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1篇 您的检索式:作者名="Dingdang Yu"
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1TET2 stabilization by 14-3-3 binding to the phosphorylated Serine 99 is deregulated by mutations in cancer显示文摘Dear Editor, The Ten-Eleven Translocation-2 (TET2) gene encodes an enzyme that catalyzes the conversion of 5-methylcytosine (5mC) to 5- hydroxymethylcytosine (5hmC), the key initial step in active DNA demethylation.1,2 TET2 and 5hmC function cooperatively as epigenetic tumor suppressors and are frequently deregulated in cancer.2 We recently reported that TET2 is a bona fide substrate of the AMP-activated kinase (AMPK)Z which phosphorylates TET2 serine 99 (S99) at its non-catalytic N-terminal region.Hao Chen Dingdang Yu Rui Fang Kimberlie Rabidou Di Wu Di Hu Peilin Jia Zhongming Zhao Zhiping Wu Yujiang Geno Shi 2019Cell Research2019,29,3:0
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