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| 1 | Apple whole genome sequences:recent advances and new prospects显示文摘In 2010,a major scientific milestone was achieved for tree fruit crops:publication of the first draft whole genome sequence(WGS)for apple(Malus domestica).This WGS,v1.0,was valuable as the initial reference for sequence information,fine mapping,gene discovery,variant discovery,and tool development.A new,high quality apple WGS,GDDH13 v1.1,was released in 2017 and now serves as the reference genome for apple.Over the past decade,these apple WGSs have had an enormous impact on our understanding of apple biological functioning,trait physiology and inheritance,leading to practical applications for improving this highly valued crop.Causal gene identities for phenotypes of fundamental and practical interest can today be discovered much more rapidly.Genome-wide polymorphisms at high genetic resolution are screened efficiently over hundreds to thousands of individuals with new insights into genetic relationships and pedigrees.High-density genetic maps are constructed efficiently and quantitative trait loci for valuable traits are readily associated with positional candidate genes and/or converted into diagnostic tests for breeders.We understand the species,geographical,and genomic origins of domesticated apple more precisely,as well as its relationship to wild relatives.The WGS has turbo-charged application of these classical research steps to crop improvement and drives innovative methods to achieve more durable,environmentally sound,productive,and consumer-desirable apple production.This review includes examples of basic and practical breakthroughs and challenges in using the apple WGSs.Recommendations for“what’s next”focus on necessary upgrades to the genome sequence data pool,as well as for use of the data,to reach new frontiers in genomics-based scientific understanding of apple. | Cameron P.Peace Luca Bianco Michela Troggio Eric van de Weg Nicholas P.Howard Amandine Cornille Charles-Eric Durel Sean Myles ZoëMigicovsky Robert J.Schaffer Evelyne Costes Gennaro Fazio Hisayo Yamane Steve van Nocker Chris Gottschalk Fabrizio Costa David Chagné Xinzhong Zhang Andrea Patocchi Susan E.Gardiner Craig Hardner Satish Kumar Francois Laurens Etienne Bucher Dorrie Main Sook Jung Stijn Vanderzande | 2019 | Horticulture Research2019，6，1： | 3 |
| 2 | Cotton genome mapping with new microsatellites from Acala ‘Maxxa’ BAC-ends显示文摘 | James E. Frelichowski Michael B. Palmer Dorrie Main Jeffrey P. Tomkins Roy G. Cantrell David M. Stelly John Yu Russell J. Kohel Mauricio Ulloa | 2006 | Molecular Genetics and Genomics2006，，5： | 1 |
| 3 | Clinical Utility of the Cobalt-Albumin Binding Assay in the Diagnosis of Intestinal Ischemia显示文摘 | Jonathan D. Polk Leonard T. Rael Michael L. Craun Charles W. Mains Deborah Davis-Merritt David Bar-Or | 2008 | The Journal of Trauma: Injury, Infection, and Critical Care2008，，： | 1 |
| 4 | Functional genomics of cell elongation in developing cotton fibers显示文摘 | A. Arpat Mark Waugh John P. Sullivan Michael Gonzales David Frisch Dorrie Main Todd Wood Anna Leslie Rod Wing Thea Wilkins | 2004 | Plant Molecular Biology2004，，6： | 1 |
| 5 | Functional genomics of cell elongation in developing cotton fibers显示文摘 | A. Arpat Mark Waugh John P. Sullivan Michael Gonzales David Frisch Dorrie Main Todd Wood Anna Leslie Rod Wing Thea Wilkins | 2004 | Plant Molecular Biology2004，，6： | 1 |
| 6 | Accuracy of five electronic pedometers for measuring distance walked显示文摘 | DAVID R. BASSETT BARBARA E. AINSWORTH SUE R. LEGGETT CLARA A. MATHIEN JAMES A. MAIN DAVID C. HUNTER GLEN E. DUNCAN | 1996 | Medicine & Science in Sports & Exercise1996，，8： | 1 |
| 7 | Blueberry and cranberry pangenomes as a resource for future genetic studies and breeding efforts显示文摘Domestication of cranberry and blueberry began in the United States in the early 1800s and 1900s,respectively,and in part owing to their f lavors and health-promoting benefits are now cultivated and consumed worldwide.The industry continues to face a wide variety of production challenges(e.g.disease pressures),as well as a demand for higher-yielding cultivars with improved fruit quality characteristics.Unfortunately,molecular tools to help guide breeding efforts for these species have been relatively limited compared with those for other high-value crops.Here,we describe the construction and analysis of the first pangenome for both blueberry and cranberry.Our analysis of these pangenomes revealed both crops exhibit great genetic diversity,including the presence-absence variation of 48.4%genes in highbush blueberry and 47.0%genes in cranberry.Auxiliary genes,those not shared by all cultivars,are significantly enriched with molecular functions associated with disease resistance and the biosynthesis of specialized metabolites,including compounds previously associated with improving fruit quality traits.The discovery of thousands of genes,not present in the previous reference genomes for blueberry and cranberry,will serve as the basis of future research and as potential targets for future breeding efforts.The pangenome,as a multiple-sequence alignment,as well as individual annotated genomes,are publicly available for analysis on the Genome Database for Vaccinium-a curated and integrated web-based relational database.Lastly,the core-gene predictions from the pangenomes will serve useful to develop a community genotyping platform to guide future molecular breeding efforts across the family. | Alan E.Yocca Adrian Platts Elizabeth Alger Scott Teresi Molla F.Mengist Juliana Benevenuto Luis Felipe V.Ferrão MacKenzie Jacobs Michal Babinski Maria Magallanes-Lundback Philipp Bayer Agnieszka Golicz Jodi L.Humann Dorrie Main Richard V.Espley David Chagné Nick W.Albert Sara Montanari Nicholi Vorsa James Polashock Luis Díaz-Garcia Juan Zalapa Nahla V.Bassil Patricio R.Munoz Massimo Iorizzo Patrick P.Edger | 2023 | Horticulture Research2023，10，11： | 0 |
| 8 | 使用可配置处理内核将DSP集成到图像处理应用中显示文摘 | David Main Vladimir Adam Martin S.Won | 2004 | 今日电子2004，，5： | 0 |
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