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| 1 | Interspecific Hybrid Sterility in Rice Is Mediated by OgTPR 1 at the S 1 Locus Encoding a Peptidase- like Protein显示文摘 | Yongyao Xie Peng Xu Jianle Huang Shengjian Ma Xianrong Xie Dayun Tao Letian Chen Yao-Guang Liu | 2017 | Molecular Plant2017，10，8： | 22 |
| 2 | THREE-DIMENSIONAL HYDROELASTIC ANALYSIS IN TIME DOMAIN WITH APPLICATION TO AN ELASTIC SHIP MODEL显示文摘According to the Price-Wu condition at the interface between flexible marine structure and the surrounding fluid flow, a solution to the three-dimensional potential flow in time domain around a flexible structure traveling in waves is expressed with a boundary integral equation in the present paper, where the Green function, satisfying the linearized free surface condition for the time-dependent problem, is employed. A hydroe-lastic analysis directly in time domain to predict loads, motions, and structural responses of ships at steady forward speed in a seaway is formulated. As a example of application, the comparisons are made among the numerical results given by present method, the experimental measurements and the prediction provided by the three-dimensional hydroelas-ticity theory in frequency domain. | Wang, Dayun Wu, Yousheng | 1998 | Journal of Hydrodynamics1998，10，4： | 8 |
| 3 | Antagonism of Protease-Activated Receptor 4 Protects Against Traumatic Brain Injury by Suppressing Neuroinflammation via Inhibition of Tab2/NF-κB Signaling显示文摘Traumatic brain injury(TBI)triggers the activation of the endogenous coagulation mechanism,and a large amount of thrombin is released to curb uncontrollable bleeding through thrombin receptors,also known as protease-activated receptors(PARs).However,thrombin is one of the most critical factors in secondary brain injury.Thus,the PARs may be effective targets against hemorrhagic brain injury.Since the PAR1 antagonist has an increased bleeding risk in clinical practice,PAR4 blockade has been suggested as a more promising treatment.Here,we explored the expression pattern of PAR4 in the brain of mice after TBI,and explored the effect and possible mechanism of BMS-986120(BMS),a novel selective and reversible PAR4 antagonist on secondary brain injury.Treatment with BMS protected against TBI in mice.mRNA-seq analysis,Western blot,and qRT-PCR verification in vitro showed that BMS significantly inhibited thrombin-induced inflammation in astrocytes,and suggested that the Tab2/ERK/NF-κB signaling pathway plays a key role in this process.Our findings provide reliable evidence that blocking PAR4 is a safe and effective intervention for TBI,and suggest that BMS has a potential clinical application in the management of TBI. | Jianing Luo Xun Wu Haixiao Liu Wenxing Cui Wei Guo Kang Guo Hao Guo Kai Tao Fei Li Yingwu Shi Dayun Feng Hao Yan Guodong Gao Yan Qu | 2021 | Neuroscience Bulletin2021，37，2： | 5 |
| 4 | Salidroside Protects Against 6-Hydroxydopamine-Induced Cytotoxicity by Attenuating ER Stress显示文摘Parkinson's disease(PD) is a neurodegenerative disease characterized by a persistent decline of dopaminergic(DA) neurons in the substantia nigra pars compacta. Despite its frequency, effective therapeutic strategies that halt the neurodegenerative processes are lacking, reinforcing the need to better understand the molecular drivers of this disease. Importantly, increasing evidence suggests that the endoplasmic reticulum(ER)stress-induced unfolded protein response is likely involved in DA neuronal death. Salidroside, a major compound isolated from Rhodiola rosea L., possesses potent antioxidative stress properties and protects against DA neuronal death. However, the underlying mechanisms are not well understood. In the present study, we demonstrate that salidroside prevents 6-hydroxydopamine(6-OHDA)-induced cytotoxicity by attenuating ER stress. Furthermore, treatment of a DA neuronal cell line(SN4741) and primary cortical neurons with salidroside significantly reduced neurotoxin-induced increases in cytoplasmic reactive oxygen species and calcium, both of which cause ER stress, and cleaved caspase-12, which is responsible for ER stress-induced cell death. Together, these results suggest that salidroside protects SN4741 cells and primary cortical neurons from 6-OHDA-induced neurotoxicity by attenuating ER stress. This provides a rationale for the investigation of salidroside as a potential therapeutic agent in animal models of PD. | Kai Tao Bao Wang Dayun Feng Wei Zhang Fangfang Lu Juan Lai Lu Huang Tiejian Nie Qian Yang | 2016 | Neuroscience Bulletin2016，32，1： | 5 |
