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| 1 | Therapy with stem cells in inflammatory bowel disease显示文摘Inflammatory bowel disease(IBD) affects a part of the young population and has a strong impact upon quality of life. The underlying etiology is not known, and the existing treatments are not curative. Furthermore, a significant percentage of patients are refractory to therapy. In recent years there have been great advances in our knowledge of stem cells and their therapeutic applications. In this context, autologous hematopoietic stem cell transplantation(HSCT) has been used in application to severe refractory Crohn's disease(CD), with encouraging results. Allogenic HSCT would correct the genetic defects of the immune system, but is currently not accepted for the treatment of IBD because of its considerable risks. Mesenchymal stem cells(MSCs) have immune regulatory and regenerative properties, and low immunogenicity(both autologous and allogenic MSCs). Based on these properties, MSCs have been used via the systemic route in IBD with promising results, though it is still too soon to draw firm conclusions. Their local administration in perianal CD is the field where most progress has been made in recent years, with encouraging results. The next few years will be decisive for defining the role of such therapy in the management of IBD. | María del Pilar Martínez-Montiel Gonzalo Jesús Gómez-Gómez Ana Isabel Flores | 2014 | World Journal of Gastroenterology2014，20，5： | 13 |
| 2 | Reduction of the closure time of postoperative enterocutaneous fistulas with fibrin sealant显示文摘AIM: To assess whether the use of fibrin sealantshortens the closure time of postoperative enterocutaneous fistulas (ECFs). METHODS: The prospective case-control study included 70 patients with postoperative ECFs with an output of < 500 mL/d, a fistulous tract of > 2 cm and without any local complication. They were divided into study (n = 23) and control groups (n = 47). Esophageal, gastric and colocutaneous fistulas were monitored under endoscopic visualization, which also allowed fibrin glue application directly through the external hole. Outcome variables included closure time, time to resume oral feeding and morbidity related to nutritional support. RESULTS: There were no differences in mean age, fistula output, and follow-up. Closure-time for all patients of the study group was 12.5 ± 14.2 d and 32.5 ± 17.9 d for the control group (P < 0.001), and morbidity related to nutritional support was 8.6% and 42.5%, respectively (P < 0.01). In patients with colonic fistulas, complete closure occurred 23.5 ± 19.5 d after the first application of fibrin glue, and spontaneous closure was observed after 36.2 ± 22.8 d in the control group (P = 0.36). Recurrences were observed in 2 patients because of residual disease. One patient of each group died during follow-up as a consequence of septic complications related to parenteral nutrition. CONCLUSION: Closure time was significantly reduced with the use of fibrin sealant, and oral feeding was resumed faster. We suggest the use of fibrin sealant for the management of stable enterocutaneous fistulas. | Jorge Avalos-González Eliseo Portilla-deBuen Caridad Aurea Leal-Cortés Abel Orozco-Mosqueda María del Carmen Estrada-Aguilar Gabriela Abigail Velázquez-Ramírez Gabriela Ambriz-González Clotilde Fuentes-Orozco Aldo Emmerson Guzmán-Gurrola Alejandro González-Ojeda | 2010 | World Journal of Gastroenterology2010，16，22： | 10 |
