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5篇 您的检索式：作者名="Deng Jiewei"

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		题名	作者	年代	出处	被引量
	1	Overexpression of amplified in breast cancer 1 (AIB1) gene promotes lung adenocarcinoma aggressiveness in vitro and in vivo by upregulating C-X-C motif chemokine receptor 4显示文摘Background:We previously found that overexpression of the gene known as amplified in breast cancer 1(AIB1)was associated with lymph node metastasis and poor prognosis in patients with lung adenocarcinoma.However,the role of AIB1 in that malignancy remains unknown.The present study aimed to investigate the function of AIB1 in the process of lung adenocarcinoma cell metastasis.Methods:A series of in vivo and in vitro assays were performed to elucidate the function of AIB1,while real-time PCR and Western blotting were utilized to identify the potential downstream targets of AIB1 in the process of lung adenocarcinoma metastasis.Rescue experiments and in vitro assays were performed to investigate whether the invasive-ness of AIB1-induced lung adenocarcinoma was mediated by C-X-C motif chemokine receptor 4(CXCR4).Results:The ectopic overexpression of AIB1 in lung adenocarcinoma cells substantially enhanced cell migration and invasive abilities in vitro and tumor metastasis in vivo,whereas the depletion of AIB1 expression substantially inhibited lung adenocarcinoma cell migration and invasion.CXCR4 was identified as a potential downstream target of AIB1 in lung adenocarcinoma.The knockdown of AIB1 greatly reduced CXCR4 gene expression at both the transcription and protein levels,whereas the knockdown of CXCR4 in cells with AIB1 ectopic overexpression diminished AIB1-induced migration and invasion in vitro and tumor metastasis in vivo.Furthermore,we found a significant positive association between the expression of AIB1 and CXCR4 in lung adenocarcinoma patients(183 cases),and the co-overexpression of AIB1 and CXCR4 predicted the poorest prognosis.Conclusions:These findings suggest that AIB1 promotes the aggressiveness of lung adenocarcinoma in vitro and in vivo by upregulating CXCR4 and that it might be usable as a novel prognostic marker and/or therapeutic target for this disease.	Liru He Haixia Deng Shiliang Liu Jiewei Chen Binkui Li Chenyuan Wang Xin Wang Yiguo Jiang Ningfang Ma Mengzhong Liu Dan Xie	2018	Cancer Communications2018，38，1：	2
	2	Multi-ingredients determination and fingerprint analysis of leaves from Ilex latifolia using ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry显示文摘	Chunlin Fan Jiewei Deng Yunyun Yang Junshan Liu Ying Wang Xiaoqi Zhang Kuokchiu Fai Qingwen Zhang Wencai Ye	2013	Journal of Pharmaceutical and Biomedical Analysis2013，，：	1
	3	Identification and determination of the major constituents in Deng's herbal tea granules by rapid resolution liquid chromatography coupled with mass spectrometry显示文摘	Deng Jiewei Fan Chunlin Yang Yunyun	2011	Journal of Pharmaceutical and Biomedical Analysis2011，56，5：	1
	4	Chemical fingerprint analysis for quality assessment and control of Bansha herbal tea using paper spray mass spectrometry 显示文摘	DENG Jiewei YANG Yunyun	2013	Anal Chim Acta2013，785，：	1
	5	Strategies for coupling solid - phase microextraction with mass spectrometry显示文摘	DENG Jiewei YANG Yunyun WANG Xiaowei	2014	TrAC Trends in Analytical Chem- istry2014，55，：	1

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