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| 1 | Heat shock protein 90 inhibition by 17-DMAG lessens disease in the MRL/Ipr mouse model of systemic lupus erythematosus显示文摘热吃惊蛋白质 90 的提高的表示(HSP90 ) 在全身的豺狼座 erythematosus (SLE ) 的肾和浆液被发现了病人和 MRL/Mp-Fas lpr /Fas lpr (MRL/lpr ) 自体免疫的老鼠。如果 HSP90 的抑制将在 MRL/lpr 老鼠减少疾病,我们调查了。在在 vivo 的 vitro,有在 IL-6 的有免疫力刺激的显示出的减少的表示以前的 HSP90 禁止者 Geldanamycin 的 mesangial 房间的预告的处理, IL-12 和号码,我们发现当与 C57BL/6 相比鼠标和 MRL/lpr 鼠标与 HSP90 禁止者 17-DMAG 对待时, HSP90 表示在 MRL/lpr 肾被提高。与 17-DMAG 对待的 MRL/lpr 老鼠显示出减少的 proteinuria 并且减少了浆液 anti-dsDNA 抗体生产。Glomerulonephritis 和 glomerular IgG 和 C3 没被 17-DMAG 的管理显著地在 MRL/lpr 影响。17-DMAG 增加了 CD8 + T 房间,减少的双 negative T 房间,减少 CD4/CD8 比率和减少的小囊的 B 房间。这些研究建议 HSP90 可以在调整 T 房间区别和激活起一个作用并且 HSP90 抑制可以在豺狼座减少发炎。 | Samuel K Shimp III Cristen B Chafin Nicole L Regna Sarah E Hammond Molly A Read David L Caudell Marissa Nichole Rylander Christopher M Reilly | 2012 | Cellular & Molecular Immunology2012，9，3： | 3 |
| 2 | Stereotactic body radiation therapy for management of spinal metastases in patients without spinal cord compression: a phase 1–2 trial显示文摘 | Xin Shelley Wang Laurence D Rhines Almon S Shiu James N Yang Ugur Selek Ibrahima Gning Ping Liu Pamela K Allen Syed S Azeem Paul D Brown Hadley J Sharp David C Weksberg Charles S Cleeland Eric L Chang | 2012 | Lancet Oncology2012，，4： | 2 |
| 3 | Constitutive renal Rel/nuclear factor-κB expression in Lewis polycystic kidney disease rats显示文摘AIM:To determine the temporal expression and pattern of Rel/nuclear factor(NF)-κB proteins in renal tissue in polycystic kidney disease(PKD). METHODS: The renal expression of Rel/NF-κB proteins was determined by immunohistochemistry, immunofluorescence and immunoblot analysis in Lewis polycystic kidney rats(LPK, a genetic ortholog of human nephronopthsis-9) from postnatal weeks 3 to 20. At each timepoint, renal disease progression and the mR NA expression of NF-κB-dependent genes(TNFa and CCL2) were determined. NF-κB was also histologicaly assessed in human PKD tissue.RESULTS: Progressive kidney enlargement in LPK rats was accompanied by increased renal cell proliferation and interstitial monocyte accumulation(peaking at weeks 3 and 10 respectively), and progressive interstitial fibrosis(with a smooth muscle actin and Sirius Red deposition significantly increased compared to Lewis kidneys from weeks 3 to 6 onwards). Rel/NF-κB proteins(phosphorylated-p105, p65, p50, c-Rel and RelB) were expressed in cystic epithelial cells(CECs) of LPK kidneys as early as postnatal week 3 and sustained until latestage disease at week 20. From weeks 10 to 20, nuclear p65, p50, Rel B and cytoplasmic IκBa protein levels, and TNFa and CCL2 expression, were upregulated in LPK compared to Lewis kidneys. NF-κB proteins were consistently expressed in CECs of human PKD. The DNA damage marker γ-H2AX was also identified in the CECs of LPK and human polycystic kidneys. CONCLUSION: Several NF-κB proteins are consistently expressed in CECs in human and experimental PKD. These data suggest that the upregulation of both the canonical and non-canonical pathways of NF-κB signaling may be a constitutive and early pathological feature of cystic renal diseases. | Michelle HT Ta Kristina G Schwensen David Liuwantara David L Huso Terry Watnick Gopala K Rangan | 2016 | World Journal of Nephrology2016，5，4： | 2 |
| 4 | Personalising pancreas cancer treatment:When tissue is the issue显示文摘The treatment of advanced pancreatic cancer has not moved much beyond single agent gemcitabine until recently when protocols such as FOLFIRINOX(fluorouracil,leucovorin,irinotecan and oxaliplatin)and nab-paclitaxelgemcitabine have demonstrated some improved outcomes.Advances in technology especially in massively parallel genome sequencing has progressed our understanding of the biology of pancreatic cancer especially the candidate signalling pathways that are involved in tumourogenesis and disease course.This has allowed identification of