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| 1 | 上海26万妇女乳房自我检查随机试验显示文摘目的论证指导妇女进行乳房自我检查(BSE)是否能有效降低乳腺癌患者的死亡率。方法自1989年10月起,上海26.6万名年龄在30~64岁的妇女,随机进入指导组(132979名)和对照组(133085名)。在指导组,最初先由医务人员做规范的BSE手法演示,随后的4年中,使用BSE录像带进行二次强化教育,并定期进行BSE指导和在医务人员监察下进行BSE操作。本研究进行5年,全部活动均被记录。队列人群随访到2000年7月,乳腺癌患者的生存状况随访到2001年12月。统计分析采用Kaplan-Meier方法、Logrank检验以及Cox模型。结果指导组检出乳腺癌864例,其中死于乳腺癌133例;对照组检出乳腺癌896例,其中死于乳腺癌130例。两组乳腺癌病例的肿块大小、TNM分期和累积死亡率的差异均无统计学意义(P均>0.05)。但是指导组比对照组有较多和较小的纤维腺瘤被检出(P<0.01)。结论对人群开展BSE教育和指导,未能降低人群的乳腺癌死亡率;接受BSE教育的妇女比没有接受教育的妇女可检出较多的和较小的良性乳房肿块。 | 高道利 David BThomas Roberta M Ray 王文婉 Charlene J Allison 陈范良 Peggy Porter 胡永伟 赵关林 潘雷达 李雯瑾 武春园 Zakia Coriaty Ilonka Evans 林明纲 Helge Stalsberg Steven Gself | 2005 | 中华肿瘤杂志2005，27，6： | 14 |
| 2 | Bacterial biota in reflux esophagitis and Barrett's esophagus显示文摘AIM: To identify the bacterial flora in conditions such as Barrett's esophagus and reflux esophagitis to determine if they are similar to normal esophageal flora.METHODS: Using broad-range 16S rDNA PCR,esophageal biopsies were examined from 24 patients [9with normal esophageal mucosa, 12 with gastroesophageal reflux disease (GERD), and 3 with Barrett's esophagus].Two separate broad-range PCR reactions were performed for each patient, and the resulting products were cloned.In one patient with Barrett's esophagus, g9 PCR clones were analyzed.RESULTS: Two separate clones were recovered from each patient (total = 48), representing 24 different species, with 14 species homologous to known bacteria,5 homologous to unidentified bacteria, and 5 were not homologous (<97% identity) to any known bacterial 16S rDNA sequences. Seventeen species were found in the reflux esophagitis patients, 5 in the Barrett's esophagus patients, and 10 in normal esophagus patients.Further analysis concentrating on a single biopsy from an individual with Barrett's esophagus revealed the presence of 21. distinct bacterial species. Members of four phyla were represented, including Bacteroidetes,Firmicutes, Proteobacteria, and Actinobacteria.Microscopic examination of each biopsy demonstrated bacteria in intimate association with the distal esophageal epithelium, suggesting that the presence of these bacteria is not transitory.CONCLUSION: These findings provide evidence for a complex, residential bacterial population in esophageal reflux-related disorders. While much of this biota is present in the normal esophagus, more detailed comparisons may help identify potential disease associations. | Zhiheng Pei Liying Yang Richard M Peek Jr Steven M Levine David T Pride Martin J Blaser | 2005 | World Journal of Gastroenterology2005，11，46： | 11 |
| 3 | 腰椎骨盆固定和三角固定术在不稳定型骶骨骨折治疗中的应用显示文摘骶骨是构成骨盆后环的蕈要结构和脊柱重力线分佑到两侧髋臼的枢纽部位,垂直不稳定型骶骨骨折多由高能量损伤引起,常合并神经损伤和多发性创伤而引起骨盆环不稳定,特殊类型的骶骨骨折可引起脊柱一骨盆的不稳定。近年来,随着研究的深入,多种内固定方法用于垂直不稳定型骶骨骨折的治疗,包括横向固定装置,如骶髂螺钉、骶骨棒、 | 易成腊 Steven Morgan David J Hak | 2011 | 中华创伤骨科杂志2011，13，4： | 8 |
| 4 | Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study显示文摘 | Pierre Fenaux Ghulam J Mufti Eva Hellstrom-Lindberg Valeria Santini Carlo Finelli Aristoteles Giagounidis Robert Schoch Norbert Gattermann Guillermo Sanz Alan List Steven D Gore John F Seymour John M Bennett John Byrd Jay Backstrom Linda Zimmerman David M | 2009 | Lancet Oncology2009，，： | 2 |
| 5 | Diabetic Retinopathy显示文摘 | Thomas W Gardner David A Antonetti Alistair J Barber Kathryn F LaNoue Steven W Levison | 2002 | Survey of Ophthalmology2002，，： | 2 |
| 6 | Androgens and esophageal cancer: What do we know?显示文摘Significant disparities exist between genders for the development and progression of several gastrointestinal(GI) diseases including cancer. Differences in incidence between men vs women for colon, gastric and hepatocellular cancers suggest a role for steroid sex hormones in regulation of GI carcinogenesis. Involvement of intrinsic gender-linked mechanisms is also possible for esophageal adenocarcinoma as its incidence is disproportionally high among men. However, the cause of the observed gender differences and the potential role of androgens in esophageal carcinogenesis remains unclear, even though the cancer-promoting role of androgen receptors(AR) shown in other cancers such as prostate and bladder suggests this aspect warrants exploration. Several