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| 1 | 应用组织型纤溶酶原激活物行静脉溶栓治疗急性缺血性卒中的时间窗延长——美国心脏协会/美国卒中协会的科学建议显示文摘美国心脏协会卒中委员会发布了关于急性缺血性卒中的现行治疗指南,其中包括应用重组组织型纤溶酶原激活物(rt—PA)行静脉溶栓的建议。尽管该药对改善神经功能预后有一定的疗效,但由于患者通常在发病3h后方能到达医院,往往已经超过了用药的时间窗。因此,大部分缺血性卒中患者未能接受rt—PA治疗。目前研究认为,增加rt—PA治疗例数的最可能方法就是延长治疗时间窗。 | del Zoppo G J Saver J L Jauch E C Adams H P Jr. | 2009 | 中国脑血管病杂志2009，6，8： | 8 |
| 2 | Expression of HER2 and bradykinin B_1 receptors in precursor lesions of gallbladder carcinoma显示文摘AIM:To determine the expression of HER2 and bradykinin B 1 receptors(B 1 R) in the two pathogenic models of gallbladder cancer:the metaplasia-dysplasia-carcinoma and the adenoma-carcinoma pathways.METHODS:Receptor proteins were visualized by immunohistochemistry on 5-μm sections of paraffin-embedded tissue.Expression of both receptors was studied in biopsy samples from 92 patients(6 males and 86 females;age ranging from 28 to 86 years,mean 56 years).High HER2 expression in specimens was additionally investigated by fluorescence in situ hybridiza-tion.Cell proliferation in each sample was assessed by using the Ki-67 proliferation marker.RESULTS:HER2 receptor protein was absent in adenomas and in normal gallbladder epithelium.On the contrary,there was intense staining for HER2 on the basolateral membrane of epithelial cells of intestinal metaplasia(22/24;91.7%) and carcinoma in situ(9/10;90%),the lesions that displayed a significantly high proliferation index.Protein up-regulation of HER2 in the epithelium with metaplasia or carcinoma in situ was not accompanied by HER2 gene amplification.A similar result was observed in invasive carcinomas(0/12).The B 1 R distribution pattern mirrored that of HER2 except that B 1 R was additionally observed in the adenomas.The B 1 R appeared either as cytoplasmic dots or labeling on the apical cell membrane of the cells composing the epithelia with intestinal metaplasia(24/24;100%) and carcinoma in situ(10/10;100%) and in the epithelial cells of adenomas.In contrast,both HER2(4/12;33%) and B 1 R(1/12;8.3%) showed a low expression in invasive gallbladder carcinomas.CONCLUSION:The up-regulation of HER2 and B1R in precursor lesions of gallbladder carcinoma suggests cross-talk between these two receptors that may be of importance in the modulation of cell proliferation in gallbladder carcinogenesis. | Cesar Toledo Carola E Matus Ximena Barraza Pamela Arroyo Pamela Ehrenfeld Carlos D Figueroa Kanti D Bhoola Maeva del Pozo Maria T Poblete | 2012 | World Journal of Gastroenterology2012，18，11： | 6 |
| 3 | Electromagnetic field and spontaneous symmetry breaking in biological matter 显示文摘 | Giudice E Del Doglia S Milani M | 1986 | Nucl Phys B1986，275，： | 2 |
| 4 | Hepatic pseudolesion: appearance of focal low attenuation in the medial segment of the left lobe at CT arterial portography显示文摘 | del Fernandez M Pilar Bernardino M E | 1991 | Radiology1991，181，3： | 2 |
| 5 | 在有煽动性、非煽动性的腹的疼痛显型的孩子的 interleukin-6 和桅杆房间的反的关系显示文摘 AIM: To investigate interleukin-6 (IL-6), mast cells, enterochromaffin cells, 5-hydroxytryptamine, and substance P in the gastrointestinal mucosa of children with abdominal pain. METHODS: Formalin-fixed paraffin-embedded gas-trointestinal biopsy blocks from patients (n = 48) with non-inflammatory bowel disease (irritable bowel syndrome and functional abdominal pain) and inflammatory bowel disease were sectioned and stained for IL-6, mast cells, enterochromaffin cells, 5-hydroxytryptamine, and substance P. All children had chronic abdominal pain as part of their presenting symptoms. Biopsy phenotype was confirmed by a pathologist, blinded to patient information. Descriptive statistics, chi-square, and independent sample t tests were used to compare differences between the inflammatory and non-inflammatory groups. RESULTS: The cohort (n = 48), mean age 