| 3 | Outcome in obscure gastrointestinal bleeding after capsule endoscopy显示文摘AIM: To investigate the clinical impact of capsule endoscopy(CE) after an obscure gastrointestinal bleeding(OGIB) episode, focusing on diagnostic work-up, followup and predictive factors of rebleeding. METHODS: Patients who were referred to Hospital del Mar(Barcelona, Spain) between 2007 and 2009 for OGIB who underwent a CE were retrospectively analyzed. Demographic data, current treatment with non-steroid antiinflammtory drugs or anticoagulant drugs, hemoglobin levels, transfusion requirements, previous diagnostic tests for the bleeding episode, as well as CE findings(significant or non-significant), work-up and patient out-comes were analyzed from electronic charts. Variables were compared by χ 2 analysis and Student t test. Risk factors of rebleeding were assessed by Log-rank test, Kaplan-Meier curves and Cox regression model. RESULTS: There were 105 patients [45.7% women, median age of 72 years old(interquartile range 56-79)] and a median follow-up of 326 d(interquartile range 123-641) included in this study. The overall diagnostic yield of CE was 58.1%(55.2% and 63.2%, for patients with occult OGIB and overt OGIB, respectively). In 73 patients(69.5%), OGIB was resolved. Multivariate analysis showed that hemoglobin levels lower than 8 g/dL at diagnosis [hazard ratios(HR) = 2.7, 95%CI: 1.9-6.3], patients aged 70 years and above(HR = 2.1, 95%CI: 1.2-6.1) and significant findings in CE(HR = 2.4, 95%CI: 1.1-5.8) were independent predictors of rebleeding. CONCLUSION: One third of the patients presented with rebleeding after CE; risk factors were hemoglobin levels < 8 g/dL, age ≥ 70 years or the presence of significant lesions. | Alex Caas-Ventura Lucia Márque Xavier Bessa Josep Maria DedeuDepartment of Gastroenterology Hospital del Mar Research Institute Pompeu Fabra University Marc Puigvehí Sílvia Delgado-Aros Ines Ana Ibáez Agustin Seoane Luis Barranco Felipe Bory Montserrat Andreu Begoa González-Suárez | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，11： | 4 |
| 4 | Clinical implications of diabetes in chronic liver disease:Diagnosis,outcomes and management,current and future perspectives显示文摘Diabetes mellitus(DM)is common in liver cirrhosis(LC).The pathophysiological association is bidirectional.DM is a risk factor of LC and LC is a diabetogenic condition.In the recent years,research on different aspects of the association DM and LC has been intensified.Nevertheless,it has been insufficient and still exist many gaps.The aims of this review are:(1)To discuss the latest understandings of the association of DM and LC in order to identify the strategies of early diagnosis;(2)To evaluate the impact of DM on outcomes of LC patients;and(3)To select the most adequate management benefiting the two conditions.Literature searches were conducted using Pub Med,Ovid and Scopus engines for DM and LC,diagnosis,outcomes and management.The authors also provided insight from their own published experience.Based on the published studies,two types of DM associated with LC have emerged:Type 2 DM(T2 DM)and hepatogenous diabetes(HD).High-quality evidences have determined that T2 DM or HD significantly increase complications and death pre and post-liver transplantation.HD has been poorly studied and has not been recognized as a complication of LC.The management of DM in LC patients continues to be difficult and should be based on drug pharmacokinetics and the degree of liver failure.In conclusion,the clinical impact of DM in outcomes of LC patients has been the most studied item recently.Nevertheless many gaps still exist particularly in the management.These most important gaps were highlighted in order to propose future lines for research. | Diego García-Compeán Emanuela Orsi Ramesh Kumar Felix Gundling Tsutomu Nishida Jesús Zacarías Villarreal-Pérez Ángel N Del Cueto-Aguilera JoséA González-González Giuseppe Pugliese | 2022 | World Journal of Gastroenterology2022，28，8： | 4 |
