|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A new pancreaticojejunostomy technique: A battle against postoperative pancreatic fistula显示文摘AIM:To present a new technique of end-to-side, ductto-mucosa pancreaticojejunostomy with seromuscular jejunal flap formation, and insertion of a silicone stent. METHODS:We present an end-to-side, duct-to-mucosa pancreaticojejunostomy with seromuscular jejunal flap formation, and the insertion of a silicone stent. This technique was performed in thirty-two consecutive patients who underwent a pancreaticoduodenectomy procedure by the same surgical team, from January 2005 to March 2011. The surgical procedure performed in all cases was classic pancreaticoduodenectomy, without preservation of the pylorus. The diagnosis of pancreatic leakage was defined as a drain output of any measurable volume of fluid on or after postoperative day 3 with an amylase concentration greater than three times the serum amylase activity. RESULTS:There were 32 patients who underwent end-to-side, duct-to-mucosa pancreaticojejunostomy with seromuscular jejunal flap formation. Thirteen of them were women and 19 were men. These data correspond to 40.6% and 59.4%, respectively. The mean age was 64.2 years, ranging from 55 to 82 years. The mean operative time was 310.2 ± 40.0 min, and was defined as the time period from the intubation up to the extubation of the patient. Also, the mean time needed to perform the pancreaticojejunostomy was 22.7 min, ranging from 18 to 25 min. Postoperatively, one patient developed a low output pancreatic fistula, three patients developed surgical site infection, and one patient developed pneumonia. The rate of overall morbidity was 15.6%. There was no 30-d postoperative mortality. CONCLUSION:This modification appears to be a significantly safe approach to the pancreaticojejunostomy without adversely affecting operative time. | Stylianos Katsaragakis Andreas Larentzakis Sotirios-Georgios Panousopoulos Konstantinos G Toutouzas Dimitrios Theodorou Spyridon Stergiopoulos Georgios Androulakis | 2013 | World Journal of Gastroenterology2013，19，27： | 12 |
| 2 | Human epidermal growth factor receptor-2 gene amplification in gastric cancer using tissue microarray technology显示文摘AIM:To assess human epidermal growth factor receptor-2 (HER2)-status in gastric cancer and matched lymph node metastases by immunohistochemistry (IHC) and chromogenic in situ hybridization (CISH).METHODS:120 cases of primary gastric carcinomas and 45 matched lymph node metastases from patients with full clinicopathological features were mounted onto multiple-punch and single-punch tissue microarrays,respectively,and examined for HER2 overexpression and gene amplification by IHC and CISH.RESULTS:Twenty-four tumors (20%) expressed HER2 immunohistochemically.An IHC score of ≥ 2+ was observed in 20 tumors (16.6%).HER2 amplification was detected by CISH in 19 tumors (15.8%) and in their matched lymph node metastases.A high concordancerate was found between HER2 positivity (as detected by IHC) and HER2 gene amplification (as detected by CISH),since 19 of the 20 IHC positive cases were amplified (95%).All amplified cases had 2+ or 3+ IHC results.Amplification was associated with intestinal phenotype (P < 0.05).No association with grading,staging or survival was found.CONCLUSION:In gastric cancer,HER2 amplification is the main mechanism for HER2 protein overexpression and is preserved in lymph node metastases. | Dimitrios Tsapralis Ioannis Panayiotides George Peros Theodore Liakakos Eva Karamitopoulou | 2012 | World Journal of Gastroenterology2012，18，2： | 8 |
