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3篇 您的检索式:作者名="Jiangfeng Shen"
    题名 作者 年代 出处 被引量
1Myosin 1D and the branched actin network control the condensation of p62 bodies显示文摘Biomolecular condensation driven by liquid-liquid phase separation(LLPS)is key to assembly of membraneless organelles in numerous crucial pathways.It is largely unknown how cellular structures or components spatiotemporally regulate LLPS and condensate formation.Here we reveal that cytoskeletal dynamics can control the condensation of p62 bodies comprising the autophagic adaptor p62/SQSTM1 and poly-ubiquitinated cargos.Branched actin networks are associated with p62 bodies and are required for their conden satio n.Myosi n 1D,a bran ched acti n-associated motor protein,drives coalesce nee of small nano scale p62 bodies into large micron-scale condensates along the branched actin network.Impairment of actin cytoskeletal networks compromises the condensation of p62 bodies and retards substrate degradation by autophagy in both cellular models and Myosin ID knockout mice.Coupling of LLPS scaffold to cytoskeleton systems may represent a general mechanism by which cells exert spatiotemporal control over phase condensation processes.Xuezhao Feng Wanqing Du Mingrui Ding Wenkang Zhao Xirenayi Xirefu Meisheng Ma Yuhui Zhuang Xiaoyu Fu Jiangfeng Shen Jinpei Zhang Xiuying Lei Daxiao Sun Qing Xi Yiliyasi Aisa Qian Chenr Ying Li Wenjuan Wang Shanjin Huang Li Yu Pilong Li Na Mi 2022Cell Research2022,32,7:1
2A social computing method for energy safety显示文摘Information and communication technologies enable the transformation of traditional energy systems into cyber-physical energy systems(CPESs),but such systems have also become popular targets of cyberattacks.Currently,available methods for evaluating the impacts of cyberattacks suffer from limited resilience,efficacy,and practical value.To mitigate their potentially disastrous consequences,this study suggests a two-stage,discrepancy-based optimization approach that considers both preparatory actions and response measures,integrating concepts from social computing.The proposed Kullback-Leibler divergence-based,distributionally robust optimization(KDR)method has a hierarchical,two-stage objective function that incorporates the operating costs of both system infrastructures(e.g.,energy resources,reserve capacity)and real-time response measures(e.g.,load shedding,demand-side management,electric vehicle charging station management).By incorporating social computing principles,the optimization framework can also capture the social behavior and interactions of energy consumers in response to cyberattacks.The preparatory stage entails day-ahead operational decisions,leveraging insights from social computing to model and predict the behaviors of individuals and communities affected by potential cyberattacks.The mitigation stage generates responses designed to contain the consequences of the attack by directing and optimizing energy use from the demand side,taking into account the social context and preferences of energy consumers,to ensure resilient,economically efficient CPES operations.Our method can determine optimal schemes in both stages,accounting for the social dimensions of the problem.An original disaster mitigation model uses an abstract formulation to develop a risk-neutral model that characterizes cyberattacks through KDR,incorporating social computing techniques to enhance the understanding and response to cyber threats.This approach can mitigate the impacts more effectively than several existing methods,even with limited data availability.To extend this risk-neutral model,we incorporate conditional value at risk as an essential risk measure,capturing the uncertainty and diverse impact scenarios arising from social computing factors.The empirical results affirm that the KDR method,which is enriched with social computing considerations,produces resilient,economically efficient solutions for managing the impacts of cyberattacks on a CPES.By integrating social computing principles into the optimization framework,it becomes possible to better anticipate and address the social and behavioral aspects associated with cyberattacks on CPESs,ultimately improving the overall resilience and effectiveness of the system’s response measures.Pengfei Zhao Shuangqi Li Zhidong Cao Paul Jen-Hwa Hu Daniel Dajun Zeng Da Xie Yichen Shen Jiangfeng Li Tianyi Luo 2024Journal of Safety Science and Resilience2024,5,1:0
3Comparison on crack propagation under tension at 150℃ of Mg-2Zn-1.5Mn alloy sheets with and without crack notch显示文摘Generally,edge crack of rolled magnesium alloy sheets initiates in the RD(rolling direction)-ND(normal direction)plane and then propagate in the RD-TD(transverse direction)plane.Hence,the Mg-2Zn-1.5Mn(ZM21)alloy sheets with and without crack notch were designed to carry out in-situ tensile experiments under 150℃(the same temperature of rolling),with the aim to understand their crack propagation mechanism.The scanning electron microscopy(SEM)and electron backscattered diffraction(EBSD)techniques were utilized to reveal microstructural evolution in real time at designated displacements.The results show that the prismatic slip,basal slip,and extension twining play synergistic role in coordinating strain during the tensile process in ZM21 alloy sheet at 150℃.In both tensile samples with and without crack notch,localized strain is mainly concentrated at relatively fine grain area and the grain boundaries or triple junctions of the grains with large basal Schmid factor(SF)difference,which eventually leads to severe surface roughening and subsequent crack initiation.Compared with the sample without crack notch,the pre-cracked sample exhibits severer deformation at the crack tip due to strain concentration.Strain gradient distribution is observed at the crack tip region in the pre-cracked sample.The crack propagation path of the sample with pre-crack is identified and the underlying mechanism is also discussed.Qiang Liu Jiangfeng Song Qiuyan Shen Liangyin Wu Bin Jiang Weimin Gan Kaihong Zheng Fusheng Pan 2023Journal of Magnesium and Alloys2023,11,5:0
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