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| 1 | 己酮可可碱对肺结节病患者肺泡巨噬细胞释放细胞因子的作用显示文摘目的 研究己酮可可碱 (POF)对肺结节病患者肺泡巨噬细胞 (AM)产生细胞因子的作用 ,并与地塞米松 (DEX)的作用相比较。方法 收集 1 4例活动期肺结节病患者的AM ,以 1 0 %RPMI为培养液 (含有 1 0 %热灭活胎牛血清、2mmol/LL 谷氨酰胺、2 0 0kU/L青霉素及 2 0 0mg/L链霉素 ) ;或1 0 %RPMI加内毒素 (LPS ,1 0 0 μg/L) ;或分别加入浓度为 0 0 1mmol/L、0 1mmol/L和1mmol/L的POF ;或加入 0 1mmol/LDEX进行AM培养 2 4h。用酶联免疫吸附 (ELISA)法测定培养上清液中细胞因子含量。结果 POF对结节病患者AM自发释放的肿瘤坏死因子α(TNF α)有剂量依赖性抑制作用 (P <0 0 0 1 ) ,而对其他自发释放的细胞因子无影响。 0 1mmol/LDEX抑制自发释放的TNF α、可溶性肿瘤坏死因子受体 (sTNFR 2 )、白细胞介素 (IL) 1 β和IL 1 0 (P <0 0 0 1或 <0 0 5 或 <0 0 1 )。除sTNFR 1外 ,POF亦抑制这些由LPS刺激的AM释放的细胞因子 (P <0 0 5或 <0 0 0 1 )。与POF相似 ,0 1mmol/LDEX同样抑制这些LPS刺激的细胞因子释放 (P <0 0 5或 <0 0 0 1 ) ,但对sTNFR 1和IL 1 β无影响。 结论 与DEX相比 ,POF有更宽的治疗窗。用在结节病治疗上可以减少皮质激素用量或可将其替代。 | 童朝辉 代华平 陈宝敏 王辰 Josune Guzman Ulrich Costabel | 2003 | 中华结核和呼吸杂志2003，26，7： | 9 |
| 2 | Stem cell treatment and cerebral palsy: Systemic review and meta-analysis显示文摘BACKGROUND Perinatal complications may result in life-long morbidities,among which cerebral palsy(CP)is the most severe motor disability.Once developed,CP is a nonprogressive disease with a prevalence of 1-2 per 1000 live births in developed countries.It demands an extensive and multidisciplinary care.Therefore,it is a challenge for our health system and a burden for patients and their families.Recently,stem cell therapy emerged as a promising treatment option and raised hope in patients and their families.AIM The aim is to evaluate the efficacy and safety of stem cell treatment in children with CP using a systematic review and meta-analysis METHODS We performed a systematic literature search on PubMed and EMBASE to find randomized controlled clinical trials(RCT)investigating the effect of stem cell transplantation in children with CP.After the review,we performed a randomeffects meta-analysis focusing on the change in gross motor function,which was quantified using the gross motor function measure.We calculated the pooled standardized mean differences of the 6-and/or 12-mo-outcome by the method of Cohen.We quantified the heterogeneity using the I-squared measure.RESULTS We identified a total of 8 RCT for a qualitative review.From the initially selected trials,5 met the criteria and were included in the meta-analysis.Patients’population ranged from 0.5 up to 35 years(n=282).We detected a significant improvement in the gross motor function with a pooled standard mean difference of 0.95(95%confidence interval:0.13-1.76)favoring the stem cell group and a high heterogeneity(I2=90.1%).Serious adverse events were rare and equally distributed among both intervention and control groups.CONCLUSION Stem cell therapy for CP compared with symptomatic standard care only,shows a significant positive effect on the gross motor function,although the magnitude of the improvement is limited.Short-term safety is present and further highquality RCTs are needed. | Simone Eggenberger Céline Boucard Andreina Schoeberlein Raphael Guzman Andreas Limacher Daniel Surbek Martin Mueller | 2019 | World Journal of Stem Cells2019，11，10： | 8 |
| 3 | 低社会经济地位与美国成年人早发冠状动脉粥样硬化性心脏病的关系显示文摘低社会经济地位(socioeconomic status,SES)的个体承担着不成比例的冠状动脉粥样硬化性心脏病(coronary heart disease,CHD)负担。在美国低收入地区,CHD仍然是死亡的主要原因。该研究旨在评估美国低SES个体的过量CHD负担,以及传统风险因素和与低SES相关因素影响所占的比例。 | Hamad R Penko J Kazi DS Coxson P Guzman D Pengxiao C.Wei Mason A Wang EA Goldman L Fiscella K Bibbins-Domingo K 周卫(译) 刘莉(审校) | 2020 | 中华高血压杂志2020，28，7： | 7 |