| 3 | Facing the challenge of venous thromboembolism prevention in patients undergoing major abdominal surgical procedures for gastrointestinal cancer显示文摘Venous thromboembolism(VTE)refers to a hypercoa-gulable state that remains an important and preven-table factor in the surgical treatment of malignancies.VTE includes two identical entities with regards to deep vein thrombosis and pulmonary embolism.The incidence of VTE after major abdominal interventions for gastro-intestinal,hepato-biliary and pancreatic neoplastic disor-ders is as high as 25%without prophylaxis.Prophylactic use of classic or low-molecular-weight heparin,anti-Xa factors,antithrombotic stocking,intermittent pneumatic compression devices and early mobilization have been described.Nevertheless,thromboprophylaxis is often dis-continued after discharge,although a serious risk may persist long after the initial triggering event,as the coagu-lation system remains active for at least 14 d post-opera-tively.The aim of this review is to evaluate the results of the current practice of VTE prevention in cancer patients undergoing major abdominal surgical operations,with special attention to adequately elucidated guidelinesand widely accepted protocols.In addition,the recent literature is presented in order to provide an update on the current concepts concerning the surgical manage-ment of the disease. | Aikaterini Mastoraki Sotiria Mastoraki Dimitrios Schizas Raphael Patras Nikolaos Krinos Ioannis S Papanikolaou Andreas Lazaris Theodore Liakakos Nikolaos Arkadopoulos | 2018 | World Journal of Gastrointestinal Oncology2018，10，10： | 7 |
| 4 | Transanal polypectomy using single incision laparoscopic instruments显示文摘Transanal excision of rectal polyps with laparoscopic instrumentation and a single incision laparoscopic port is a novel technique that uses technology originally developed for abdominal procedures from the natural orifice of the rectum. Transanal endoscopic microsurgery (TEM) is a well established surgical approach for certain benign or early malignant lesions of the rectum, under specific indications. Our technique is a hybrid technique of transanal surgery, a reasonable method for polyp resection without the need of the sophisticated and expensive instrumentation of TEM which can be applied whenever endoscopic or conventional transanal surgical removal is not feasible. | Dimitrios Dardamanis Dimitrios Theodorou George Theodoropoulos Andreas Larentzakis Maria Natoudi Georgia Doulami Christina Zoumpouli Haridimos Markogiannakis Stylianos Katsaragakis George C Zografos | 2011 | World Journal of Gastrointestinal Surgery2011，3，4： | 6 |
| 5 | Role of surgery in colorectal liver metastases:Too early or too late?显示文摘As colorectal cancer and colorectal liver metastases become a serious public health problem,new treatment modalities are needed in order to achieve better results. In the last decade there has been very important progress in oncology,with new and more effective chemotherapeutic agents administered alone or in combination improving the resectability rate in up to 40%of patients with colorectal liver metastases.Advances in interventional radiology,in particular,with the use of portal vein embolization and radiofrequency thermal ablation are new strategies allowing major liver resections and treatment of small liver metastases or early recurrences.Surgery,however,remains the gold standard strategy with intention to treat.In this review article we will describe the advanced role of surgery in the multidisciplinary approach to colorectal liver metastases,and the clinical problems the liver surgeon has to deal with,such as theresectability of the metastases,the presence of bilobar liver lesions and extrahepatic disease,the impact of chemotherapy in already resectable liver metastases,the problem of vanishing metastases after chemotherapy and the dilemma of staged or combined liver and colon operations and which organ first in the clinical scenario of synchronous colorectal liver metastases. | Dimitrios Dimitroulis Nikolaos Nikiteas Theodore Troupis Dimitrios Patsouras Panayiotis Skandalakis Gregory Kouraklis | 2010 | World Journal of Gastroenterology2010，16，28： | 5 |
| 6 | Capsule endoscopy retention as a helpful tool in the management of a young patient with suspected small-bowel disease显示文摘Capsule endoscopy is an easy and painless procedure permitting visualization of the entire small-bowel during its normal peristalsis. However, important problems exist concerning capsule retention in patients at risk of small bowel obstruction. The present report describes a young patient who had recurrent episodes of overt gastrointestinal bleeding of obscure origin, 18 years after small bowel resection in infancy for ileal atresia. Capsule endoscopy was performed, resulting in capsule retention in the distal small bowel. However, this event contributed to patient management by clearly identifying the site of obstruction and can be used to guide surgical intervention, where an anastomotic ulcer is identified. | Chryssostomos Kalantzis Periklis Apostolopoulos Panagiota Mavrogiannis Dimitrios Theodorou Xenophon Papaharalampous Ioannis Bramis Nikolaos Kalantzis | 2007 | World Journal of Gastroenterology2007，13，8： | 5 |
