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| 1 | Ultrasensitive detection of cancer biomarker microRNA by amplification of fluorescence of lanthanide nanoprobes显示文摘癌症 biomarker microRNAs (miRNAs ) 的敏感察觉具有为癌症诊断和治疗的重要重要性。尽管如此,在存在 miRNA 生物鉴定的察觉敏感被 miRNA 的结构的特征严重地限制(包括小长度和高顺序相同) 因为大多数这些方法基于目标扩大。此处,我们经由 nanoprobe 的唯一的策略向低丰富的 miRNA 的敏感、特定的察觉汇报一条新奇途径提高溶解的荧光扩大,展示分子的烽火结构的一根俘获探针在被设计。借助于这策略, miRNA-21 与象 1.38 fM 一样低的察觉限制从 10 fM 在一个线性范围被检测到 100 下午。最新发达的生物传感器的高选择被对一个目标的好歧视与单个底的失配表明。而且,这试金被用于低于 10.1% 在 90.2%-108% 的范围和变化的系数与恢复增加进胎儿的牛的浆液样品的 miRNA-21 的察觉,显示它到在新窗户中的 RNA 免疫分析和早癌症 diagnosis.Open | Lianyu Lu Datao Tu Yan Liu Shanyong Zhou Wei Zheng Xueyuan Chen | 2018 | Nano Research2018，11，1： | 6 |
| 2 | A strategy for accurate detection of glucose in human serum and whole blood based on an upconversion nanoparticles-polydopamine nanosystem显示文摘 | Yan Liu Datao Tu Wei Zheng Lianyu Lu Wenwu You Shanyong Zhou Ping Huang Renfu Li Xueyuan Chen | 2018 | Nano Research2018，11，6： | 5 |
| 3 | 'Chameleon-like' optical behavior of lanthanide-doped fluoride nanoplates for multilevel anti-counterfeiting applications显示文摘Lanthanide-based luminescent anti-counterfeiting materials are widely used in various kinds of products.However,the emission color of traditional lanthanide-based luminescent materials usually remains nearly unaltered upon different excitation lights,which may only work for single-level anti-counterfeiting.Herein,the NaYbF4∶2%Er@NaYF4 core/shell nanoplates (NPs) with 'chameleon-like' optical behavior are developed.These NPs display single-band red or green downshifting (DS) emission upon excitation at 377 or 490 nm,respectively.Upon 980 nm excitation,the color of upconversion (UC) emission can be finely tuned from green to yellow,and to red with increasing the excitation power density from 0.1 to 4.0 W/cm^2.The proposed materials readily integrate the advantages of excitation wavelength-dependent DS single-band emissions and sensitive excitation power-dependent UC multicolor emissions in one and the same material,which has never been reported before.Particularly,the proposed NPs exhibit excellent performance as security labels on trademark tag and security ink on painting,thus revealing the great potential of these lanthanide-doped fluoride NPs in multilevel anti-counterfeiting applications. | Wenwu You Datao Tu Renfu Li Wei Zheng Xueyuan Chen | 2019 | Nano Research2019，12，6： | 3 |
| 4 | A facile "ship-in-a-bottle" approach to construct nanorattles based on upconverting lanthanide-doped fluorides显示文摘格格声结构由于唯一的 core@void@shell 体系结构和函数的集成是对 nanomaterials 的设计和申请的大兴趣的一个话题。此处,我们开发了一个新奇 ship-in-a-bottle 方法制作 upconverting (UC ) 由把做 lanthanide 的氟化物合并到空 mesoporous 的光 nanorattles 硅石。nanorattles 的尺寸和氟化物的充满的数量能很好被控制。另外,硅石壳的修正(与苯撑和胺组) 并且有效 UC 氟化物的变化(NaYF 4:Yb,Er, NaLuF 4:Yb,Er, NaGdF 4:Yb,Er 和 LiYF 4:Yb,Er) 乐意地被完成。产生 nanorattles 展出了一个高能力和反癌症药 doxorubicin (纪录影片) 的 pH 依赖的版本。而且,我们由从 UC 氟化物利用精力转移过程到纪录影片在 proof-of-concept 监视 UC 药版本采用了这些 nanorattles,因此作为有效癌症 theranostic 揭示 nanorattles 的大潜力代理人。 | Shan Lu Datao Tu Xingjun Li Renfu Li Xueyuan Chen | 2016 | Nano Research2016，9，1： | 3 |
