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| 1 | Effects of mycophenolate mofetil vs cyclosporine administration on graft survival and function after islet allotransplantation in diabetic rats显示文摘AIM: To develop an experimental model of islet allotransplantation in diabetic rats and to determine the positive or adverse effects of MMF as a single agent. METHODS: Thirty-six male Wistar rats and 18 male Lewis rats were used as recipients and donors respectively. Diabetes was induced by the use of streptozotocin (60 mg/kg) intraperitoneally. Unpurified islets were isolated using the collagenase digestion technique and transplanted into the splenic parenchyma. The recipients were randomly assigned to one of the following three groups: group A (control group) had no immunosuppression; group B received cyclosporine (CsA) (5 mg/kg); group C receivedmycophenolate mofetil (MMF) (20 mg/kg). The animalswere killed on the 12th d. Blood and grafted tissues were obtained for laboratory and histological assessment. RESULTS: Median allograft survival was significantly higher in the two therapy groups than that in the controls (10 and 12 d for CsA and MMF respectively vs 0 d for the control group, P<0.01). No difference in allograft survival between the CsA and MMF groups was found. However,MMF had less renal and hepatic toxicity and allowed weight gain.CONCLUSION: Monotherapy with MMF for immunosu ppression was safe in an experimental model of islet allotransplantation and was equally effective with cyclosporine, with less toxicity. | Constantin Fotiadis Paraskevi Xekouki Apostolos E Papalois PantelisT Antonakis Ioannis Sfiniadakis Dimitrios Flogeras Eleutheria Karampela George Zografos | 2005 | World Journal of Gastroenterology2005，11，18： | 7 |
| 2 | Modifications of the construction and voting mechanisms of the random forests algorithm显示文摘 | EVANTHIA E TRIPOLITI DIMITRIOS I FOTIADIS GEORGE MANIS | 2013 | Data & Knowledge Engineer- ing2013，87，7： | 1 |
| 3 | Guided ultrasound wave propagation in intact and healing long bones显示文摘 | Vasilios C. Protopappas Dimitrios I. Fotiadis Konstantinos N. Malizos | 2006 | Ultrasound in Medicine & Biology2006，，5： | 1 |
| 4 | The structure of the human 4F2hc-LAT1 heteromeric amino acid transporter显示文摘Amino acids are biologically important molecules that serve as energy source, building blocks of proteins, precursors for metabolites and signaling compounds in all living cells.Transport of proteinogenic amino acids and related substances across biological membranes is mediated by membrane embedded proteins:the amino acid transporters. These membrane proteins belong to different solute carrier (SLC)families (http://gffzzbd972c7397f44534hwbx9vnqno0vq6cux.ffgz.tsg.suse.edu.cn) and transfer amino acids in and out between compartments inside cells, between different cells and between organs. Amino acid transporters have diverse important physiological functions and their absence, overexpression and malfunction can lead to human diseases. | Dimitrios Fotiadis Jean-Marc Jeckelmann | 2019 | Science China(Life Sciences)2019，62，6： | 1 |
| 5 | Modifica- tions of the Construction and Voting Mechanisms of the Random Forests Algorithm显示文摘 | Evanthia E Tripohti Dimitrios I Fotiadis George Manis | 2013 | Data and Knowledge Engineering2013，87，9： | 1 |
| 6 | PBOND:Web Server for the Prediction of Proline and Non-Proline cis/trans Isomerization显示文摘PBOND is a web server that predicts the conformation of the peptide bond between any two amino acids. PBOND classifies the peptide bonds into one out of four classes, namely cis imide (cis-Pro), cis amide (cis-nonPro), trans imide (trans-Pro) and trans amide (trans-nonPro). Moreover, for every prediction a reliability index is computed. The underlying structure of the server consists of three stages: (1) feature extraction, (2) feature selection and (3) peptide bond clas- sification. PBOND can handle both single sequences as well as multiple sequences for batch processing. The predictions can either be directly downloaded from the web site or returned via e-mail. The PBOND web server is freely available at http://gffzz70a901033e944207hwbx9vnqno0vq6cux.ffgz.tsg.suse.edu.cn/pbond.html. | Konstantinos P. Exarchos Themis P. Exarchos Costas Papaloukas Anastassios N. Troganis Dimitrios I. Fotiadis | 2009 | Genomics, Proteomics & Bioinformatics2009，7，3： | 0 |
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