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| 1 | CD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development显示文摘Angiogenesis,最新形成的血容器从先存在发芽的一个过程,为脊椎动物开发和成年动态平衡是重要的。以前的研究证明了 neuronal 指导分子 netrin-1 参予脉管的系统的 angiogenesis 和形态发生。Netrin-1 在 angiogenesis 展出双活动:支持或禁止 angiogenesis。netrin-1 的 anti-angiogenic 活动被 UNC5B 受体调停。然而, netrin-1 怎么支持 angiogenesis,仍然保持不清楚。这里,我们报导那 CD146,免疫球蛋白总科的 endothelial transmembrane 蛋白质,是为 netrin-1 的受体。Netrin-1 与高亲密关系绑在 CD146,导致 endothelial 房间激活并且以一种 CD146 依赖的方式的下游的发信号。在由特定的 anti-CD146 抗体的 netrin-CD146 相互作用的鼠科的内皮细胞层或混乱的 cd146 基因的有条件的大美人堵住或减少 netrin-1-induced angiogenesis。在 zebrafish 胚胎, downregulating 任何一个 netrin-1a 或 CD146 与惹人注目的类似导致脉管的缺点。而且,将宫外的脉管的发芽由 netrin-1 overexpression 导致了的 CD146 块击倒。一起,我们的数据揭开 CD146 在 angiogenesis 为 CD146 作为为 netrin-1 并且也的以前未知的受体揭示功能的 ligand,表明在脊椎动物开发期间在 angiogenesis 发信号的 netrin-CD146 的参与。 | Tao Tu Chunxia Zhang Huiwen Yan Yongting Luo Ruirui Kong Pushuai Wen Zhongde Ye Jianan Chen Jing Feng Feng Liu Jane Y Wu Xiyun Yan | 2015 | Cell Research2015，25，3： | 23 |
| 2 | Regulation of cytokine production during phagocytosis of apoptotic cells显示文摘自我忍耐的损失和汽车反应的淋巴细胞的扩大是汽车免疫的基础。当保证的协调过程与非病理学的结果调整了细胞质和压力反应, Apoptosis 和由吞噬细胞的 apoptotic 房间的快速的清理通常发生。在 apoptotic 房间的清理的缺点将贡献自我反应的淋巴细胞的产生,它驾驶象风湿性关节炎(RA ) 和全身的豺狼座 erythematosus (SLE ) 那样的自体免疫的混乱。cytokines (IL-12, IL-23,和 IL-27 ) 和 IL-10 的 IL-12 家庭被吞噬细胞的巨噬细胞生产并且在对病原体的有免疫力的回答期间在介绍抗原的房间(APC ) 和受动器淋巴细胞的规定起关键作用。这些 cytokines 和他们的 dysregulated 活动的不恰当的表示强烈在几自体免疫的疾病的致病被含有。由吞噬细胞的 APC 的支持 inflammatory 和反煽动性的 cytokines 的生产精巧地作为内在的机制的部分在 apoptotic 房间的摄取期间被调整阻止煽动性的自体免疫的反应。怎么导出房间的信号调整的 apoptotic cytokine 生产糟糕被理解。由我们的组的最近的研究证明由激活的巨噬细胞的 apoptotic 房间的那个吞噬作用由激活一个新奇抄写抑压者导致 IL-12 p35 基因表示的强壮的抑制,我们把它称为 GC 有约束力的蛋白质(GC-BP ) ,通过酷氨酸 dephosphorylation。我们开始也正在理解位于 apoptotic 下面的分子的机制由吞噬细胞的 IL-10 的被触发房间的生产。阐明的这些研究愿望帮助一些新奇有免疫力的规章的机制并且与潜力探索对汽车抗原的有免疫力的回答的规定为自体免疫的混乱的处理发现新治疗学的目标。 | Elaine Y Chung Sun Jung Kim Xiao Jing Ma | 2006 | Cell Research2006，16，2： | 9 |
| 3 | Proliferation and pluripotency potential of ectomesenchymal cells derived from first branchial arch显示文摘 | Lin Y Yan Z Liu L Qiao J Jing W Wu L Chert X Li Z Tang W Zheng X Tian W | 2006 | 中国生物学文摘2006，20，5： | 3 |
| 4 | Quality control measures for lowering the seroconversion rate of hemodialysis patients with hepatitis B or C virus显示文摘BACKGROUND: Hemodialysis (HD) patients are at high risk of infection by hepatitis B virus (HBV) or hepatitis C virus (HCV). The present study was designed to determine the impact of quality control measures on the prevention of transmission of blood-borne viruses. METHODS: A total of 6182 adult maintenance HD patients from all HD units in Zhejiang Province were recruited on January 1, 2007. The baseline demographic and clinical characteristics were recorded and all patients were followed up until death or survival at 4 years later. The Quality Control Standards of Hemodialysis were gradually implemented in HD units. The HBV or HCV seroconversion rates of the recruited patients were