| 5 | Highly efficient luminescent Ⅰ-Ⅲ-Ⅵ semiconductor nanoprobes based on template-synthesized CuInS2 nanocrystals显示文摘CuInS2 semiconductor nanocrystals (NCs) exhibit large absorption coefficient, size-dependent photoluminescence and low toxicity, making them excellent candidates in a variety of bioapplications. However, precise control of both their composition and morphology to improve the luminescent efficiency remains a great challenge via conventional direct synthesis. Herein, we present a novel low-temperature template synthesis of highly efficient luminescent CuInS2 nanoprobes from In2S3 NCs via a facile cation exchange strategy. The proposed strategy enables synthesis of a series of CuInS2 NCs with broad size tunability from 2.2 to 29.6 nm. Through rationally manipulating the stoichiometry of Cu/In, highly efficient luminescence of CuInS2 with the maximum quantum yield of 28.6% has been achieved, which is about one order of magnitude improvement relative to that of directly synthesized NCs. By virtue of the intense emission of CuInS2 nanoprobes, we exemplify their application in sensitive homogeneous biodetection for an important biomolecule of adenosine triphosphate (ATP) with the limit of detection down to 49.3 nM. Moreover, the CuInS2 nanoprobes are explored for ATP-targeted cancer cell imaging, thus revealing their great potentials in the field of cancer diagnosis and prognosis. | Xian Li Datao Tu Shaohua Yu Xiaorong Song Wei Lian Jiaojiao Wei Xiaoying Shang Renfu Li Xueyuan Chen | 2019 | Nano Research2019，12，8： | 3 |
| 6 | Porosity Effects on Mechanical Properties of 3D Random Fibrous Materials at Elevated Temperatures显示文摘In this study,we prepare the specimens of three-dimensional random fibrous(3D RF)material along its through-the-thickness(TTT)and in-plane(IP)directions.The experimental tests of tensile and compressive properties as well as fracture toughness of 3D RF material are performed at elevated temperatures.Then,the porosity(83%,87%and 89%)and temperature dependence of the tensile and compressive strength,elastic modulus,fracture toughness and fracture surface energy of the 3D RF materials for both the TTT and IP directions are analyzed.From the results of the tensile strength and elastic modulus versus material porosities at various temperatures,we find that tensile strength and elastic modulus for the TTT direction are more sensitive to the porosity,but not for the IP direction.Fracture toughness increases firstly and then decreases at a certain critical temperature.Such critical temperature is found to be the lowest for the porosity of 83%.On the other hand,at below 1073 K,the temperature-dependent fracture surface energies with three porosities for the TTT direction show similar variation trends. | Datao Li Wenshan Yu Wei Xia Qinzhi Fang Shengping Shen | 2020 | Acta Mechanica Solida Sinica2020，33，1： | 2 |
| 7 | Multiplexed intracellular detection based on dual-excitation/dualemission upconversion nanoprobes显示文摘Multiplexed intracellular detection is desirable in biomedical sciences for its higher eficiency and accuracy compared to the single-analyte detection.However,it is very challenging to construct nanoprobes that possess multiple fluorescent signals to recognize the different intracellular species synchronously.Herein,we proposed a novel dual-excitation/dual-emission upconversion strategy for multiplexed detection through the design of upconversion