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| 1 | Structural basis of AMPK regulation by adenine nucleotides and glycogen显示文摘激活安培的蛋白质 kinase (AMPK ) 为糖尿病,肥胖,和癌症的治疗是一个中央细胞的精力传感器和精力动态平衡,和一个有希望的药目标的管理者。这里我们人的 α 的现在的低分辨率的水晶结构; 1 β 2 γ 1 holo-AMPK 建筑群跳了到它的 allosteric 调节的人安培和肝糖模仿 cyclodextrin,两个在 phosphorylated (4.05 Å) 并且 non-phosphorylated (4.60 Å) 状态。另外,我们解决了 2.95 Å人的 kinase 领域(KD ) 的结构跳了到邻近的 autoinhibitory 领域(帮助) 并且表现了广泛生物化学并且 mutational 研究。一起,这些研究由安培和肝糖说明 allosteric AMPK 调整的内在的机制,其绑定改变在交替的帮助(安培) 和糖类绑定模块(肝糖) 之间的 equilibria 相互作用。 | Xiaodan Li Lili Wang X Edward Zhou Jiyuan Ke Parker W de Waal Xin Gu M H Eileen Tan Dongye Wang Donghai Wu H Eric Xu Karsten Melcher | 2015 | Cell Research2015，25，1： | 8 |
| 2 | Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-1igase signaling effector DWARF3显示文摘 | Li-Hua Zhao X Edward Zhou Wei Yi Zhongshan Wu Yue Liu Yanyong Kang Li Hou Parker W de Waal Suling Li Yi Jiang Adrian Scaffidi Gavin R Flematti Steven M Smith Vinh Q Lam Patrick R Griffin YonghongWang Jiayang Li Karsten Melcher H Eric Xu | 2015 | Cell Research2015，25，11： | 7 |
| 3 | Functional optoacoustic neuro-tomography for scalable whole-brain monitoring of calcium indicators显示文摘Non-invasive observation of spatiotemporal activity of large neural populations distributed over entire brains is a longstanding goal of neuroscience.We developed a volumetric multispectral optoacoustic tomography platform for imaging neural activation deep in scattering brains.It can record 100 volumetric frames per second across scalable fields of view ranging between 50 and 1000 mm^(3) with respective spatial resolution of 35–200μm.Experiments performed in immobilized and freely swimming larvae and in adult zebrafish brains expressing the genetically encoded calcium indicator GCaMP5G demonstrate,for the first time,the fundamental ability to directly track neural dynamics using optoacoustics while overcoming the longstanding penetration barrier of optical imaging in scattering brains.The newly developed platform thus offers unprecedented capabilities for functional whole-brain observations of fast calcium dynamics;in combination with optoacoustics'well-established capacity for resolving vascular hemodynamics,it could open new vistas in the study of neural activity and neurovascular coupling in health and disease. | X Luís Deán-Ben Gali Sela Antonella Lauri Moritz Kneipp Vasilis Ntziachristos Gil G Westmeyer Shy Shoham Daniel Razansky | 2016 | Light(Science & Applications)2016，5，1： | 5 |
| 4 | 万古霉素最低抑菌浓度对甲氧西林敏感金黄色葡萄球菌心内膜炎预后的影响显示文摘金黄色葡萄球菌(金葡菌)引起的心内膜炎病死率高。万古霉素最低抑菌浓度(MIC )能影响耐甲氧西林金葡菌所致血流感染的结果,最近的数据显示,其对甲氧西林敏感金葡菌也有类似作用。本文目的是评价万古霉素M IC对氯唑西林治疗的左心金葡菌感染性心内膜炎疗效的影响。 | Cervera C Casaeda X de la Maria CG 范亚新 张菁 | 2015 | 中国感染与化疗杂志2015，15，3： | 4 |
| 5 | The structural basis of the dominant negative phenotype of the Gαi1β1Y2 G203A/A326S heterotrimer显示文摘 | Ping LIU Ming-zhu JIA X Edward ZHOU Parker W DE WAAL Bradley M DICKSON Bo LlU Li HOU Yan-ting YIN Ya n-yong KANG Yi SHI Karsten MELCHER H Eric XU Yi JIANG | 2016 | Acta Pharmacologica Sinica2016，37，9： | 3 |