| 4 | Differences in standing balance between patients with diplegic and hemiplegic cerebral palsy显示文摘Maintaining standing postural balance is important for walking and handling abilities in patients with cerebral palsy.This study included 23 patients with cerebral palsy(seven with spastic diplegia and16 with spastic hemiplegia),aged from 7 to 16 years of age.Standing posture balance measurements were performed using an AMTI model OR6-7 force platform with the eyes open and closed.Patients with diplegic cerebral palsy exhibited greater center of pressure displacement areas with the eyes open and greater center of pressure sway in the medial-lateral direction with the eyes open and closed compared with hemiplegic patients.Thus,diplegic patients exhibited weaker postural balance control ability and less standing stability compared with hemiplegic cerebral palsy patients. | Valeska Gatica Rojas Guillermo Méndez Rebolledo Eduardo Guzman Muoz Natalia Ibarra Cortés Caterine Berrios Gaete Carlos Manterola Delgado | 2013 | Neural Regeneration Research2013，8，26： | 6 |
| 5 | Gamma-aminobutyric acid A receptors in Alzheimer's disease: highly localized remodeling of a complex and diverse signaling pathway显示文摘Alzheimer’s disease(AD),the predominant form of dementia,is a chronic,incurable neurodegenerative disorder presenting with symptoms includ-ing progressive memory loss and disturbed emotional state.It has been estimated that dementia affects over 47 million people worldwide(Prince et al.,2015),and with 60–80%of cases attributable to AD.The primary pathological hallmarks of AD are neuronal death,the deposition of insolu-ble amyloid-beta(Aβ)plaques,the accumulation of hyperphosphorylated tau neurofibrillary tangles(NFTs),and the widespread dysregulation | Andrea Kwakowsky Beatriz Calvo-Flores Guzman Karan Govindpani Henry J. Waldvogel Richard L. Faull | 2018 | Neural Regeneration Research2018，13，8： | 4 |
| 6 | Treatment of Displaced Calcaneus Fractures Using a Minimally Invasive Sinus Tarsi Approach显示文摘 | Hospodar Paul Guzman Camilo Johnson Paul Uhl Richard | 2008 | Orthopedics (Online)2008，，11： | 3 |
| 7 | Morphological Characterization and Hydrodynamic Behavior of Shortfin Mako Shark(Isurus oxyrinchus)Dorsal Fin Denticles显示文摘The shortfin mako shark(Isurus oxyrinchus)is one of the fastest marine fishes,reaching speeds of up to 70 km·h^-1.Their speed is related to the skin surface design composed of dermal denticles.Denticles vary in size and shape according to placement on the body and minimize turbulence around the body.The objective of this study is to analyze the interaction between seawater flow and denticles on the dorsal fin.High-resolution microscopy(scanning electron microscopy and confocal microscopy)were used to measure defined parts of the dermal denticles.These measurements,along with ratios based on length-to-width define three morphologies(rounded,semi-rounded,long)that were 3D reconstructed.Computational fluid dynamics simulated fluid passage over reconstructed denticles and describe hy-drodynamic efficiency under different conditions.An increase in angle of inclination produced a relevant increase in the drag coefficient,especially for high velocity inlets.The lowest drag coefficient values were found in long and semi-rounded,followed by rounded mor-phologies.The hydrodynamic behavior of shark skin demonstrates a relation to the morphological characteristics of dermal denticles on the dorsal fin.It is concluded that the best hydroefficiency relies on the rounded morphology and may serve to design hydrodynamically efficient surfaces or manmade assemblies. | Fernandez-Waid Patricia Diez Guzman Bidaguren Inigo Izagirre Urtzi Blanco Jesus Maria Soto Manu | 2019 | Journal of Bionic Engineering2019，16，4： | 3 |
