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| 1 | Comparative profile for COVID-19 cases from China and North America: Clinical symptoms, comorbidities and disease biomarkers显示文摘BACKGROUND Large inter-individual and inter-population differences in the susceptibility to and outcome of severe acute respiratory syndrome coronavirus 2 or coronavirus disease 2019(COVID-19)have been noted.Understanding these differences and how they influence vulnerability to infection and disease severity is critical to public health intervention.AIM To analyze and compare the profile of COVID-19 cases between China and North America as two regions that differ in many environmental,host and healthcare factors related to disease risk.METHODS We conducted a meta-analysis to examine and compare demographic information,clinical symptoms,comorbidities,disease severity and levels of disease biomarkers of COVID-19 cases from clinical studies and data from China(105 studies)and North America(19 studies).RESULTS COVID-19 patients from North America were older than their Chinese counterparts and with higher male:Female ratio.Fever,cough,fatigue and dyspnea were the most common clinical symptoms in both study regions(present in about 30%to 75%of the cases in both regions).Meta-analysis for the prevalence of comorbidities(such as obesity,hypertension,diabetes,cardiovascular diseases,chronic obstructive pulmonary disease,cancer,and chronic kidney diseases)in COVID-19 patients were all significantly more prevalent in North America compared to China.Comorbidities were positively correlated with age but at a significantly younger age range in China compared to North American.The most prevalent infection outcome was acute respiratory distress syndrome which was 2-fold more frequent in North America than in China.Levels of C-reactive protein were 4.5-fold higher in the North American cases than in cases from China.CONCLUSION The differences in the profile of COVID-19 cases from China and North America may relate to differences in environmental-,host-and healthcare-related factors between the two regions.Such inter-population differences-together with intrapopulation variability-underline the need to characterize the effect of health inequities and inequalities on public health response to COVID-19 and can assist in preparing for the re-emergence of the epidemic. | Alaa Badawi Denitsa Vasileva | 2021 | World Journal of Clinical Cases2021，9，1： | 1 |
| 2 | Identification and synthesis of three cyclodidepsipeptides as potential precur- sors of enniatin B in Fusarium sporotrichioides显示文摘 | ANDR/JA S DENITSA Y EMILIYA C | 2011 | Journal of Molecular Structure2011，985，2： | 1 |
| 3 | The effect of muscle fatigue on in vivo tibial strains显示文摘 | Charles Milgrom Denitsa R Radeva-Petrova Aharon Finestone | 2007 | Journal of Biomechanics2007，40，： | 1 |
| 4 | The Pseudomonas aeruginosa transcriptome in planktonic cultures and static biofilms using RNA sequencing显示文摘 | Andreas D Denitsa E Monika S | 2012 | Plos one2012，7，31： | 1 |
| 5 | The Anachronism of the Voice-Exit Paradigm:institutional investors and corporate govemance in the UK显示文摘 | Photis Lysandrou Denitsa Stoyanova | | 0，，11： | 1 |
| 6 | Effect of collagen I and fibronectin on the adhesion, elasticity and cytoskeletal organization of prostate cancer cells 显示文摘 | Denitsa D Padula D Schieker M | 2010 | Biochem Biophys Res Commun2010，402，2： | 1 |
| 7 | Biological activities of selected polyphenol-rich fruits related to immunity and gastrointestinal health显示文摘 | Petko Denev Maria Kratchanova Milan Ciz Antonin Lojek Ondrej Vasicek Plamena Nedelcheva Denitsa Blazheva Reneta Toshkova Elena Gardeva Liliya Yossifova Pavel Hyrsl Libor Vojtek | 2014 | Food Chemistry2014，，： | 1 |
| 8 | Tenomodulin is necessary for tenocyte proliferation and tendon maturation显示文摘 | Denitsa D Ernst BH Reinhard F | 2005 | Mol Cell Biol2005，25，： | 1 |
| 9 | Tenomodulin is necessary for tenocyte proliferation and tendon maturation 显示文摘 | Denitsa D Ernst BH Reinhard F | 2005 | Mol Cell Biol2005，25，： | 1 |
| 10 | Evaluation of the combined activity of benzimidazole arylhydrazones as new anti-Parkinsonian agents:monoamine oxidase-B inhibition,neuroprotection and oxidative stress modulation显示文摘Neuroprotective drugs and selective monoamine oxidase inhibitors can slow down the progression and improve symptoms of Parkinson’s disease(PD).Since there is an implication of oxidative stress in the pathophysiological mechanisms of the disease,the compounds possessing an ability to reduce the oxidative stress are prime candidates for neuroprotection.Thereby our current study is focused on the development of new multi-target PD drugs capable of inhibiting the activity of monoamine oxidase-B while exerting neuroprotective and antioxidant properties.A small series of benzimidazole derivatives containing hydroxy and methoxy arylhydrazone fragments has been synthesized and the neurotoxicity of the compounds has been evaluated in vitro on neuroblastoma SH-SY5Y cells and on isolated rat brain synaptosomes by measuring the cell viability and the levels of reduced glutathione and a good safety profile has