| 7 | Recurrent aggressive mesenteric desmoid tumor successfully treated with sorafenib: A case report and literature review显示文摘BACKGROUND Desmoid tumors(DT) are locally advanced but histologically benign monoclonal neoplasms that can occur from any musculoaponeurotic structure. The aim of this report is to analyze a rare clinical case of an aggressive intra-abdominal DT successfully treated with sorafenib.CASE SUMMARY A 36-year-old man presented with increasing colicky abdominal pain and a selfpalpable mass in his left abdomen. Fourteen years earlier he was diagnosed with a large intra-abdominal tumor, which adhered to the left colonic flexure, part of the major gastric curvature and the spleen. Subsequent exploratory laparotomy revealed a voluminous mass in the epigastrium, arising from the posterior surface of the stomach and invading the superior mesenteric vessels, transverse mesocolon and the small bowel mesentery. As the tumor was unresectable, a jejunojejunal bypass was performed. Traditional therapeutic interventions proved insufficient, and the patient was started on sorafenib with a subsequent fulldisease response.CONCLUSIONDT's pathogenesis has been associated with mutations in the adenomatous polyposis coli(APC) gene or beta-catenin gene CTNNB1, sex steroids or previous surgical trauma. Local treatment modalities, such as surgery or radiotherapy, are implemented in aggressively progressing or symptomatic patients. Sorafenib is a hopeful therapeutic option against DTs, while several pharmacological agents have been successfully used. | Aikaterini Mastoraki Dimitrios Schizas Chrysovalantis Vergadis Leon Naar Alexios Strimpakos Michail G Vailas Natasha Hasemaki George Agrogiannis Theodore Liakakos Nikolaos Arkadopoulos | 2019 | World Journal of Clinical Oncology2019，10，4： | 4 |
| 8 | Virtual endoscopy of the urinary tract显示文摘技术突破推进了诊断成像的时间、空间的决定,并且 3 维(3-D ) 重建技术被介绍了进日常临床的实践。虚拟内视镜检查法(VE ) 是在 3-D 空格放大代表性的图象的感觉的一种非侵略的技术,提供病理学的区域和他们的包围结构的精确空间关系。许多计算机算法能被用来产生 3-D 图象,利用螺线计算了断层摄影术或磁性的回声成像(MRI ) 的在也固有的信息。VE 图象通过空机关启用 endoluminal 航行,因此模仿常规内视镜检查法。几临床的研究验证了虚拟膀胱镜检查的诊断用途,它在膀胱肿瘤的察觉有高敏感和特性率。在肾盂,输尿管和尿道的虚拟探索的出版经验令人鼓舞却仍然少见。VE 是一只保险箱,能与 ureteropelvic 连接阻塞在病人的长期的后续被使用的非侵略的方法,膀胱肿瘤和输尿管或尿道狭窄。它的主要限制是无能为组织病理学说的检查和联系电离放射危险提供活体检视织物标本(除非 MRI 被使用) 。在 endoluminal 狭窄或阻塞的情况中,然而, VE 向头部地允许虚拟 endoluminal 航行并且对小型机关枪的一种尾耳的片断。得出结论, VE 提供评估泌尿道的一个不太侵略的方法,特别为比放射线学者不太熟悉代表性的成像的临床医生。 | George C.Kagadis Dimitrios Siablis Evangelos N.Liatsikos Theodore Petsas George C. Nikiforidis | 2006 | Asian Journal of Andrology2006，8，1： | 4 |
| 9 | VL30 retrotransposition signals activation of a caspaseindependent and p53-dependent death pathway associated with mitochondrial and lysosomal damage显示文摘长终端重复(LTR ) 的影响房间命运上的 retrotransposition 是未知的。这里,我们在转变 SV40 的老鼠 SVTT1 房间在房间死亡上调查了 VL30 retrotransposition 的效果。VL30 retrotransposon 的 Transfection 减少了由 17 褶层的 SVTT1 的 clonogenicity,作为与父母 NIH3T3 房间相比。频率和房间死亡率在 retrotransposition 积极的 SVTT1 被发现的 retrotransposition 的相关层次克隆房间,展出 DNA 破碎,原子冷凝作用, multinucleation 和细胞质的 vacuolization。受动器 caspases 的激活的分析揭示了 caspase 独立的房间死亡机制。然而,房间死亡与感应的 p53 和 Bcl-2 和 Hsp70 蛋白质表示的美洲狮伪和 Bax 和 downregulation 的伴随物 upregulation 被联系。而且,我们发现了大 T 抗原(副)/p53 和 p53 translocation 的 colocalization 的部分损失到线粒体,导致外部膜 permeabilization (MOMP ) 由 lysosomal 膜 permeabilization (LMP ) 伴随了的 mitochondrial。有趣地,有抗氧化剂 N-acetylcysteine 的处理废除了细胞死亡,建议导出 mitochondrial 的反应的氧种类的参与,并且导致了 retrotransposition 频率的增加。重要地,当 VL30 动员被导致,房间死亡的正式就职是 retrotransposon 特定的 VL30;相反, non-LTR L1 的动员(LINE-1,长散布的原子 element-1 ) , B2 和 LTR MusD retrotransposons 减少了。第一次,我们的结果提供 VL30 retrotransposition 调停的充分证据经由 mitochondrial 和 lysosomal 损坏的房间死亡,揭开是的 retrotransposition 的角色在触发房间死亡激活 mitochondrial-lysosomal 串音的一个原子信号。 | Dimitrios Noutsopoulos Georgios Markopoulos Georgios Vartholomatos Evangelos Kolettas Nicolaos Kolaitis Theodore Tzavaras | 2010 | Cell Research2010，20，5： | 3 |
