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| 1 | AFM-compatible microfluidic platform for affinity- based capture and nanomechanical characterization of circulating tumor cells显示文摘Circulating tumor cells(CTCs)carried by the patient’s bloodstream are known to lead to the metastatic spread of cancer.It is becoming increasingly clear that an understanding of the nanomechanical characteristics of CTCs,such as elasticity and adhesiveness,represents advancements in tracking and monitoring cancer progression and metastasis.In the present work,we describe a combined microfluidic–atomic force microscopy(AFM)platform that uses antibody–antigen capture to routinely isolate and nanomechanically characterize CTCs present in blood samples from prostate cancer patients.We introduce the reversible assembly of a microfluidic device and apply refined and robust chemistry to covalently bond antibodies onto its glass substrate with high density and the desired orientation.As a result,we show that the device can efficiently capture CTCs from patients with localized and metastatic prostate cancer through anti-EpCAM,anti-PSA,and anti-PSMA antibodies,and it is suitable for AFM measurements of captured intact CTCs.When nanomechanically characterized,CTCs originating from metastatic cancer demonstrate decreased elasticity and increased deformability compared to those originating from localized cancer.While the average adhesion of CTCs to the AFM tip surface remained the same in both the groups,there were fewer multiple adhesion events in metastatic CTCs than there were in their counterparts.The developed platform is simple,robust,and reliable and can be useful in the diagnosis and prognosis of prostate cancer as well as other forms of cancer. | Muhammedin Deliorman Farhad K.Janahi Pavithra Sukumar Ayoub Glia Roaa Alnemari Samar Fadl Weiqiang Chen Mohammad A.Qasaimeh | 2020 | Microsystems & Nanoengineering2020，6，1： | 2 |
| 2 | Evaluation of hepatoprotective effect of Gentiana olivieri herbs on subacute administration and isolation of active principle显示文摘 | Didem Deliorman Orhan Mustafa Aslan G?knur Aktay Ender Ergun Erdem Yesilada Fatma Ergun | 2003 | Life Sciences2003，，20： | 2 |
| 3 | Iridoids from Galium aparine 显示文摘 | Deliorman D Calis I Ergun F | 2001 | Phar- maceut Biol2001，39，： | 1 |
| 4 | Capture efficiency of Escherichia coli in fimbriaemediated immunoimmobilization显示文摘 | Suo Z Yang X Deliorman M | 2012 | Langmuir2012，28，2： | 1 |
| 5 | Evaluation of hepato-protective effect of Gentiana olivieri herbs on sub- aeutead ministration and isolation of active principle 显示文摘 | DELIORMAN O D ASLAN M A G | 2003 | Life Sciences2003，72，20： | 1 |
| 6 | Evaluation of hepato-protective effect of Gentiana olivieri herbs on subacutead ministration and isolation of active principle显示文摘 | DELIORMAN O D ASLAN M AKTAY G | 2003 | Life Sciences2003，72，20： | 1 |
| 7 | Evaluation of hepatoprotcctive effect of Gentiana olivieri herbs on subacute administration and isolation of active principle 显示文摘 | Didem Deliorman Orhan Mustafa Asian G knur Aktay | 2003 | Life Sciences2003，72，20： | 1 |
| 8 | Iridoids from Gatium aparine 显示文摘 | DELIORMAN D CALIS I ERGUN F | 2001 | Pharmaeeut Biol2001，39，： | 1 |
| 9 | Evaluation of hepatoprotective effect of Gentiana olivieri herbs on subacute administration and isolation of active principle显示文摘 | Didem Deliorman Orhan Mustafa Aslan G?knur Aktay Ender Ergun Erdem Yesilada Fatma Ergun | 2003 | Life Sciences2003，，20： | 1 |
| 10 | In vivo antidiabetic and antioxidant potential of Helichrysum plicatum ssp. plicatum capitulums in streptozotocin-induced-diabetic rats显示文摘 | Mustafa Aslan Didem Deliorman Orhan Nilüfer Orhan Ekrem Sezik Erdem Yesilada | 2006 | Journal of Ethnopharmacology2006，，1： | 1 |
| 11 | Evaluation of hepato-protective effect of Gentiana olivieri herbs on subaeutead ministration and isolation of active principle显示文摘 | Deliorman Orhan D Asian M Aktay G et a! | 2003 | Life Sciences2003，72，20： | 1 |
| 12 | Evaluation of hepatoprotective effect of Gentiana olivieri herbs on subacute ad- ministration and isolation of active principle 显示文摘 | DELIORMAN OD ASLAN M AKTAY G | 2003 | Life Sci2003，72，20： | 1 |
| 13 | Hypoglycemic activity and antioxidant potential of some medicinal plants traditionally used in Turkey for diabetes显示文摘 | Mustafa Aslan Nilüfer Orhan Didem Deliorman Orhan Fatma Ergun | 2010 | Journal of Ethnopharmacology2010，，2： | 1 |
| 14 | Bacteria survive multiple puncturings of their cell walls 显示文摘 | Suo Z Avci R Deliorman M | 2009 | Langmuir2009，25，： | 1 |
| 15 | In vivo activity assessment of a “honey-bee pollen mix” formulation显示文摘 | Esra Küpeli Akkol Didem Deliorman Orhan Ilhan Gürbüz Erdem Yesilada | 2010 | Pharmaceutical Biology2010，，3： | 1 |
| 16 | Evaluation of hepatoprotective effect of Gentiana olivieri herbs on subacuteadministration and isolation of active principle显示文摘 | Deliorman Orhan D Aslan M Aktay G | 2003 | Life sciences2003，72，20： | 1 |
| 17 | Evaluation of hepatoprotectire effect of Gentiana olivieri herbs on subacute administration and isolation of active principle 显示文摘 | Deliorman OD Asian M Aktay G | 2003 | Life Sci2003，72，20： | 1 |
| 18 | Evaluation of hepatoproteefive effect of Gentiana olivieri herbs on subacute administration and isolation of active principle显示文摘 | Didem Deliorman Orhan Mustafa Asian Gknur Aktay | 2003 | Life science2003，72，20： | 1 |
| 19 | Iridoids from Gatium apafine 显示文摘 | Deliorman D Calis I Ergun F | 2001 | Pharmaceut Biol2001，39，： | 1 |
| 20 | Hypoglycemic activity and antioxidant potential of some medicinal plants traditionally used in Turkey for diabetes显示文摘 | Mustafa Aslan Nilüfer Orhan Didem Deliorman Orhan Fatma Ergun | 2010 | Journal of Ethnopharmacology2010，，2： | 1 |
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