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| 1 | Efficacy of prone position in acute respiratory distress syndrome patients: A pathophysiology-based review显示文摘Acute respiratory distress syndrome(ARDS) is a syndrome with heterogeneous underlying pathological processes. It represents a common clinical problem in intensive care unit patients and it is characterized by high mortality. The mainstay of treatment for ARDS is lung protective ventilation with low tidal volumes and positive end-expiratory pressure sufficient for alveolar recruitment. Prone positioning is a supplementary strategy available in managing patients with ARDS. It was first described 40 years ago and it proves to be in alignment with two major ARDS pathophysiological lung models; the 'sponge lung'- and the 'shape matching'-model. Current evidence strongly supports that prone positioning has beneficial effects on gas exchange, respiratory mechanics, lung protection and hemodynamics as it redistributes transpulmonary pressure, stress and strain throughout the lung and unloads the right ventricle. The factors that individually influence the time course of alveolar recruitment and the improvement in oxygenation during prone positioning have not been well characterized. Although patients' response to prone positioning is quite variable and hard to predict, large randomized trials and recent meta-analyses show that prone position in conjunction with a lung-protective strategy, when performed early and in sufficient duration, may improve survival in patients with ARDS. This pathophysiology-based review and recent clinical evidence strongly support the use of prone positioning in the early management of severe ARDS systematically and not as a rescue maneuver or a last-ditch effort. | Vasilios Koulouras Georgios Papathanakos Athanasios Papathanasiou Georgios Nakos | 2016 | World Journal of Critical Care Medicine2016，5，2： | 39 |
| 2 | Helicobacter pylori and colorectal neoplasia:Is there acausal link?显示文摘Ever since Helicobacter pylori(H. pylori) was recognized as an infectious cause of gastric cancer, there has been increasing interest in examining its potential role in colorectal carcinogenesis. Data from casecontrol and cross-sectional studies, mostly relying on hospital-based samples, and several meta-analyses have shown a positive statistical relationship between H. pylori infection and colorectal neoplasia. However, the possibility exists that the results have been influenced by bias, including the improper selection of patients and disparities with respect to potential confounders. While the evidence falls short of a definitive causal link, it appears that infection with H. pylori /H. pylori-related gastritis is associated with an increased, although modest, risk of colorectal adenoma and cancer. The pathogenic mechanisms responsible for this association remain uncertain. H. pylori has been detected in colorectal malignant tissues; however, the possibility that H. pylori is a direct activator of colonic carcinogenesis remains purely hypothetical. On the other hand, experimental data have indicated a series of potential oncogenic interactions between these bacteria and colorectal mucosa, including induction and perpetuation of inflammatory responses, alteration of gut microflora and release of toxins and/or hormonal mediators, such as gastrin, which may contribute to tumor formation. | Vasilios Papastergiou Stylianos Karatapanis Sotirios D Georgopoulos | 2016 | World Journal of Gastroenterology2016，22，2： | 22 |
| 3 | BAS-ADAM:An ADAM Based Approach to Improve the Performance of Beetle Antennae Search Optimizer显示文摘In this paper,we propose enhancements to Beetle Antennae search(BAS)algorithm,called BAS-ADAIVL to smoothen the convergence behavior and avoid trapping in localminima for a highly noin-convex objective function.We achieve this by adaptively adjusting the step-size in each iteration using the adaptive moment estimation(ADAM)update rule.The proposed algorithm also increases the convergence rate in a narrow valley.A key feature of the ADAM update rule is the ability to adjust the step-size for each dimension separately