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| 1 | Molecular cloning, functional analysis and localization of a novel gene encoding polygalacturonase-inhibiting protein in Chorispora bungeana显示文摘 | Di Cuixia Li Ming Long Feng | 2009 | Planta2009，231，： | 1 |
| 2 | Molecular cloning, functional analysis and localization of a novel gene encoding polygalacturonase-inhibiting protein in Chorispora bungeana显示文摘 | Cuixia Di Ming Li Feng Long Muqun Bai Yajie liu Xiaolin Zheng Shijian Xu Yun Xiang Zhenglong Sun Lizhe An | 2009 | Planta2009，，1： | 1 |
| 3 | 3-60 RNA Splicing: A New Player in the Carbon Ion Irradiation -Induced Cell Death显示文摘Recently, RNA processing has emerged as a novel pathway that may contribute to the maintenance of genome stability[1]. Alternative splicing is a key molecular mechanism for increasing the functional diversity of the eukaryotic proteomes, but it also often altered in cancer. Mounting evidence indicates that alternative splicing, the process that allows production of multiple mRNA variants from each gene, contributes to the heterogeneity of the disease[2]. Although the mechanism of alternative splicing variant in cancer is unclear, the cancer-specific alternative splicing variants have been observed in a variety of human cancers and cancer cell lines and have been connected to tumorgenesis. | Di Cuixia Zhang Hong | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 4 | DeltNp73 Expression in Human Cervical Carcinoma HeLa Cells Exposed to Ionizing Radiation of Different LET显示文摘 | Di Cuixia Zhang Hong Wang Zhenhua | 2011 | IMP & HIRFL Annual Report2011，，1： | 0 |
| 5 | Analysis of Different Chinese Medicine Inhibit Liver Cancer Cell HepG2 Growth显示文摘 | Yang Lina Sun Chao Zhang Hong Wang Xiaohu Di Cuixia | 2011 | IMP & HIRFL Annual Report2011，，1： | 0 |
| 6 | 3-57 Protective Effect of Diallyl Disulfide on Carbon Ion Irradiation-induced Cell Death in Mouse Testis via p73 Signaling Pathway, But Not p53显示文摘Diallyl Disulfide (DADS) is the main organosulfur component of garlic and it is known for multiple pharmacologicalactions. Currently, DADS has been well documented to ameliorate the testis injuries caused by X-rayirradiation[1??4]. However, the effect of DADS against heavy-ion-induced testis damage, particularly cell apoptosis,is still largely unknown. In this regard, based on ground experiments at accelerators, this study has been undertakento estimate the protective mechanisms of DADS against carbon ion-induced cell apoptosis at the level ofsignal transduction pathway in mouse testis. | Di Cuixia Zhang Hong Han Lu | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 7 | 3-62 Impact of Carbon Ion Irradiation on Spermatogenic Cells Apoptosis in Pubertal Mice*显示文摘There has been a considerable improvement in men of child-bearing age undergoing radiotherapy which oftenconcerned about the possibility of future children[1]. In this investigation, we used TUNEL assay to analyzespermatogenic cells apoptosis in pubertal mice testes after carbon ion irradiation (CIR) that evaluate the impactof CIR on spermatogenesis in pubertal mice.The 4 weeks of Swiss-Webster mice were whole-body irradiated with 0, 1 and 4 Gy, respectively. Testes werecollected 14 d after irradiation. The histological changes in testicular tissue were observed and the apoptotictesticular cells were examined. The Johnsen score reflected the quantitative assessment of seminiferous tubules(Fig. 1(d)). Significant damage to the seminiferous tubule was observed in the irradiated groups (P < 0:001).Quantitative analysis of spermatogenic cells apoptosis is shown in Fig. 1(h). A significant increase in TUNELpositivecells was found in the seminiferous tubule in the irradiated groups (P <0:001). Our results showed TUNELpositivespermatogenic cells were mainly spermatogonia, spermatocytes, early spermatids and late spermatids, andthese cells seemed to be initially more susceptible to CIR toxicity. | Li Hongyan Zhang Hong Xie Yi Di Cuixia | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 8 | 3-69 Effects of Carbon-ion Beam Irradiation on MSH2 Expression in HepG2 Cells显示文摘Primary liver cancer (namely hepatocellular carcinoma, HCC) represents the third most frequent cause of cancerdeath. National Comprehensive Cancer Network guidelines suggest that radiotherapy (RT) can be considered asan important role for unresectable HCC[1]. Heavy ion radiotherapy (e.g. carbon ion) has showed a strong role forkilling malignancies especially for radioresistant malignancies that are insensitive to conventional radiotherapy, suchas X-ray.The mismatch repair (MMR) is a highly conserved DNA repair pathway that recognizes and repairs base-pairingerrors during DNA replication or recombination. When the genes (mainly including MutS and MutL families) thatmediate MMR are mutated or epigenetically silenced, the predisposition to cancer is significantly increased. MMRdeficiency can be inherited, as in the case of Lynch syndrome also known as hereditary non-polyposis colorectalcarcinoma (HNPCC). MSH2 protein