calculated and compared every year during the observation period. RESULTS: The prevalence of HBV was 8.3% at the beginning of the study, and 6.6% for HCV. With the implementation of the HD quality control measures, the HBV seroconversion rate tended to decrease year by year (χ 2 =6.620, P=0.085), and the HCV seroconversion rate decreased significantly (χ 2 =10.41, P=0.015). Compared with the data in 2007, the HBV seroconversion rate (χ 2 =4.204, P=0.040, relative risk ratio 0.393, 95% CI 0.156-0.991) and the HCV seroconversion rate (χ 2 =7.373, P=0.007, relative risk ratio 0.386, 95% CI 0.189-0.787) decreased significantly in 2010. CONCLUSION: Quality control measures for HD decreased the seroconversion rates of HBV or HCV in HD patients, showing that updated quality control measures reduce the risk for transmission of blood-borne viruses in the HD population. | Jing Yuan,Yi Yang, Fei Han, Ping Zhang, Xiao-Ying Du, Hua Jiang and Jiang-Hua Chen The Kidney Disease Center, First Affiliated Hospital, Zhejiang University School of Medicine (Yuan J, Yang Y, Han F, Zhang P, Du XY, Jiang H and Chen JH) and Hemodialysis Quality Control Center of Zhejiang Province (Yuan J, Zhang P, Du XY and Chen JH), Hangzhou 310003, China | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，3： | 2 |
| 5 | 膀胱与前列腺并发性原发癌的患病率及克隆性显示文摘偶发性前列腺癌常在膀胱癌患者行根治性膀胱前列腺切除术后标本的组织学评估中被发现。然而,目前尚缺乏偶发性前列腺癌的临床意义及其与膀胱癌克隆相关性的定论性分析。因此,作者进行一项包含919例膀胱癌的单中心回顾性研究以及包含19 868例行膀胱根治切除术的膀胱癌患者的荟萃分析。 | Jing Y Zhang R Ma P 林心语 余英豪 | 2018 | 临床与实验病理学杂志2018，34，10： | 2 |
| 6 | In vivo chondrogenesis of adult bone-marrow-derived autologous mesenchymal stem cells显示文摘 | Chen J Wang C Lu S Wu J Guo X Duan C Dong L Song Y Zhang J Jing D Wu L Ding J Li D | 2006 | 中国生物学文摘2006，20，5： | 2 |
| 7 | Microproteinuria for detecting calcineurin inhibitor-related nephrotoxicity after liver transplantation显示文摘AIM: To investigate whether microproteinuria could be used as an early and sensitive indicator to detect calcineurin inhibitor (CNI)-related nephrotoxicity after liver transplantation. METHODS: All liver transplant recipients with normal serum creatinine (SCr) and detectable microproteinuria at baseline were included in this study. The renal function was monitored by the blood clearance of 99mTc-diethylenetriaminepentaacetic acid every 6 mo. Microproteinuria, SCr and blood urea nitrogen (BUN) were measured at entry and at subsequent follow-up visits. The patients were divided into different groups according to the mean values of glomerular filtration rate (GFR) at the follow-up time points: Group 1, GFR decreased from baseline by 0%-10%; Group 2, GFR decreased from baseline by 11%-20%; Group 3, GFR decreased from baseline by 21%-40%; Group 4, GFR decreased from baseline by > 40% and/or SCr was increasing. RESULTS: A total of 143 patients were enrolled into this study (23 females and 120 males). The mean follow-up was 32 mo (range 16-36 mo). Downward trends in renal function over time were observed in