been shown.The 2-hydroxy-4-methoxy substituted arylhydrazone 7 was the least toxic on neuronal SH-SY5Y cells and showed the lowest neurotoxicity in rat brain synaptosomes.The neuroprotective properties of the test compounds were further assessed using two models:H2O2-induced oxidative stress on SH-SY5Y cells and 6-hydroxydopamine-induced neurotoxicity in rat brain synaptosomes.Compound 7 showed more pronounced neuroprotective activity on SH-SY5Y cells,compared to the referent melatonin and rasagiline.It also preserved the synaptosomal viability and the reduced glutathione levels;the effects were stronger than those of rasagiline and comparable to melatonin.All the tested compounds were capable to inhibit human monoamine oxidase-B enzyme to a significant extent,however,compound 7 exerted the most prominent inhibitory activity,similar to selegiline and rasagiline.The carried out molecular docking studies revealed that the activity is related to the appropriate molecular structure enabling the ligand to enter deeper in the narrow and highly lipophylic active site pocket of the human monoamine oxidase-B and has a favoring interaction with the key amino acid residues Tyr326 and Cys172.Since much scientific evidence points out the implication of iron dyshomeostasis in PD,the compounds were tested to reduce the ferrous iron induced oxidative molecular damage on biologically important molecules in an in vitro lecithin containing model system.All the investigated compounds denoted protection effect,stronger than the one of the referent melatonin.In order to support the assignments of the significant neuroprotective and antioxidant pharmacological activities,the radical-scavenging mechanisms of the most promising compound 7 were evaluated using DFT methods.It was found that the most probable free radicals scavenging mechanism in nonpolar phase is the hydrogen atom transfer from the amide group of compound 7,while in polar medium the process is expected to occur by a proton transfer.The current study outlines a perspective leading structure,bearing the potential for a new anti-PD drug.All performed procedures were approved by the Institutional Animal Care Committee of the Medical University of Sofia(Bulgarian Agency for Food Safety with Permission№190,approved on February 6,2020). | Neda Anastassova Denitsa Aluani Anton Kostadinov Miroslav Rangelov Nadezhda Todorova Nadya Hristova-Avakumova Maria Argirova Nikolay Lumov Magdalena Kondeva-Burdina Virginia Tzankova Denitsa Yancheva | 2021 | Neural Regeneration Research2021，16，11： | 0 |
| 11 | 收益率飙升对冲基金爱上美国国债显示文摘●昔日沉寂的美债市场波动加剧,对赚快钱的投资者来说颇具吸引力维尼尔·班萨利(Vineer Bhansali)现在睡得不怎么好,也没有参加那么多他喜欢的长跑,但他享受着一生中最美好的时光。 | Denitsa Tsekova Liz Capo McCormick 孟洁冰(译) | 2023 | 商业周刊(中文版)2023，，21： | 0 |
| 12 | 市场惨淡 美股投资者苦不堪言显示文摘全球股市暴跌,他的股票投资贬值,他还可以忍受。他在Sushi Swap和Avalanche等加密货币上的投资价值腰斩,他也仍然愿意坚持。然而对于约瑟夫·皮佐费拉托(Joseph Pizzoferrato)来说,FTX Group的崩溃是不可承受之痛,他所有剩余的积蓄都在该平台一个锁定的交易账户中。“损失1万美元简直击垮了我,”皮佐费拉托说,“如果我有朝一日重新投资加密货币,那我肯定只用额外的钱投资,而不会是毕生积蓄。”他供职于内华达州一家寿险公司,在2020年封控居家期间开始短线交易。 | Denitsa Tsekova 汪泽(译) | 2023 | 商业周刊(中文版)2023，，1： | 0 |
| 13 | 市值蒸发5万亿美元 亚洲股市需关注五件事显示文摘亚洲股市市值蒸发近5万亿美元后,投资者对反弹充满希望,押注一些去年最棘手的问题将在2023年成为助力。中国优化疫情防控措施和美联储紧缩周期放缓,将是推动MSCI亚太指数从2008年以来表现最糟的一年中迅速复苏的关键。随着中国优化疫情防控措施,美元从高点回落,令人宽慰的迹象已经浮现,但投资者将需要更多催化剂。 | Denitsa Tsekova 汪泽(译) | 2023 | 商业周刊(中文版)2023，，1： | 0 |
| 14 | In situ frequency gating and beam splitting of vacuum- and extreme-ultraviolet pulses显示文摘Monochromatization of high-harmonic sources has opened fascinating perspectives regarding time-resolved photoemission from all phases of matter.Such studies have invariably involved the use of spectral filters or spectrally dispersive optical components that are inherently lossy and technically complex.Here we present a new technique for the spectral selection of near-threshold harmonics and their spatial separation from the driving beams without any optical elements.We discover the existence of a narrow phase-matching gate resulting from the combination of the non-collinear generation geometry in an extended medium,atomic resonances and absorption.Our technique offers a filter contrast of up to 104 for the selected harmonics against the adjacent ones and offers multiple temporally synchronized beamlets in a single unified scheme.We demonstrate the selective generation of 133,80 or 56 nm femtosecond pulses from a 400-nm driver,which is specific to the target gas.These results open new pathways towards phase-sensitive multi-pulse spectroscopy in the vacuum-and extreme-ultraviolet,and frequencyselective output coupling from enhancement cavities. | Rajendran Rajeev Johannes Hellwagner Anne Schumacher Inga Jordan Martin Huppert Andres Tehlar Bhargava Ram Niraghatam Denitsa Baykusheva Nan Lin Aaron von Conta Hans Jakob Wörner | 2016 | Light(Science & Applications)2016，5，1： | 0 |
| 15 | 激进投资遭到重挫 女股神还能挽回投资者吗?显示文摘2021年,围绕ARK Investment Management的狂热情绪达到高潮时,投资者已经向该公司旗下的交易所交易基金(ETF)投入惊人的420亿美元。更令人难以置信的是:其中四分之三的资金现在还在。ARK 2020年表现抢眼,其光芒几乎盖过了华尔街所有的机构,而之后该公司经历了残酷的12个月。 | Sam Potter Elaine Chen Denitsa Tsekova Emily Graffeo 汪泽(译) | 2022 | 商业周刊(中文版)2022，，2： | 0 |
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