11.9 years (SD = 2.9), 54.2% females, 90% Caucasian, was comprised of a non-inflammatory (n = 26) and an inflammatory (n = 22) phenotype. There was a significant negative correlation between substance P expression and mast cell count (P = 0.05, r = -0.373). Substance P was found to be expressed more often in female patient biopsies and more intensely in the upper gastrointestinal mucosa as compared to the lower mucosa. There were significantly increased gastrointestinal mucosal immunoreactivity to IL-6 (P = 0.004) in the inflammatory phenotype compared to non-inflammatory. Additionally, we found significantly increased mast cells (P = 0.049) in the mucosa of the non-inflammatory phenotype compared to the inflammatory group. This difference was particularly noted in the lower colon biopsies. CONCLUSION: The findings of this study yield preliminary evidence in identifying biomarkers of undiagnosed abdominal pain in children and may suggest candidate genes for future evaluation. | Wendy A Henderson Ravi Shankar Tara J Taylor Arseima Y Del Valle-Pinero David E Kleiner Kevin H Kim Nader N Youssef | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，6： | 2 |
| 6 | Comparison of pathogenic and spoilage bacterial levels on refrigerated poultry parts following treatment with trisodium phosphate 显示文摘 | DEL RIO E CAPITA R PRIETO M | 2006 | Food Microbiology2006，23，2： | 1 |
| 7 | Cyclodextrins and their uses: a review显示文摘 | E M Martin Del Valle | 2004 | Process Biochemistry2004，39，： | 1 |
| 8 | The cells of Cajal-Retzius: still a mystery one century after显示文摘 | Soriano E Del Rio JA | 2005 | Neuron2005，46，3： | 1 |
| 9 | The use of unenhanced Doppler sonography in the evaluation of solid breast lesions显示文摘 | del Cura JL Elizagaray E Zabala R | 2005 | AJR2005，184，6： | 1 |
| 10 | Bean abscission cellulase:Characterization of a cDNA clone and regulation of gene expression by ethylene and auxin显示文摘 | TUCKER ML SEXTON R DEL CAMPLLLO E | 1955 | Plant Physiol1955，88，： | 1 |
| 11 | Improving the Cercospora leaf spot management model for sugar beet in Minnesota and North Dakota 显示文摘 | Khan J Del Rio L E Nelson R | 2007 | Plant Disease2007，91，9： | 1 |
| 12 | Stress proteins induced by arsenic 显示文摘 | Del Razo L M QuintaniUa - Vega B Brambila - Colom- bres E | 2001 | Toxicology and Applied Pharmacology2001，177，2： | 1 |
| 13 | Setup ad- justment of multiple lots using a sequential monte carlo meth- od显示文摘 | LIAN Z COLSIMO B M DEL CASTILLO E | 2006 | Technometries2006，48，3： | 1 |
| 14 | Activa- tion of Racl by shear stress in endothelial cells mediates both cytoskeletal reorganization and effects on gene expression 显示文摘 | TZIMA E DEL POZO M A KIOSSES W B | 2002 | EMBO J2002，21，24： | 1 |
| 15 | Laparoscopic testicular autotransplantation显示文摘 | Sánchez de Badajoz E Miguélez Lago C del Rosal Samaniego JM | 1992 | Arch Esp Urol1992，45，10： | 1 |
| 16 | 查看详情显示文摘 | del Olmo E Barboza B Ybarra M.I Lopez-Perez J.L Carron R Sevilla M.A Boselli C Feliciano A.S | | 0，，： | 1 |
| 17 | MicroRNA-21 in pancreatic cancer:correlation with clinical outcome and pharmacologic aspects underlying its role in the modulation of gemcitabine activity显示文摘 | Giovannetti E Funel N Peters G J Del Chiaro M Erozenci LA Vasile E | | 0，，： | 1 |
| 18 | Live anatomy ofthe perineal body in patients with third-degree rectocele显示文摘 | Wagenlehner FM Del Amo E Santoro GA | 2013 | Colorectal Dis2013，15，11： | 1 |
| 19 | Bayesian modelingand optimization of functional responses affected by noise factors显示文摘 | Del Castillo E Colosimo B M Alshraideh H | 2012 | Journal of Quality Technology2012，44，2： | 1 |
| 20 | Lip and oral venous varices treated by photocoagulation with high-intensity diode laser显示文摘 | Azevedo LH Del Vechio A Nakajima E | 2013 | Quintessence Int2013，44，2： | 1 |
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