| 1 | Long Non-coding RNA Derived from lncRNA–mRNA Co-expression Networks Modulates the Locust Phase Change显示文摘Long non-coding RNAs(lncRNAs)regulate various biological processes ranging from gene expression to animal behavior.Although protein-coding genes,microRNAs,and neuropeptides play important roles in the regulation of phenotypic plasticity in migratory locust,empirical studies on the function of lncRNAs in this process remain limited.Here,we applied high-throughput RNA-seq to compare the expression patterns of lncRNAs and mRNAs in the time course of locust phase change.We found that lncRNAs responded more rapidly at the early stages of phase transition.Functional annotations demonstrated that early changed lncRNAs employed different pathways in isolation and crowding phases to cope with changes in the population density.Two overlapping hub lncRNA loci in the crowding and isolation networks were screened for functional verification.One of them,LNC1010057,was validated as a potential regulator of locust phase change.This work offers insights into the molecular mechanism underlying locust phase change and expands the scope of lncRNA functions in animal behavior. | Ting Li Bing Chen Pengcheng Yang Depin Wang Baozhen Du Le Kang | 2020 | Genomics, Proteomics & Bioinformatics2020，18，6： | 1 |
| 2 | FAWMine:An integrated database and analysis platform for fall armyworm genomics显示文摘Fall armyworm(Spodoptera frugiperda),a native insect species in the Americas,is rapidly becoming a major agricultural pest worldwide and is causing great damage to corn,rice,soybeans,and other crops.To control this pest,scientists have accumulated a great deal of high-throughput data of fall armyworm,and nine versions of its genomes and transcriptomes have been published.However,easily accessing and performing integrated analysis of these omics data sets is challenging.Here,we developed the Fall Armyworm Genome Database(FAWMine,http://gffzzb594a1ad88cd4938hnwbo0u995cnu6qcq.ffgz.tsg.suse.edu.cn/fawmine/)to maintain genome sequences,structural and functional annotations,transcriptomes,co-expression,protein interactions,homologs,pathways,and single-nucleotide variations.FAWMine provides a powerful framework that helps users to perform flexible and customized searching,present integrated data sets using diverse visualization methods,output results tables in a range of file formats,analyze candidate gene lists using multiple widgets,and query data available in other InterMine systems.Additionally,stand-alone JBrowse and BLAST services are also established,allowing the users to visualize RNA-Seq data and search genome and annotated gene sequences.Altogether,FAWMine is a useful tool for querying,visualizing,and analyzing compiled data sets rapidly and efficiently.FAWMine will be continually updated to function as a community resource for fall armyworm genomics and pest control research. | Pengcheng Yang Depin Wang Wei Guo Le Kang | 2021 | Insect Science2021，28，3： | 1 |
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