant setting(OS:23.4 mo vs 20.6 mo,P=0.192;DFS:23.9 mo vs 20.5 mo,P=0.718).On the contrary,when patients did not receive chemotherapy,PALN disease had substantially shorter OS(5.5 mo vs 14.2 mo;P=0.015)and DFS(4.4 mo vs 9.8 mo;P<0.001).PALN involvement was not identified as an independent predictor for OS after multivariable analysis,while it was for DFS doubling the risk of recurrence.CONCLUSION PALN involvement does not affect OS when patients complete the indicated treatment pathway for PDAC,surgery and chemotherapy,and should not be considered as a contraindication to resection. | Rupaly Pande Shafiq Chughtai Manish Ahuja Rachel Brown David C Bartlett Bobby V Dasari Ravi Marudanayagam Darius Mirza Keith Roberts John Isaac Robert P Sutcliffe Nikolaos A Chatzizacharias | 2022 | World Journal of Gastrointestinal Surgery2022，14，5： | 2 |
| 2 | Management of atrial fibrillation in seven European countries after the publication of the 2010 ESC Guidelines on atrial fibrilla- tion: primary results of the prevention of thromboemolic events--European Registry in Atrial Fibrillation (PREFER in AF)显示文摘 | Kirchhof P Ammentorp B Darius H | 2014 | Europaee2014，16，1： | 1 |
| 3 | Acute endophthalmitis following intravitreal triamcinolone acetonide injection显示文摘 | Darius M Moshfeghi Peter K Kaiser Ingrid U Scott Jonathan E Sears Matthew Benz Juan P Sinesterra Richard S Kaiser Sophie J Bakri Raj K Maturi Jonathan Belmont Paul M Beer Timothy G Murray Hugo Quiroz-Mercado William F Mieler | 2003 | American Journal of Ophthalmology2003，，5： | 1 |
| 4 | Small Subunit rDNA sequence analysis of symbiotic dinoflagellates from seven scleractinian corals in a tahitian lagoon 显示文摘 | Darius H T Martin P M V Grimont P A D | 2000 | J Phycol2000，36，： | 1 |
| 5 | Combined interpretation of PP and PS data provides direct access to elastic rock properties显示文摘 | GAROTTA R GRANGER P Y DARIU H | 2002 | The Leading Edge2002，21，6： | 1 |
| 6 | Understanding the Determinants of Managerial Ownership and the Link Between Ownership and Performance 显示文摘 | Charles P Himmelberg R Glenn Hubbard Darius Palia | 1999 | Journal of Financial Economics1999，53，： | 1 |
| 7 | The spatial variability of some aspects of topsoil fertility in two Belgian fields 显示文摘 | Delcourt H Darius P L Baerdemaeker J D | 1996 | Computers and Electronics in Agriculture1996，14，： | 1 |
| 8 | Color-coded perfused blood volume imaging using multidetector CT: initial results of whole-brain peffusion analysis in acute cerebral ischemia 显示文摘 | Stephan P Tobias F Darius G | 2007 | Eur Radiol2007，17，： | 1 |
| 9 | The market reaction to international cross-listings:evidence from Depositary Receipts显示文摘 | | 1999 | Journal of Financial Economics1999，，51： | 1 |
| 10 | The effectof fruit factors on the bruise susceplihility of apples 显示文摘 | Van Zeebroeck M Van Linden V Darius P | 2007 | Postharvest Biology and Technology2007，46，1： | 1 |
| 11 | Understanding the Determinants of Managerial Ownership and the Link Between Ownership and Performance显示文摘 | Charles P Himmelberg R Glenn Hubbard Darius Palia | 1999 | Journal of Financial Economics1999，53，3： | 1 |
| 12 | The legal environmem and corporate valuation: Evidence from cross -border takeover 显示文摘 | David R Kuipers Darius P Miller Ajay Patel | 2009 | International Review of Economies&Finance2009，56，10： | 1 |
