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| 1 | Genome-wide MicroRNA Expression Profiles in COPD: Early Predictors for Cancer Development显示文摘Chronic obstructive pulmonary disease(COPD) significantly increases the risk of developing cancer. Biomarker studies frequently follow a case-control set-up in which patients diagnosed with a disease are compared to controls. Longitudinal cohort studies such as the COPD-centered German COPD and SYstemic consequences-COmorbidities NETwork(COSYCONET) study provide the patient and biomaterial base for discovering predictive molecular markers. We asked whether microRNA(miRNA) profiles in blood collected from COPD patients prior to a tumor diagnosis could support an early diagnosis of tumor development independent of the tumor type. From 2741 participants of COSYCONET diagnosed with COPD, we selected 534 individuals including 33 patients who developed cancer during the follow-up period of 54 months and 501 patients who did not develop cancer, but had similar age, gender and smoking history. Genome-wide miRNA profiles were generated and evaluated using machine learning techniques. For patients developing cancer we identified nine miRNAs with significantly decreased abundance(two-tailed unpaired t-test adjusted for multiple testing P < 0.05), including members of the miR-320 family. The identified mi RNAs regulate different cancer-related pathways including the MAPK pathway(P = 2.3 x 10^(-5)). We also observed the impact of confounding factors on the generated miRNA profiles, underlining the value of our matched analysis. For selected miRNAs, qRT-PCR analysis was applied to validate the results. In conclusion, we identified several miRNAs in blood of COPD patients, which could serve as candidates for biomarkers to help identify COPD patients at risk of developing cancer. | Andreas Keller Tobias Fehlmann Nicole Ludwig Mustafa Kahraman Thomas Laufer Christina Backes Claus Vogelmeier Caroline Diener Frank Biertz Christian Herr Rudolf A. Jorres Hans-Peter Lenhof Eckart Meese Robert Bals | 2018 | Genomics, Proteomics & Bioinformatics2018，16，3： | 9 |
| 2 | A systematic review and meta-analysis of laparoscopic versus open distal pancreatectomy for benign and malignant lesions of the pancreas: It’s time to randomize显示文摘 | Arianeb Mehrabi Mohammadreza Hafezi Jalal Arvin Majid Esmaeilzadeh Camelia Garoussi Golnaz Emami Julia K?ssler-Ebs Beat Peter Müller-Stich Markus W. Büchler Thilo Hackert Markus K. Diener | 2014 | Surgery2014，，： | 4 |
| 3 | Distal Pancreatectomy: Risk Factors for Surgical Failure in 302 Consecutive Cases显示文摘 | J?rg Kleeff Markus K. Diener Kaspar Z?graggen Ulf Hinz Markus Wagner Jeannine Bachmann J?rg Zehetner Michael W. Müller Helmut Friess Markus W. Büchler | 2007 | Annals of Surgery2007，，4： | 3 |