potentially actionable mutations that may be targeted by new biological agents.The heterogeneity of pancreatic cancer makes tumour tissue collection important with the aim of being able to personalise therapies for the individual as opposed to a one size fits all approach to treatment of the condition.This paper reviews the developments in this area of translational research and the ongoing clinical studies that will attempt to move this into the everyday oncology practice. | Katrin M Sjoquist Venessa T Chin Lorraine A Chantrill Chelsie O'Connor Chris Hemmings David K Chang Angela Chou Marina Pajic Amber L Johns Adnan M Nagrial Andrew V Biankin Desmond Yip | 2014 | World Journal of Gastroenterology2014，20，24： | 2 |
| 5 | Genome sequence and analysis of the soil cellulolytic actinomyeete Thermobifidafusca YX 显示文摘 | Athanasios L Konstantinos M Natalia I lain A Miriam L Genevieve D Michele M Alia L Susan L Alex C Paul R David BW Nikos K | 2007 | J Bacteriol2007，189，6： | 1 |
| 6 | Accelerated Amyloid Deposition in the Brains of Transgenic Mice Coexpressing Mutant Presenilin 1 and Amyloid Precursor Proteins显示文摘 | David R Borchelt Tamara Ratovitski Judy van Lare Michael K Lee Vicki Gonzales Nancy A Jenkins Neal G Copeland Donald L Price Sangram S Sisodia | 1997 | Neuron1997，，4： | 1 |
| 7 | Prevention and Control of Influenza with Vaccines Recommendations of the Advisory Committee on Immunization Practices (ACIP), 2010显示文摘 | Fiore Anthony E Uyeki Timothy M Broder Karen Finelli Lyn Euler Gary L Singleton James A Iskander John K Wortley Pascale M Shay David K Bresee Joseph S Cox Nancy J | 2010 | MMWR. Morbidity and Mortality Weekly Report2010，，： | 1 |
| 8 | Silk as a biomaterial显示文摘 | CHARU V DAVID L K | 2007 | Progress in Polymer Science2007，32，： | 1 |
| 9 | Outcome of transurethral prostatectomy for the palliative management of lower urinary tract symptoms in men with prostate cancer显示文摘 | Vincent J G Vinod K David L | 2006 | Int J Urol2006，13，6： | 1 |
| 10 | Medication er- rors and adverse drug events in pediatric inpatients显示文摘 | Rainu K David W Christopher L | 2001 | JA- MA2001，285，16： | 1 |
| 11 | Effects of Endotoxin on Lung Pericytes in Vitro 显示文摘 | Joseph K David L | 1998 | Microvasc Res1998，56，2： | 1 |
| 12 | The natural progression of peanut allergy: resolution and the possibility of recurrence显示文摘 | David M F Conover M K Christie L | 2003 | J Allergy Clin Immunol2003，112，1： | 1 |
| 13 | Application of isotope dilution for precise measurement of Zr/Hf and 176 Hf/177 Hf ratios by mass spectrometry (ID-TIMS/ID-MC-ICP-MS)显示文摘 | David K Birk J L Telouk P | 1999 | Chemical Geology1999，157，： | 1 |
| 14 | Application of isotope dilution for precise measurement of Zr/Hf and 176Hf/177Hf ratios by mass spectrometry (ID-TIMS/ID-MC-ICP-MS) 显示文摘 | David K Birck J L Telouk P Allègre C J | 1999 | Chem Geol1999，157，12： | 1 |
| 15 | Mo- lecular cloning and characterization of the human clock gene: expression in the suprachiasmatic nuclei 显示文摘 | THOMAS D L STEEVE S DAVID P K | 1999 | Genomics1999，，57： | 1 |
| 16 | Fault tree analysis and treatment plant instrumentation 显示文摘 | David L K Richard C A | 1981 | Journal of Water Pollution Control Federation1981，53，1： | 1 |
| 17 | Management of general surgical problems in the pregnant patient显示文摘 | David M Melnick Wendy L Wahl Vanessa K Dalton | 2004 | The American Journal of Surgery2004，，2： | 1 |
| 18 | A new approach to determine autogenous shrinkage of mortar at an early age considering temperature history显示文摘 | Ahmed L David C Abdelhafid K | 2000 | Cement and Concrete Research2000，，30： | 1 |
| 19 | Application of stable isotopes to identify problems in large-scale water transfer in Grand Canyon National Park显示文摘 | Neil L Ingraham Kim Zukosky David K Kreamer | 2001 | Environmental Science & Technology2001，35，4： | 1 |
| 20 | The effects of sequential introduction of brand extention显示文摘 | Keller K L David A Aaker | | 0，，02： | 1 |
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