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| 1 | Altered vasoactive intestinal peptides expression in irritable bowel syndrome patients and rats with trinitrobenzene sulfonic acid-induced colitis显示文摘AIM: To investigate the vasoactive intestinal peptides(VIP) expression in irritable bowel syndrome(IBS) and trinitrobenzene sulfonic acid(TNBS) induced colitis.METHODS: The VIP gene expression and protein plasma levels were measured in adult participants(45.8% male) who met Rome Ⅲ criteria for IBS for longer than 6 mo and in a rat model of colitis as induced by TNBS.Plasma and colons were collected from naive and inflamed rats.Markers assessing inflammation(i.e.,weight changes and myeloperoxidase levels) were assessed on days 2,7,14 and 28 and compared to controls.Visceral hypersensitivity of the rats was assessed with colo-rectal distension and mechanical threshold testing on hind paws.IBS patients(n = 12) were age,gender,race,and BMI-matched with healthy controls(n = 12).Peripheral whole blood and plasma from fasting participants was collected and VIP plasma levels were assayed using a VIP peptide-enzyme immunoassay.Human gene expression of VIP was analyzed using a custom PCR array.RESULTS: TNBS induced colitis in the rats was confirmed with weight loss(13.7 ± 3.2 g) and increased myeloperoxidase activity.Visceral hypersensitivity tocolo-rectal distension was increased in TNBS treated rats up to 21 d and resolved by day 28.Somatic hypersensitivity was also increased up to 14 d post TNBS induction of colitis.The expression of an inflammatory marker myeloperoxidase was significantly elevated in the intracellular granules of neutrophils in rat models following TNBS treatment compared to naive rats.This confirmed the induction of inflammation in rats following TNBS treatment.VIP plasma concentration was significantly increased in rats following TNBS treatment as compared to naive animals(P < 0.05).Likewise,the VIP gene expression from peripheral whole blood was significantly upregulated by 2.91-fold in IBS patients when compared to controls(P < 0.00001; 95%CI).VIP plasma protein was not significantly different when compared with controls(P = 0.193).CONCLUSION: Alterations in VIP expression may play a role in IBS.Therefore,a better understanding of the physiology of VIP could lead to new therapeutics. | Arseima Y Del Valle-Pinero LeeAnne B Sherwin Ethan M Anderson Robert M Caudle Wendy A Henderson | 2015 | World Journal of Gastroenterology2015，21，1： | 7 |
| 2 | Staging of brain pathology related to sporadic Parkinson’s disease显示文摘 | Heiko Braak Kelly Del Tredici Udo Rüb Rob A.I de Vos Ernst N.H Jansen Steur Eva Braak | 2002 | Neurobiology of Aging2002，，2： | 2 |
| 3 | Effect of Daflon 500mg,a flavonoid drug,on neurological signs,level of free radicals and electroretinogram in the gerbil after ischemia reperfusion injury显示文摘 | Del barre G Calnon F | 1995 | Int J Microcirc Clin Exp1995，15，1： | 1 |
| 4 | Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair 显示文摘 | Kuhn B del Monte F Hajjar R J | 2007 | Nat Med2007，13，8： | 1 |
| 5 | The use of particle concentration fluorescence immunoassay technology for the analysis of rDNA products显示文摘 | Del Tito B J Jr | 1991 | J Ind Microbiol1991，8，2： | 1 |
| 6 | Stress proteins induced by arsenic 显示文摘 | Del Razo L M QuintaniUa - Vega B Brambila - Colom- bres E | 2001 | Toxicology and Applied Pharmacology2001，177，2： | 1 |
| 7 | Setup ad- justment of multiple lots using a sequential monte carlo meth- od显示文摘 | LIAN Z COLSIMO B M DEL CASTILLO E | 2006 | Technometries2006，48，3： | 1 |
| 8 | Activa- tion of Racl by shear stress in endothelial cells mediates both cytoskeletal reorganization and effects on gene expression 显示文摘 | TZIMA E DEL POZO M A KIOSSES W B | 2002 | EMBO J2002，21，24： | 1 |
| 9 | 查看详情显示文摘 | del Olmo E Barboza B Ybarra M.I Lopez-Perez J.L Carron R Sevilla M.A Boselli C Feliciano A.S | | 0，，： | 1 |
| 10 | Bayesian modelingand optimization of functional responses affected by noise factors显示文摘 | Del Castillo E Colosimo B M Alshraideh H | 2012 | Journal of Quality Technology2012，44，2： | 1 |
| 11 | Redox modulation of protein kinase/phosphatase balance in melanoma cells: the role of endogenous and gamma - glutamyltransferase - dependent H202 production显示文摘 | PIERI L DOMINICI S DEL BELLO B | 2003 | Biochim Biophys Acta2003，1621，1： | 1 |
| 12 | Inframammary fold reconstruction with a deepithelialized skin flap显示文摘 | Wechselberger G Del Frari B Pulzl P | 2003 | Ann Plast Surg2003，50，4： | 1 |
| 13 | Successful tocilizumab treatment in a child with refractory Takayasu arteritis显示文摘 | Bravo Mancheno B Perm F Guez Vazquez Del Rey Mdel M | 2012 | Pediatrics2012，130，： | 1 |
| 14 | Separation of organic amine compounds on silica gel with reversed- phase eluents 显示文摘 | Bidlingmeyer B A Del Rios J K Korpi J | 1982 | Analytical Chemistry1982，54，： | 1 |
| 15 | Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair显示文摘 | Kuhn B del Monte F Hajjar R J | 2007 | Nat Med2007，13，8： | 1 |
| 16 | Primary IgA nephropathy is more severe in TGF-beta1 high secretor patients显示文摘 | Brezzi B Del Prete D Lupo A | 2009 | J Nephrol2009，22，6： | 1 |
| 17 | Antioxidant activity of different fractions of Spirulina platensis protein extract显示文摘 | Estrada P Bescos B P Villar del Fresno A M | 2001 | Farmaco2001，56，： | 1 |
| 18 | Tortuosity,kinking,and coiling of the carotid artery:expression of atherosclerosis or aging显示文摘 | Del Corso L Moruzzo D Conte B | | 0，，05： | 1 |
| 19 | Between subjects variability in haemoglobin and dose are not associated with the erythropoiesis-stimulating agent used to treat anaemia in dialysis: a meta-analysis显示文摘 | Pérez-Ruixo J J Cucala-Ramos M Garcia-Gonzalo E Del Val Romero B Valveny N | 2013 | Br J Clin Pharmacol2013，75，： | 1 |
| 20 | Value of indirect hem agglutination and coagglutiation test for serotyping Haemophilus parasuis显示文摘 | Del Rio M L Gut ierrez B C Rodriguez Ferri E F | 2003 | Clin Microbio 12003，41，2： | 1 |
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