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| 1 | Nitrification monitoring in activated sludge by oxygen uptake rate (OUR) measurements 显示文摘 | Surmaczgorska J Gernaey K Demuynck C | 1996 | Water Research1996，30，5： | 1 |
| 2 | Nitri-fica- tion monitoring in activated sludge by oxygen uptake rate (OUR)measure- meats显示文摘 | SURMACZ - GORSKA J GERNAEY K DEMUYNCK C et 'al | 1996 | Wat Res1996，30，5： | 1 |
| 3 | Short report,high-dose folinicacid,5-fluorouracil bolus and continuous infusion in poor-prognosis patients with advanced measurable gastric cancer显示文摘 | Louvet C de Gramont A Demuynck B | 1991 | Ann Oncol1991，2，： | 1 |
| 4 | Nitrification monitoring in activated sludge by oxygen uptake rate (OUR) measurements 显示文摘 | Surmacz-Gorska J Gernaey K Demuynck C | 1996 | Water Research1996，30，5： | 1 |
| 5 | Nitrification monitoring in activated sludge by oxygen uptake rate (OUR) measurements显示文摘 | Surmacz - Gorska J Gernaey K Demuynck C | 1996 | Wat Res1996，30，5： | 1 |
| 6 | Nitrification monitoring in activated sludge by oxygen up take rate (OUR)measurements显示文摘 | SURMACZ J GERNANEY K DEMUYNCK C | 1996 | Wat Res1996，30，5： | 1 |
| 7 | Nitrification monitoring in activated sludge by oxygen uptake rate (OUR) 显示文摘 | Surmacz-Gorska J Gernaey K Demuynck C | 1996 | Water Research1996，30，： | 1 |
| 8 | High - dose folinic acid,5 - fluorouracil bolus and continuons infusion in poor prognosis patients with advanced measurable gastric cancer 显示文摘 | de Gramont A Demuynck B | 1991 | Annals of Oncology1991，2，： | 1 |
| 9 | High dose folinic acid, 5- fluorouracil bolus and continuons infusion in poor-prognosis patients with advanced measurable gastric cancer 显示文摘 | Louvet C de Gramont A Demuynck B | 1991 | Ann Oncol1991，2，3： | 1 |
| 10 | Metal-protein binding patterns in the polychaete worm Nereis diversicolor during short-term acute cadmium stress 显示文摘 | Demuynck S Dhainaut C N | 1994 | Comp Biochem Physiol1994，108，： | 1 |
| 11 | Theobroma cacao improves bone growth by modulating defective ciliogenesis in a mouse model of achondroplasia显示文摘A gain-of-function mutation in the fibroblast growth factor receptor 3 gene(FGFR3)results in achondroplasia(ACH),the most frequent form of dwarfism.Constitutive activation of FGFR3 impairs bone formation and elongation and many signal transduction pathways.Identification of new and relevant compounds targeting the FGFR3 signaling pathway is of broad importance for the treatment of ACH,and natural plant compounds are prime drug candidate sources.Here,we found that the phenolic compound(-)-epicatechin,isolated from Theobroma cacao,effectively inhibited FGFR3’s downstream signaling pathways.Transcriptomic analysis in an Fgfr3 mouse model showed that ciliary mRNA expression was modified and influenced significantly by the Indian hedgehog and PKA pathways.(-)-Epicatechin is able to rescue mRNA expression impairments that control both the structural organization of the primary cilium and ciliogenesis-related genes.In femurs isolated from a mouse model(Fgfr3^(Y367C/+))of ACH,we showed that(-)-epicatechin eliminated bone growth impairment during 6 days of ex vivo culture.In vivo,we confirmed that daily subcutaneous injections of(-)-epicatechin to Fgfr3^(Y367C/+) mice increased bone elongation and rescued the primary cilium defects observed in chondrocytes.This modification to the primary cilia promoted the typical columnar arrangement of flat proliferative chondrocytes and thus enhanced bone elongation.The results of the present proof-of-principle study support(-)-epicatechin as a potential drug for the treatment of ACH. | Ludovic Martin Nabil Kaci Catherine Benoist-Lasselin Marine Mondoloni Suzanne Decaudaveine Valentin Estibals Maxence Cornille Léa Loisay Justine Flipo Benoît Demuynck Maria de la Luz Cádiz-Gurrea Florent Barbault Salvador Fernández-Arroyo Laurent Schibler Antonio Segura-Carretero Emilie Dambroise Laurence Legeai-Mallet | 2022 | Bone Research2022，10，1： | 1 |
| 12 | High-does folinic acid,5 -fluorour acid bolus and continuous infusion in poor-prognosis patients with advanced measurable gastric cancer显示文摘 | Louvel C De Gramonf A Demuynck B | 1997 | Ann1997，2，： | 1 |
| 13 | Nitrification monitoring in activated sludge by oxygen uptake rate (OUR) measurements 显示文摘 | Surmacz-Gorsha J Gernaey K Demuynck C | 1996 | Wat Res1996，30，5： | 1 |
| 14 | High-dose folinic acid ,5-fluorouracil bolus and continuous infusion in poor-prognosis patients with advanced measurable gastric cancer 显示文摘 | Louvet C de Gramont A Demuynck B | 1991 | Annals of Oncology1991，2，： | 1 |
| 15 | Nitrification monitoring in activated sludge by oxygen uptake rate (OUR) measurements显示文摘 | Surmaczgorska J Gernaey K Demuynck C Vanrolleghem P Verstraete W | | 0，，05： | 1 |
| 16 | Nitrification monitoring in activated sludge by oxygen uptake rate (OUR) measurements显示文摘 | Surmacz G J Gernaey K Demuynck C | 1996 | Water Res1996，30，5： | 1 |
| 17 | Rotational spectrum of CBr by kinetic microwave spectroscopy of 193-nm photolysis products of bromoform显示文摘 | Hassouna M Walters A Demuynck C | 2000 | J Mol Spectrosc2000，200，1： | 1 |
| 18 | Sucrose laurate gels as a percutaneous delivery system for oestradiol in rabbits显示文摘 | Vermeire A Demuynck C Vandenbossche G | 1996 | J Pharm Pharmacol1996，48，： | 1 |
| 19 | Mechanisms of CVD diamond nucleation and growth on mechanically scratched and virgin Si(100) surfaces 显示文摘 | Demuynck L Amault J C Speisser C | 1997 | Diamond Relat Mater1997，6，： | 1 |
| 20 | Nitrification monitoring in activated sludge by oxygen uptake rate(OUR) measurements显示文摘 | Surmacz-Gorska J Gernaey K Demuynck C | 1996 | Water Res1996，30，5： | 1 |
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