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| 1 | 中国≥50岁人群中带状疱疹的发病率和疾病负担情况:来自综合医疗保健网络的数据显示文摘带状疱疹(HZ)是以伴发疼痛的水疱性皮疹为特征,主要影响老年人和免疫功能低下的人群。中国HZ的流行病学数据提示,我国50岁以上未接种HZ疫苗人群的相关数据仍然不足。本研究旨在评估我国≥50岁人群中HZ的流行病学特征、疾病负担和相关危险因素。在鄞州区电子健康档案数据库中选取2015年1月1日至2017年12月31日期间,年龄≥50岁的HZ患者进行评估,使用ICD‑10编码确定HZ及其并发症。 | Sun X Wei Z Lin H 邵萌萌(编译) | 2021 | 中华医学杂志2021，101，43： | 24 |
| 2 | Abnormal subchondral bone remodeling and its association with articular cartilage degradation in knees of type 2 diabetes patients显示文摘Type 2 diabetes(T2 D) is associated with systemic abnormal bone remodeling and bone loss. Meanwhile,abnormal subchondral bone remodeling induces cartilage degradation, resulting in osteoarthritis(OA).Accordingly, we investigated alterations in subchondral bone remodeling, microstructure and strength in knees from T2 D patients and their association with cartilage degradation. Tibial plateaus were collected from knee OA patients undergoing total knee arthroplasty and divided into non-diabetic(n = 70) and diabetes(n = 51) groups. Tibial plateaus were also collected from cadaver donors(n = 20) and used as controls.Subchondral bone microstructure was assessed using micro-computed tomography. Bone strength was evaluated by micro-finite-element analysis. Cartilage degradation was estimated using histology. The expression of tartrate-resistant acidic phosphatase(TRAP), osterix, and osteocalcin were calculated using immunohistochemistry. Osteoarthritis Research Society International(OARSI) scores of lateral tibial plateau did not differ between non-diabetic and diabetes groups, while higher OARSI scores on medial side were detected in diabetes group. Lower bone volume fraction and trabecular number and higher structure model index were found on both sides in diabetes group. These microstructural alterations translated into lower elastic modulus in diabetes group. Moreover, diabetes group had a larger number of TRAP^+ osteoclasts and lower number of Osterix^+ osteoprogenitors and Osteocalcin^+ osteoblasts. T2 D knees are characterized by abnormal subchondral bone remodeling and microstructural and mechanical impairments, which were associated with exacerbated cartilage degradation. In regions with intact cartilage the underlying bone still had abnormal remodeling in diabetes group, suggesting that abnormal bone remodeling may contribute to the early pathogenesis of T2 D-associated knee OA. | Yan Chen Yong-Can Huang Chun Hoi Yan Kwong Yuen Chiu Qingjun Wei Jingmin Zhao X Edward Guo Frankie Leung William W Lu | 2017 | Bone Research2017，5，4： | 10 |
| 3 | Painting a specific chromosome with CRISPR/Cas9 for live-cell imaging显示文摘 | Yuexin Zhou Ping Wang Feng Tian Ge Gao Lei Huang Wensheng Wei X Sunney Xie | 2017 | Cell Research2017，27，2： | 7 |
| 4 | Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-1igase signaling effector DWARF3显示文摘 | Li-Hua Zhao X Edward Zhou Wei Yi Zhongshan Wu Yue Liu Yanyong Kang Li Hou Parker W de Waal Suling Li Yi Jiang Adrian Scaffidi Gavin R Flematti Steven M Smith Vinh Q Lam Patrick R Griffin YonghongWang Jiayang Li Karsten Melcher H Eric Xu | 2015 | Cell Research2015，25，11： | 7 |
