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| 1 | Diabetes-related alterations in the enteric nervous system and its microenvironment显示文摘Gastric intestinal symptoms common among diabetic patients are often caused by intestinal motility abnormalities related to enteric neuropathy. It has recently been demonstrated that the nitrergic subpopulation of myenteric neurons are especially susceptible to the development of diabetic neuropathy. Additionally, different susceptibility of nitrergic neurons located in different intestinal segments to diabetic damage and their different levels of responsiveness to insulin treatment have been revealed. These findings indicate the importance of the neuronal microenvironment in the pathogenesis of diabetic nitrergic neuropathy. The main focus of this review therefore was to summarize recent advances related to the diabetes-related selective nitrergic neuropathy and associated motility disturbances. Special attention was given to the findings on capillary endothelium and enteric glial cells. Growing evidence indicates that capillary endothelium adjacent to the myenteric ganglia and enteric glial cells surrounding them are determinative in establishing the ganglionic microenvironment. Additionally, recent advances in the development of new strategies to improve glycemic control in type 1 and type 2 diabetes mellitus are also considered in this review. Finally, looking to the future, the recent and promising results of metagenomics for the characterization of the gut microbiome in health and disease such as diabetes are highlighted. | Mária Bagyánszki Nikolett Bódi | 2012 | World Journal of Diabetes2012，3，5： | 11 |
| 2 | Plasminogen kringle 5-engineered glioma cells block migration of tumor- associated macrophages and suppress tumor vascularization and progres- sion.显示文摘 | Perri SR Nalbantoglu J Annabi B Koty Z Lejeune L Francois M Di Falco MR Beliveau R Galipeau J | 2005 | 中国神经肿瘤杂志2005，3，3： | 8 |
| 3 | Human immunodeficiency virus-related primary central nervous system lymphoma: factors influencing survival in 111 patients显示文摘BACKGROUND: The current study evaluated factors influencing survival in patients diagnosed with human immunodeficiency virus (HIV)-related primary central nervous system lymphoma (PCNSL), with a focus on the effects of therapeutic radiotherapy (RT) and highly active antiretroviral therapy (HAART). METHODS: A retrospective chart review of patients with a diagnosis of HIV-related PCNSL at one of five university hospitals between 1987 and 1998 was performed. Clinical details including antiretroviral agent use, brain imaging scan results, RT use, and survival outcomes were recorded. RESULTS: One hundred eleven patients with HIV-related PCNSL were identified. The annual incidence decreased significantly between 1992 and 1995 and between 1996 and 1998 (P=0.04). | Newell ME Hoy JF Cooper SG DeGraaff B Grulich AE Bryant M Millar JL Brew BJ Quinn DI | 2004 | 中国神经肿瘤杂志2004，2，2： | 4 |
| 4 | Alleviated mucosal and neuronal damage in a rat model of Crohn's disease显示文摘AIM:To establish a rat model suitable to investigate the repetitive relapsing inflammations(RRI)characteristic to Crohn’s disease.METHODS:Colitis was induced by 2,4,6-trinitrobenzenesulfonic acid(TNBS).RRI were mimicked by repeating administrations of TNBS.Tissue samples were taken from control,once,twice and three times treated rats from the inflamed and adjacent non-inflamed colonic segments at different timepoints during the acute intestinal inflammation.The means of the ulcerated area were measured to evaluate the macroscopic mu-cosal damage.The density of myenteric neurons was determined on whole mounts by Hu C/Hu D immunohistochemistry.Heme oxygenase-1(HO-1)expression was evaluated by molecular biological techniques.RESULTS:TNBS-treated rats displayed severe colitis,but the mortality was negligible,and an increase of body weight was characteristic throughout the experimental period.The widespread loss of myenteric neurons,and marked but transient HO-1 up-regulation were demonstrated after the first TNBS administration.After repeated doses the length of the recovery time and extent of the ulcerous colonic segments were markedly decreased,and the neuronal loss was on a smaller scale and was limited to the inflamed area.HO-1 m RNA level was notably greater than after a single dose and overexpression was sustained throughout the timepoints examined.Nevertheless,the HO-1protein up-regulation after the second TNBS treatment proved to be transient.Following the third treatment HO-1 protein expression could not be detected.CONCLUSION:Experimentally provoked RRI may exert a protective preconditioning effect against the mucosal and neuronal damage.The persistent up-regulation of HO-1 m RNA expression may correlate with this. | Petra Talapka Lajos István Nagy Alexandra Pál Marietta Zita Poles Anikó Berkó Mária Bagyánszki László Géza Puskás éva Fekete Nikolett Bódi | 2014 | World Journal of Gastroenterology2014，20，44： | 3 |