also can modulate the homologous recombination that is a prominent doublestrandbreak (DSB) repair pathway. | Miao Guoying Zhang Hong Di Cuixia | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 9 | 3-70 Capsazepine, a TRPV1 Antagonist, Enhances Radiation Sensitivity in Human Hepatocellular Carcinoma HepG2 Cells显示文摘Transient receptor potential vanilloid 1(TRPVl) that is known as capsaicin receptor is a non-selective cationion channel[1]. TRPV1 can regulate Ca2+ influx, participate in a variety of physiological and pathological processof tumor[2]. One such agent is Capsazepine (CPZ) that is now widely used as a selective vanilloid type 1 receptor(TRPV1) antagonist. CPZ can be directly actived on the capsaicin receptor, blocked its biological effects, and abolishedosteosarcoma-induced hyperalgesia when administered subcutaneously at doses ranging from 3 to 10 mg/kg,blocked calcium channels[3]. However, the mechanisms underlying the anticancer effects of CPZ have not fully beenunderstood. Whether CPZ can induce apoptosis of human hepatocellular carcinoma cell line HepG2 is not known.Therefore, the objective of the study reported here was to determine whether CPZ can enhance radiation sensitivityin HepG2 cell, and impact on cell proliferation. | Han Lu Di Cuixia Zhang Hong | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 10 | 外泌体作为药物载体的临床应用研究显示文摘Exosomes denote a family of nano-sized membrane extracellular vesicles with a diameter in the range of 40-130 nm that are secreted by most cell types of the body[1].Initial studies suggest that this extracellular vesicle is a metabolic waste that cells secrete.However,more and more studies have shown that exosomes act as mediators of cell-to-cell signaling and participate in a variety of physiological and pathological activities in organisms[2].Due to such characteristics,analyzing the specific biomarkers[3]carried therein is expected to be a non-invasive method for diagnosis and monitoring of tumors.Additionally,exosomes are not only important for tumor immunity,tumor invasion,metastasis and tumor resistance,but also has important value in the diagnosis and treatment of tumor.Exosomes can exert important effects in various disease models[4].Overall studies give an idea that exosomes play both cancer-promoting and malignant functions in malignant tumors[5]. | Zhang Hong Di Cuixia Li Hongyan | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 11 | 二烯丙基二硫协同重离子诱导的癌细胞内源性和外源性凋亡显示文摘Charged particle radiation may exert highly lethal effects even on radioresistant tumors.Although extensive researches are studying the carcinogenesis and carbon ion beam therapy,there is still space to improve the radiosensitivity to cervical cancer in order to reduce radiation dosage.The combination of particle therapy with drug is now rapidly gaining practice in clinics with great expectations for cancer cure[1��3].Thus,strategies to minimize the side effects of radiotherapy while preserving their radiotherapeutic efficacy are needed.Recently,significant attention has been focused on natural radio protective agent in vegetables and fruits.DADS,a major organosulfur compound derived from garlic,induces cell death in various cancer cells but shows little or no cytotoxicity in normal cells as single drugs.Therapeutic approaches based on the combination of high-LET carbon beams and DADS aim at increasing clinical responses while lowering the radiation dosages and cancer cell resistance.The advantage of combination stems from the fact that each one can have a single target or mechanism of action or this combination may share the same target or mechanism of action against cancer cells.Therefore,in this study,we clarify the effect of DADS on the radiation-regulated cell apoptosis,as well as alterations of crucial mediator of the apoptosis pathway in HeLa cells. | Di Cuixia Zhang Qianjing Chen Yuhong Zhang Hong | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 12 | Molecular Mechanism of SF3b1 in Carbon Ion Irradiation-Induced A poptosis in Cancer Cells显示文摘Charged particle radiation may exert highly lethal effects even on radioresistant tumors[1].Although extensive researches are studying the carcinogenesis and carbon ion beam therapy,there is still space to improve the radiosensitivity to cervical cancer in order to reduce radiation dosage. | Di Cuixia Chen Yuhong Zhang Xuetian Zhang Qianjing Zhang Hong Li Qiang | 2019 | IMP & HIRFL Annual Report2019，，1： | 0 |
| 13 | 重离子辐射诱导癌细胞非p53依赖的凋亡机制研究显示文摘Radiotherapy is widely used for the definitive and adjuvant treatment of numerous cancers[1].However,resistance to radiotherapy remains an important concern[2].Various factors including p53 mutation or deletion[3],overexpression of DNA repair proteins[4],and tumor microenvironment[5]have been proposed to play roles in radioresistance.Among the radioresistant factors,p53 mutation or deletion is regarded as a good candidate for radioresistant markers[6].The tumor suppressor p53 is well established as the guardian of the genome,regulating cell cycle arrest,DNA repair,senescence,and apoptosis[7].Mutation of p53 occurs in more than 50%of human cancers,which significantly increases cellular resistance to-irradiation[8].Additionally,there is growing evidence that mutation or deletion of p53 tumors cells is inherently resistant to radiation and perhaps other conventional anticancer treatments,i.e.,chemotherapy[9].This intrinsic mechanism of resistance is responsible for a significant number of tumor recurrences[10]. | Zhang Hong Xie Yi Di Cuixia Li Hongyan | 2017 | IMP & HIRFL Annual Report2017，，1： | 0 |
