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| 1 | 慢性牙周炎中核因子κB受体活化子、护骨素和肿瘤坏死因子-α的蛋白表达显示文摘目的 比较慢性牙周炎牙槽骨吸收处肉芽组织中的核因子κB受体活化子 (RANKL)、护骨素 (OPG)和肿瘤坏死因子(TNF) -α的水平 ,研究慢性牙周炎牙槽骨吸收与这些调节因子间的关系。方法 应用鼠抗人单克隆抗体、半定量分析及数字成像技术分析慢性牙周炎组织中RANKL、OPG和TNF α的蛋白表达。结果 慢性牙周炎牙槽骨吸收处肉芽组织中有较高的RANKL和TNF α蛋白表达 ,OPG蛋白表达相对较低 (P <0 .0 5 ) ;非牙周炎组织中显示较强的OPG蛋白表达和较弱的RANKL和TNF -α蛋白水平 (P <0 .0 5 ) ;OPG蛋白表达与牙周组织中内皮细胞相关。结论 RANKL可能与慢性牙周炎牙槽骨吸收相关 ;RANKL和OPG平衡的变化在慢性牙周炎骨吸收的分子机制中起重要调节作用 ;TNF | 刘琪 David Haynes Mark Bartold | 2004 | 口腔医学2004，24，6： | 15 |
| 2 | Role of polyethylene particles in peri-prosthetic osteolysis:A review显示文摘There is convincing evidence that particles produced by the wear of joint prostheses are causal in the periprosthetic loss of bone,or osteolysis,which,if it progresses,leads to the phenomenon of aseptic loosening.It is important to fully understand the biology of this bone loss because it threatens prosthesis survival,and loosened implants can result in peri-prosthetic fracture,which is disastrous for the patient and presents a difficult surgical scenario.The focus of this review is the bioactivity of polyethylene(PE)particles,since there is evidence that these are major players in the development and progression of osteolysis around prostheses which use PE as the bearing surface.The review describes the biological consequences of interaction of PE particles with macrophages,osteoclasts and cells of the osteoblast lineage,including osteocytes.It explores the possible cellular mechanisms of action of PE and seeks to use the findings to date to propose potential nonsurgical treatments for osteolysis.In particular,a nonsurgical approach is likely to be applicable to implants containing newer,highly cross-linked PEs(HXLPEs),for which osteolysis seems to occur with much reduced PE wear compared with conventional PEs.The caveat here is that we know little as yet about the bioactivity of HXLPE particles and addressing this constitutes our next challenge. | Gerald J Atkins David R Haynes Donald W Howie David M Findlay | 2011 | World Journal of Orthopedics2011，2，10： | 11 |
| 3 | On the CFD modelling of Taylor flow in microchannels显示文摘 | Raghvendra Gupta David F. Fletcher Brian S. Haynes | 2009 | Chemical Engineering Science2009，，12： | 2 |
| 4 | Information Asymmetries,Financial Structure,and Financial Intermediation显示文摘 | Hayne and David Pyle | 1977 | Journal of Finance1977，32，： | 1 |
| 5 | Information Asymmetries,Financial Structure and Financial Intermediation显示文摘 | HAYNE LELAND DAVID H PYLE | | 0，，08： | 1 |
| 6 | Information Asymmetries,Financial Structure and Financial Intermediation显示文摘 | E David H | 1977 | Journal of Finance1977，，5： | 1 |
| 7 | Information asymmetries, financial structure and financial intermediation 显示文摘 | Hayne E David H | 2002 | Journal of Finance2002，，7： | 1 |
| 8 | Informational Asymmetries,Financial Structure,and Financial Intermediation显示文摘 | LELAND HAYNE E PYLE DAVID H | 1977 | The Journal of Finance1977，32，2： | 1 |
| 9 | Informational Asymme- tries, Financial Structure and Financial Intermediation显示文摘 | Hayne Elkland David H Pyle | 1977 | Jour- nal of Finace1977，，7： | 1 |
| 10 | Interleukin-17–Dependent Autoimmunity to Collagen Type V in Atherosclerosis显示文摘 | Melanie L. Dart Ewa Jankowska-Gan Guorui Huang Drew A. Roenneburg Melissa R. Keller Jose R. Torrealba Aaron Rhoads Byoungjae Kim Joseph L. Bobadilla Lynn D. Haynes David S. Wilkes William J. Burlingham Daniel S. Greenspan | 2010 | Circulation Research2010，，9： | 1 |
| 11 | 改进实效型试验的报告质量:CONSORT声明的扩充(2)显示文摘实效型试验旨在为临床实践决策提供依据,但报告得不好会降低其实用性。CONSORT和Practihc小组描述了对CONSORT指南的修改,帮助读者评估研究结果的适用性。 | Merrick Zwarenstein Shaun Treweek Joel J Gagnier Douglas G Altman Sean Tunis Brian Haynes Andrew D Oxman David Moher 汪谋岳(译) | 2009 | 英国医学杂志中文版2009，12，3： | 1 |
| 12 | Taylor flow heat transfer in microchannels—Unification of liquid–liquid and gas–liquid results显示文摘 | Zhenhui Dai Zhenyi Guo David F. Fletcher Brian S. Haynes | 2015 | Chemical Engineering Science2015，，： | 1 |
| 13 | Information asymme- tries, financial structure, and financial intermediation 显示文摘 | LELAND HAYNE PYLE DAVID H | 1977 | Journal of Finance1977，，32： | 1 |
| 14 | NASA radar altimeter for the TOPEX/POSEIDON project显示文摘 | Alfred R Zieger David W Hancock George S Hayne Craig L Purdy | 1991 | Proceedings of the IEEE1991，79，6： | 1 |
| 15 | Information Asymmetry,Financial Structure, and Financial Intermediation 显示文摘 | Leland Hayne and David Pyle | 1977 | The Journal of Finance1977，，32： | 1 |
| 16 | CFD approaches for the simulation of hydrodynamics and heat transfer in Taylor flow显示文摘 | Azadeh N. Asadolahi Raghvendra Gupta David F. Fletcher Brian S. Haynes | 2011 | Chemical Engineering Science2011，，22： | 1 |
| 17 | Validation of a CFD model of Taylor flow hydrodynamics and heat transfer显示文摘 | Azadeh N. Asadolahi Raghvendra Gupta Sharon S.Y. Leung David F. Fletcher Brian S. Haynes | 2011 | Chemical Engineering Science2011，，1： | 1 |
| 18 | Information Asymmetries,Financial Structure and Financial Intermediation显示文摘 | Hayne E David H | 1977 | Journal of Finance1977，，5： | 1 |
| 19 | Heat transfer in well-characterised Taylor flow显示文摘 | Sharon S.Y. Leung Yang Liu David F. Fletcher Brian S. Haynes | 2010 | Chemical Engineering Science2010，，24： | 1 |
| 20 | Informational Asymmetries, Financial Structure and Financial Intermediation 显示文摘 | HAYNE E DAVID H | 1977 | The Journal of Finance1977，，5： | 1 |
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