| 6 | 前蛋白转化酶枯草杆菌蛋白酶kexin-9在肾病综合征相关性高胆固醇血症中的作用显示文摘肾病综合征中,肾脏足细胞损害可导致严重的高胆固醇血症,迫切需要新的治疗方法。前蛋白转化酶枯草杆菌蛋白酶kexin-9(proprotein convertase subtilisin/kexin type 9,PCSK9)逐渐成为血浆总胆固醇水平和治疗目标的重要调节因子。 | 刘莉 叶鹏 Haas ME Levenson AE Sun X Liao WH Rutkowski JM de Ferranti SD Schumacher VA Scherer PE Salant DJ Biddinger SB | 2016 | 中华高血压杂志2016，24，7： | 3 |
| 7 | An advanced signal processing technique for impedance cardiography显示文摘 | Wang X Sun H H Van de Water J M | 1995 | IEEE Trans Biomed Eng1995，42，2： | 2 |
| 8 | Criteria for robust stability and stabilization of uncertain linear systems with state delay显示文摘 | Li X de Souza C E | | 0，，： | 2 |
| 9 | The prognostic value of spontaneous apoptosis, Bax, Bcl-2, and p53 in oral squamous cell carcinoma of the tongue 显示文摘 | XIE X CLAUSEN O P DE ANGELIS P | 1999 | Cancer1999，86，6： | 1 |
| 10 | Epidemiologic classification of human papillomavirus types associated with cervical cancer显示文摘 | Munoz N Bosch F X de Sanjosé S | 2003 | New Engl J Med2003，348，6： | 1 |
| 11 | Microcystic transitional cell carcinoma; a report of 2 cases arising in the renal pelvis显示文摘 | Leroy X Leteurtre E De La Taille A | 2002 | Arch Pathol Lab Med2002，126，7： | 1 |
| 12 | Woddwide human papillomavims etiology of cervical adenocarcinoma and its cofactors: implications for screening and prevention 显示文摘 | Castellsague X Dtaz M de Sanjose S | 2006 | J Natl Cancer lnst2006，98，： | 1 |
| 13 | Worldwide prevalence and genotype distribution of cervical human papillomavirus DNA in women with normal cytology:a meta-analysis显示文摘 | de Sanjosé S Diaz M Caatellsagué X | 2007 | Lancet Infect Dis2007，7，7： | 1 |
| 14 | Estradiol induced physical association of neuronal nitric oxide synthase with NMDA receptor and promotes nitric oxide formation via estrogen receptor activation in primary neuronal cultures 显示文摘 | d'Anglemont de Tassigny X Campagne C Steculorum S | 2009 | J Eurochem2009，109，1： | 1 |
| 15 | Proteomic anal- ysis of the cambial region in juvenile Eucalyptus grandis at three ages 显示文摘 | Celedon P A F de Andrade A Meireles K G X | 2007 | Proteomics2007，7，13： | 1 |
| 16 | Epidemiologic classification of human papillomavlrus types associated with cervical cancer 显示文摘 | Munoz N Bosch F X de Sanjose S | 2003 | N Engl J Med2003，348，： | 1 |
| 17 | Nodular fasciitis:correlation of MRI findings and histopathology显示文摘 | WANG X L DE SCHEPPER A M VAN HOENACKER F | 2002 | Skeletal Radiol2002，31，： | 1 |
| 18 | The SH2 domain containing inositol 5 -phosphatase SHIP2 controls phosphatidylinositol 3,4,5-trisphosphate levels in CHO-IR cells stimulated by insulin 显示文摘 | Blero D De Smedt F Pesesse X | 2001 | Biochem Biophys Res Comm2001，282，3： | 1 |
| 19 | The prospects of HPV vaccination in cervical cancer prevention: results of a new inde- pendent trial显示文摘 | Bosch F X de Sanjose S Castellsague X | 2011 | Cancer Discov2011，1，5： | 1 |
| 20 | Removal of PAHs from water using an immature coal (leonardite) 显示文摘 | Zeled6n-Torufio Z C Lao-Luque C De las Heras F X C | 2007 | Chemosphere2007，67，3： | 1 |
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