| 10 | LINX^(■) reflux management system to bridge the “treatment gap” in gastroesophageal reflux disease: A systematic review of 35 studies显示文摘BACKGROUND Gastroesophageal reflux disease(GERD) occurs when the reflux of stomach contents causes troublesome symptoms and/or complications. When medical therapy is insufficient, surgical therapy is indicated and, until now, Laparoscopic fundoplication(LF) constitutes the gold-standard method. However, magnetic sphincter augmentation(MSA) using the LINX^® Reflux Management System has recently emerged and disputes the standard therapeutic approach.AIM To investigate the device’s safety and efficacy in resolving GERD symptoms.METHODS This is a systematic review conducted in accordance to the PRISMA guidelines.We searched MEDLINE, Clinicaltrials.gov, EMBASE, Cochrane Central Register of Controlled Trials CENTRAL databases from inception until September 2019.RESULTS Overall, 35 studies with a total number of 2511 MSA patients were included and analyzed. Post-operative proton-pump inhibitor(PPI) cessation rates reached 100%, with less bloating symptoms and a better ability to belch or vomit in comparison to LF. Special patient groups(e.g., bariatric or large hiatal-hernias)had promising results too. The most common postoperative complication was dysphagia ranging between 6% and 83%. Dilation due to dysphagia occurred in 8% of patients with typical inclusion criteria. Esophageal erosion may occur in up to 0.03% of patients. Furthermore, a recent trial indicated MSA as an efficient alternative to double-dose PPIs in moderate-to-severe GERD.CONCLUSION The findings of our review suggest that MSA has the potential to bridge the treatment gap between maxed-out medical treatment and LF. However, further studies with longer follow-up are needed for a better elucidation of these results. | Dimitrios Schizas Aikaterini Mastoraki Eleni Papoutsi Vassilis G Giannakoulis Prodromos Kanavidis Diamantis Tsilimigras Dimitrios Ntourakis Orestis Lyros Theodore Liakakos Dimitrios Moris | 2020 | World Journal of Clinical Cases2020，8，2： | 3 |
| 11 | Management of primary retroperitoneal synovial sarcoma: A case report and review of literature显示文摘BACKGROUND Synovial sarcoma(SS) is a rare type of soft tissue sarcoma that is usually developed from areas where synovial tissue exists, especially at the extremities.Nevertheless, several cases of retroperitoneal SS(RSS) have been described. We herein report a case of RSS presented in our institution.CASE SUMMARY A 69-year-old female patient was admitted with a large, palpable, firm mass in the right abdominal space SS. Computerized tomography scan depicted a concentric, sharply marinated retro-peritoneal lesion which was displacing the right kidney and the lower edge of the liver. Subsequently, the patient underwent surgical excision of the mass with additional right nephrectomy and resection of the right adrenal gland and a part of the diaphragm. The final histological diagnosis of the tumour was grade II monophasic RSS.CONCLUSION RSS is encountered in the biphasic type, the monophasic fibrous, and the monophasic epithelial category as well. Relevant clinical manifestations are not always documented at early stages. Therefore, the final diagnosis is posed after complete histological examination taking into consideration the results of immunochemistry and genetic analysis. Therapeutic approach happens often late when metastases at the lungs and the liver are apparent. Thus, 5-year survival rates remain low. | Aikaterini Mastoraki Dimitrios Schizas Ioannis S Papanikolaou George Bagias Nikolaos Machairas George Agrogiannis Theodore Liakakos Nikolaos Arkadopoulos | 2019 | World Journal of Gastrointestinal Surgery2019，11，1： | 2 |