| 13 | Incidental gallbladder cancer diagnosis confers survival advantage irrespective of tumour stage and characteristics显示文摘BACKGROUND Incidental gallbladder cancer(IGBC)represents 50%-60%of gallbladder cancer cases.Data are conflicting on the role of IGBC diagnosis in oncological outcomes.Some studies suggest that IGBC diagnosis does not affect outcomes,while others that overall survival(OS)is longer in these cases compared to non-incidental diagnosis(NIGBC).Furthermore,some studies reported early tumour stages and histopathologic characteristics as possible confounders,while others not.AIM To investigate the role of IGBC diagnosis on patients’overall survival,especially after surgical treatment with curative intent.METHODS Retrospective analysis of all patient referrals with gallbladder cancer between 2008 and 2020 in a tertiary hepatobiliary centre.Statistical comparison of patient and tumour characteristics between IGBC and NIGBC subgroups was performed.Survival analysis for the whole cohort,surgical and non-surgical subgroups was done with the Kaplan-Meier method and the use of log rank test.Risk analysis was performed with univariable and multivariable Cox regression analysis.RESULTS The cohort included 261 patients with gallbladder cancer.65%of cases had NIGBC and 35%had IGBC.A total of 90 patients received surgical treatment(66%of IGBC cases and 19%of NIGBC cases).NIGBC patients had more advanced T stage and required more extensive resections than IGBC ones.OS was longer in patients with IGBC in the whole cohort(29 vs 4 mo,P<0.001),as well as in the non-surgical(14 vs 2 mo,P<0.001)and surgical subgroups(29 vs 16.5 mo,P=0.001).Disease free survival(DFS)after surgery was longer in patients with IGBC(21.5 mo vs 8.5 mo,P=0.007).N stage and resection margin status were identified as independent predictors of OS and DFS.NIGBC diagnosis was identified as an independent predictor of OS.CONCLUSION IGBC diagnosis may confer a survival advantage independently of the pathological stage and tumour characteristics.Prospective studies are required to further investigate this,including detailed pathological analysis and molecular gene expression. | Moath Alarabiyat Syed Soulat Raza John Isaac Darius Mirza Ravi Marudanayagam Keith Roberts Manuel Abradelo David C Bartlett Bobby V Dasari Robert P Sutcliffe Nikolaos A Chatzizacharias | 2022 | World Journal of Gastroenterology2022，28，18： | 1 |
| 14 | Combined interpretation of PP and PS data provides direct access to elastic rock properties 显示文摘 | Garotta R Granger P Y Dariu H | 2002 | The Leading Edge2002，21，6： | 1 |
| 15 | Simultaneous inversion of PP and PS wave AVO/AVA data using simulated annealing 显示文摘 | Dariu H Garotta R Granger P Y | 2003 | SEG Technical program Expanded Abstracts2003，20，1： | 1 |
| 16 | Acute endophthalmitis following intravitreal triamcinolone acetonide injection显示文摘 | Darius M Moshfeghi Peter K Kaiser Ingrid U Scott Jonathan E Sears Matthew Benz Juan P Sinesterra Richard S Kaiser Sophie J Bakri Raj K Maturi Jonathan Belmont Paul M Beer Timothy G Murray Hugo Quiroz-Mercado William F Mieler | 2003 | American Journal of Ophthalmology2003，，5： | 1 |
| 17 | Common species determine richness patterns in biodiversity indicator taxa显示文摘 | Peter B P Darius W | 2007 | Biological Conservation2007，138，12： | 1 |
| 18 | Management of alriai Ii- brillation in seven European countries after the pubiicalion of the 2010 ESC Guidelines on atrial fibrillation:primary results of the PREvention of thromboemolic events--European Registry in Atrial Fibrillation (PREFER in AF)显示文摘 | Kirchhof P Ammentorp B Darius H | 2014 | Europace2014，16，1： | 1 |
| 19 | Management of atrial fibrillation in seven European countries after the publication of the 2010 ESC Guidelines on atrial fibrillation : primary results of the PREvention oF thromboemolic events--European Registry in Atrial Fibrillation (PREFER in AF)显示文摘 | KIRCHHOF P AMMENTORP B DARIUS H | 2014 | Europace2014，16，1： | 1 |
| 20 | The comparative germination ecology of nine mmex species 显示文摘 | Van ASSCHE J Van NERUM D DARIUS P | 2002 | Plant Ecology2002，159，2： | 1 |
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