| 8 | Ambient air quality and the risk for Chronic Obstructive Pulmonary Disease among Metro Manila Development Authority traffic enforcers in Metro Manila:An exploratory study显示文摘Background::Air pollution and poor ambient air quality are significantly related to multiple health risks.One associated disease is chronic obstructive pulmonary disease(COPD),a preventable disease with several contributing factors and one of the leading causes of morbidity/mortality locally and globally.A potentially high-risk population are traffic enforcers who are constantly exposed to air pollution.In the Philippines,the MMDA has the widest coverage in traffic management.The study determined the risk of COPD among Metro Manila Development Authority(MMDA)traffic enforcers in relation to ambient air quality level,as well as identified other factors that increase the risk of developing COPD.Methods::Fifty-two MMDA traffic enforcers deployed in PM 2.5 air quality sensor areas in Metro Manila from 2016 to 2018 were recruited through stratified sampling.The International Primary Airways Guidelines(IPAG)questionnaire was utilized to measure risk of COPD.Respiratory health and working history were obtained through questionnaires.Department of environment and natural resources provided PM 2.5 ambient air quality data which aided in the construction of the Exposure-Month Index.Ordinal logistic regression was used to examine the association of PM 2.5 together with the relevant factors and the risk of COPD.Results::We found statistically significant associations between PM 2.5 and COPD among high risk category[odds risk(OR):1.24,95%confidence interval(CI):1.07-1.44].Age(Moderate,OR:1.16,95%CI:0.98-1.38 and High,OR:10.06,95%CI:4.02-25.17)and chest pain(Moderate,OR:68.65,95%CI:1.71-2.75×103)were potential risk factors,whereas body mass index(BMI)(OR:0.05,95%CI:0.01-0.53)exhibited protective effect.Conclusions::Exposure to PM 2.5 was associated with an increased risk of COPD among high-risk category MMDA traffic enforcers.Age and chest pain were potential risk factors to risk of COPD,whereas BMI exhibited a potential protective effect.Results of this study can be used for clinical management of high-risk populations,such that of MMDA traffic enforcers. | Xerxes Seposo Audrey Lynn A.Arcilla Jose Guillermo N.De Guzman III Enrico Miguel S.Dizon Andrea Nova R.Figuracion Christina Micaela M.Morales Pauleena Katriona A.Tugonon Geminn Louis C.Apostol | 2021 | Chronic Diseases and Translational Medicine2021，7，2： | 3 |
| 9 | IL-12I、L-18和TNF-α在外源性过敏性肺泡炎发病中的作用显示文摘目的从临床的角度出发、评价肺泡巨噬细胞(alveolar macrophages,AM)的产物白介素-12(IL-12)、白介素-18(IL-18)和肿瘤坏死因子-α(TNF-α)在外源性过敏性肺泡炎(extrinsic allergic alveolitis,EAA)炎症形成及发病中的作用。方法收集11例EAA患者和10例正常对照的AM,以10%RPMI(含有10%热灭活胎牛血清、2 mmol/LL-谷氨酰胺、200 kU/L青霉素及200mg/L链霉素)为培养液,加或不加内毒素(LPS,100μg/L)进行AM培养24 h。用ELISA方法测定培养上清液中细胞因子含量。结果与对照组相比,无论有无内毒素刺激,IL-18和TNF-α的水平在EAA患者中均明显增加(P<0.05或P<0.01)。EAA患者自发释放的IL-12的水平很低,内毒素刺激后明显升高(P<0.01)。结论IL-12、IL-18和TNF-α可能参与EAA炎症和肉芽肿形成过程,在其发病中起重要作用。 | 童朝辉 陈宝敏 王辰 Guzman Josune Costabel Ulrich | 2006 | 首都医科大学学报2006，27，1： | 3 |