nanoparticles(UCNP)loaded with two dyes for sensitization and quenching of the upconversion luminescence(UCL),respectively.Based on the two independent energy transfer processes of near-infrared(NIR)dye IR845 to UCNP and UCNP to visible dye PAPS-Zn,CIO-and Zn2+were simultaneously detected with a limit of detection(LOD)of41.4 and 10.5 nM,respectively.By tilizing a purpose built 830/980 nm dual-laser confocal microscope,both intrinsic and exogenous CIO and Zn2+in live MCF-7 cells have been accurately quantified.Such dual-excitation/dual-emission ratiometric UCL detection mode enables not only monitoring multiple intracellular analytes but also eliminating the detection deviation caused by inhomogeneous probe distribution in cells.Through modulation of NIR dye and visible dye with other reactive groups,the nanoprobes can be extended to analyze various intraellular species,which provides a promising tool to study the biological activities in live cells and diagnose diseases. | Jianxi Ke Shan Lu Zhuo Li Xiaoying Shang Xingjun Li Renfu Li Datao Tu Zhuo Chen Xueyuan Chen | 2020 | Nano Research2020，13，7： | 2 |
| 8 | Estimation of failure probability of oil and gas transmission pipelines by fuzzy fault tree analysis显示文摘 | DONG Yuhua YU Datao | 2005 | Journal of Loss Prevention in the Process Industries2005，18，2： | 1 |
| 9 | Estimation of failure probability of oil and gas transmission pipelines by fuzzy fault tree analysis 显示文摘 | Dong Yuhua Yu Datao | 2005 | Journal of Loss Prevention in the Process Industries2005，18，： | 1 |
| 10 | Estimation of failure probability of oil and gas transmission pipelines by fuzzy fault tree analysis显示文摘 | Dong Yuhua Yu Datao | 2005 | Journal of Loss Prevention in the Process Industries2005，18，： | 1 |
| 11 | Amine-functional- ized lanthanide-doped KGdF4 nanocrystals as potential optical/ magnetic muhimodal bioprobes 显示文摘 | Ju Qiang Tu Datao Liu Yongsheng | 2011 | Journal of the American Chemical Society2011，134，2： | 1 |
| 12 | Lanthanide-doped inorganic nanocrystals as luminescent biolabels显示文摘 | Ju Qiang Tu Datao Liu Yongsheng | 2012 | Combinato-rial Chemistry High Throughput Screening2012，15，7： | 1 |
| 13 | Estimation of failure probability of oil and gas transmission pipelines by fuzzy fault tree analysis显示文摘 | Dong Yuhua Yu Datao | 2005 | Journal of Loss Prevention in the Process Industries2005，18，2： | 1 |
| 14 | Active inductor shunt peaking in high-speed VCSEL driver design显示文摘An all-transistor active-inductor shunt-peaking structure has been used in a prototype of 8 Gbps highspeed VCSEL driver which is designed for the optical link in ATLAS liquid Argon calorimeter upgrade.The VCSEL driver is fabricated in a commercial 0.25μm Silicon-on-Sapphire(SoS)CMOS process for radiation tolerant purpose.The all-transistor active-inductor shunt-peaking is used to overcome the bandwidth limitation from the CMOS process.The peaking structure has the same peaking efect as the passive one,but takes a small area,does not need linear resistors and can overcome the process variation by adjust the peaking strength via an external control.The design has been taped out,and the prototype has been proven by the preliminary electrical test results and bit error ratio test results.The driver achieves 8 Gbps data rate as simulated with the peaking.We present the all-transistor active-inductor shunt-peaking structure,simulation and test results in this paper. | 梁福田 GONG Datao HOU Suen LIU Chonghan LIU Tiankuan SU Da-Shung TENG Ping-Kun XIANG Annie YE Jingbo 金革 | 2013 | Chinese Physics C2013，37，11： | 1 |
