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| 1 | GDF-15 Level Correlates with CMKLR1 and VEGF-A in Tumor-free Margin in Colorectal Cancer显示文摘Colorectal cancer(CRC)is the third most frequently diagnosed cancer worldwide,responsible for over 880000 deaths each year.Growth/differentiation factor 15(GDF-15)is reported to be a promising diagnostic and prognostic factor in CRC.It induces pleiotropic effects in tumor cells:proliferation,sternness,invasion and metastasis.Some studies indicate that GDF-15 may stimulate angiogenesis in malignant neoplasms.However,it has not been investigated in CRC yet.The aim of our study was to determine the level of GDF-15 and the concentrations of hypoxia-inducible factor-la(HIF-1α),VEGF-A and chemokine-like receptor 1(CMKLR1)in tumor and margin specimens of CRC in relation to histological grade and TNM staging.The study comprised 33 samples of tumor and margin tissues obtained from CRC patients.To assess the concentration of GDF-15,HIF-1α,VEGF-A and CMKLR1,commercially available enzyme-linked immunosorbent assay(ELISA)kits were used.We found significantly increased levels of GDF-15 and CMKLR1 in tumor tissue compared to margin tissue and higher concentrations of HIF-1α and VEGF-A in margin tissue than in tumor tissue.The levels of GDF-15 and HIF-1α were significantly correlated with VEGF-A and CMKLR1 in margin tissue.In CRC,the increased level of GDF-15 might stimulate angiogenesis through upregulation of HIF-1α,VEGF A and CMKLR1 expression.Our study is the first one to reveal the correlation between the levels of GDF-15 and CMKLR1 in CRC.The elevated levels of HIF-1α and VEGF-A in tumor-free margin tissues suggest that noncancer cells in the tumor microenvironment are an important source of proangiogenic factors. | Sylwia Mielcarska Kamila Stopifnska Miriam Dawidowicz Agnieszka Kula Pawel Kicamer Alicja Prawdric Senkowska Ewa Nowakowska Zajde Katarzyna Walkiewicz Dariusz Waniczek Elzbieta Swietochowska | 2021 | Current Medical Science2021，41，3： | 3 |
| 2 | On practical prob- lems in estimation of antioxidant activity of compounds by DPPH method (Problems in estimation of antioxidant activity)显示文摘 | Dawidowicz A L Wianowska D Olszowy M | 2012 | Food Chemistry2012，131，3： | 1 |
| 3 | Immobilization of ceUulase and D-xylanase complexes from Aspergillus terreus F-413 on controlled porosity glasses显示文摘 | Jerzy Rogalski Janusz Szczodrak Andrzej Dawidowicz | 1985 | Enzyme and Microbial Technology1985，，7： | 1 |
| 4 | On practical problems in estimation of antioxidant activity of compounds by DPPH method (problems in estimation of antioxidant activity)显示文摘 | ANDRZEI L DAWIDOWICZ DOROTA W | 2012 | Food Chemistry2012，131，3： | 1 |
| 5 | Detection of moving targets with multi- channel airborne passive Radar 显示文摘 | Dawidowicz B | 2012 | IEEE A&E SYSTEM2012，4248，： | 1 |
| 6 | Static and dynamic superheated water extraction of essential oil components from Thymus vulgaris L显示文摘 | Dawidowicz A L Rado E Wianowska D | | 0，，： | 1 |
| 7 | DPCA detection of moving targets in airborne passive radar显示文摘 | DAWIDOWICZ B KULPA K S MALANOWSKI M | 2012 | IEEE Transactions on Aerospace and Electronic Systems2012，48，2： | 1 |
| 8 | Detection of moving targets with multichannel airborne passive radar显示文摘 | DAWIDOWICZ B SAMCZYNSKI P MALANOWSKI M | 2012 | IEEE Aerospace and Electronic Systems Magazine2012，27，11： | 1 |
| 9 | The role of human lungs in the biotransformation of propofol 显示文摘 | DAWIDOWICZ AL FORNAL E MARDAROWICZ M | 2000 | Anesthesilogy2000，93，4： | 1 |
| 10 | Trade-offs in diel vertical migration by zooplankton the costs of predator avoidance显示文摘 | Dawidowicz P Loose C J | 1994 | Ecology1994，75，： | 1 |
| 11 | Biomanipulation in shallow lakes: state of the art 显示文摘 | Perrow M R Meijer M L Dawidowicz P | 1997 | Hydrobiologia1997，，： | 1 |
| 12 | Biomanipulation in shallow lake:state of the art显示文摘 | Perrow M R Meijer M Dawidowicz P | 1997 | Hydrobiologia1997，，： | 1 |
| 13 | Influ- ence of propofol concentration in human plasma on free fraction of the drug 显示文摘 | DAWIDOWICZ AL KALITYNSKI M KOBIELSKI | 2006 | Chemieo-Biological Interactions2006，159，： | 1 |
| 14 | The level of jasmonic acid in Arabidopsis thaliana and Phaseolus coccineus plants under heavy metal stress 显示文摘 | Maksymiec W Wianowska Da Dawidowicz A L | 2005 | Journal of Plant Physiology2005，162，： | 1 |
| 15 | The role of human lungs in the biotransformation of propofol显示文摘 | Dawidowicz A L Fomal E Mardarowicz M | 2001 | Anesthesiology2001，93，4： | 1 |
| 16 | The role of human lungs in biotransformation of propofol显示文摘 | DAWIDOWICZ A L FORNAL E MARDAROWICZ M | 2000 | Anesthesiology2000，93，4： | 1 |
| 17 | Bioma nipulation in shallow lake: State of the art显示文摘 | PERROW M R MEIJER M DAWIDOWICZ P | 1997 | Hydrobiologia1997，，： | 1 |
| 18 | Change of propofol concentration in cerebrospinal fluid continuous infusion显示文摘 | Dawidowicz AL Kalitynski R Nestorowicz A | 2002 | Anaesth Analg2002，95，5： | 1 |
| 19 | Cerebrospinal fluid and blood propofol concentration during total intravenous anaesthesia for neurosurgery 显示文摘 | Dawidowicz AL Fijalkowska A Nestorowicz A | 2003 | Br J Anaesth2003，90，1： | 1 |
| 20 | influence of Propofol concentration in human plasma on free fraction of the drug 显示文摘 | DawidowiczAL Kalitynski M Kobielski | 2006 | Chemico-Biological Interactions2006，159，： | 1 |
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