| 4 | 不锈钢研发的最新进展——奥氏体、铁素体和双相不锈钢显示文摘评价了近期不锈钢的部分工业发展状况。对于奥氏体不锈钢而言,有两大引人注目的合金开发方向:低镍奥氏体不锈钢和高氮奥氏体不锈钢。这两类合金的设计目的不同,尤其是强度方面,但其合金开发原理和科研方法很相似,都围绕着氮这一合金元素对强度、塑性和耐蚀性的积极作用展开。现在人们已经相当了解氮对固溶强化、晶界强化和加工硬化的影响以及如何充分利用这些影响来开发全球市场所需的材料。在耐蚀性方面,铁素体、奥氏体和双相不锈钢彼此竞争,有关其耐蚀性比较的实验室数据也越来越多。但是,对于实际应用和合金选择而言,仅仅是实验室的数据是不够的,因此文章给出了多年来对24种工业生产的不锈钢暴露在室外海洋大气环境下的最新耐蚀性研究结果。希望在不久的将来能将更多制造商提供的钢种纳入到此项耐蚀性研究中来。这既能帮助消费者合理地选择合金,也可以帮助钢铁生产企业开发合适的钢种。 | Markus O Speidel Markus Diener | 2011 | 世界钢铁2011，11，1： | 3 |
| 5 | The Satisfaction With Life Scale显示文摘 | Ed Diener Robert A. Emmons Randy J. Larsen Sharon Griffin | 1985 | Journal of Personality Assessment1985，，1： | 3 |
| 6 | MATCH试验:氯吡格雷对近期短暂性脑缺血发作或缺血性卒中高危患者动脉粥样硬化的治疗研究显示文摘MATCH(Management of Atherothrombosis with Clopidogel in High—Risk Patients with Recent Transient Ischemic or Ischemic Stroke)试验是针对近期发生短暂性脑缺血发作(TIA)或缺血性卒中患者进行的大规模临床研究,为一项国际性多中心随机双盲对照临床试验。初级目标是评价氯吡格雷与阿司匹林联合应用能否获得更多临床效益以及进一步减少缺血事件(心肌梗死、缺血性卒中、血管性死亡事件及因急性缺血事件再住院)的发生。共有28个国家的507个医疗中心参与了该项研究,共纳入7599例受试者,随访18个月。 | Diener HC Bogousslavsky J Brass LM 王蔚 | 2009 | 中国现代神经疾病杂志2009，9，1： | 3 |
| 7 | MEASURING QUALITY OF LIFE: ECONOMIC, SOCIAL, AND SUBJECTIVE INDICATORS显示文摘 | Ed Diener Eunkook Suh | 1997 | Social Indicators Research1997，，1： | 2 |
| 8 | The wealth of nations revisited: Income and quality of life显示文摘 | ED Diener Carol Diener | 1995 | Social Indicators Research1995，，3： | 2 |
| 9 | 用压力调节喷射的共轨系统显示文摘奥地利AVL公司试验研究了一种可用压力调节的共轨系统,现将该系统的工作原理及对改善发动机排放与燃烧的结果介绍如下。 | Thomas Kammer Diener 胡林峰 | 2001 | 内燃机燃油喷射和控制2001，，1： | 2 |
| 10 | Assessing subjective well-being: Progress and opportunities显示文摘 | Ed Diener | 1994 | Social Indicators Research1994，，2： | 2 |
| 11 | Open arch reconstruction in the endovascular era: Analysis of 721 patients over 17 years显示文摘 | Himanshu J. Patel Christopher Nguyen Amy C. Diener Mary C. Passow Diane Salata G. Michael Deeb | 2011 | The Journal of Thoracic and Cardiovascular Surgery2011，，6： | 2 |
| 12 | PERSONALITY, CULTURE, AND SUBJECTIVE WELL-BEING: Emotional and Cognitive Evaluations of Life显示文摘 | Ed Diener Shigehiro Oishi Richard E. Lucas | 2003 | Annual Review of Psychology2003，，： | 2 |
| 13 | Subjective well-being:three decades of progress显示文摘 | | 1999 | Psychological Bulletin1999，125，2： | 1 |
| 14 | Factors predicting the subjeetive well-being of nations显示文摘 | Diener M Diener C | 1995 | Journal of Personality and Social Psychology1995，69，： | 1 |
| 15 | Subjective Well-Being显示文摘 | | 1984 | Psychological Bulletin1984，95，3： | 1 |
| 16 | New directions in subjective well - being research : The cutting edge 显示文摘 | Diener E Biswas - Diener R | 2000 | Indian Journal of Clincal Psychology2000，，27： | 1 |
| 17 | Subjective well-being显示文摘 | Diener E | 1984 | Psychol Bull1984，95，3： | 1 |
| 18 | Subjective well-being显示文摘 | Diener E | 1984 | Psychological Bulletin1984，95，3： | 1 |
| 19 | Subjective Well--Being显示文摘 | Diener E | 1984 | Psychology Bulletin1984，95，3： | 1 |
| 20 | Subjective well-being显示文摘 | Diener E | 1984 | Psychol1984，95，3： | 1 |
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