instead of using the same step-size.Since ADAM is traditionally used with gradient-based optimization algorithms,therefore we first propose a gradient estimation model without the need to differentiate the objective function.Resultantly,it demonstrates excellent performance and fast convergence rate in searching for the optimum of noin-convex functions.The efficiency of the proposed algorithm was tested on three different benchmark problems,including the training of a high-dimensional neural network.The performance is compared with particle swarm optimizer(PSO)and the original BAS algorithm. | Ameer Hamza Khan Xinwei Cao Shuai Li Vasilios N.Katsikis Liefa Liao | 2020 | IEEE/CAA Journal of Automatica Sinica2020，7，2： | 20 |
| 4 | Resolution of non-alcoholic steatohepatitis by rosuvastatin monotherapy in patients with metabolic syndrome显示文摘AIM: To investigate the effect of rosuvastatin monotherapy on non-alcoholic steatohepatitis(NASH). At present there is no effective treatment for non-alcoholic fatty liver disease or its advanced form NASH.METHODS: This prospective study included 20 biopsy proven patients with NASH, metabolic syndrome(Met S) and dyslipidaemia. Biochemical parameters of the blood of the patients and an ultrasonography of the liver were performed at baseline. Then patients receivedlifestyle advice and were treated for a 12 mo period with rosuvastatin(10 mg/d) monotherapy. Patients were re-evaluated during the study at 3 mo intervals, during which biochemical parameters of the blood were measured including liver enzymes. A repeat biopsy and ultrasonography of the liver were performed at the end of the study in all 20 patients. Changes in liver enzymes, fasting plasma glucose, serum creatinine, serum uric acid(SUA), high sensitivity C reactive protein(hs CRP) and lipid profile were assessed every 3 mo. The primary endpoint was the resolution of NASH and the secondary endpoints were the changes in liver enzyme and lipid values.RESULTS: The repeat liver biopsy and ultrasonography showed complete resolution of NASH in 19 patients, while the 20 th, which had no improvement but no deterioration either, developed arterial hypertension and substantial rise in triglyceride levels during the study, probably due to changes in lifestyle including alcohol abuse. Serum alanine transaminase, aspartate transaminase, and γ-glutamyl transpeptidase were normalised by the 3rd treatment month(ANOVA P < 0.001), while alkaline phosphatase activities by the 6th treatment month(ANOVA, P = 0.01). Fasting plasma glucose and glycated haemoglobin were significantly reduced(P < 0.001). Lipid values were normalised by the 3rd treatment month. No patient had Met S by the 9th treatment month. Body mass index and waist circumference remained unchanged during the study. Thus, changes in liver pathology and function should be attributed solely to rosuvastatin treatment. A limitation of the study is the absence of a control group.CONCLUSION: These findings suggest that rosuvastatin monotherapy could ameliorate biopsy proven NASH and resolve Met S within 12 mo. These effects and the reduction of fasting plasma glucose and SUA levels may reduce the risk of vascular and liver morbidity and mortality in NASH patients. These findings need confirmation in larger studies. | Konstantinos Kargiotis Vasilios G Athyros Olga Giouleme Niki Katsiki Evangelia Katsiki Panagiotis Anagnostis Chrysoula Boutari Michael Doumas Asterios Karagiannis Dimitri P Mikhailidis | 2015 | World Journal of Gastroenterology2015，21，25： | 18 |
| 5 | Treatment of Helicobacter pylori infection:Meeting the challenge of antimicrobial resistance显示文摘Treatment of Helicobacter pylori(H.pylori)infection is paramount for the management of prevalent gastrointestinal disorders including peptic ulcer disease and gastric cancer.Due to the wide increase in prevalence of H.pylori resistance to antibiotics,clarithromycin-based triple therapies are not any more suitable for unconditional empiric use,and should not be recommended,unless local resistance to this antibiotic is low(<20%).Alternative strategies have been proposed to overcome the issue of increasing clarithromycin