| 15 | The influence of YS-I on the Dll4-Notchl signaling pathway显示文摘在这研究,我们在表明小径的 Dll4-Notch1 调查了角色和 p43 和 YS-1 (recombinant 人 p43 蛋白质) 的分子的机制。p43 蛋白质指向的活跃、小介入的 RNA 和 recombinant plasmid 被用来感染人的脐的静脉 endothelial 房间(HUVEC ) 。三维的发芽模型, endothelial 房间移植试金,并且发芽并且试管形成试金被用来在 angiogenesis 推出 p43 和 YS-1 的函数。半量的反向的抄写聚合酶链反应和西方的污点分析被执行在在 HUVEC 发信号的 Dll4-Notch1 检测 p43 的效率。它被发现 p43 的那 silencing 和 overexpression 能 upregulate Dll4 槽口并且刺激 angiogenesis。p43 在 angiogenesis 起一个复杂作用。当集中在 100 nM 下面时,它支持 angiogenesis;相反,当集中是超过 100 nM 时,它禁止 angiogenesis。在这研究,我们发现 p43 的表示水平在 60 nM 下面。然而, recombinant 人 p43 蛋白质, YS-1,发芽的禁止的 endothelial 房间,和 YS-1 的 500 g/ml 稀释了 Dll4-Notch1 发信号的激活。这些结果建议 YS-1 能直接通过 Dll4-Notch1 信号 transduction 小径禁止 angiogenesis,当 p43 在这条发信号的小径起一个 modulating 作用时。 | Li Sun Qingqing Yang Ping Wang Datao Liu Wenlu Liang Sensen Lin Shengtao Yuan | 2014 | Acta Biochimica et Biophysica Sinica2014，46，1： | 1 |
| 16 | Estimation of failure probability of oil and gas transmission pipelines by fuzzy fault tree analysis显示文摘 | Dong Yuhua Yu Datao | 2005 | Journal of Loss Prevention in the Process Industries2005，18，2： | 1 |
| 17 | Estimation of failure probability of oil and gas transmission显示文摘 | DONG Yuhua YU Datao | 2005 | Journal of Loss Prevention in the Process Industries2005，，18： | 1 |
| 18 | Firm elevation of the reconstructed auricle with a retroauricular fascial flap wrapping an EH (a mixture of epoxide acrylate malelic and hydroxyapatite) composite wedge显示文摘 | Qun Zhang Ruhong Zhang Feng Xu Peihong Jin Jinfang Wu Datao Li Wenshin Chin | 2009 | Journal of Plastic Reconstructive & Aesthetic Surgery2009，，9： | 1 |
| 19 | Exosomes from antler stem cells alleviate mesenchymal stem cell senescence and osteoarthritis显示文摘Dear Editor,Stem cell therapy holds enormous and revolutionary promise to treat various age-related diseases,such as diabetes,heart failure,and Parkinson’s disease.However,low retention and survival rate of delivered stem cells,partially due to immunological rejection,constitute major hurdles for the clinical implementation of stem cell therapy(Lei et al.,2021a).Since mounting evidence showed that several types of stem cells mainly exert their therapeutic effects through the secretion of paracrine effects,exosomes,which are released by stem cells and execute most paracrine functions,have begun to draw attention in the field(Tran and Damaser,2015).Exosomes are membrane-enclosed vesicles with an average diameter of∼100 nanometers secreted by the cells,containing cytokines. | Jinghui Lei Xiaoyu Jiang Wei Li Jie Ren Datao Wang Zhejun Ji Zeming Wu Fang Cheng Yusheng Cai Zheng-Rong Yu Juan Carlos Izpisua Belmonte Chunyi Li Guang-Hui Liu Weiqi Zhang Jing Qu Si Wang | 2022 | Protein & Cell2022，13，3： | 1 |
| 20 | Estimation of failure probability of oil and gas transmission pipelines by fuzzy fault tree analysis显示文摘 | Dong Yuhua Yu Datao | 2005 | Journal of Loss Prevention in the Process Industries2005，18，： | 1 |
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