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您的检索式：作者名="Daxiao Sun"
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| 1 | Polyubiquitin chain-induced p62 phase separation drives autophagic cargo segregation显示文摘错误褶层蛋白质能被选择 autophagy 降级。占优势的看法由 autophagosomes 是标注 ubiquitin 的错误褶层蛋白质被支架蛋白质 p62 装配进总数,并且总数然后被吞没并且降级。这里,我们报导 p62 在在 photobleaching 以后有象高球状,经历熔化的能力,和恢复那样的像液体的性质的 vivo 形成微滴。Recombinant p62 不在 vitro 经历阶段分离;然而,补充说到 p62 的 K63 polyubiquitin 链导致 p62 阶段分离,它导致高度分子的重量 ubiquitin 的丰富在 p62 微滴发信号。从 p62 / 房间与 cytosol 混合 recombinant p62 也以一种 polyubiquitination 依赖的方式导致 p62 阶段分离。机械学地, p62 阶段分离依赖于 p62 聚合,在 p62 和 ubiquitin 之间的相互作用,和 polyubiquitin 链的原子价。而且, p62 阶段分离能被象 phosphorylation 那样的 translational 以后修正调整。最后,我们证明在 p62 的联系疾病的变化能影响阶段分离。我们建议那 polyubiquitin 导致链的 p62 阶段分离运动 autophagic 货物集中和分离。 | Daxiao Sun Rongbo Wu Jingxiang Zheng Pilong Li Li YU | 2018 | Cell Research2018，28，4： | 21 |
| 2 | Myosin 1D and the branched actin network control the condensation of p62 bodies显示文摘Biomolecular condensation driven by liquid-liquid phase separation(LLPS)is key to assembly of membraneless organelles in numerous crucial pathways.It is largely unknown how cellular structures or components spatiotemporally regulate LLPS and condensate formation.Here we reveal that cytoskeletal dynamics can control the condensation of p62 bodies comprising the autophagic adaptor p62/SQSTM1 and poly-ubiquitinated cargos.Branched actin networks are associated with p62 bodies and are required for their conden satio n.Myosi n 1D,a bran ched acti n-associated motor protein,drives coalesce nee of small nano scale p62 bodies into large micron-scale condensates along the branched actin network.Impairment of actin cytoskeletal networks compromises the condensation of p62 bodies and retards substrate degradation by autophagy in both cellular models and Myosin ID knockout mice.Coupling of LLPS scaffold to cytoskeleton systems may represent a general mechanism by which cells exert spatiotemporal control over phase condensation processes. | Xuezhao Feng Wanqing Du Mingrui Ding Wenkang Zhao Xirenayi Xirefu Meisheng Ma Yuhui Zhuang Xiaoyu Fu Jiangfeng Shen Jinpei Zhang Xiuying Lei Daxiao Sun Qing Xi Yiliyasi Aisa Qian Chenr Ying Li Wenjuan Wang Shanjin Huang Li Yu Pilong Li Na Mi | 2022 | Cell Research2022，32，7： | 1 |
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