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| 1 | Laparoscopic vs open approach to resection of hepatocellular carcinoma in patients with known cirrhosis:Systematic review and meta-analysis显示文摘AIM: To review the currently available literature comparing laparoscopic to open resection of hepatocellular carcinoma(HCC) in patients with known liver cirrhosis.METHODS: A literature search of MEDLINE, EMBASE, and Cochrane databases was conducted. The search terms used included(laparoscopic OR laparoscopy) AND(hepatic or liver) AND(surgery or resection) AND 'hepatocellular carcinoma' AND(cirrhosis or cirrhotic). Furthermore, to widen the search, we also used the 'related articles' section. Studies reporting a comparison of outcomes and methods of open vs laparoscopic hepatic resection for HCC in patients with liver cirrhosis were included. Meta-analysis of results was performed using a random effects model to compute relative risk(RR) and for dichotomous variablesand standard mean differences(SMD) for continuous variables.RESULTS: A total of 420 patients from 4 cohort studies were included in final analysis. Patients undergoing laparoscopic procedures had statistically less blood loss compared to the open cohort, SMD of-1.01(95%CI:-1.23-0.79), P < 0.001, with a reduced risk of transfusion, RR = 0.19(95%CI: 0.09-0.38), P < 0.001. A wider clearance at tumour resection margins was achieved following a laparoscopic approach, SMD of 0.34(95%CI: 0.08-0.60), P = 0.011. No significant difference was noted between laparoscopic and open resection operative times, SMD of-0.15(95%CI: 0.35-0.05), P = 0.142. The overall RR of suffering from postoperative morbidity is 0.25 in favour of the open surgery cohort(95%CI: 0.17-0.37), P < 0.001. Patients under-going laparoscopic surgery had significantly shorter length of stays in hospital compared to the open cohort, SMD of-0.53(95%CI:-0.73 to-0.32), P < 0.001.CONCLUSION: This review suggests that laparoscopic resection of hepatocellular carcinoma in patients with cirrhosis is safe and may provide improved patient outcomes when compared to the open technique. | Ahmed Twaij Philip H Pucher Mikael H Sodergren Tamara Gall Ara Darzi Long R Jiao | 2014 | World Journal of Gastroenterology2014，20，25： | 16 |
| 2 | Experience with laparoscopic color-ectal surgery for malignant disease显示文摘 | Guillon P J Darzi A Monson J R | 1993 | Surg Oncol1993，2，511： | 1 |
| 3 | Surgical ward round quality and impact on variable patient outcomes显示文摘 | Pucher PH Aggarwal R Darzi | 2014 | Ann Surg2014，259，2： | 1 |
| 4 | Lattice Boltzmann simulation of nanofluidin lid-driven cavity显示文摘 | Nemati H Farhadi M Sedighi K Fattahi E Darzi A A R | 2010 | International Communications in Heat and Mass Transfer2010，37，10： | 1 |
| 5 | Laparoscopic skills training and assessment 显示文摘 | Aggarwal R Moorthy K Darzi A | 2004 | British Journal of Surgery2004，，91： | 1 |
| 6 | Experience with laparoscopic colorectal surgery for malignant disease显示文摘 | GUILLON P J DARZI A MONSON J R | 1993 | Surg Oncol1993，21，： | 1 |
| 7 | Laparoscopic skills training and assessmen显示文摘 | Aggarwal R Moorthy K Darzi A | 2004 | Br J Surg2004，，91： | 1 |
| 8 | Preparing for precision medicine显示文摘 | Mirnezami R Nicholson J Darzi A | 2012 | N Engl J Med2012，366，6： | 1 |
| 9 | Experience with laparoscopie colorectal surgery for malignant disease显示文摘 | Guillon P J Darzi A Monson J R | 1993 | Surg Oncol1993，2，1： | 1 |
| 10 | Simulation- optimization modeling of conjunctive use of surface water and groundwater显示文摘 | Safavi H R Darzi F Madho M A | 2010 | Water Re- sources Management2010，24，10： | 1 |
| 11 | Stereoeontrolled synthesis of 2, 4, 5-trisubstituted tetrahydropyrans显示文摘 | AL-MUTAIRI F H CROSBY S R DARZI J | 2001 | Chem Comm2001，，： | 1 |
| 12 | Numerical In- vestigations of Unconstrained Melting of Nano-Enhanced Phase Change Material (NEPCM) Inside a Spherical Con- tainer 显示文摘 | S F Hosseinizadeh A A R Darzi F L Tan | 2012 | International Journal of Thermal Sciences2012，51，： | 1 |
| 13 | Preparing for precision medicine显示文摘 | Mirnezami R NicholsonJ Darzi A | 2012 | N EnglJ Med2012，366，6： | 1 |
| 14 | Preparing for precision medi- cine显示文摘 | Mirnezami R Nicholson J Darzi A | 2012 | N Engl J ned2012，，366： | 1 |
| 15 | Existence of solution for a nonlocal boundary value problem with fractional q-derivatives显示文摘 | Neamaty A Yadollahzadeh M Darzi R | 2015 | Journal of Fractional Calculus and Applications2015，6，2： | 1 |
| 16 | Simulation-optimization modeling of conjunctive use of surface water and groundwater 显示文摘 | SAFAVI H R DARZI F MARINO M A | 2010 | Water Resources Management2010，24，10： | 1 |
| 17 | Preparing for precision medicine显示文摘 | Mirnezami R Nicholson J Darzi A | 2012 | NEnglJ Med2012，366，6： | 1 |
| 18 | Compression anastomosis revisited显示文摘 | AGGARWAL R DARZI A | 2005 | J Am Coll Surg2005，201，6： | 1 |
| 19 | Finite element simulation and parametric studies of perfobond rib con- nector显示文摘 | A1- Darzi S Y K Chen A R Liu Y Q | 2007 | American Journal of Applied Science2007，4，3： | 1 |
| 20 | Simulation to enhance patient safety:why aren't we there yet? 显示文摘 | Aggarwal R Darzi A | 2011 | Chest2011，140，4： | 1 |
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