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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 3 | LIGHT, a New Member of the TNF Superfamily, and Lymphotoxin α Are Ligands for Herpesvirus Entry Mediator显示文摘 | Davide N Mauri Reinhard Ebner Rebecca I Montgomery Kristine D Kochel Timothy C Cheung Guo-Liang Yu Steve Ruben Marianne Murphy Roselyn J Eisenberg Gary H Cohen Patricia G Spear Carl F Ware | 1998 | Immunity1998，，： | 1 |
| 4 | Host plant evaluation behaviour of Bemisia tabaci and its modification by external uptake of imidacloprid显示文摘 | RUFUS I MATTHEW C DAVID N B | 1999 | Physiol Entomol1999，24，： | 1 |
| 5 | Adeptive resource provisioning for read intensive multi-tier applications in the cloud显示文摘 | Waheed I Matthew N D David C | 2011 | Future Generation Computer Systems2011，27，6： | 1 |
| 6 | N2-Ar-He compositions in fluid inclusions: Indicators of fluid source 显示文摘 | David I N John A M | 1994 | Geochimica et Cosmochimica Acta1994，58，3： | 1 |
| 7 | Microsurgical third ventriculostomy with Stenting in intrinsic brain tumors involving anterior third ventricle显示文摘 | David I Alexander N Dmitry N | | 0，，5： | 1 |
| 8 | Contrasting grey system theory to probability and fuzzy显示文摘 | DAVID K W N DENG J I | 1995 | Sigice Bulletin1995，64，3： | 1 |
| 9 | Cystatin C and beta2-microglobulin: markers of glomerular filtration in critically ill children显示文摘 | Jos e David Herrero-Mor i n Seraf i n M a laga Nuria Fern a ndez | 2007 | Critical Care2007，11，3： | 1 |
| 10 | Mechanical behavior of coated T91 steel in contact with lead - bismuth liquid alloy at 300℃ 显示文摘 | Proriol Serre I Diop I David N | 2011 | Surface and Coatings Technology2011，205，19： | 1 |
| 11 | Holocene oscillations in temperature and salinity of the surface subpolar Northat lantic显示文摘 | David J R Thornalley H E mcCave I N | 2009 | Nature2009，457，： | 1 |
| 12 | Unusual alternative splicing within the human kallikrein genes KLK2 and KLK3 gives rise to novel prostate-specific proteins 显示文摘 | David A Mabjeesh N Azar I | 2002 | J Biol Chem2002，277，18： | 1 |
| 13 | Latent dirichlet allocation显示文摘 | DAVID M B ANDREW Y N MICHAEL I J | 2003 | Journal of Machine Learning Research2003，3，： | 1 |
| 14 | Electronic control of Ca^2+ signalling in neuronal cells using an organic electronic ion pump 显示文摘 | loakim I Peter K David N | 2007 | Nature Materials2007，6，9： | 1 |
| 15 | Visitors'evaluation of an historical district: Repertory Grid Analysis and Laddering Analysis with pho- tographs显示文摘 | Taketo N David A Shoji I | 2006 | Tourism Management2006，27，3： | 1 |
| 16 | Latent Dirichlet Allocation 显示文摘 | David M B Andrew Y N Michael I J | 2003 | Journal of Machine Learning Research2003，，3： | 1 |
| 17 | Knowledge Warehouse : An Architectural Integration of Knowledge Management, Decision Support, Artificial Intelligence and Data Warehousing 显示文摘 | Hamid R N David M S Lakshmi S I | 2002 | Decision Support Systems2002，33，： | 1 |
| 18 | Sentinel lymph node biopsy for staging breast cancer 显示文摘 | Cowan C David N | 1998 | Am J Surg1998，178，6： | 1 |
| 19 | Latent Dirichlet allocation显示文摘 | David M B Andrew Y N Michael I J | 2003 | Journal of Machine Learning Research2003，3，1： | 1 |
| 20 | Erythrocytebinding activity of Plasmodium yoelii apical membrane antigen-1 expressed on the surface of transfected COS-7 cells显示文摘 | TRESA S F STEFAN H I DAVID L N | 2001 | Mol Biochem Parasitol2001，117，3： | 1 |
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