| 5 | 笋芽顶端分生组织在竹秆横切面形态形成中的作用与机制研究显示文摘竹秆的横切面主要由表皮、皮层、维管组织、基本组织及髓腔(早期为髓组织)组成。这些组织均由笋芽茎顶端分生组织分化发育而来,且其在生长发育过程中促使了竹秆横切面形态(本文特指:竹秆横切面外轮廓形状、围度及壁-腔结构)的形成。然而,人们对于这一生长发育过程的生物学机制知之甚少。本研究利用解剖学、数学模拟等方法,对 20 种具不同秆径竹种的笋芽顶端分生组织进行了分析。研究结果发现,笋芽顶端分生组织指状形态的维持是竹子产生圆柱形竹秆的基础;在顶端分生组织细胞数目增加的同时,线性增加原体细胞数目应是竹子在演化过程中产生大径竹秆且保持规则壁-腔结构的方式。进一步通过研究一个竹壁增厚且壁-腔架构紊乱的稳定变异体———实肚竹( Phyllostachys nidularia f. farcta)发现,其笋芽顶端分生组织细胞数目减少且原体/原套细胞数比值降低使其产生了高比例的壁组分组织(指基本分生组织与肋状分生组织)与低比例的髓组织。上述 2 种组织的比例失衡,使得实肚竹笋芽在后续发育中壁组分组织随机挤入到了髓组织中,最终形成了实肚竹异常的竹秆横切面形态(竹壁多样化增厚且壁-腔结构紊乱)。此外,相对较小的顶端分生组织,使得实肚竹笋芽产生了较少的内源激素,如其生长素含量仅约为其原种篌竹的 67. 5%,各细胞分裂素含量也显著低于篌竹笋芽。转录组分析进一步发现,在实肚竹笋芽中与激素及代谢相关的功能基因呈显著下调表达。这些生理与分子变化最终导致了实肚竹竹秆矮化、秆径减小且生物量降低。本论文的研究结果为研究竹秆横切面发育提供了一个重要的视角,同时也为实肚竹厚壁茎秆的形成提出了一个合理的机制。 | Wang Y Sun X Ding Y Fei Z Jiao C Fan M Yao B Xin P Chu J Wei Q 王雨珺 魏强 | 2019 | 世界竹藤通讯2019，17，3： | 5 |
| 6 | More synergetic cooperation of Yamanaka factors in induced pluripotent stem cells than in embryonic stem cells显示文摘在 pluripotency 的正式就职的核心管理者最近在体的房间 reprogramming 期间被发现了的 Yamanaka 因素的角色。我们的以前的学习发现 Yamanaka 因素在维持胚胎的茎(ES ) 房间 pluripotency 调整一个发展发信号网络。这里,我们完全证实 reprogrammed 导致了 pluripotent 茎(iPS ) 细胞并且由薄片薄片试金在这些细胞分析了 Yamanaka 因素的全球倡导者占有。我们发现 565 基因的倡导者是由在 iPS 房间的四个 Yamanaka 因素的合作界限, 10 褶层增加什么时候与他们在 ES 房间的绑定相比。,在 ES 房间 Oct4, Sox2,或 Klf4 在 iPS 房间在激活并且镇压的基因同等地散布的一个单个 Yamanaka 因素占据的倡导者在激活的主要在镇压基因和 c-Myc 散布了。薄片薄片数据的小径分析表明 Yamanaka 因素在 iPS 房间, 12 在之中是普通的调整了 16 条发展发信号小径, 4 与在 ES 房间调整的小径相比是唯一的。我们进一步在 iPS 房间分析了另一最近出版的薄片薄片数据集并且观察了类似的结果,显示出为揭示 pluripotency 维护和新生的性质的薄片薄片正小径分析的力量。下次,我们试验性地测试了压抑的发信号小径之一并且发现它的抑制确实改进了房间 reprogramming 的效率。一起拿,我们建议有一个核心为 pluripotency 必要的发展发信号网络与 TGF- ,刺猬, Wnt,是的 p53 压抑(殷) 管理者和 Jak-STAT,房间周期,焦点的粘附, adherens 连接作为活跃(杨) ;并且 Yamanaka 因素 synergistically 在 Yin-Yang 调整他们导致 pluripotency 的平衡方法。 | Jinyan Huang Taotao Chen Xiaosong Liu Jing Jian Jinsong Li Dangsheng Li X Shirley Liu Wei Li Jiuhong Kang Gang Pei | 2009 | Cell Research2009，19，10： | 4 |
| 7 | Interleukin-10 gene polymorphisms and hepatocellular carcinoma susceptibility:A meta-analysis显示文摘AIM: To assess the association between Interleu-kin-10 (IL-10) gene IL-10-1082 (G/A), IL-10-592(C/A), IL-10-819 (T/C) polymorphisms and hepatocellular carcinoma (HCC) susceptibility.METHODS: Two investigators independently searched the Medline, Embase, China National Knowledge Infrastructure, and Chinese Biomedicine Database. Summary odds ratios (ORs) and 95% conf idence intervals (95% CIs) for IL-10 polymorphisms and HCC were cal-culated in a fixed-effects model (the Mantel-Haenszel method) and a random-effects model (the DerSimonian and Laird method) when appropriate. RESULTS: This meta analysis included seven eligiblestudies, which included 1012 HCC cases and 2308 controls. Overall, IL-10-1082 G/A polymorphism was not associated with the risk of HCC (AA vs AG + GG, OR = 1.11, 95% CI = 0.90-1.37). When stratifying for ethnicity, the results were similar (Asian, OR = 1.12, 95% CI = 0.87-1.44; non-Asian, OR = 1.10, 95% CI = 0.75-1.60). In the overall analysis, the IL-10 polymorphism at position -592 (C/A) was identified as a genetic risk factor for HCC among Asians; patients carrying the IL-10-592*C allele had an increased risk of HCC (OR = 1.29, 95% CI = 1.12-1.49). No association was observed between the IL-10-819 T/C polymorphism and HCC susceptibility (TT vs TC + CC, OR = 1.02, 95% CI = 0.79-1.32).CONCLUSION: This meta-analysis suggests that IL-10-592 A/C polymorphism may be associated