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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | 柑桔黄龙病的鉴定和柯赫氏定理(英文)显示文摘黄龙(梢)病被认为是世界柑橘生产上的毁灭性病害已超过一个世纪,但该病害的病原学至今还没有清晰地建立起来。根据16S rRNA基因序列分析,一组被称为'Candidatus Liberibacter species'的难培养细菌被认为与黄龙病相关。然而,要确定'Ca.Liberibacter spp.'是黄龙病病原的柯赫氏定理并没有真正完成。令我们担忧的是,近年来有些文献频频指出'Ca.Liberibacter spp.'是黄龙病的病原,其实该细菌与柑橘寄主的直接病理反应还没有完全确定。我们建议,在黄龙病病原学清楚之前,文献报道在这方面需要有准确的阐述。 | Chen J Deng X Civerolo E L Lee R F Jones J B Zhou C Hartung J S Manjunath K L Brlansky R H | 2011 | 植物病理学报2011，41，2： | 10 |
| 3 | Auxiliary principle and iterative algorithms for generalized set-valued strongly nonlinear mixed variational-like inequalities显示文摘 | Huang N J Deng C X | 2001 | J Math Anal Appl2001，256，： | 2 |
| 4 | Characterization of two new gene cassettes, aadA5 and dfrA17 显示文摘 | White P A Mclver C J Deng Y | 2000 | FEMS Microbiol Lett2000，182，2： | 2 |
| 5 | Dendritic catalysts for asymmetric transfer hydrogenation显示文摘 | Chen Y C Wu T F Deng J G | 2001 | Chem Commun2001，，： | 1 |
| 6 | Electrochemical behavior of LiMn2O4 and LiCoO2 thin film produced with pulsed laser deposition显示文摘 | Striebel K A Deng C Z Cairns E J | 1996 | J Electrochem Soc1996，143，6： | 1 |
| 7 | Gene profiling involved in immature CD4^+ T lymphocyte responsible for systemic lupus erythematosus显示文摘 | Deng YJ Huang ZX Zhou C J | 2006 | Molecular Immunol2006，43，9： | 1 |
| 8 | Factors affecting Agrobactcrium-mediated transformation and regeneration of sweet orange and citrange 显示文摘 | Yu C H Huang S Chen C X Deng Z A Ling P and Gmitter F O J | 2002 | Plant Cell Tissue and Organ Culture2002，71，： | 1 |
| 9 | Multiplc functional groups of varying ratios in metal-organic frameworks 显示文摘 | Deng H X Doonan C J Furukawa H | 2010 | Science2010，327，： | 1 |
| 10 | Large-pore apertures in a series of metal-organic frameworks显示文摘 | Deng H Grunder S Cordova K E Valente C Furukawa H Hmadeh M Gandara F Whalley A C Liu Z Asahina S Kazumori H O'Keeffe M Terasaki O Stoddart J F Yaghi O M | 2012 | Science2012，336，： | 1 |
| 11 | Inter-company comparison using modified TOPSIS with objective weights显示文摘 | H DENG C H YEH R J WILLIS | | 0，，04： | 1 |
| 12 | Ruthenium-Catalyzed Oxidative Cross-Coupling of Chelating Arenes and Cycloalkanes显示文摘 | Deng G Zhao L Li C J | 2008 | Angew Chem Int Ed2008，47，： | 1 |
| 13 | Development of pressurized hot water extraction followed by headspace solid-phase microextraction and gas chromatography-mass spectrometry for determinaction of ligustilides in Ligusticum chuanxiong and Angelica sinensis显示文摘 | Deng C H Jie J Wang X C | 2005 | J Sep Sci2005，28，11： | 1 |
| 14 | Relation between bone mineral density, bone loss and the risk of cardiovascular disease in a Chinese cohort显示文摘 | Shen C Deng J Zhou R | 2012 | Am J Cardiol2012，110，8： | 1 |
| 15 | Stability analysis of linear fractional differential system with multiple time delays显示文摘 | Deng W Li C Lu J | 2007 | Nonlinear Dynamics2007，48，4： | 1 |
| 16 | An automatic and quantitative on-chip cell migration assay using self-assembled monolayers combined with real-time cellular impedance sensing显示文摘 | Wang L Zhu J Deng C | 2008 | Lab on a Chip2008，8，6： | 1 |
| 17 | Auxiliary Principle and Iterative Algorithms for Generalized Set-Valued Strongly Nonlinear Mixed Variational-like Inequalities 显示文摘 | Huang N J Deng C X | 2001 | J Math Anal Appl2001，256，： | 1 |
| 18 | Displacement back analysis for a steep slope at the Three Gorges project site显示文摘 | DENG J H LEE C F | 2001 | International Journal of Rock Mechanics & Mining Sciences2001，38，： | 1 |
| 19 | Multiresponsive chiroptical switch of an azobenzene-containing lipid:solvent,temperature,and photoregulated supramolecular chirality显示文摘 | Duan P F Li Y G Li L C Deng J G Liu M H | 2011 | Journal of Physical Chemistry B2011，115，13： | 1 |
| 20 | Identifying the radioactive coefficient of an evolutional type heat conduction equa-tion by optimization method显示文摘 | Deng Z C Yang L Yu J N | | 0，，： | 1 |
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