| 5 | Transcription Factors:Potential Cell Death Markers in Parkinson's Disease显示文摘Parkinson's disease(PD) is a neurodegenerative disease with a long preclinical phase. The continuous loss of dopaminergic(DA) neurons is one of the pathogenic hallmarks of PD. Diagnosis largely depends on clinical observation, but motor dysfunctions do not emerge until70%–80% of the nigrostriatal nerve terminals have been destroyed. Therefore, a biomarker that indicates the degeneration of DA neurons is urgently needed. Transcription factors are sequence-specific DNA-binding proteins that regulate RNA synthesis from a DNA template. The precise control of gene expression plays a critical role in the development, maintenance, and survival of cells,including DA neurons. Deficiency of certain transcription factors has been associated with DA neuron loss and PD. In this review, we focus on some transcription factors and discuss their structure, function, mechanisms of neuroprotection, and their potential for use as biomarkers indicating the degeneration of DA neurons. | Ronglin Wang Shaosong Yang Tiejian Nie Gang Zhu Dayun Feng Qian Yang | 2017 | Neuroscience Bulletin2017，33，5： | 4 |
| 6 | Acrolein Induces Systemic Coagulopathy via Autophagy-dependent Secretion of von Willebrand Factor in Mice after Traumatic Brain Injury显示文摘Traumatic brain injury(TBI)-induced coagulopathy has increasingly been recognized as a significant risk factor for poor outcomes,but the pathogenesis remains poorly understood.In this study,we aimed to investigate the causal role of acrolein,a typical lipid peroxidation product,in TBI-induced coagulopathy,and further explore the underlying molecular mechanisms.We found that the level of plasma acrolein in TBI patients suffering from coagulopathy was higher than that in those without coagulopathy.Using a controlled cortical impact mouse model,we demonstrated that the acrolein scavenger phenelzine prevented TBI-induced coagulopathy and recombinant ADAMTS-13 prevented acrolein-induced coagulopathy by cleaving von Willebrand factor(VWF).Our results showed that acrolein may contribute to an early hypercoagulable state after TBI by regulating VWF secretion.mRNA sequencing(mRNA-seq)and transcriptome analysis indicated that acrolein over-activated autophagy,and subsequent experiments revealed that acrolein activated autophagy partly by regulating the Akt/mTOR pathway.In addition,we demonstrated that acrolein was produced in the perilesional cortex,affected endothelial cell integrity,and disrupted the blood-brain barrier.In conclusion,in this study we uncovered a novel pro-coagulant effect of acrolein that may contribute to TBI-induced coagulopathy and vascular leakage,providing an alternative therapeutic target. | Wenxing Cui Xun Wu Dayun Feng Jianing Luo Yingwu Shi Wei Guo Haixiao Liu Qiang Wang Liang Wang Shunnan Ge Yan Qu | 2021 | Neuroscience Bulletin2021，37，8： | 3 |
| 7 | Acrolein Aggravates Secondary Brain Injury After Intracerebral Hemorrhage Through Drp1-Mediated Mitochondrial Oxidative Damage in Mice显示文摘Clinical advances in the treatment of intracranial hemorrhage(ICH)are restricted by the incomplete understanding of the molecular mechanisms contributing to secondary brain injury.Acrolein is a highly active unsaturated aldehyde which has been implicated in many nervous system diseases.Our results indicated a significant increase in the level of acrolein after ICH in mouse brain.In primary neurons,acrolein induced an increase in mitochondrial fragmentation,loss of mitochondrial membrane potential,generation of reactive oxidative species,and release of mitochondrial cytochrome c.Mechanistically,acrolein facilitated the translocation of dynaminrelated protein 1(Drpl)from the cytoplasm onto the mitochondrial membrane and led to excessive mitochondrial fission.Further studies found that treatment with hydralazine(an acrolein scavenger)significantly reversed Drpl translocation and the morphological damage of mitochondria after ICH.In parallel,the neural apoptosis,brain edema,and neurological functional deficits induced by ICH were also remarkably alleviated.In conclusion,our results identify acrolein as an important contributor to the secondary brain injury following ICH.Meanwhile,we uncovered a novel mechanism by which Drpl-mediated mitochondrial oxidative damage is involved in acroleininduced brain injury. | Xun Wu Wenxing Cui Wei Guo Haixiao Liu Jianing Luo Lei Zhao Hao Guo Longlong Zheng Hao Bai Dayun Feng Yan Qu | 2020 | Neuroscience Bulletin2020，36，10： | 3 |
