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	题名	作者	年代	出处	被引量
1	Bidirectional effect of Wnt signaling antagonist DKK1 on the modulation of anthrax toxin uptake显示文摘LRP6,a co-receptor for the morphogen Wnt,aids endocytosis of anthrax complexes.Here we report that Dickkopf1(DKK1)protein,a secreted LRP6 ligand and antagonist,is also a modulator of anthrax toxin sensitivity.shRNA-mediated gene silencing or TALEN-mediated gene knockout of DKK1 reduced sensitivity of cells to PA-dependent hybrid toxins.However,unlike the solely inhibitory effect on Wnt signaling,the effects of DKK1 overexpression on anthrax toxicity were bidirectional,depending on its endogenous expression and cell context.Fluorescence microscopy and biochemical analyses showed that DKK1 facilitates internalization of anthrax toxins and their receptors,an event mediated by DKK1-LRP6-Kremen2 complex.Monoclonal antibodies against DKK1 provided dose-dependent protection to macrophages from killing by anthrax lethal toxin(LT).Our discovery that DKK1 forms ternary structure with LRP6 and Kremen2 in promoting PA-mediated toxin internalization provides a paradigm for bacterial exploitation of mechanisms that host cells use to internalize signaling proteins.	QIAN LiLi CAI ChangZu YUAN PengFei JEONG Sun-Young YANG XiaoZhou DEALMEIDA Venita ERNST James COSTA Michael COHEN Stanley N. WEI WenSheng	2014	Science China(Life Sciences)2014，57，5：	2
2	Lactate and base deficit are predictors of mortality in critically ill patients with cancer显示文摘	Hajjar LA Nakamura RE DeAlmeida JP	2011	Clinics (Sao Paulo)2011，66，12：	1
3	Heterolysis and Homolysis in Supercritical Water 显示文摘	Brittain A DeAlmeida C	1987	ACS Symp Ser1987，329，：	1
4	Flavonol monoglycosides isolated from the antiviral fractions of Persea americana (Lauraceae) leaf infusion显示文摘	MIRANDA M M SIMONI I C	1998	Phylother Res1998，12，8：	1
5	Particle swarm-based olfactory guided search 显示文摘	MARQUES L NUNES U DEALMEIDA A T	2006	Autonomous Robotics2006，，20：	1
6	One-pot synthesis of a chitosan-based hydrogel as a potential device for magnetic biomaterial 显示文摘	Alexandre T Paulino Marcos R Guilherme Elisangela A M S deAlmeida	2009	Journal of Magnetism and Magnetic Materials2009，321，17：	1
7	The invariance of the total direct DNA strand break yield显示文摘	BERNAL M A deALMEIDA C E SAMPAIO C	2011	Medical Physics2011，38，7：	1
8	Regulation of the pituitary somatotroph cell by GHRH and its receptor显示文摘	Mayo KE Miller T DeAlmeida V	2000	Recent Prog Horm Res2000，55，：	1
9	A hybrid genetic algorithm for assembly line balancing 显示文摘	GONCALVES J F DeALMEIDA J R	2002	doumal of Heuristics2002，8，6：	1
10	Induction of cdc2a and cyc1At expression in Arabidopsis thaliana during early phases of nematode-induced feeding cell formation显示文摘	NIEBEL A DEALMEIDA E J HEMERLY A	1996	The Plant Journal1996，10，6：	1
11	E pidural hematomas of the posterior cranial fossa显示文摘	Bor-Seng-Shu E Aguriar PH deAlmeida Leme RJ	2004	Neursurg Focus2004，16，2：	1
12	Chromosome banding in AmphibiaXH rest tivtion endonuclease banding 显示文摘	SCHMID M DeALMEIDA C G	1988	Chromosoma1988，96，：	1
13	Characteristics of slow chlorophyll fluorescence emission in four Coffea arabica genotypes submitted to water stress显示文摘	Dealmeida A A F Maestri M	1996	Photosymhetlea1996，32，2：	1
14	In vitro and in vivo efficacy of the triazole TAK 187 against cryptococcus neoformans显示文摘	DeAlmeida GM Dodge RK	1998	Antimicrob Agents Chemother1998，42，10：	1
15	Transvee aortic con- striction in mice显示文摘	Dealmeida AC van Oort Pal Wehtns XH	2010	J Vis Exp2010，，38：	1
16	Functional and morphological evidence for a ventricular conduction system in zebrafish and Xenopus hearts显示文摘	Sedmera D Reckova M deAlmeida A	2003	Am J Physiol Heart Circ Physiol2003，284，4：	1
17	The soluble wnt receptor Frizzled8CRD-hFc inhibits the growth of teratocareinomas in vivo显示文摘	DeAlmeida V I Miao L Ernst J A	2007	Cancer Re-search2007，67，：	1
18	The Yersinia high -patho- genicity island is present in different members of the family Enter- obacteriaceae 显示文摘	BACH S DeALMEIDA A CARNIEI E	2000	FEMS Microbiol Lett2000，183，2：	1
19	Transmission E- lectron Microscopy Characterization of a Nb Mieroalloyed Steel for Carburizing at High Temperatures显示文摘	De Morais R F Reguly A DeAlmeida L H	2006	J Mater Eng and Perfrra2006，15，4：	1
20	Participation of doubly fed induction wind generators in system frequency regulation显示文摘	Dealmeida R G Pecas Lopes J A		0，，03：	1

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