resistance,and some of them are already implemented in clinical practice.These comprise:(1)adoption of novel,more effective,empirical treatments:bismuth quadruple,sequential,non-bismuth quadruple(concomitant),dual-concomitant(hybrid),and levofloxacin-based regimens,the latter mainly designated as second-line/rescue options;(2)perspectives for a susceptibility-guided(tailored)therapeutic approach based on culture-free molecular testing methods;and(3)adjunct use of probiotics to improve eradication rates.The present article is aimed to provide a comprehensive overview of current and emerging strategies in the treatment of H.pylori infection,focusing on the challenge of antimicrobial resistance. | Vasilios Papastergiou Sotirios D Georgopoulos Stylianos Karatapanis | 2014 | World Journal of Gastroenterology2014，20，29： | 18 |
| 6 | Type 2 diabetes is associated with a worse functional outcome of ischemic stroke显示文摘AIM: To assess whether ischemic stroke severity and outcome is more adverse in patients with type 2 diabetes mellitus(T2DM). METHODS: Consecutive patients hospitalized for acute ischemic stroke between September 2010 and June 2013 were studied prospectively(n = 482; 40.2% males, age 78.8 ± 6.7 years). T2 DM was defined as self-reported T2 DM or antidiabetic treatment. Stroke severity was evaluated with the National Institutes of Health Stroke Scale(NIHSS) score at admission. The outcome was assessed with the modified Rankin scale(m RS) score at discharge and with in-hospital mortality. Adverse outcome was defined as m RS score at discharge ≥ 2 or in-hospital death. The length of hospitalization was also recorded.RESULTS: T2 DM was present in 32.2% of the study population. Patients with T2 DM had a larger waist circumference, higher serum triglyceride and glucose levels and lower serum high-density lipoprotein cholesterol levels as well as higher prevalence of hypertension, coronary heart disease and congestive heart failure than patients without T2 DM. On the other hand, diabetic patients had lower low-density lipoprotein cholesterol levels and reported smaller consumption of alcohol than non-diabetic patients. At admission, the NIHSS score did not differ between patients with and without T2DM(8.7 ± 8.8 and 8.6 ± 9.2, respectively; P = NS). At discharge, the m RS score also did not differ between the two groups(2.7 ± 2.1 and 2.7 ± 2.2 in patients with and without T2 DM, respectively; P = NS). Rates of adverse outcome were also similar in patients with and without T2DM(62.3% and 58.5%, respectively; P = NS). However, when we adjusted for the differences between patients with T2 DM and those without T2 DM in cardiovascular risk factors, T2 DM was independently associated with adverse outcome [relative risk(RR) = 2.39; 95%CI: 1.21-4.72, P = 0.012]. Inhospital mortality rates did not differ between patients with T2 DM and those without T2DM(9.0% and 9.8%, respectively; P = NS). In multivariate analysis adjusting for the difference in cardiovascular risk factors between the two groups, T2 DM was again not associated with in-hospital death. CONCLUSION: T2 DM does not appear to affect ischemic stroke severity but is independently associated with a worse functional outcome at discharge. | Konstantinos Tziomalos Marianna Spanou Stella D Bouziana Maria Papadopoulou Vasilios Giampatzis Stavroula Kostaki Vasiliki Dourliou Maria Tsopozidi Christos Savopoulos Apostolos I Hatzitolios | 2014 | World Journal of Diabetes2014，5，6： | 15 |
| 7 | Treatment of Helicobacter pylori infection: Past, present and future显示文摘Helicobacter pylori(H. pylori) is a major human patho-gen associated with significant morbidity and mortal-ity. However, after decades of efforts, treatment of H. pylori remains a challenge for physicians, as there is no universally effective regimen. Due to the rising prevalence of antimicrobial resistance, mainly to clar-ithromycin, efficacy of standard triple therapies has declined to unacceptably low levels in most parts of the world. Novel regimens, specifically experimented to improve the therapeutic outcome against antibiotic-resistant H. pylori strains, are now recommended as first-line empirical