| 8 | Mapping and breeding value evaluation of a semi-dominant semidwarf gene in upland rice显示文摘Plant height is an important trait related to yield potential and plant architecture.A suitable plant height plays a crucial role in improvement of rice yield and lodging resistance.In this study,we found that the traditional upland landrace 'Kaowenghan'(KWH) showed a special semi-dwarf phenotype.To identify the semi-dwarf gene from KWH,we raised BC2 F4 semi-dwarf introgression lines(IL) by hybridization of the japonica rice cultivar 'Dianjingyou1'(DJY1) and KWH in a DJY1 background.The plant height of the homozygous semi-dwarf IL(IL-87) was significantly reduced compared with that of DJY1.The phenotype of the F1 progeny of the semi-dwarf IL-87 and DJY1 showed that the semi-dwarf phenotype was semidominant.QTL mapping indicated that the semi-dwarf phenotype was controlled by a major QTL q DH1 and was localized between the markers RM6696 and RM12047 on chromosome 1.We also developed near-isogenic lines(NIL) from the BC3 F3 population,and found that the yield of homozygous NIL(NIL-2)was not significantly different compared to DJY1.Breeding value evaluation through investigation of the plant height of the progeny of NIL(NIL-2) and cultivars from different genetic background indicate that the novel semi-dwarf gene shows potential as a genetic resource for rice breeding. | Xiaoqian Chen Peng Xu Jiawu Zhou Dayun Tao Diqiu Yu | 2018 | Plant Diversity2018，40，5： | 3 |
| 9 | Silencing myostatin gene by RNAi in sheep embryos显示文摘 | Dayun Tang Huabin Zhu Jianmin Wu Hanzhong Chen Yan Zhang Xueming Zhao Xiaoliang Chen Weihua Du Dong Wang Xiukun Lin | 2012 | Journal of Biotechnology2012，，3： | 2 |
| 10 | Development and application of perfect SSR markers in cotton显示文摘Background:This study aimed to develop a set of perfect simple sequence repeat(SSR)markers with a single copy in the cotton genome,to construct a DNA fingerprint database suitable for authentication of cotton cultivars.We optimized the polymerase chain reaction(PCR)system for multi-platform compatibility and improving detection efficiency.Based on the reference genome of upland cotton and 10×resequencing data of 48 basic cotton germplasm lines,single-copy polymorphic SSR sites were identified and developed as diploidization SSR markers.The SSR markers were detected by denaturing polyacrylamide gel electrophoresis(PAGE)for initial screening,then fluorescence capillary electrophoresis for secondary screening.The final perfect SSR markers were evaluated and verified using 210 lines from different sources among Chinese cotton regional trials.Results:Using bioinformatics techniques,1246 SSR markers were designed from 26626 single-copy SSR loci.Adopting a stepwise(primary and secondary)screening strategy,a set of 60 perfect SSR markers was selected with high amplification efficiency and stability,easy interpretation of peak type,multiple allelic variations,high polymorphism information content(PIC)value,uniform chromosome distribution,and single-copy characteristics.A multiplex PCR system was established with ten SSR markers using capillary electrophoresis detection.Conclusions:A set of perfect SSR markers of cotton was developed and a high-throughput SSR marker detection system was established.This study lays a foundation for large-scale and standardized construction of a cotton DNA fingerprint database for authentication of cotton varieties. | WU Yuzhen HUANG Longyu ZHOU Dayun FU Xiaoqiong LI Chao WEI Shoujun PENG Jun KUANG Meng | 2020 | Journal of Cotton Research2020，3，3： | 2 |
