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| 1 | Hospital contacts with alcohol problems prior to liver cirrhosis or pancreatitis diagnosis显示文摘AIM To evaluate prior hospital contacts with alcohol problems in patients with alcoholic liver cirrhosis and pancreatitis. METHODS This was a register-based study of all patients diagnosed with alcoholic liver cirrhosis or pancreatitis during 2008-2012 in Denmark. Hospital contacts with alcohol problems(intoxication, harmful use, or dependence) in the 10-year period preceding the diagnosis of alcoholic liver cirrhosis and pancreatitis were identified.RESULTS In the 10 years prior to diagnosis, 40% of the 7719 alcoholic liver cirrhosis patients and 40% of the 1811 alcoholic pancreatitis patients had at least one prior hospital contact with alcohol problems. Every sixth patient(15%-16%) had more than five contacts. A similar pattern of prior hospital contacts was observed for alcoholic liver cirrhosis and pancreatitis. Around 30% were diagnosed with alcohol dependence and 10% with less severe alcohol diagnoses. For the majority, admission to somatic wards was the most common type of hospital care with alcohol problems. Most had their first contact with alcohol problems more than five years prior to diagnosis.CONCLUSION There may be opportunities to reach some of the patients who later develop alcoholic liver cirrhosis or pancreatitis with preventive interventions in the hospital setting. | Gro Askgaard Soren Neermark David A Leon Mette S Kjaer Janne S Tolstrup | 2017 | World Journal of Hepatology2017，9，36： | 1 |
| 2 | Detection of beryllium by laser-induced-breakdown spectroscopy显示文摘 | Leon J Radziemski David A Cremers Thomas R Loree | 1983 | Spectrochimica Acta Part B: Atomic Spectroscopy1983，38，： | 1 |
| 3 | Detection of chlorine and fluorine in air by laser-induced breakdown spectrometry显示文摘 | DAVID A C LEON J R | 1983 | Anal Chem1983，55，8： | 1 |
| 4 | Antiepileptic Drugs for Bipolar Disorder and the Risk of Suicidal Behavior: A 30-Year Observational Study显示文摘 | Leon Andrew C Solomon David A Li Chunshan Fiedorowicz Jess G Coryell William H Endicott Jean Keller Martin B | 2012 | The American Journal of Psychiatry2012，，： | 1 |
| 5 | Early Stent Thrombosis in Patients With Acute Coronary Syndromes Treated With Drug-Eluting and Bare Metal Stents: The Acute Catheterization and Urgent Intervention Triage Strategy Trial显示文摘 | Jiro Aoki Alexandra J. Lansky Roxana Mehran Jeffery Moses Michel E. Bertrand Brent T. McLaurin David A. Cox A Michael Lincoff E Magnus Ohman Harvey D. White Helen Parise Martin B. Leon Gregg W. Stone | 2009 | Circulation2009，，5： | 1 |
| 6 | Low serum truncated- BDNF isoform correlates with higher cognitive impairment in schizophrenia显示文摘 | Davide Carlino a Emiliano Leone b | 2011 | Journal of Psychiatric Research2011，45，： | 1 |
| 7 | Liver cirrhosis mortality rates in Britain, 1950 to 2002显示文摘 | David A Leon Jim McCambridge | 2006 | The Lancet . 2006 (9511)2006，，： | 1 |
| 8 | The age-dependent effect of anisometropia magnitude on anisometropia amblyopia severity显示文摘 | Leon A Donahue SP David G | 2008 | J AAPOS2008，12，2： | 1 |
| 9 | Liver cirrhosis mortality rates in Britain from 1950 to 2002: an analysis of routine data显示文摘 | David A Leon Jim McCambridge | 2006 | The Lancet2006，，9504： | 1 |
| 10 | Improved Hepascore in hepatitis C predicts reversal in risk of adverse outcome显示文摘AIM To establish if serial Hepascore tests(referred to as delta Hepascore) in those with chronic hepatitis C(CHC) correlate with the increase and/or decrease in risk of liver related complications.METHODS Three hundred and forty-six CHC patients who had two Hepascore tests performed were studied. During 1944 patient years follow-up 28(8.1%) reached an endpoint. The Hepascore is a serum test that provides clinically useful data regarding the stage of liver fibrosis andsubsequent clinical outcomes in chronic liver disease.RESULTS Patients with a baseline Hepascore > 0.75 had a significantly increased rate of reaching a composite endpoint consisting of hepatocellular carcinoma, liver death, and/or decompensation(P < 0.001). In those with an initial Hepascore > 0.75, a subsequent improved Hepascore showed a significantly decreased risk for the composite endpoint(P = 0.004). There were no negative outcomes in those with a stable or improved delta Hepascore. The minimum time between tests that was found to give a statically significant result was in those greater than one year(P = 0.03).CONCLUSION In conclusion, Hepascore is an accurate predictor of liver related mortality and liver related morbidity in CHC patients. Of note, we have found that there is a decreased risk of mortality and morbidity in CHC patients when the patient has an improving delta Hepascore. Repeat Hepascore tests, when performed at a minimum one-year interval, may be of value in routine clinical practice to predict liver related clinical outcomes and to guide patient management. | Angus W Jeffrey Yi Huang W Bastiaan de Boer Leon A Adams Gerry MacQuillan David Speers John Joseph Gary P Jeffrey | 2017 | World Journal of Hepatology2017，9，19： | 0 |
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