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| 1 | Liver transplantation for cholangiocarcinoma:Current status and new insights显示文摘Cholangiocarcinoma is a malignant tumor of the biliary system that can be classified into intrahepatic(i CCA),perihiliar(ph CCA) and distal. Initial experiences with orthotopic liver transplantation(OLT) for patientswith i CCA and ph CCA had very poor results and this treatment strategy was abandoned. In the last decade,thanks to a strict selection process and a neoadjuvant chemoradiation protocol,the results of OLT for patients with non-resectable phC CA have been shown to be excellent and this strategy has been extended worldwide in selected transplant centers. Intrahepatic cholangiocarcinoma is a growing disease in most countries and can be diagnosed both in cirrhotic and in non-cirrhotic livers. Even though OLT is contraindicated in most centers,recent investigations analyzing patients that were transplanted with a misdiagnosis of HCC and were found to have an iC CA have shown encouraging results. There is some information suggesting that patients with early stages of the disease could benefit from OLT. In this review we analyze the current stateof-the-art of OLT for cholangiocarcinoma as well as the new insights and future perspectives. | Gonzalo Sapisochín Elena Fernández de Sevilla Juan Echeverri Ramón Charco | 2015 | World Journal of Hepatology2015，7，22： | 8 |
| 2 | ON THE EXISTENCE OF ZERO POINTS OF A CONTINUOUS FUNCTION显示文摘A sufficient condition is given to assert that a continuous mapping between Rm and Rn has a zero. The constructive proof of the result is based upon continuation methods and supplies the existence of a path leading to the zero point. | J.M. SorianoDepartamento de Andlisis Matematico, Facultad de Matemdticas, Universidad de Sevilla, Aptdo. 1160, Sevilla 41080, Spain | 2002 | Acta Mathematica Scientia2002，22，2： | 7 |
| 3 | Compliant lightweight non-invasive standalone“Marine Skin”tagging system显示文摘Current marine research primarily depends on weighty and invasive sensory equipment and telemetric network to understand the marine environment,including the diverse fauna it contains,as a function of animal behavior and size,as well as equipment longevity.To match animal morphology and activity within the surrounding marine environment,here we show a physically flexible and stretchable skin-like and waterproof autonomous multifunctional system,integrating Bluetooth,memory chip,and high performance physical sensors.The sensory tag is mounted on a swimming crab(Portunus pelagicus)and is capable of continuous logging of depth,temperature,and salinity within the harsh ocean environment.The fully packaged,ultra-lightweight(<2.4 g in water),and compliant“Marine Skin”system does not have any wired connection enabling safe and weightless cuttingedge approach to monitor and assess marine life and the ecosystem’s health to support conservation and management of marine ecosystems. | Joanna M.Nassar Sherjeel M.Khan Seneca J.Velling Andrea Diaz-Gaxiola Sohail F.Shaikh Nathan R.Geraldi Galo A.Torres Sevilla Carlos M.Duarte Muhammad M.Hussain | 2018 | npj Flexible Electronics2018，2，1： | 4 |
| 4 | Effect of sewage sludge and sugarcane bagasse biochar on soil properties and sugar beet production显示文摘Recently, biochar has shown to be an alternative to waste disposal and a source of nutrients, acting as a soil amendment. The effects of two types of biochar on soil properties and sugar beet production as well as potential for carbon(C) sequestration were evaluated: biochar produced from sewage sludge(SB) and biochar produced from a 1:1 mixture of sewage sludge and sugarcane bagasse(MB). A greenhouse pot experiment was conducted using a sandy loam soil from