treatment options providing high ef-ficacy(reportedly > 90% in intention to treat analysis) even in high clarithromycin resistance settings. These include the bismuth quadruple, concomitant, sequential and hybrid therapies. Due to the rapid development of quinolone resistance, levofloxacin-based regimens should be reserved as second-line/rescue options. Adjunct use of probiotics has been proposed in order to boost eradication rates and decrease occurrence of treatment-related side effects. Molecular testing meth-ods are currently available for the characterization of H. pylori therapeutic susceptibility, including genotypic detection of macrolide resistance and evaluation of the cytochrome P450 2C19 status known to affect the me-tabolism of proton pump inhibitors. In the future, use of these techniques may allow for culture-free, non-invasive tailoring of therapy for H. pylori infection. | Vasilios Papastergiou Sotirios D Georgopoulos Stylianos Karatapanis | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，4： | 11 |
| 8 | Low T3 syndrome and long-term mortality in chronic hemodialysis patients显示文摘AIM:To investigate the predictive value of low free T3 for long-term mortality in chronic hemodialysis(HD) patients and explore a possible causative role of chronic inflammation.METHODS:One hundred fourteen HD patients(84 males) consecutively entered the study and were assessed for thyroid function and two established markers of inflammation,high sensitivity C-reactive protein(hs CRP) and interleukin-6(IL-6).Monthly blood samples were obtained from all patients for three consecutive months during the observation period for evaluation of thyroid function and measurement of inflammatory markers.The patients were then divided in two groups based on the cut-off value of 1.8 pg/m L for mean plasma free T3,and were prospectively studied for a mean of 50.3 ± 30.8 mo regarding cumulative survival.The prognostic power of low serum f T3 levels for mortality was assessed using the Kaplan-Meier method and univariate and multivariate regression analysis.RESULTS:Kaplan-Meier survival curve showed a negative predictive power for low free T3.In Cox regression analysis low free T3 remained a significant predictor of mortality after adjustment for age,diabetes mellitus,hypertension,hs CRP,serum creatinine and albumin.Regarding the possible association with inflammation,free T3 was correlated with hs CRP,but not IL-6,and only at the first month of the study.CONCLUSION:In chronic hemodialysis patients,low plasma free T3 is a significant predictor of all-cause mortality.Further studies are required to identify the underlying mechanisms of this association. | Stylianos Fragidis Konstantinos Sombolos Elias Thodis Stylianos Panagoutsos Euthymia Mourvati Maria Pikilidou Aikaterini Papagianni Ploumis Pasadakis Vasilios Vargemezis | 2015 | World Journal of Nephrology2015，4，3： | 9 |
| 9 | Influence of fly ash and sewage sludge application on wheat biomass production,nutrients availability,and soil properties显示文摘The influence of fly ash(FA)applied alone and/or with sewage sludge(SS)on wheat(Triticum vulgare)grain yield,biomass production and soil properties was studied in a field experiment.The results showed that both FA and SS significantly increased grain yield and plant biomass.FA applied alone increased significantly soil pH and EC while FA applied together with SS did not significantly affect them compared to mono FA treatment.Soil pH and EC values increased with time in FA and FA-SS treatments.SS increased soil organic matter and total N content and SS applied together with FA increased also available soil B.From the plant nutrients tested only tissue N concentration was increased significantly in all treatments compared to control.Copper,Zn,Mn,Ni,and Pb at both available and total concentrations are significantly affected. | Christos Tsadilas Vasilios Samaras E.Evangelou Sabry M.Shaheen | 2014 | International Journal of Coal Science & Technology2014，1，2： | 8 |
