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| 1 | Outcomes and patients' perspectives of transition from paediatric to adult care in inflammatory bowel disease显示文摘AIM: To describe the disease and psychosocialoutcomes of an inflammatory bowel disease(IBD) transition cohort and their perspectives.METHODS: Patients with IBD, aged > 18 years, who had moved from paediatric to adult care within 10 years were identified through IBD databases at three tertiary hospitals. Participants were surveyed regarding demographic and disease specific data and their perspectives on the transition process. Survey response data were compared to contemporaneously recorded information in paediatric service case notes. Data were compared to a similar age cohort who had never received paediatric IBD care and therefore who had not undergone a transition process. RESULTS: There were 81 returned surveys from 46 transition and 35 non-transition patients. No statistically significant differences were found in disease burden, disease outcomes or adult roles and responsibilities between cohorts. Despite a high prevalence of mood disturbance(35%), there was a very low usage(5%) of psychological services in both cohorts. In the transition cohort, knowledge of their transition plan was reported by only 25/46 patients and the majority(54%) felt they were not strongly prepared. A high rate(78%) of discussion about work/study plans was recorded prior to transition, but a near complete absence of discussion regarding sex(8%), and other adult issues was recorded. Both cohorts agreed that their preferred method of future transition practices(of the options offered) was a shared clinic appointment with all key stakeholders. CONCLUSION: Transition did not appear to adversely affect disease or psychosocial outcomes. Current transition care processes could be optimised, with better psychosocial preparation and agreed transition plans. | Alice L Bennett David Moore Peter A Bampton Robert V Bryant Jane M Andrews | 2016 | World Journal of Gastroenterology2016，22，8： | 3 |
| 2 | Lymphoepithelial cysts and cystic lymphangiomas: Underrecognized benign cystic lesions of the pancreas显示文摘AIM: To identify their diagnostic and prognostic clinical characteristics in a large series.METHODS: Retrospective review of clinicopathologic and imaging characteristics of patients diagnosed with lymphoepithelial cysts and cystic lymphangiomas of the pancreas at Massachusetts General Hospital.RESULTS: Twelve patients were identified between 1/1/1997 and 8/1/2007. Their median age was 55.5 years(range 19-78 years), and 6 were females. The le-sion was incidentally discovered in half of the patients.Contrast enhanced computed tomography demonstrat-ed that the cysts had thin walls, without calcifications, pancreatic duct dilation or pancreatic parenchyma inva-sion. Endoscopic ultrasound with fine needle aspiration(EUS/FNA) confirmed the diagnosis of a lymphoepithe-lial cyst in 3 patients, one of whom was spared an op-eration and continues to do well after 6 years. Eleven patients had a resection: 3 pancreaticoduodenecto-mies, 7 distal pancreatectomies, and 1 enucleation. The median size of the cysts was 3 cm(range 2-20 cm). At a median follow-up of 57 mo no recurrences or other pancreas-related conditions occurred.CONCLUSION: Lymphoepithelial cysts and cystic lymphangiomas of the pancreas can be diagnosed with a combination of contrast-enhanced computed tomog-raphy scans and EUS/FNA. If the lesion is asymptom-atic, an operation might be avoided. | Ioannis T Konstantinidis Avinash Kambadakone Onofrio A Catalano Dushyant V Sahani Vikram Deshpe David G Forcione Jennifer A Wargo Carlos Fernandez-del Castillo Keith D Lillemoe Andrew L Warshaw Cristina R Ferrone | 2014 | World Journal of Gastrointestinal Surgery2014，6，7： | 2 |