| 10 | 小胶质细胞介导的神经元周围网络降解促进疼痛显示文摘周围神经损伤后脊髓背角小胶质细胞激活促进疼痛敏化产生。活化的小胶质细胞如何选择性地增强脊髓伤害性感受通路的机制目前尚不清楚。该研究发现在周围神经损伤后,小胶质细胞降解脊髓背角I层细胞外基质结构以及神经元周围网络(PNNs)。位于脊髓背角I层的PNNs选择性地包裹脊髓-臂旁核投射神经元,整合脊髓伤害性感受信息,并向脊髓上脑区传递并诱发疼痛感觉。小胶质细胞对PNNs的降解增强了投射神经元的活动并诱导疼痛相关行为。因此,神经损伤诱导的PNNs降解是小胶质细胞选择性地增加脊髓伤害性感受通路信号输出并引起疼痛敏化的一种机制。 | 袁宝童(译) 高永静(校) Tansley S Gu N Guzman AU | 2022 | 中国疼痛医学杂志2022，28，10： | 3 |
| 11 | A transparent aqueous-saturated sand surrogate for use in physical modeling显示文摘 | Ivan L. Guzman Magued Iskander Eduardo Suescun-Florez Mehdi Omidvar | 2014 | Acta Geotechnica2014，，2： | 3 |
| 12 | The anti-microbial peptide LL-37 modulates immune responses in the palatine tonsils where it is exclusively expressed by neutrophils and a subset of dendritic cells显示文摘 | Sigrun L. Sigurdardottir Ragna H. Thorleifsdottir Andrew M. Guzman Gudmundur H. Gudmundsson Helgi Valdimarsson Andrew Johnston | 2011 | Clinical Immunology2011，，2： | 2 |
| 13 | Current systematic reviews and meta-analyses of COVID-19显示文摘BACKGROUND Coronavirus disease 2019(COVID-19)has left a significant impact on the world's health,economic and political systems;as of November 20,2020,more than 57 million people have been infected worldwide,with over 1.3 million deaths.While the global spotlight is currently focused on combating this pandemic through means ranging from finding a treatment among existing therapeutic agents to inventing a vaccine that can aid in halting the further loss of life.AIM To collect all systematic reviews and meta-analyses published related to COVID-19 to better identify available evidence,highlight gaps in knowledge,and elucidate further meta-analyses and umbrella reviews that are yet to be performed.METHODS We explored studies based on systematic reviews and meta-analyses with the keyterms,including severe acute respiratory syndrome(SARS),SARS virus,coronavirus disease,COVID-19,and SARS coronavirus-2.The included studies were extracted from Embase,Medline,and Cochrane databases.The publication timeframe of included studies ranged between January 01,2020,to October 30,2020.Studies that were published in languages other than English were not considered for this systematic review.The finalized full-text articles are freely accessible in the public domain.RESULTS Searching Embase,Medline,and Cochrane databases resulted in 1906,669,and 19 results,respectively,that comprised 2594 studies.515 duplicates were subsequently removed,leaving 2079 studies.The inclusion criteria were systematic reviews or meta-analyses.860 results were excluded for being a review article,scope review,rapid review,panel review,or guideline that produced a total of 1219 studies.After screening articles were categorized,the included articles were put into main groups of clinical presentation,epi-demiology,screening and diagnosis,severity assessment,special populations,and treatment.Subsequently,there was a second subclassification into the following groups:gastrointestinal,cardiovascular,neurological,stroke,thrombosis,anosmia and dysgeusia,ocular manifestations,nephrology,cutaneous manifestations,D-dimer,lymphocyte,anticoagulation,antivirals,convalescent plasma,immunosuppressants,corticosteroids,hydroxychloroquine,renin-angiotensin-aldosterone system,technology,diabetes