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| 1 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 2 | Severe Hand, Foot, and Mouth Disease Associated with Coxsackievirus A6 - Alabama, Connecticut, California, and Nevada, November 201 1 - February 2012显示文摘 | McIntyre Mary G Stevens Kelly M Davidson Sherri Pippin Tina Magill Dagny Kulhanjian Julie A Kelly Daniel Greenhow Tara L Salas Maria L Yagi Shigeo Padilla Tasha Berumen Ricardo Glaser Carol Landry Marie Louise Lott Jason Chen Lei Paulson | 2012 | EN2012，，12： | 2 |
| 3 | RNA polymerase Ⅲ transcribes human microRNAs显示文摘 | Lanier W Davidson B L | 2006 | Nat Struct Mol Biol2006，13，12： | 1 |
| 4 | Interleukin-10 modulates the severity of hypersensitivity pneumonitis in mice显示文摘 | Gudmundsson G Bosch A Davidson B L | 1998 | Am J Respir Cell Mol Biol1998，19，5： | 1 |
| 5 | Schwertmannite inwet,acid and oxic microenvironments beneath polar and polyther-mal glaciers显示文摘 | Raiswell R Benning L G Davidson L | 2009 | Geology2009，37，5： | 1 |
| 6 | Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty (RECORD4): a randomised trial显示文摘 | Turpie A G Lassen M R Davidson B L | 2009 | Lancet2009，373，9676： | 1 |
| 7 | Impact of intracoronaryaspiration thrombectomy during primary angioplasty on left ventricu-lar remodelling in patients with anterior ST elevation myocardial in-farction显示文摘 | De Luca L Sardella G Davidson CJ | 2006 | Heart2006，92，： | 1 |
| 8 | Impact of intra-coro nary aspiration thrombectomy during primary angioplasty on left ventricular remodelling in patients with anterior ST elevation my-ocardial infarction显示文摘 | De Luea L Sardella G Davidson CJ | | 0，，： | 1 |
| 9 | A novel bocavir- us associated with acute gastroenteritis in Australian children 显示文摘 | Arthur J L Higgins G D Davidson G P | 2009 | PLoSPathog2009，5，10： | 1 |
| 10 | RNA polymerase Ⅲ transcribes human microRNAs 显示文摘 | Borchert G M Lanier W Davidson B L | 2006 | Nat Struct Mol Biol2006，13，12： | 1 |
| 11 | Degradtion of wheat starch in a single screw extruder:characteristics of extruded starch polymers显示文摘 | V J Davidson D Paton L L Diosady G Larocwue | 1984 | Journal of Food Science1984，49，： | 1 |
| 12 | Characterization of electrostatic discharges from insulating surfaces 显示文摘 | Davidson J L Williams T J Bailey A G et al | 2001 | Journal of Electrostatics2001，5152，1： | 1 |
| 13 | Rivarox- aban versus enoxaparin for thromboprophylaxis after total knee arthroplasty(RECORD4) : a randomised tri- al显示文摘 | Turpie A G Lassen M R Davidson B L | 2009 | Lancet2009，373，9676： | 1 |
| 14 | Application of boron isotopes for identifying contaminants such as fly ash leachate in groundwater显示文摘 | DAVIDSON G R BASSETT R L | 1993 | Environmental Sciences & Technology1993，27，： | 1 |
| 15 | A novelbocavirus associated with acute gastroenteritis in Australian children显示文摘 | Arthur J L Higgins G D Davidson G P | 2009 | PLoS Pathog2009，5，10： | 1 |
| 16 | Partial neu- roprotection by nNOS inhibition during profound asphyxia in preterm fetal sheep显示文摘 | Drury P P Davidson J O Van den Heuij L G | 2013 | Exp Neurol2013，250，： | 1 |
| 17 | A novel bocavirus associated with acute gastroenteritis in Australian children 显示文摘 | Arthur J L Higgins G D Davidson G P | 2009 | PLoS Pathog2009，5，10： | 1 |
| 18 | Cell cycle control of wnt receptor activation显示文摘 | Davidson G Shen J Huang Y L | 2009 | Developmental Cell2009，17，： | 1 |
| 19 | Impact of intracoronary aspiration thrombectomy during primary angioplasty on left ventricular remodelling in patients with anterior ST elevation myocardial infarction显示文摘 | De Luca L Sardella G Davidson CJ | 2006 | Heart2006，92，7： | 1 |
| 20 | Riva- roxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty ( RECORD4 ) : a randomised tria显示文摘 | TURPIE A G LASSEN M R DAVIDSON B L | 2009 | Lancet2009，373，9676： | 1 |
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