| 5 | Structural and molecular features of intestinal strictures in rats with Crohn's-like disease显示文摘AIM: To develop a new rat model we wanted to gain a better understanding of stricture formation in Crohn's disease(CD).METHODS: Chronic colitis was induced locally by the administration of 2,4,6-trinitrobenzenesulfonic acid(TNBS). The relapsing inflammation characteristic to CD was mimicked by repeated TNBS treatments. Animals were randomly divided into control, once, twice and three times TNBS-treated groups. Control animals received an enema of saline. Tissue samples were taken from the strictured colonic segments and also adjacent proximally and distally to its 60, 90 or 120 d after the last TNBS or saline administrations. The frequency and macroscopic extent of the strictures were measured on digital photographs. The structural features of strictured gut wall were studied by light- and electron microscopy. Inflammation related alterations in TGF-beta 2 and 3, matrix metalloproteinases 9(MMP9) and TIMP1 m RNA and protein expression were determined by quantitative real-time PCR and western blot analysis. The quantitative distribution of caspase 9 was determined by post-embedding immunohistochemistry.RESULTS: Intestinal strictures first appeared 60 d after TNBS treatments and the frequency of them increased up to day 120. From day 90 an intact lamina epithelialis, reversible thickening of lamina muscularis mucosae and irreversible thickening of the muscularis externa were demonstrated in the strictured colonic segments. Nevertheless the morphological signs of apoptosis were frequently seen and excess extracellular matrix deposition was recorded between smooth muscle cells(SMCs). Enhanced caspase 9 expression on day 90 in the SMCs and on day 120 also in myenteric neurons indicated the induction of apoptosis. The m RNA expression profile of TGF-betas after repeated TNBS doses was characteristic to CD, TGF-beta 2, but not TGF-beta 3 was up-regulated. Overexpression of MMP9 and down-regulation of TIMP1 were demonstrated. The progressive increase in the amount of MMP9 protein in the strictures was also obvious between days 90 and 120 but TIMP1 protein was practically undetectable at this time.CONCLUSION: These findings indicate that aligned structural and molecular changes in the gut wall rather than neuronal cell death play the primary role in stricture formation. | Petra Talapka Anikó Berkó Lajos István Nagy Lalitha Chandrakumar Mária Bagyánszki László Géza Puskás éva Fekete Nikolett Bódi | 2016 | World Journal of Gastroenterology2016，22，22： | 3 |
| 6 | 遗传性肥胖与心房颤动的关系显示文摘观察性研究已经确定了体质量指数(body mass index,BMI)与心房颤动之间的关联。然而,从观察性研究中推断因果关系会受到混杂因素、逆因果关系和偏倚的影响。该研究的主要目的是应用BMI的遗传学预测因子评估BMI与心房颤动之间的因果关系。方法:纳入1987-2002年期间在美国、冰岛和荷兰实施的7个前瞻性人群队列研究中基线无心房颤动的欧洲血统个体51 646人, | 刘莉 叶鹏 Chatterjee NA Giulianini F Geelhoed B Lunetta KL Misialek JR Niemeijer MN Rienstra M Rose LM Smith AV Arking DE Ellinor PT Heeringa J Lin H Lubitz SA Soliman EZ Verweij N Alonso A Benjamin EJ Gudnason V Stricker BH van der Harst P Chasman DI Albert CM | 2017 | 中华高血压杂志2017，25，2： | 2 |
| 7 | Effect of various surface modifications of wood flour on the properties of PP/wood composites显示文摘 | Lívia Dányádi János Móczó Béla Pukánszky | 2009 | Composites Part A2009，，2： | 2 |
| 8 | Low plateletalpha2beta1 levels in type I von Willebrand disease correlate withimpaired platelet function in a high shear stress system显示文摘 | Di Paola J Federici A B Mannucci P M | 1999 | Blood1999，93，11： | 1 |
| 9 | Artificial neural networks allow the use of simultaneous measurements of Alzheimer disease markers for early detection of the disease显示文摘 | Di Luca M Grossi E Borroni B | 2005 | J Transl Med2005，3，： | 1 |
| 10 | Determination the temperature of petroleum formation from the kinetic properties of petroleum asphaltenes显示文摘 | Rolando di Primio Horsfield B Guzman-Vega M A | 2000 | Nature2000，406，： | 1 |
| 11 | Deter- mining the temperature of petroleum formation from the kinetic properties of petroleum asphaltenes显示文摘 | DI PRIMIO R HORSFIELD B GUZMAN-VEGA M A | 2000 | Nature2000，406，： | 1 |
| 12 | Expression of Gn- RH receptor gene in human ectopie endometrial cells and inhi- bition of their proliferation by leuprolide acetate显示文摘 | Borroni R Di Blasio A M Gaffuri B | 2000 | Mol Cell Endocrinol2000，159，122： | 1 |
| 13 | Successful use of central venous catheter as permanent hemodialysis access:84-month follow-up in lucania显示文摘 | Di Ioril B Lopez T Procida M | 2001 | Blood pu nif2001，19，1： | 1 |
| 14 | Kinetic and catalytic aspects of the formation of poly( ethylene tereph- thalate) (PET) investigated with model molecules 显示文摘 | APICELLA B DI SERIO M FIOCCA L | 1998 | J App Polymer Sci1998，69，12： | 1 |
| 15 | Vasopressin and thirst in patients with posterior pituitary ectopia and hypopituitarism显示文摘 | Lu-Kezic M Righini V di Natale B | 2000 | Clin Endocrinol(Oxf)2000，53，1： | 1 |
| 16 | Successful use of central venous catheter as permanent hemodialysis access:84-month follow-Up in lucania显示文摘 | Di Iorio B Lopez T Procida M | 2001 | Blood Purif2001，19，1： | 1 |
| 17 | Improvement of solubility and stability of valsartan by hydroxypropyl-\boldbeta-cyclodextrin 显示文摘 | CAPPELLO B DI MAIO C IERVOLINO M | 2006 | J lrtcl Phenom Macro2006，54，3： | 1 |
| 18 | Interrelationship between the phar- macokinetics and pharmacodynamies of cefaelor advanced formulation in patients with acute exacetbation of chronic bronchitis显示文摘 | Cazzola M Di Perna E Boveri B | 2000 | J Chemother2000，12，3： | 1 |
| 19 | Effect of various surface modifications of wood flour on the properties of PP/wood Composites显示文摘 | Lívia Dányádi János Móczó Béla Pukánszky | 2010 | Composites Part A:Applied Polymer Science2010，41，2： | 1 |
| 20 | Determin-ing the temperature of petroleum formation from the kinet-ic properties of petroleum asphaltenes显示文摘 | Primio R di Horsfield B Guzman Vega M A | | 0，，： | 1 |
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