mellitus,obesity,pregnancy,children,mental health,smoking,cancer,and transplant.CONCLUSION Among the included articles,it is clear that further research is needed regarding treatment options and vaccines.With more studies,data will be less heterogeneous,and statistical analysis can be better applied to provide more robust clinical evidence.This study was not designed to give recommendations regarding the management of COVID-19. | Mahmoud Nassar Nso Nso Mostafa Alfishawy Anastasia Novikov Salim Yaghi Luis Medina Bahtiyar Toz Sofia Lakhdar Zarwa Idrees Yungmin Kim Dawa Ongyal Gurung Raheel S Siddiqui David Zheng Mariam Agladze Vikram Sumbly Jasmine Sandhu Francisco Cuevas Castillo Nadya Chowdhury Ravali Kondaveeti Sakil Bhuiyan Laura Guzman Perez Riki Ranat Carlos Gonzalez Harangad Bhangoo John Williams Alaa Eldin Osman Joyce Kong Jonathan Ariyaratnam Mahmoud Mohamed Ismail Omran Mariely Lopez Akwe Nyabera Ian Landry Saba Iqbal Anoosh Zafar Gondal Sameen Hassan Ahmed Daoud Bahaaeldin Baraka Theo Trandafirescu Vincent Rizzo | 2021 | World Journal of Virology2021，10，4： | 2 |
| 14 | Application of central composite designs to the preparation of poly caprolactone nanoparticles by solvent displacement 显示文摘 | Molpeceres J Guzman M Aberturas MR | 1996 | J Pharm Sci1996，85，： | 2 |
| 15 | 己酮可可碱对外源性过敏性肺泡炎治疗作用的初步研究显示文摘目的 通过研究己酮可可碱 (POF)对外源性过敏性肺泡炎 (EAA)患者肺泡巨噬细胞(AM)产生的细胞因子的作用 ,探讨其治疗EAA的可能性 ,并与地塞米松 (DEX)的作用进行比较。方法 入选EAA患者 9例 ,通过支气管肺泡灌洗收AM ,并以 10 %RPMI为培养液或 10 %RPMI加内毒素 (LPS ,10 0 μg/L) ;或分别加入浓度为 0 0 1mmol/L、0 1mmol/L、1mmol/L的POF ;或加入 0 1mmol/LDEX进行AM培养 2 4h。用ELISA方法测定培养上清液中细胞因子含量。结果 POF可抑制EAA患者AM自发释放的TNFα和IL 10 ,此作用有剂量依赖关系 (P <0 0 0 1和P <0 0 5 )。POF对其他自发释放的细胞因子则无影响。 0 1mmol/LDEX只抑制自发释放的TNFα(P <0 0 5 )。除IL 1β和可溶性肿瘤坏死因子受体外 ,POF和 0 1mmol/LDEX均抑制LPS刺激的其他细胞因子的释放 (P <0 0 0 1或P <0 0 1或P <0 0 5 )。结论 POF对EAA的炎症有一定的抑制作用 ,然而POF治疗EAA及其他肺部疾病的临床价值 ,需要进一步的临床试验来评价。 | 童朝辉 陈宝敏 代华平 王辰 Josune Guzman Ulrich Costabel | 2004 | 中华医学杂志2004，84，6： | 2 |
| 16 | 防晒用 大豆油活性成分显示文摘在护肤和护发产品中加入紫外线吸收剂已经变得非常普遍。现在大豆油作为一种新的防晒活性成分开始大量使用到护肤和护发产品中,并对其他紫外线吸收剂形成竞争压力。2002年初美国农业部(USDA)所属的农业研究服务所(ARS)获得了这项专利,它们的新产品名为SoyScreen,由大豆油和阿魏酸为原料制成,是一种广谱紫外线光吸收剂。 | Doris de Guzman | 2003 | 化工文摘2003，，2： | 2 |
| 17 | Comparison between hepaticojejunostomy and hepaticoduodenostomy after excision of choledochal cyst in children:a cohort study显示文摘Objective Hepaticojejunostomy(HJ)and hepaticoduodenostomy(HD)are commonly used biliary reconstruction techniques after choledochal cyst excision.HD has been suggested to be a more physiologic alternative during reconstruction.The objective of this study is to compare operative time,hospital stay,morbidity(leak,cholangitis,ileus,and obstruction),and mortality between HJ and HD after cyst excision.Methods This is a 14-year retrospective cohort study of pediatric patients(≤18 years old)who underwent choledochal cyst excision and subsequent biliary reconstruction at the Philippine Children’s Medical Center.Data were taken from inpatient charts,operative technique,OPD logbook,readmission,and OPD charts.results There were 122 patients:56%HD and 44%HJ.Majority were female(72%),with 1:2.6 male to female ratio.The average age was 36.1 months,with a mean follow-up of 32.8 months(range 6 months-14 years).The most common cyst was type I(87%).Operative time was longer for HJ compared with HD(321.3 vs 203.6 min;p=0.000).Hospital stay was longer with HJ compared