| 12 | Diagnosis and endoscopic treatment of esophago-bronchial fistula due to gastric heterotopy显示文摘Heterotopic gastric mucosa patches are congenital gastrointestinal abnormalities and have been reported to occur anywhere along the gastrointestinal tract from mouth to anus.Complications of heterotopic gastric mucosa include dysphagia,upper gastrointestinal bleeding,upper esophageal ring stricture,adenocarcinoma and fistula formation.In this case report we describe the diagnosis and treatment of the first case of esophago-bronchial fistula due to heterotopic gastric mucosa in mid esophagus.A 40-year old former professional soccer player was referred to our department for treatment of an esophago-bronchial fistula.Microscopic examination of the biopsies taken from the esophageal fistula revealed the presence of gastric heterotopic mucosa.We decided to do a non-surgical therapeutic endoscopic procedure.A sclerotherapy catheter was inserted through which 1 mL of ready to use synthetic surgical glue was applied in the fistula and it closed the fistula opening with excellent results. | Konstantinos H Katsanos Dimitrios K Christodoulou Sevasti Kamina Kosmidou Maria Evangelia Lambri Stavroula Theodorou Konstantinos Tsampoulas Mitsi Vasiliki Epameinondas V Tsianos | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，4： | 2 |
| 13 | Easyloop knot: a simple and safe extracorporeal knot显示文摘 | MICHAEL PATTAS DIMITRIOS THEODOROU EMMANUEL LAGOUDIANAKIS | 2006 | The American Journal of Surgery2006，191，6： | 1 |
| 14 | Applying robust multibit watermarks to digital images显示文摘 | Dimitrios Tsolis Spiridon Nikolopoulos Lambros Drossos Spyros Sioutas Theodore Papatheodorou | 2008 | Journal of Computational and Applied Mathematics2008，，1： | 1 |
| 15 | Plasma Adiponectin Levels and Five-Year Survival After First-Ever Ischemic Stroke显示文摘 | Stamatis P. Efstathiou Dimitrios I. Tsioulos Aphrodite G. Tsiakou Yannis E. Gratsias Angelos V. Pefanis Theodore D. Mountokalakis | 2005 | Stroke2005，，9： | 1 |
| 16 | Role of platelet-rich plasma in ischemic heart disease: An update on the latest evidence显示文摘Myocardial infarction is the most common cause of congestive heart failure. Novel strategies such as directly reprogramming cardiac fibroblasts into cardiomyocytes are an exciting area of investigation for repair of injured myocardial tissue. The ultimate goal is to rebuild functional myocardium by transplanting exogenous stem cells or by activating native stem cells to induce endogenous repair. Cell-based myocardial restoration, however, has not penetrated broad clinical practice yet. Plateletrich plasma, an autologous fractionation of whole blood containing high concentrations of growth factors, has been shown to safely and effectively enhance healing and angiogenesis primarily by reparative cell signaling. In this review, we collected all recent advances in novel therapies as well as experimental evidence demonstrating the role of platelet-rich plasma in ischemic heart disease, focusing on aspects that might be important for future successful clinical application. | Eleftherios Spartalis Periklis Tomos Demetrios Moris Antonios Athanasiou Charalampos Markakis Michael D Spartalis Theodore Troupis Dimitrios Dimitroulis Despina Perrea | 2015 | World Journal of Cardiology2015，7，10： | 1 |
| 17 | Intracranial aneurysms: reproduction of the surgical view using 3D-CT angiography显示文摘 | Dimitrios Siablis George C. Kagadis Maria T. Karamessini Dimitrios Konstantinou Dimitrios Karnabatidis Theodore Petsas George C. Nikiforidis | 2004 | European Journal of Radiology2004，，1： | 1 |
| 18 | Pancreatic Islet Cell Transplantation: An Update显示文摘 | Dimitrios T. Hatziavramidis Theodore M. Karatzas George P. Chrousos | 2013 | Annals of Biomedical Engineering2013，，3： | 1 |
| 19 | The relationship of Helicobacter pylori infection and colon neoplasia, on the basis of meta-analysis显示文摘 | Theodore Rokkas Panos Sechopoulos Dimitrios Pistiolas Fotis Kothonas Georgios Margantinis Georgios Koukoulis | 2013 | European Journal of Gastroenterology & Hepatology2013，，11： | 1 |
| 20 | Differentiation between patients with acute upper gastrointestinal bleeding who need early urgent upper gastrointestinal endoscopy and those who do not. A prospective study显示文摘 | Adam B Adamopoulos Nikolaos M Baibas Stamatis P Efstathiou Dimitrios I Tsioulos Athanasios G Mitromaras Amalia A Tsami Theodore D Mountokalakis | 2003 | European Journal of Gastroenterology & Hepatology2003，，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员