the study groups. SCr and BUN increased significantly only in Group 4 patients (P < 0.001). β2-microglobulin (β2m) and α1-microglobulin (α1m) significantly increased with the subtle change of renal function in recipients who were exposed to CNI-based immunosuppression regimens. The reductions in GFR were closely correlated with elevated α1m (r2 = -0.728, P < 0.001) and β2m (r2 = -0.787, P < 0.001). CONCLUSION: β2m and α1m could be useful as early and sensitive indicators of CNI-induced nephrotoxicity. | Jing Li Bin Liu Lu-Nan Yan Lan-Lan Wang Wan Y Lau Bo Li Wen-Tao Wang Ming-Qing Xu Jia-Yin Yang Fu-Gui Li | 2009 | World Journal of Gastroenterology2009，15，23： | 2 |
| 8 | A new SPD process for spheroidal cast iron显示文摘 | Zhao X Jing T F Gao Y W | 2004 | Materials Letters2004，58，： | 1 |
| 9 | A cluster-based power-efficient MAC protocol for event-driven sensing applications显示文摘 | LAZAROU G Y LI Jing PICONE J | 2007 | Ad hoc Networks2007，5，7： | 1 |
| 10 | A formaldehyde-free flame retardant wood particleboard system based on two component polyurethane adhesive 显示文摘 | Tang Y Wang D Y Jing X K | 2008 | J App Polym Sci2008，108，： | 1 |
| 11 | Experimental (SERS) and theoretical (DFT) studies on the adsorption behaviors of 1-cysteine on gold/silver nanoparticles 显示文摘 | Jing C Fang Y | 2007 | Chemical Physics2007，332，1： | 1 |
| 12 | Genetic variant BDNF (Va166Met) polymorphism alters anxiety-related behavior 显示文摘 | CHEN Z Y JING D BATH K G | 2006 | Science2006，314，： | 1 |
| 13 | Plant proteomics in the post-genomic era显示文摘 | Guo Y M Shen S H Jing Y X | 2002 | Acta Bot Sin2002，44，6： | 1 |
| 14 | Investigation on 1,4-Dichlorophthalazine-derivetized Cinchona Alkaloids-catalyzed Asymmetric 'Interrupted' Feist-B6nary Reaction 显示文摘 | Jin Y Liu X Y Jing L L | 2007 | Chirality2007，19，5： | 1 |
| 15 | Changes in biologicaland virulent characteristics of Helicobacter pyloriexposed to high salt 显示文摘 | Xu Y Jing JJ Gong YH | 2011 | Asian Pac J Cancer Prev2011，12，10： | 1 |
| 16 | Development of transgenic Artemisia annua (Chinese wormwood) plants with an en- hanced content of artemisinin, an effective anti-malarial drug, by hairpin-RNA-mediated gene silencing 显示文摘 | Zhang L Jing F Y Li F P | 2009 | Bioteehnology and Applied Biochemistry2009，52，： | 1 |
| 17 | Effect of zinc on biochemical parameters and changes in related gene expression assessed by cDNA microarrays in pituitary of growing rats显示文摘 | SUN J Y JING M Y WANG J F | 2006 | Nutrition2006，22，2： | 1 |
| 18 | 查看详情显示文摘 | Liu J Shao S Y Chen L Xie Z Y Cheng Y X Geng Y H Wang L X Jing X B Wang F S | | 0，，14： | 1 |
| 19 | Work-related pesticide poi- soning among farmers in two villages of Southern China: a cross-sec- tional survey 显示文摘 | Zhang X J Zhao W Y Jing R W | 2011 | BMC Public Health2011，11，6： | 1 |
| 20 | Antioxidant activity and mechanism of rhizoma cimieifugae显示文摘 | LI X C JING L GAO Y X | 2012 | Chemistry Central Journal2012，6，1： | 1 |
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