| 5 | Insulin resistance impairs sustained response rate to peginterferon plus ribavirin in chronic hepatitis C patients显示文摘 | Manuel Romero-Gómez Maria Del Mar Viloria Raúl J. Andrade Javier Salmerón Moisés Diago Conrado M. Fernández-Rodríguez Raquel Corpas Marina Cruz Lourdes Grande Luis Vázquez Paloma Mu?oz-de-Rueda Pilar López-Serrano Ana Gila María L. Gutiérrez Celia Pérez A | 2005 | Gastroenterology2005，，3： | 2 |
| 6 | Combination studies between polycationic peptides and clinically used antibiotics against Gram-positive and Gram-negative bacteria 显示文摘 | Giacometti A Cirioni () Del Prete M S | 2000 | Peptides2000，21，： | 2 |
| 7 | Dendritic cell-mediated cross presentation of antigens derived from colon carcinoma cells exposed to a highly eytotoxie multidrug regimen with gemcitabine, oxaliplatin, 5 fluorouracil,and leucovorin, elicits a powerful human antigenspecific CTL response with antitumor activity in vitro显示文摘 | Correale P Cusi M G Del Vecchio M T Aquino A Prete S P Tsang K Y | 2005 | J Immunol2005，175，： | 1 |
| 8 | Heat transfer enhancement in oscillatory flows of newtonian and viscoe lastic fluids显示文摘 | Lambert A A Cuevas S del Rio J A | 2009 | International Journal of Heat and Mass Transfer2009，52，： | 1 |
| 9 | Soil inhabiting nema- todes of the genera Trischistoma, Tripylina and Tripyla from Mexico and the USA with descriptions of new species 显示文摘 | Cid del Prado-Vera I Ferris H Nadler S A | 2010 | Journal of Nema- tode Morphology and Systematics2010，13，： | 1 |
| 10 | Universal influenza DNA vaccine encoding conserved CD4+ T cell epitopes protects against lethal viral challenge in HLA-DR transgenic mice显示文摘 | Alexander J Bilsel P del Guercio MF Stewart S MarinkovicPetrovic A Southwood S | | 0，，： | 1 |
| 11 | Therapeutic application of noncytotoxic molecular targeted therapy in gliomas : growth factor receptors and angiogenesis inhibitors 显示文摘 | Idbaih A Ducray F Del Rio M S | 2008 | Oncologist2008，13，9： | 1 |
| 12 | A new method of standartization of health-promoting pomegranate fruit (Punica granatum) extract 显示文摘 | Jimenez Del Rio M Ramazanov A Sikorski S | 2006 | J Georgian Med News2006，140，： | 1 |
| 13 | Plasma homocysteine concentration, C677T MTHFR genotype, and 844ins68bp CBS genotype in young adults with spontaneous cervical artery dissection and atherothrombotic stroke显示文摘 | Pezzini A Del Zotto E Archetti S | 2002 | Stroke2002，33，： | 1 |
| 14 | Retrieval by shape simi-larity with perceptual distance and effective indexing显示文摘 | Berretti S Del Bimbo A Pala P | 2000 | IEEE Transactions on Multimedia2000，2，4： | 1 |
| 15 | Preparation of MoS2 and WS2 catalysts by in situ decomposition of ammonium thiosalts显示文摘 | Alonso G Del Valle M Cruz J Petranovskii V LiceaClaverie A Fuentes S | | 0，，： | 1 |
| 16 | The importance of first-phase insulin secretion:implications for the therapy of type 2 diabetes metlitus显示文摘 | Del Prato S Tiengo A | 2001 | Diabetes Metab Res Rev2001，17，3： | 1 |
| 17 | Fractional retention of technetium-99m-sestamibi as an index of P-glycoprotein expression in untreated breast cancer patients显示文摘 | Del Vecchio S Ciarmiello A Pace L | 1997 | J Nucl Med1997，38，9： | 1 |
| 18 | Chitosan as a potential natural compound to control pre and post - harvest diseases of horticultural commodities显示文摘 | Bautista - Banos S Hemandez - Lauzardo A N Velazquez - del Valle M G | 2006 | Crop Pro- tection2006，25，2： | 1 |
| 19 | Thermal modification of consolidated oriented strand boards: effects on dimensional stability, mechanical properties, chemical composition and surface color 显示文摘 | DEL MENEZZI C H S TOMASELLI I OKINO E Y A | 2009 | Earepean journal of wood & wood products2009，67，： | 1 |
| 20 | linoleic acid oxidation and transfer into milk in stunted lactating women with contrasting body mass indexes显示文摘 | Villalpando S Del Prado M Lance A | 2001 | Am J Clin Nutr2001，74，6： | 1 |
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