with HCC among Asians. IL-10-1082 G/A and IL-10-819 T/C polymorphisms were not detected to be related to the risk for HCC. | Yong-Gang Wei, Fei Liu, Bo Li, Xi Chen, Yu Ma, Lv-Nan Yan, Tian-Fu Wen, Ming-Qing Xu, Wen-Tao Wang, Jia-Yin YangYong-Gang Wei, Fei Liu, Bo Li, Xi Chen, Yu Ma, Lv-Nan Yan, Tian-Fu Wen, Ming-Qing Xu, Wen-Tao Wang, Jia-Yin Yang, Department of Liver and Vascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Prov- ince, China Author contributions: Wei YG and Liu F designed the study, collected and analyzed the data and wrote the manuscript Li B collected and analyzed the data and wrote the manuscript Chen X and Ma Y collected and analyzed the data Yan LN analyzed the data and contributed to the discussion Wen TF and Xu MQ revised the manuscript Wang WT and Yang JY contributed to the discussion Wei YG and Liu F contributed equally to this work. | 2011 | World Journal of Gastroenterology2011，17，34： | 3 |
| 8 | Caffeic acid phenethyl ester blocks free radical generation and 6-hydroxydopamine-induced neurotoxicity显示文摘 | Ma Z Wei X Fontanilla C Noelker C Dodel R Hampel H Du Y | 2006 | 中国生物学文摘2006，20，10： | 3 |
| 9 | 查看详情显示文摘 | X L Wang Y H Chen R J Wei | | 中国物理快报(英文版)0，，： | 3 |
| 10 | The genetic heterozygosity and fitness of tetraploid embryos and embryonic stem cells are crucial parameters influencing survival of mice derived from embryonic stem cells by tetraploid embryo aggregation显示文摘 | Li X Wei W Yong J Jia Q Yu Y Di K | 2006 | 中国生物学文摘2006，20，7： | 3 |
| 11 | Common non-synonymous polymorphisms in the BRCA1 Associated RING Domain (BARD1) gene are associated with breast cancer susceptibility:a case-control analysis显示文摘The BRCA1 Associated RING Domain(BARD1) gene has been identified as a high penetrance gene for breast cancer, whose germline and somatic mutations were reported in both non-BRCA1/2 hereditary site-specific and sporadic breast cancer cases. BARD1 plays a crucial role in tumor repression, along with its heterodimeric partner BRCA1. In the current study, we tested the hypothesis that common non-synonymous polymorphisms in BARD1 are associated with breast cancer susceptibility in a case-control study of 507 patients with incident breast cancer and 539 frequency-matched cancer-free controls in Chinese women. We genotyped all three common(minor allele frequency (MAF) > 0.10) non-synonymous polymorphisms(Pro24Ser, Arg378Ser, and Val507Met) in BARD1. We found that the BARD1 Pro24Ser variant genotypes(24Pro/Ser and 24Ser/Ser) and Arg378Ser variant homozygote 378Ser/Ser were associated with a significantly decreased breast cancer risk, compared with their wild-type homozygotes, respectively. Furthermore, a significant locus-locus interaction was evident between Pro24Ser and Arg378Ser (P-int = 0.032). Among the 378Ser variant allele carriers, the 24Pro/Pro wild-type homozygote was associated with a significantly increased breast cancer risk (adjusted OR = 1.81, 95% CI = 1.11-2.95), but the subjects having 24Pro/Ser or Ser/Ser variant genotypes had a significantly decreased risk(adjusted OR = 0.74, 95% CI = 0.56-0.99). In stratified analysis, this locus-locus interaction was more evident among subjects without family cancer history, those with positive estrogen receptor (ER) and individuals with negative progesterone receptor(PR). These findings indicate that the potentially functional polymorphisms Pro24Ser and Arg378Ser in BARD1 may jointly contribute to the susceptibility of breast cancer. | Huo, X Hu, Z. B Zhai, X. J Wang, Y Wang, S Wang, X. C Qin, J. W Chen, W. S Jin, G. F Liu, J. Y Gao, J Wei, Q. Y Wang, X. R Shen, H. B | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 3 |