studies have demonstrated expression of ARs in esophageal cancer. However, only one study has suggested a potential link between AR signaling and outcome- poorer prognosis. Two groups have analyzed data from cohorts with prostate cancer and one of these found a decreased incidence of esophageal squamous and adenocarcinoma after androgen deprivation therapy. However, very limited information is available about the effects of androgen and AR-initiated signaling on esophageal cancer cell growth in vitro and in vivo. Possible mechanisms for androgens/AR involvement in the regulation of esophageal cancer growth are considered, and the potential use of AR as a prognostic factor and clinical target is highlighted, although insufficient evidence is available to support clinical trials of novel therapies. As esophageal adenocarcinoma is a gender linked cancer with a large male predominance further studies are warranted to clarify the role of androgens and ARs in shaping intracellular signaling and genomic responses in esophageal cancer. | Olga A Sukocheva Bin Li Steven L Due Damian J Hussey David I Watson | 2015 | World Journal of Gastroenterology2015，21，20： | 2 |
| 7 | Adipocyte iron regulates adiponectin and insulin sensitivity显示文摘 | Gabrielsen J Scott Gao Yan Simcox Judith A Huang Jingyu Thorup David Jones Deborah Cooksey Robert C Gabrielsen David Adams Ted D Hunt Steven C Hopkins Paul N Cefalu William T McClain Donald A | 2012 | EN2012，，10： | 2 |
| 8 | Doped Nanocry- stals 显示文摘 | David J Norris Alexander L Efros Steven C Erwin | 2008 | Science2008，319，5871： | 1 |
| 9 | Subcritical Water Chromatography with Flame Ionization Detection 显示文摘 | David J Steven B | 1997 | Anal Chem1997，69，： | 1 |
| 10 | The importance of spatial scale for conservation and assessment of anuran populations in coastal wetlands of the Western Great Lakes, USA显示文摘 | Steven J P David R M Robert W H | 2005 | Landscape Ecol2005，20，4： | 1 |
| 11 | CCSweep:antomatic decomposition of multi-sweep volumes显示文摘 | David R White Sunil Saigal Steven J Owen | 2004 | Engineering with Computers2004，20，3： | 1 |
| 12 | Neural correlates of anxiety associated with obsessive-compulsive symptom dimensions in normal volunteers显示文摘 | David Mataix-Cols Sarah Cullen Kezia Lange Fernando Zelaya Christopher Andrew Edson Amaro Michael J Brammer Steven C.R Williams Anne Speckens Mary L Phillips | 2003 | Biological Psychiatry2003，，6： | 1 |
| 13 | Effect of hydrothermal aging on oxygen storage/release and activity in a commercial automotive catalys显示文摘 | Steven J S David N B | 1995 | Appl Catal B:Environ1995，6，2： | 1 |
| 14 | Oxidation of CO by NO over Rh(Ⅲ)显示文摘 | Steven J | 1993 | Journal of Catalysis1993，144，： | 1 |
| 15 | A prospective clinicopathological and endoscopic evaluation of flat and depressed colorectal lesions in the United Kingdom显示文摘 | David P Hurlstone Simon S Cross Ian Adam Andrew J Shorthouse Steven Brown David S Sanders Alan J Lobo | 2003 | The American Journal of Gastroenterology2003，，11： | 1 |
| 16 | Linkage of the β-like w-globin gene to α-like globin genes in an Australian Marsupial supports the chromosome duplication model for separation of globin gene clusters 显示文摘 | DAVID W RORY M H STEVEN J B | 2004 | J Mol Evol2004，58，： | 1 |
| 17 | Strain-based constitutive model with mixed evolution rules for concrete显示文摘 | DAVID J STEVENS L DAJIN L | 1992 | Journal of Engineering Mechanics1992，118，6： | 1 |
| 18 | Keratinocyle interleukin-10 expression is upresulated in tape-stripped skin, poison ivy dermatitis, and Sezary Syndrome, but not in psoriatic plaques显示文摘 | Brian J David P Steven L | 1994 | J Immunol1994，73，： | 1 |
| 19 | The importance of lattice defects in katanin-mediated microtubule severing in vitro显示文摘 | Liza J D David J O Steven M B | 2002 | Biophys J2002，82，6： | 1 |
| 20 | Scintigraphic Assessment of Regionalized Defects in Myocardial Sympathetic Innervation and Blood Flow Regulation in Diabetic Patients With Autonomic Neuropathy显示文摘 | Martin J Stevens Firat Dayanikli David M Raffel Kevin C Allman Tracy Sandford Eva L Feldman Donald M Wieland James Corbett Marcus Schwaiger | 1998 | Journal of the American College of Cardiology1998，，7： | 1 |
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