| 10 | Retinol-binding protein, acute phase reactants and Helicobacter pylori infection in patients with gastric adenocarcinoma显示文摘AIM: To determine the serum levels of c-reactive protein (CRP), transferrin (TRF), a2-macroglobulin (A2M),ceruloplasmin (CER), a1-acid glycoprotein (AAG), prealbumin (P-ALB) and retinol-binding protein (RBP) in gastric carcinoma patients and to explore their possible correlation with underlying Helicobacter pylori (H pylon)infection.METHODS: We measured the serum levels of CRP, TRF,A2M, CER, AAG, P-ALB, and RBP in 153 preoperative patients (93 males; mean age: 63.1±11.3 years) with non-cardia gastric adenocarcinoma and 19 healthy subjects.RESULTS: The levels of CRP, CER, RBP, andAAG in cancer patients were significantly higher than those in healthy controls (P<0.0001), while no difference was found regarding the TRF, P-ALB, and A2M levels. Cancer patients with H pylori infection had significantly lower RBP values compared to non-infected ones (P<0.0001)and also higher values of CRP and AAG (P = 0.09 and P = 0.08, respectively).CONCLUSION: High serum levels of CRP, CER and AAG in cancer patients do not seem to be related to H pylori infection. Retinol-binding protein seems to discriminate between infected and non-infected patients with gastric carcinoma. Further studies are needed to explore if it is directly involved in the pathogenesis of the disease or is merely an epiphenomenon. | Nicolas Tsavaris Christos Kosmas Petros Kopterides Dimitrios Tsikalakis Hlias Skopelitis Fotini Sakelaridi Nikitas Papadoniou Michalis Tzivras Vasilios Balatsos Christos Koufos Athanasios Archimandritis | 2005 | World Journal of Gastroenterology2005，11，45： | 7 |
| 11 | Non-interventional management of resistant hypertension显示文摘Hypertension is one of the most popular fields of re-search in modern medicine due to its high prevalence and its major impact on cardiovascular risk and con-sequently on global health. Indeed, about one third of individuals worldwide has hypertension and is under increased long-term risk of myocardial infarction, stroke or cardiovascular death. On the other hand, resistant hypertension, the 'uncontrollable' part of arterial hy-pertension despite appropriate therapy, comprises a much greater menace since long-standing, high levels of blood pressure along with concomitant debilitating entities such as chronic kidney disease and diabetes mellitus create a prominent high cardiovascular risk milieu. However, despite the alarming consequences, resistant hypertension and its effective management still have not received proper scientific attention. As-pects like the exact prevalence and prognosis are yet tobe clarified. In an effort to manage patients with resis-tant hypertension appropriately, clinical doctors are still racking their brains in order to find the best therapeutic algorithm and surmount the substantial difficulties in controlling this clinical entity. This review aims to shed light on the effective management of resistant hyper-tension and provide practical recommendations for cli-nicians dealing with such patients. | Michael Doumas Costas Tsioufis Charles Faselis Antonios Lazaridis Haris Grassos Vasilios Papademetriou | 2014 | World Journal of Cardiology2014，6，10： | 5 |
| 12 | Potential role of imaging in assessing harmful effects on spermatogenesis in adult testes with varicocele显示文摘Varicocele is characterized by an abnormal dilatation and retrograde blood flow in the spermatic veins. Varicocele is the leading correctable cause of male infertility. Although it is highly prevalent in infertile men, it is also observed in individuals with normal fertility. Determining which men are negatively affected by varicocele would enable clinicians to better select those men who will benefit from treatment. To assess the functional status of the testes in men with varicocele, color Doppler sonographic parameters were evaluated. Testicular arterial blood flow was significantly reduced in men with varicocele, reflecting an impairment of spermatogenesis. An improvement in the testicular blood supply was found after varicocelectomy on spectral Doppler analysis. Testicular contrast harmonic imaging and elastography might improve our knowledge about the influence of varicocele on intratesticular microcirculation and tissue