| 12 | Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite显示文摘As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed.Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results. | Shuang-Nan Zhang TiPei Li FangJun Lu LiMing Song YuPeng X u CongZhan Liu Yong Chen XueLei Cao QingCui Bu Zhi Chang Gang Chen Li Chen TianXiang Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong Yuan Yuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan Can Gungor ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge Ou JinLu Qu Na Sai RenCheng Shang GuoHong Shen Liang Sun Ying Tan Lian Tao YouLi Tuo Chen Wang ChunQin Wang GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BaiYang Wu BoBing Wu Mei Wu GuangCheng Xiao ShaoLin Xiong LinLi Yan JiaWei Yang Sheng Yang YanJi Yang QiBin Yi Bin Yuan AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang ShenYi Zhangs Shu Zhang Tong Zhang WanChang Zhang Wei Zhang WenZhao Zhang Yi Zhang YiFei Zhang YongJie Zhang Yue Zhang Zhao Zhang Zhi Zhang ZiLiang Zhang HaiSheng Zhao XiaoFan Zhao ShiJie Zheng JianFeng Zhou YuXuan Zhu Yue Zhu RenLin Zhuang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 2 |
| 13 | 逆向半回收——改良的solumbra取栓技术显示文摘血管内治疗急性缺血性卒中已经成为一项标准的治疗技术。多重神经血管装置的结合使用可为技术的改良提供更多的可能性。我们描述了一种改良的取栓技术——使用远端颅内导管(distal intracranial catheter,DIC)在取栓之前半回收取栓装置。这项技术的成功运用包括回拉DIC使支架完全释放,前推DIC部分地回收支架,从而使支架在取栓之前形成锥形,更好地嵌合和固定血栓、缩短取栓行程,同时减少血管内皮损伤。该项技术可作为血栓切除术的一个良好选择,并可提高取栓效率。 | 魏铭 李宏 Wei M Wei Z Li X | 2017 | 中国卒中杂志2017，12，7： | 2 |
| 14 | 能源回报趋势对我国经济增长的影响分析显示文摘随着开采难度的增加,化石能源生产过程中的能源消耗量不断增长,可供于经济社会能够真正使用的净能源量也随之变动,这将对我国的经济增长产生不可估量的影响。基于此,本文从'净能源'角度提出化石能源供应净量的概念,并预测至2025年我国化石能源产量、净进口量、生产过程中的消耗量;进而,将取得的重要参数和预测数据应用到能源型生产函数中,通过Lingo软件模拟出化石能源供应净量的变动对我国经济增长的影响,计算得出:在基准情景下,我国GDP增速呈逐步放缓的趋势,2011-2015年间为9.26%,2016-2020年间为6.01%,2021-2025年间为4.29%,目前正处于高速增长阶段过渡到中速增长阶段甚至是低速增长阶段的新时期。 | 胡燕 冯连勇 齐超 王宏伟 William X Wei | 2014 | 技术经济与管理研究2014，，2： | 2 |
| 15 | Influence of Fe^3+ ions on the photocatalytic activity of TiO2 films prepared by micro-plasma oxidation method显示文摘 | Wu X H Wei Q Jiang Z H | 2006 | Thin Solid Films2006，496，2： | 1 |
| 16 | Embryonic stem cell transplantation for the treatment of myocardial infarction: Immune privilege or rejection 显示文摘 | Yuan X Zhang H Wei YJ | 2007 | Transpl Immunol2007，18，2： | 1 |
| 17 | Effects of incubation temperatures on embryonic development in the Asian yellow pond turtle 显示文摘 | Zhu X P Wei C Q Zhao W H | 2006 | Aquaculture2006，259，： | 1 |
| 18 | Structure and properties of nano-hydroxyapatite/polymer composite scaffolds for bone tissue engineering 显示文摘 | Wei G Ma P X | 2004 | Biomaterials2004，25，： | 1 |
| 19 | A modified transcystic biliary decompression after laparoscopic choledochotomy显示文摘 | Wei Q Cai X Yang J | 2004 | J Laparoendosc Adv Surg Tech A2004，14，1： | 1 |
| 20 | 显示文摘 | Padture N P Wei X Z | 2003 | J Am CeramSoc2003，86，： | 1 |
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