| 3 | Personalising pancreas cancer treatment:When tissue is the issue显示文摘The treatment of advanced pancreatic cancer has not moved much beyond single agent gemcitabine until recently when protocols such as FOLFIRINOX(fluorouracil,leucovorin,irinotecan and oxaliplatin)and nab-paclitaxelgemcitabine have demonstrated some improved outcomes.Advances in technology especially in massively parallel genome sequencing has progressed our understanding of the biology of pancreatic cancer especially the candidate signalling pathways that are involved in tumourogenesis and disease course.This has allowed identification of potentially actionable mutations that may be targeted by new biological agents.The heterogeneity of pancreatic cancer makes tumour tissue collection important with the aim of being able to personalise therapies for the individual as opposed to a one size fits all approach to treatment of the condition.This paper reviews the developments in this area of translational research and the ongoing clinical studies that will attempt to move this into the everyday oncology practice. | Katrin M Sjoquist Venessa T Chin Lorraine A Chantrill Chelsie O'Connor Chris Hemmings David K Chang Angela Chou Marina Pajic Amber L Johns Adnan M Nagrial Andrew V Biankin Desmond Yip | 2014 | World Journal of Gastroenterology2014，20，24： | 2 |
| 4 | Silk as a biomaterial显示文摘 | CHARU V DAVID L K | 2007 | Progress in Polymer Science2007，32，： | 1 |
| 5 | Synthesis and evaluation of novel 1-(2-acylhydrazinocarbonyl)-cycloalkyl carboxamides as interleukin- 1 b converting enzyme(ICE)inhibitors 显示文摘 | David L S Justin S Steven V O | 2006 | Bioorganic & Medicinal Chemistry Letters2006，16，： | 1 |
| 6 | Phosphorus Trans- port Pathways to Streams in Tile-Drained Agricultural Watersheds 显示文摘 | GENTRY L E DAVID M B ROYER T V | 2007 | Journal of Environmental Quality2007，36，2： | 1 |
| 7 | Genotypic differences in polyembryo formation and somatic embryogenesis increment in wheat (Triticum aestivum L.), following 2,4-D treatment显示文摘 | Rosario Linacero Marisa G. López-Bilbao Concepción Romero David A. Laurie Ana M. Vázquez | 1996 | Euphytica1996，，3： | 1 |
| 8 | Sorption of tetracycline and chlortetracycline on K-and Ca-Saturated soil clays, humic substances, and Clay-Humic complexes 显示文摘 | Jutta R V P David A L | 2007 | Environ Sci Technol2007，41，： | 1 |
| 9 | Effect of direct liquid water injection and interdigitated flow field on the performance of proton exchange membrane fuel cells显示文摘 | David L Wood Jung S Yi Trung V Nguyen | 1996 | Electrochimica Acta1996，43，24： | 1 |
| 10 | Clinical utility of a commercial LAM-ELISA assay for TB diagnosis in HIV- infected patients using urine and sputum samples 显示文摘 | Dheda K Davids V Lenders L | 2010 | PLoS One2010，5，3： | 1 |
| 11 | The NIH human microbiome project显示文摘 | NIH HMP Working Group Peterson J Garges S Giovanni M McInnes P Wang L Schloss JA Bonazzi V McEwen JE Wetterstrand KA Deal C Baker CC Di Francesco V Howcroft TK Karp RW Lunsford RD Wellington CR Belachew T Wright M Giblin C David H Mills M Salomon R Mullins C Akolkar B Begg L Davis C Grandison L Humble M Khalsa J Little AR Peavy H Pontzer C Portnoy M Sayre MH Starke-Reed P Zakhari S Read J Watson B Guyer M | 2009 | Genome Res2009，19，12： | 1 |
| 12 | Ex Vivo bone formation in bovine trabecular bone cultured in a dynamic 3D bioreactor is enhanced by compressive mechanical strain显示文摘 | David V Guignandon A Martin A Malaval L Lafage-Proust MH Rattner A Mann V Noble B Jones DB Vico L | | 0，，： | 1 |
| 13 | Vision-based active safety system for automatic stopping显示文摘 | VICENTE M DAVID F L JORGE V | 2012 | Expert systems with applications2012，39，11： | 1 |
| 14 | Effect of Transmitter Turn off Time on Transient Soundings显示文摘 | David V Fitterman and Waiter L Anderson | 1987 | Geoexploration1987，24，2： | 1 |
| 15 | Training a neural-network based intrusion detector to recognize novel attacks显示文摘 | Susan C L David V H | 2001 | IEEE Transactions on systems man and cybernetics-part a:System and Humans2001，31，： | 1 |
| 16 | Practical application of on-line hot strip inspection system at hoogovens 显示文摘 | DAVID G P MARTIN P L HANEGHEM A V | 1995 | Iron and Steel Engineer1995，72，7： | 1 |
| 17 | Application of high-frequency rheology measurements for analyzing protein-protein interactions in high protein concentration solutions using a model monoclonal antibody (IgG2) 显示文摘 | Atul S Advait V B David L Z | 2006 | Journal of Pharmaceutical Sciences2006，95，9： | 1 |
| 18 | Parametric reverse correlation reveals spatial linearity of retinotopic human V1 BOLD response显示文摘 | HANSEN K A DAVID S V GALLANT J L | 2004 | Neuroimage2004，23，1： | 1 |
| 19 | An extensive cochlodinium bloom along the Western coast of Palawan, Philippines显示文摘 | AZANZA R V DAVID L T BORJA R T BAUIA I U FUKUYO Y | 2008 | Harmful Algae2008，7，： | 1 |
| 20 | Pilot-scale subcritical water remediation of polycyclic aromatic hydrocarbon and pesticide-contaminated soil显示文摘 | LAGADEC A J M DAVID J M ALAN V L | 2000 | Environ Sci Technol2000，34，： | 1 |
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