with HD(7.7 vs 6.8 days;p=0.002).Mortality rate was low at 1.6%while morbidity was at 13.9%in both groups.Although morbidity was higher among those who underwent HD,there was no significant difference between the two procedures.Anastomotic leak(4%)and cholangitis(7.4%)were observed in HD,and ileus(7.4%)was observed in the HJ group.Conclusions In our series,HD provided less operative time and hospital stay than with HJ.We did not observe bile gastritis after HD as compared with others.It is suggested that longer follow-up is needed to confirm such findings. | Johann Paulo Suico Guzman Leandro L Resurreccion III Marcus Lester R Suntay Renato G Bernaldez | 2019 | World Journal of Pediatric Surgery2019，2，2： | 2 |
| 18 | Clinical and radiographic subtypes of vascular cognitive impairment in a clinic-based cohort study显示文摘 | Kenneth Rockwood Sandra E. Black Xiaowei Song David B. Hogan Serge Gauthier Chris MacKnight Robert Vandorpe Antonio Guzman Patrick Montgomery Andrew Kertesz Remi W. Bouchard Howard Feldman | 2005 | Journal of the Neurological Sciences2005，，1： | 2 |
| 19 | 大链壶菌卵孢子的研究 2.葵花子浸膏人工培养卵孢子的研究显示文摘通过实验研究了葵花子浸膏(SFE)用于人工培养大链壶菌卵孢子的可行性以及其最适浓度。并比较了不同接种物的培养效果。 | 苏晓庆 D. R. Guzman | 1990 | 贵阳医学院学报1990，15，2： | 2 |
| 20 | Development and test verification of air temperature model for Chinese solar and Spainish Almeria-type greenhouses显示文摘Growth can be defined as an increment in biomass or an increment in weight or height of the organs of the plant influenced by physiological processes.Many of these processes have their limits genetically determined,but climate and irrigation play an important role.Because of its importance,microclimate has been extensively studied in the modeling as a surrounding condition which is imposed by the exterior climate.The main objective of this work was to develop a temperature model based on the energy balance dynamics at two different greenhouse locations-South-eastern Spain and Northern China,and the traditional structures of Chinese solar greenhouse and Almería-type multi-span greenhouse were taken into account.The final model was developed by combining the external conditions,the actuator influence and the crop growth,where the temperature is influenced by soil,crop,cover,actuators,back wall and greenhouse geometry.The model took into account the energy lost by convective and conductive fluxes,as well as the energy supplied by solar radiation and heating systems.The soil and the back wall are the main media for energy storage.The temperature dynamic was determined by a physical model,which considered the energy balance from a holistic point of view-as a sub-model for a customizable interface among the external climate,the plant and the greenhouse system.The influences of different subsystems included in the temperature model were analyzed and evaluated.The results showed a high R^(2)value of 0.94 for Beijing and 0.95 for Almeria,and the average error was low,of which the MAE and RMSE were 0.71 and 1.365 for Almeria and 0.62 and 1.102 for Beijing,respectively.Thus,the model can be considered as a powerful tool for control design purposes in microclimate systems. | Jorge Antonio Sanchez-Molina Li Ming Francisco Rodriguez Jose Luis Guzman Wang Hui Yang Xinting | 2017 | International Journal of Agricultural and Biological Engineering2017，10，4： | 2 |
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