stiffness, respectively, providing possible information on the early damage of testicular structure by varicocele. Magnetic resonance imaging(MRI), with measurement of apparent diffusion coefficient has been used to assess the degree of testicular dysfunction and to evaluate the effectiveness of varicocele repair. Large prospective studies are needed to validate the possible role of functional sonography and MRI in the assessment of early defects of spermatogenesis in testes with varicocele. | Athina C Tsili Olga N Xiropotamou Anastasios Sylakos Vasilios Maliakas Nikolaos Sofikitis Maria I Argyropoulou | 2017 | World Journal of Radiology2017，9，2： | 4 |
| 13 | Water-Lubricated Ni-Based Composite(Ni-Al_2O_3,Ni-SiC and Ni-ZrO_2)Thin Film Coatings for Industrial Applications显示文摘In this work,pure nickel and Ni-based nanocomposite coatings(N1-Al_2O_3,Ni-SiC and Ni-ZrO_2) were produced on steel substrate by using pulse electrodeposition technique.The industrial performance tests were conducted to evaluate the wear resistance,corrosion resistance,adhesion strength and wettability behaviour of newly developed coatings.Rolling contact ball-on-disc tribometer was used to assess anti-wear behaviour of these coatings under waterlubricated contacts.The results showed that the wear- and corrosion resistance properties of nickel alumina and Ni-SiC composite coatings significantly improved than that of pure Ni and Ni-ZrO_2 coatings.The adhesion and wettability results of Ni-Al_2O_3 composite showed better performance when compared to the rest of the coatings.The effects of incorporating nanoparticles on the surface microstructure,interface adhesion and distribution of the particles were also investigated.The coatings were characterized by using scanning electron microscopy,X-ray diffraction analysis and 3D white light interferometry.The wear failure behaviour of these coatings was further examined by post-test surface observation under optical microscope. | Rizwan Sarwar Bajwa Zulfiqar Khan Vasilios Bakolas Wolfgang Braun | 2016 | Acta Metallurgica Sinica(English Letters)2016，29，1： | 4 |
| 14 | Quantum beetle antennae search:a novel technique for the constrained portfolio optimization problem显示文摘In this paper,we have formulated quantum beetle antennae search(QBAS),a meta-heuristic optimization algorithm,and a variant of beetle antennae search(BAS).We apply it to portfolio selection,a well-known finance problem.Quantum computing is gaining immense popularity among the scientific community as it outsmarts the conventional computing in efficiency and speed.All the traditional computing algorithms are not directly compatible with quantum computers,for that we need to formulate their variants using the principles of quantum mechanics.In the portfolio optimization problem,we need to find the set of optimal stock such that it minimizes the risk factor and maximizes the mean-return of the portfolio.To the best of our knowledge,no quantum meta-heuristic algorithm has been applied to address this problem yet.We apply QBAS on real-world stock market data and compare the results with other meta-heuristic optimization algorithms.The results obtained show that the QBAS outperforms swarm algorithms such as the particle swarm optimization(PSO)and the genetic algorithm(GA). | Ameer Tamoor KHAN Xinwei CAO Shuai LI Bin HU Vasilios N.KATSIKIS | 2021 | Science China(Information Sciences)2021，64，5： | 4 |
| 15 | Nonbismuth Quadruple “Concomitant” Therapy Versus Standard Triple Therapy, Both of the Duration of 10 Days, for First-Line H. Pylori Eradication: A Randomized Trial显示文摘 | Sotirios Georgopoulos Vasilios Papastergiou Elias Xirouchakis Foteini Laoudi Philipos Lisgos Charikleia Spiliadi Nikitas Papantoniou Stylianos Karatapanis | 2013 | Journal of Clinical Gastroenterology2013，，3： | 3 |