| 11 | Genome and Comparative Transcriptomics of African Wild Rice Oryza Iongistaminata Provide Insights into Molecular Mechanism of Rhizomatousness and Self-Incompatibility显示文摘Dear Editor, Oryza Iongistaminata is an African wild rice species with AA genome type possessing special traits that are highly valued for improving cultivated rice,such as strong resistance to biotic and abiotic stresses (Song et al.,1995) for improving resistance of cultivars,rhizomatousness for perennial breeding (Glover et al.,2010),and self-incompatibility (SI) for new ways to produce hybrid seeds (Ghesquiere,1986).Deciphering the genome of O.longistaminata will be the key to uncovering the mechanism of these hallmark traits and improving cultivated rice. | Yesheng Zhang Shilai Zhang Hui Liu Binying Fu Lijuan Li Min Xie Yue Song Xin Li Jing Cai Wenting Wan Ling Kui Hui Huang Jun Lyu Yang Dong Wensheng Wang Liyu Fluang Jing Zhang Qinzhong Yang Qinfi Shan Qiong Li Wangqi Huang Dayun Tao Muhua Wang Mingsheng Chen Yeisoo Yu Rod A. Wing Wen Wang Fengyi Hu | 2015 | Molecular Plant2015，8，11： | 1 |
| 12 | Inheritance and mapping of male sterility restoration gene in upland japonica restorer lines显示文摘 | Dayun Tao Peng Xu Jing Li Fengyi Hu Youqiong Yang Jiawu Zhou XueLing Tan Monty P. Jones | 2004 | Euphytica2004，，3： | 1 |
| 13 | Assessing the Impact of Agricultural Technology Using Propensity Score Matching Analysis in Rural China显示文摘 | Wu Haitao Ding Shijun Sushil Pandey Tao Dayun | 2012 | Asian Economic Journal2012，24，6： | 1 |
| 14 | Natural alleles of a uridine 5'-diphospho-glucosyltransferase gene responsible for differential endosperm development between upland rice and paddy rice显示文摘Traditional upland rice generally exhibits insufficient grains resulting from abnormal endosperm development compared to paddy rice. However, the underlying molecular mechanism of this trait is poorly understood. Here,we cloned the uridine 5’-diphospho(UDP)-glucosyltransferase gene EDR1(Endosperm Development in Rice) responsible for differential endosperm development between upland rice and paddy rice by performing quantitative trait loci analysis and map-based cloning. EDR1 was highly expressed in developing seeds duringgrain filling. Natural variations in EDR1 significantly reduced the UDP-glucosyltransferase activity of EDR1 YZNcompared to EDR1 YD1,resulting in abnormal endosperm development in the near-isogenic line, accompanied by insufficient grains and changes in grain quality.By analyzing the distribution of the two alleles EDR1 YD1 and EDR1 YZNamong diverse paddy rice and upland rice varieties, we discovered that EDR1 was conserved in upland rice, but segregated in paddy rice. Further analyses of grain chalkiness in the alleles of EDR1 YD1 and EDR1 YZNvarieties indicated that rice varieties harboring EDR1 YZNand EDR1 YD1 preferentially showed high chalkiness, and low chalkiness,respectively. Taken together, these results suggest that the UDP-glucosyltransferase gene EDR1 is an important determinant controlling differential endosperm development between upland rice and paddy rice. | Zihao Wu Xiao Zhang Guimei Chang Jun Yang Jinpeng Wan Feijun Wang Dayun Tao Jiawu Zhou Lianguang Shang Peng Xu Diqiu Yu | 2022 | Journal of Integrative Plant Biology2022，64，1： | 1 |
| 15 | Silencing myostatin gene by RNAi in sheep embryos显示文摘 | Dayun Tang Huabin Zhu Jianmin Wu Hanzhong Chen Yan Zhang Xueming Zhao Xiaoliang Chen Weihua Du Dong Wang Xiukun Lin | 2012 | Journal of Biotechnology2012，，3： | 1 |
| 16 | Studies on the low-salt Chinese potherb mustard ( Brassica juncea , Coss.) pickle. I—The effect of a homofermentative l (+)-lactic acid producer Bacillus coagulans on starter culture in the low-salt Chinese potherb mustard pickle fermentation显示文摘 | Dayun Zhao Xiaolin Ding | 2007 | LWT - Food Science and Technology2007，，3： | 1 |
| 17 | Analysis of volatile components during potherb mustard ( Brassica juncea , Coss.) pickle fermentation using SPME–GC-MS显示文摘 | Dayun Zhao Jian Tang Xiaolin Ding | 2006 | LWT - Food Science and Technology2006，，3： | 1 |
| 18 | Interactions between poppet vibration and cavitation in relief valve 显示文摘 | YI Dayun LU Liang ZOU Jun | 2014 | Journal ofMechanical Engineering Science2014，229，8： | 1 |
| 19 | Real time loop-mediated isothermal amplification using a portable fluorescence scanner for rapid and simple detection of Vibrio parahaemolyticus显示文摘 | MinYing Yi Li Ling Sucharit B. Neogi YaoSen Fan DaYun Tang Shinji Yamasaki Lei Shi Lei Ye | 2014 | Food Control2014，，： | 1 |
| 20 | Assessing the Impact of Agricultural Technology Using Propensity Scare Matching Analysis in Rural China 显示文摘 | Wu Haitao Ding Shijun Sushil Pandey Tao Dayun | 2012 | Asian Economic Journal2012，，6： | 1 |
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