the Brazilian savanna under treatments of MB applications at 2.5%, 5.0%, 7.5%, and 10.0%, SB application at 5.0%, and a conventional fertilization(CF) using lime and mineral fertilizers, with no fertilization as a control. After incubation for 45 d, seedlings were transplanted into each pot and cultivated for 55 d. Biochar characterization showed that pyrolysis reduced the biomass volume drastically, but concentrated the trace elements per unit of biochar weight. The MB treatments increased soil total C(by 27.8%) and pH(by 0.6), reduced the concentrations of nutrients, except for potassium(K), and chromium(Cr), and did not significantly alter lead(Pb) and cadmium(Cd) concentrations. Results of stable isotopes showed that all biochar treatments increased the total soil C stock and stability, suggesting a potential for application in C sequestration, and improved overall soil fertility. However, the biochar treatments also increased the concentrations of trace elements in the soil and plants. The sugar beet yields at 10.0% MB and 5.0% SB corresponded to 55%and 29% of the yield obtained in the CF treatment, respectively. These results may be due to biochar nutrients not being bioavailable when required by plants or to biochar nutrient adsorption. | Barbara Samartini Queiroz ALVES Katherin Prissila Sevilla ZELAYA Fernando COLEN Ledivan Almeida FRAZÃO Alfredo NAPOLI Sanjai J.PARIKH Luiz Arnaldo FERNANDES | 2021 | Pedosphere2021，31，4： | 4 |
| 5 | Pellet morphology, culture rheology and lovastatin production in cultures of Aspergillus terreus显示文摘 | J.L. Casas López J.A. Sánchez Pérez J.M. Fernández Sevilla E.M. Rodríguez Porcel Y. Chisti | 2004 | Journal of Biotechnology2004，，1： | 2 |
| 6 | A randomized phase II study to compare oxaliplatin plus 5-fluorouracil and leucovorin (FOLFOX4) versus oxaliplatin plus raltitrexed (TOMOX) as first-line chemotherapy for advanced colorectal cancer显示文摘 | Cristina Gravalos Antonieta Salut Carlos García-Girón Rocío García-Carbonero Ana León Isabel Sevilla Joan Maurel Beatriz Esteban Eduardo García-Rico Adolfo Murias Hernán Cortés-Funes | 2012 | Clinical and Translational Oncology2012，，8： | 2 |
| 7 | Kinetics of the Anti-oxidant Response to Salinity in the Halophyte Cakile maritima显示文摘在抗氧化剂酶(超级氧化物 dismutase ,过氧化氢酶(猫),过氧化物酶(邮政部门), ascorbate 过氧化物酶( APX ), monodehydroascorbate reductase , dehydroascorbate reductase ( DHAR ),和 glutathionereductase ( GR ))的活动的 NaCI 应力的效果,抗氧化剂分子( ascorbate 和谷胱甘肽),并且氧化应力( malondialdehyde ( MDA ),电解质漏,和 H_2O_2 集中)的参数在 Cakilemaritima 被调查,沿着突尼斯的海岸经常的盐土植物。幼苗面对盐(100, 200,和 400 mmol/L NaCI ) 被种。植物在 20 天周期性地被收获。生长面对 0-100 mmol/L NaCI 是最大的。在 400 mmol/L NaCI,生长显著地减少了。C 的 Thesalt 忍耐。在中等咸度, maritima 与氧化应力的最低价值 oftheparameters 陈述语气被联系,也就是,邮政部门,猫, APX, DHAR, andGR 和高织物的最高的活动 ascorbate 和谷胱甘肽满足。然而,延长了暴露到高咸度在 anti-oxidantactivities 和高 MDA 导致了减少内容,电解质漏,和 H_2O_2 集中。这些结果建议 anti-oxidantsystems 参予 C 的忍耐。maritima 将节制咸度。 | Nader Ben Amor Ana Jimenez Wided Megdiche Marianne Lundqvist Francisca Sevilla Chedly Abdelly | 2007 | Journal of Integrative Plant Biology2007，49，7： | 2 |
| 8 | WJH 6^(th) Anniversary Special Issues(1): Management of hepatocellular carcinoma Management of “very early” hepatocellular carcinoma on cirrhotic patients显示文摘Due to the advances in screening of cirrhotic patients, hepatocellular carcinoma(HCC) is being diagnosed in earlier stages. For this reason the number of patients diagnosed of very early HCC(single tumors ≤ 2 cm) is continuously increasing. Once a patient has been diagnosed with this condition, treatment strategies include liver resection, local therapies or liver transplantation. The decision on which therapy should the patient undergo depends on the general patients performance status and liver disease. Anyway, even in patients with similar conditions, the best treatment offer is debatable. In this review we analyze the state of the art on the management of very early HCC on cirrhotic patients to address the best treatment strategy for this patient population. | Gonzalo Sapisochin Elena Fernandez de Sevilla Juan Echeverri Ramón Charco | 2014 | World Journal of Hepatology2014，6，11： | 2 |