| 16 | Current status and emerging challenges in the treatment of hepatitis C virus genotypes 4 to 6显示文摘Hepatitis C virus(HCV) genotypes 4, 5 and 6 are mainly present in Africa, the Middle East and Asia and they have been less extensively studied with respect to epidemiology, natural disease history and therapeutic endpoints. Response rates to a 48-wk combined peginterferon/ribavirin treatment range to 40%-69% for HCV 4, 55%-60% for HCV 5 and 60%-90% for HCV 6. Response-guided schedules are recommended to optimize the outcomes of peginterferon/ribavirin treatment in HCV 4 and, in form of preliminarydata, for HCV 6, but no data are yet available to support such an individualization of therapy for HCV 5. Recently, the direct-acting antivirals(DAAs) with pan-genotypic activities simeprevir, sofosbuvir and daclatasvir have been recommended in triple regimens with peginterferon/ribavirin for the treatment of HCV genotypes 4 to 6 infections. In the future, DAA-based interferon-free therapies are awaited to drastically improve treatment outcomes in HCV. However, efforts to improve treatment outcomes with peginterferon/ribavirin should continue, as the HCV 4-6 infected population is mainly based in resource-limited settings with restricted access to the costly DAAs. | Vasilios Papastergiou Stylianos Karatapanis | 2015 | World Journal of Clinical Cases2015，3，3： | 3 |
| 17 | Current options for the treatment of Helicobacter pylori显示文摘 | Sotirios D Georgopoulos Vasilios Papastergiou Stylianos Karatapanis | 2013 | Expert Opinion on Pharmacotherapy2013，，2： | 3 |
| 18 | Evaluation of Corvis ST tonometer with the updated software in glaucoma practice显示文摘AIM: To evaluate the agreement of biomechanically corrected intraocular pressure(b-IOP) and central corneal thickness(CCT) measurements obtained with the updated Corvis ST tonometer versus Goldmann applanation tonometry(GAT) and optical-based corneal pachymetry(OB-CCT) in controls, patients with ocular hypertension(OHT) and primary open angle glaucoma(POAG).Additionally, we examined the differences in corneal deformation parameters provided by the updated Corvis ST among the three groups.METHODS: For each participant, GAT IOP, OB-CCT and measurements with a Corvis ST with updated software were obtained.Bland-Altman analysis was used to assess the agreement between the two measurement methods.RESULTS: A consecutive series of 80 eyes from 80 participants(30 with POAG, 25 with OHT and 25 normal controls) were included in this prospective study.The mean GAT IOP of all eyes was 17.2±3.6 mm Hg, and the mean b-IOP was 15.9±3.7 mm Hg(Spearman’s rho=0.767, P<0.001).The 95% limits of agreement(Lo As) ranged from-3.1 mm Hg to 5.5 mm Hg for GAT IOP and b-IOP.b-IOP was not correlated with OB-CCT(Spearman’s rho=-0.13 P=0.917).Meanwhile there was a weak positive corelation between OB-CCT and GAT IOP–b-IOP difference(Spearman’s rho=0.378, P=0.001).The mean OB-CCT was 549.5±36.4 μm, and the Corvis-CCT was 556.1±41.5 μm(Spearman’s rho=0.900, P<0.001).No statistically significant difference in the new indices provided by the updated Corvis ST was detected among the three groups.Compared with control eyes, POAG eyes had a significantly reduced applanation time 2 after adjusting for OB-CCT and GAT IOP(P=0.048).CONCLUSION: Corvis b-IOP and CCT correlate well with GAT IOP and OB-CCT.b-IOP is not affected by CCT, which might be an advantage, especially in thick or thin corneas.Corvis ST yields shorter applanation time 2 measurements in patients with POAG, which might reflect altered corneal viscoelasticity. | Ioannis Halkiadakis Vasilios Tzimis Alexandros Gryparis Ioannis Markopoulos Vasiliki Konstadinidou Elias Zintzaras Michalis Tzakos | 2022 | International Journal of Ophthalmology(English edition)2022，15，3： | 2 |
| 19 | Nonbismuth Quadruple “Concomitant” Therapy Versus Standard Triple Therapy, Both of the Duration of 10 Days, for First-Line H. Pylori Eradication: A Randomized Trial显示文摘 | Sotirios Georgopoulos Vasilios Papastergiou Elias Xirouchakis Foteini Laoudi Philipos Lisgos Charikleia Spiliadi Nikitas Papantoniou Stylianos Karatapanis | 2013 | Journal of Clinical Gastroenterology2013，，3： | 2 |
| 20 | Low-dose drug combination therapy: An alternative first-line approach to hypertension treatment显示文摘 | L.Michael Prisant Matthew R. Weir Vasilios Papademetriou Michael A. Weber Isaac A. Adegbile Demissie Alemayehu Martin P. Lefkowitz Albert A. Carr | 1995 | American Heart Journal1995，，2： | 2 |
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