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| 1 | Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction显示文摘Zika 病毒(ZIKV ) 的最近的爆发为治疗学加亮迫切需要。朊酶建筑群 NS2B-NS3 在 flaviviral polyprotein 处理期间起必要作用,并且因此代表一个吸引人的药目标。这里,我们开发了裂口酶识别直接指向 flavivirus NS2B-NS3 相互作用的 orthosteric 禁止者的基于互补的高产量的屏蔽试金。由屏蔽一个总数 2 816 同意了并且 investigational 药,我们识别了三个有势力候选人, temoporfin, niclosamide,和 nitazoxanide,,有 nanomolar 力量的 flavivirus NS2B-NS3 相互作用禁止者。显著地,在老鼠的在人的胎盘、神经的祖先房间的大多数有势力化合物, temoporfin,不是仅仅禁止的 ZIKV 复制,而且阻止的导致 ZIKV 的 viremia 和死亡当模特儿。结构的停靠建议 temoporfin 潜在地绑保持批评 NS2B 残余的 NS3 衣袋,因此禁止以一种非竞争的方式处理的 flaviviral polyprotein。当这些药已经在 USA 或另外的国家在另外的指示任何一个为临床的使用被同意了,他们由 ZIKV 和另外的 flaviviruses 为感染的管理代表有希望、容易开发的治疗。 | Zhong Li Matthew Brecher Yong-Qiang Deng Jing Zhang Srilatha Sakamuru Binbin Liu Ruili Huang Cheri A Koetzner Christina A Allen Susan A Jones Haiying Chen Na-Na Zhang Min Tian Fengshan Gao Qishan Lin Nilesh Banavali Jia Zhou Nathan Boles Menghang Xia Laura D Kramer Cheng-Feng Qin Hongmin Li | 2017 | Cell Research2017，27，8： | 11 |
| 2 | Development of a highly sensitive monoclonal antibody based ELISA for detection of benzo pyrene in potable water显示文摘 | Matschu|at D Deng A Niessner R | 2005 | Analyst2005，130，7： | 1 |
| 3 | Molecular signatures determining coronary artery and saphenous vein smooth muscle cell phenotypes : distinct responses to stimuli 显示文摘 | Deng D X Spin J M Tsalenko A | 2006 | Arterioscler Thromb Vasc Biol2006，26，5： | 1 |
| 4 | DNA methyltransferases 1 and 3B are required for hepatitis C virus infection in cell culture显示文摘 | Chen C Pan D Deng A | 2013 | Virology2013，441，1： | 1 |
| 5 | Cardiovascular Risk Factors in Patients on Dialysis显示文摘 | Deng D Forbes A | 2015 | Nephrol Nurs J2015，42，1： | 1 |
| 6 | Phosphodiesterase 5 inhibition improves synaptic function, memory, and amylaid-beta load in an Alzheimer' s disease mouse model 显示文摘 | Puzzo D Staniszewski A Deng SX | 2009 | J Neurosci2009，29，25： | 1 |
| 7 | A molecular dynamics model of melting and glass transition in a idealized 2-demention material显示文摘 | Deng D Argon A S Yip S | 1989 | Philos Trans Roy1989，329，： | 1 |
| 8 | Purification and characterization of a membrane- bound linoleic acid isomerase from Clostridium sporogenes 显示文摘 | Peng S S Deng M D Grund A D | 2007 | Enzyme and Microbial Technology2007，40，4： | 1 |
| 9 | Direct removal in the mouse of a floxed neo gene from a three-loxp conditional knockout allele by two novel approaches 显示文摘 | Li C Garrett-Beal L Larson D Wynshaw-Boris A Deng CX | 2001 | Genesis2001，30，1： | 1 |
| 10 | Enhanced pre-synaptic glutamate release in deep-dorsal horn contributes to calcium channel alpha-2-delta-1 protein-mediated spinal sensitization and behavioral hypersensitivity显示文摘 | Nguyen D Deng P Matthews E A | | 0，，： | 1 |
| 11 | Linoleic acid isomerase from Propionibacterium acnes: purification, characterization, molecular cloning, and heterologous expression 显示文摘 | Deng M D Grund A D Schneider K J | 2007 | Appl Biochem Biotechnol2007，143，3： | 1 |
| 12 | Characteristics of a widespread community cluster of H275Y oseltamivir-resistant A (H1N1) pdm09 influenza in Australia显示文摘 | Hurt A C Hardie K Wilson N J Deng Y M Oshourn M Leang S K Lee R T Iannello P Gehrig N Shaw R Wark P Caldwell N Givney R C Xue L Maurer- Stroh S Dwyer D E Wang B Smith D W Levy A Booy R Dixit R Merritt T Kelso A Dalton C Durrheim D Barr I G | 2012 | J Infect Dis2012，206，2： | 1 |
| 13 | A new heuristic recursive algorithm for the strip rectangular packing problem 显示文摘 | ZHANG D F KANG Y DENG A S | 2006 | Computers & Operations Research2006，33，8： | 1 |
| 14 | Characterization of gear pumps fabricated by LIGA 显示文摘 | Deng K Dewa A S Ritter D C | 1998 | Microsystem Technologies1998，4，4： | 1 |
| 15 | Development of an inverse method to estimate overall building and ventilation parameters of large commercial buildings 显示文摘 | REDDY T A DENG S CLARIDGE D E | 1999 | Journal of Solar Energy Engineering1999，121，： | 1 |
| 16 | Genome-wide association study of flowering time and grain yield traits in a worldwide collection of rice germplasm 显示文摘 | Huang X Zhao Y Wei X Li C Wang A Zhao Q Li W Guo Y Deng L Zhu C Fan D Lu Y Weng Q Liu K Zhou T Jing Y SiL DongG Huang T Lu T Feng Q Qian Q Li J Han B | 2011 | Nature Genetics2011，44，1： | 1 |
| 17 | A new heuristic recursive algorithm for the strip rectangular packing problem显示文摘 | Zhang D F Kang Y Deng A S | 2006 | Computers and Operations Research2006，33，8： | 1 |
| 18 | An effective hybrid algorithm for the problem of packing circles into a larger contai-ning circle显示文摘 | Zhang D F Deng A S | | 0，，： | 1 |
| 19 | Toward N-doped gra- phene via solvothermal synthesis显示文摘 | Deng D H Pan X L Yu L A | 2011 | Chemistry of Materi- als2011，23，5： | 1 |
| 20 | Effect of kidney-reinforcing and marrow -beneficial traditional Chinese medicine-intervened serum on the proliferation and osteogenic differentiation of bone marrow stromal ceils显示文摘 | Zhou D A Deng YN Liu L | 2015 | Exp Ther Med2015，9，91： | 1 |
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