| 9 | Correlation between gene expression and GO semantic similarity显示文摘 | Sevilla J L Segura V Podhorski A | 2005 | Ieee-Acm Transactions on Computational Biology and Bioinformatiocs2005，2，4： | 1 |
| 10 | 查看详情显示文摘 | del Olmo E Barboza B Ybarra M.I Lopez-Perez J.L Carron R Sevilla M.A Boselli C Feliciano A.S | | 0，，： | 1 |
| 11 | Catalytic hydrogenation of linoleic acid to stearic acid over different Pd - and Ru - supported catalysts 显示文摘 | MAKI - ARVELA P KUUSISTO J MATEOS SEVILLA E | 2008 | Appl Catal A2008，345，2： | 1 |
| 12 | Supraglottic laryngeetomy : analysis of 267 cases 显示文摘 | Sevilla Ma | 2008 | Eur Arch Otorhino laryngo12008，265，： | 1 |
| 13 | Correlation between gone expression and CO semantic similarity显示文摘 | SEVILLA J L SEGURA V PODHORSKI A | 2005 | IEEE/ACM Trans on Computational Biology and Bioinformatics2005，2，4： | 1 |
| 14 | Potential impacts of climate variability on dengue hemorrhagic fever in honduras, 2010 显示文摘 | Zamhrano LI Sevilla C Reyes-Garcfa SZ | 2012 | Trop Biomed2012，29，4： | 1 |
| 15 | The Effect of Health on Economic Growth: A Production Function Approach显示文摘 | Bloom D E Canning D Sevilla J | 2004 | World Development2004，32，1： | 1 |
| 16 | Discipline styles in families with children with attention deficit hyperactivity disorder: their influence on the course of the disorder 显示文摘 | Miranda Casas A Grau Sevilla D Marco Taberner R | 2007 | Rev Neurol2007，44，2： | 1 |
| 17 | Crosstalk between cdk5 and MEK ERK signalling upon opioid receptor stimulation leads to upregulation of activator p25 and MEK1 inhibition in rat brain显示文摘 | Ramos Miguel A García Sevilla JA | 2012 | Neuroscience2012，215，： | 1 |
| 18 | Ultrahigh surface area poly- pyrrole-based carbons with superior performance for hydrogen storage显示文摘 | Sevilla M Mokaya R Fuertes A B | 2011 | Energy &Environmental Science2011，4，8： | 1 |
| 19 | Bubble formation in a planar water-air-water jet: effects of the nozzle geometry and the injection conditions显示文摘 | GUTIIRREZ-MONTES C BOLAlqOS-JIMINEZ R SEVILLA A | 2014 | International Journal of Multiphase Flow2014，65，3： | 1 |
| 20 | Investigation of low grade thermal energy storage systems with phase changing materials显示文摘The use of phase changing materials(PCMs)for energy storage has been in the focus of scientific research for a while,primarily focusing on building cooling/heating applications due to favourable melting temperature ranges.In this paper we simulated the suitability of encapsulated Paraffin Wax on a small scale in a low temperature thermal energy storage system using COMSOL Multiphysics.Heat absorption and heating dynamics were analysed for different inlet designs and velocities,and the thermal gradient was evaluated across the tank geometry in a number of charging scenarios.Results show that paraffin wax proves to be a good storage medium based on its fast charging and good latent heat absorption.The study found that although an addition of a second inlet to the system yields higher final temperatures and improves the heat transfer rate,it does so minimally and therefore is not notably beneficial.Both designs follow the same heating dynamics independently on the final temperatures.Lastly,higher or lower velocities benefit the system based on the design. | Law Torres Sevilla Jovana Radulovic | 2021 | Energy and Built Environment2021，2，4： | 1 |
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