| 14 | 二烯丙基二硫辐射保护的分子机理研究显示文摘High-linear energy transfer(LET)heavy ions produce more cytotoxic and genotoxic damage to cells in comparison with low-LET ionizing irradiation,such as X-rays or-rays[1].Our previous studies demonstrated that exposure to heavy ions such as carbon ions caused decrease in testicular weight and sthenospermia,which affects the testicular development and breeding activity of males.The reason is that the organ systems with proliferating cells are very sensitive,and the testis is a radiosensitive organ.Additionally,in space travel,astronaut exposed to high-LET galactic cosmanic rays at higher radiation doses and dose rates than humans received on Earth.It is an unavoidable problem for long duration manned interplanetary missions.Furthermore,in hadrontherapy,although high-LET heavy ions as an innovative modality of high precision tool for the treatment of cancer such as testis and prostate tumor,potential damage to healthy tissues surrounding the tumor target along its penetrating path should still be considered.Given space radiation protection and cancer therapy,there is a demand for reliable agent for protection of the testis against heavy-ion radiation. | Di Cuixia Zhang Qianjing Zhang Hong | 2017 | IMP & HIRFL Annual Report2017，，1： | 0 |
| 15 | 二烯丙基二硫促进重离子诱导的癌细胞凋亡显示文摘Recently,significant attention has been focused on natural radiosensitive agent in vegetables and fruits[1].Diallyl disulfide(DADS;i.e,CH2=CH-CH2-S-S-CH2-CH=CH2),an oil-soluble compound extracted from garlic(Allium sativum L.)documents as a potent compound to prevent cancer,genotoxicity,nephrotoxicity,and hepatotoxicity[2].Although DADS has been reported to provide the anticancer activity in several cancer types by inhibiting cell cycle arrest and inducing apoptosis,the molecular effect of DADS on high-LET carbon beams-regulated proliferation,cell cycle arrest and cell death is currently unknown。 | Zhang Qianjing Di Cuixia Zhang Hong | 2017 | IMP & HIRFL Annual Report2017，，1： | 0 |
| 16 | 3 - 81 PCBP1 Promotes Inhibitory Effect of Ionizing Radiation on Cervical Cancer HeLa Cells显示文摘 | Di Cuixia Zhang Hong | 2012 | IMP & HIRFL Annual Report2012，，1： | 0 |
| 17 | 4-58 Role of Diallyl Disul de in Carbon Ion Beams{induced Cancer Cell Apoptosis显示文摘Cervical cancer represents the third most common cause of female mortality[1].Radiotherapy remains the mainstay of treatment,especially in advanced cervical cancer.The patients’survival rate can be determined by their responsiveness to radiotherapeutic treatment[2-4].Although conventional X-ray treatment is an effective modality for a wide variety of human cancers,poor results may sometimes occur.High linear energy transfer(LET)charged particle radiation has several potential advantages over the treatment with low-LET radiation,such as an inverted depth–dose distribution,a higher relative biological effectiveness,a reduction in oxygen enhancement ratio,and a lower cellular capability for repair of radiation injury,making it potentially superior to low-LET radiation,such as X-rays,in the treatment of malignant solid tumors. | Di Cuixia Zhang Hong | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
| 18 | 3 - 92 Radiosensitizing Effect of Diallyl Disulfide on S180 Sarcoma-bearing Mice显示文摘 | Xu Shuai Zhang Hong Liu Yang Zhao Qiuyue Di Cuixia Sun Chao Ma Xiaofei Li Hongyan | 2012 | IMP & HIRFL Annual Report2012，，1： | 0 |
| 19 | 3 - 93 Impact of Carbon Ion Irradiation on Cauda Epididymis Histology in Infant Mice显示文摘 | Li Hongyan Zhang Hong Xie Yi Liu Yang Di Cuixia Liu Yuanyuan | 2012 | IMP & HIRFL Annual Report2012，，1： | 0 |
| 20 | 4-64 Selective ATP Hydrolysis Inhibition in F1Fo ATP Synthase Enhances Radiosensitivity of Non-small-cell Lung Cancer Cells(A549)显示文摘F1Fo ATP synthase,or named ATPase(EC 3.6.1.3)(referred as the same enzyme hereafter)catalyzes the phosphorylation of ADP to ATP by exploiting a the transmembrane proton motive force(Δp)produced by the oxidation of nutrient substrates in mitochondrial respiration in all organisms.However,under peculiar physiological conditions when mitochondrial respiration is impaired which lead to the electrochemical gradient across the inner membrane collapse,the F1Fo ATP synthase switches its catalytic activity from ATP synthesis to ATP hydrolysis for maintaining theΔp. | Wang Yupei Zhang Hong Si Jing Zhou Rong Gan Lu Di Cuixia Sun Chao | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
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