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| 1 | The relationship of Imp2 and DR3 genes with susceptibility to type Ⅰ diabetes mellitus in south China Han population显示文摘AIN To study the relationship of Imp2 and DR3genes with type Ⅰ diabetes mellitus.NETHODS Imp2 genotypes and DR3 wereidentified in 68 patients with type Ⅰ diabetesmellitus(Ⅰ-DM)and 71 healthy controls.Then,Ⅰ-DM patients and controls were respectivelyallocated into DR3-positive and DR3-negativegroups.The frequencies of Imp2 and DR3 genein random subjects,and Imp2 genotypes in DR3-matched subjects were compared between Ⅰ-DMpatients and controls.At the same time,Ⅰ-DMpatients were divided into 3 groups based on theonset age of diabetics:group A≤14 years,group B 15-30 years and group C≥31 years.RESULTS The frequency of DR3 in Ⅰ-DMpatients was significantly higher than that incontrols(47% vs 21%,P<0.005),and it wassignificantly higher in group A than that in groupB+C(70% vs 36%,x^2=7.07,P<0.01).Therewas a significant difference among groups withdifferent onset age of diabetics(x^2=8.19,rp=0.33,P<0.05).In random subjects,thefrequency of Imp2.R/R in Ⅰ-DM patients waslower(43% vs 61%,P<0.05)and Imp2.R/Hhigher(53% vs 28%,P<0.05)than that incontrols,and there was no significant differenceamong groups with different onset age ofdiabetics.In DR3-positive subjects,thefrequency of Imp2.R/R in Ⅰ-DM patients waslower(47% vs 87%,P<0.05)and Imp2-R/H higher(47% vs 13%,P<0.05)than that incontrols.In DR3-negative subjects,thefrequency of Imp2.R/H in Ⅰ-DM patients washigher than that in controls(58% vs 32%,P<0.01),but the frequency of Imp2-R/R and Imp2H/H was not significantly different betweenthese two groups.CONCLUSION DR3 gene may be one of thesusceptible genes of Ⅰ-DM,and significantlyrelated to the onset age of diabetics,and thepersons with DR3 may have an younger onsetage of diabeteS.The Imp2-R/R may be theprotective genotype of Ⅰ-DM,and Imp2-R/H thesusceptible genotype.These were not affectedby DR3 gene.Imp-2 genotypes were not relatedwith the onset age of diabetics. | Ding HL Cheng H Fu ZZ Deng QL Yan L Yan T | 2000 | World Journal of Gastroenterology2000，6，1： | 7 |
| 2 | Sofosbuvir and ledipasvir fixed-dose combination with and without ribavirin in treatment-naive and previously treated patients with genotype 1 hepatitis C virus infection (LONESTAR): an open-label, randomised, phase 2 trial显示文摘 | Eric Lawitz Fred F Poordad Phillip S Pang Robert H Hyland Xiao Ding Hongmei Mo William T Symonds John G McHutchison Fernando E Membreno | 2013 | The Lancet2013，，： | 5 |
| 3 | Theoretical study of BexZn1-xO alloys显示文摘 | Ding S F Fan G H Li S T | 2007 | Physiea B2007，394，： | 1 |
| 4 | Prevalence of antibody against hepatitis E virus in variousspecies of non-human primates:evidence of widespread infection in Japanese monkeys(Macaca fuscata)显示文摘 | Hirano M Ding X Tran H T | 2003 | Jpn J Infect2003，56，： | 1 |
| 5 | 显示文摘 | Kong H Z Wee A T S Ding J | 2004 | International Journal of Nanoscience2004，3，45： | 1 |
| 6 | The Differential Expres- sion of Hepatic Genes Between Prelaying and Laying Geese显示文摘 | S T Ding C F Yen P H Wang | 2007 | Poultry Science2007，86，： | 1 |
| 7 | Heat transfer characteristics of refrigerant-based nanofluid flow boiling inside a horizontal smooth tube 显示文摘 | PENG H DING G L JIANG W T | 2009 | International Journal of Refrigeration2009，32，6： | 1 |
| 8 | Analysis of nonylphenol polyethoxycarboxylates and their related metabolites by on-line derivatization and ion-trap gas chromatography- mass spectrometry 显示文摘 | DING W H CHEN C T | 1999 | Journal of Chromatography A1999，862，1： | 1 |
| 9 | Leaf-inspired hierarchical porous CdS/Au/N-TiO2 heterostructures for visible light photocatalytic hydrogen evolution显示文摘 | Zhou H Ding L Fan T X | 2014 | Applied Catalysis B-Environmental2014，147，： | 1 |
| 10 | Molecular charac- terization of field azoxystrobin-resistant isolates of Botrytis ci nerea 显示文摘 | Jiang J H Ding L S Michailides T J | 2009 | Pesticide Biochemistry and Physiology2009，93，： | 1 |
| 11 | New families of binary sequences with optimal three-level autocorrelation 显示文摘 | Ding Cunsheng Helleseth T Martinsen H M | 2001 | IEEE Trans Inform Theory2001，47，1： | 1 |
| 12 | Hydrox ylation of phenol catalyzed by copper Keggin-type heteropoly co mpounds with hydrogen peroxide显示文摘 | Zhang H P Zhang X M Ding Y Yah L Ren T Suo J S | 2002 | New J Chem2002，26，： | 1 |
| 13 | The gut microbiota as an environmental factor that regulates fat storage 显示文摘 | Bickhed F Ding H Wang T | 2004 | Proe Nail Acad Sci USA2004，101，15： | 1 |
| 14 | Small-wavelength form error compensation during hydrodynamic polishing显示文摘 | Hung T C Ding C H | 2011 | In- ternational Journal of Machine Tools and Manufacture2011，51，12： | 1 |
| 15 | 查看详情显示文摘 | Yan L W Duan X R Ding X T Dong J Q Yang Q W Liu Y Zou X L Liu D Q Xuan W M Chen L Y Rao J Song X M Huang Y Mao W C Wang Q M Li Q Cao Z Li B Cao J Y Lei G J Zhang J H Li X D Chen W Cheng J Cui C H Cui Z Y Deng Z C Dong Y B Feng B B Gao Q D Han X Y Hong W Y | | 0，，： | 1 |
| 16 | Structure of severe fever with thrombocytopenia syndrome virus nucleocapsid protein in complex with suramin reveals therapeutic potential显示文摘 | Jiao L Y Ouyang S Y Liang M F Niu F F Shaw N Wu W Ding W Jin C Peng Y Zhu Y P Zhang F S Wang T Li C Zuo X B Luan C H Li D X Liu Z J | 2013 | J Virol2013，87，12： | 1 |
| 17 | Chaotic artificial bee colony algo- rithm for system Identification of a small - scale unmanned heli- copter显示文摘 | DING L WU H T YAO Y | 2015 | International Journal of Aerospace Engineering2015，，1956： | 1 |
| 18 | Intelligent worksituation fadt diagnosis and fault-tolerant system for roasting process of shaft furnace显示文摘 | Chai T Y Wu F H Ding J L | 2007 | Journal of Systems and Control Engineering2007，221，6： | 1 |
| 19 | The gut microbiota as an envi-ronmental factor that regulates fat storage显示文摘 | Backhed F Ding H Wang T ci al | 2004 | Proc Natl Acad SciU S A2004，101，15： | 1 |
| 20 | The gut microhiota as an environmental factor that regulates fat storage 显示文摘 | Bfickhed F Ding H Wang T | 2004 | Proc Natl Acad Sci USA2004，101，44： | 1 |
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